Hepatitis resulting from liver-specific expression and recognition of self-antigen

Journal of Autoimmunity

Volumn 31, Issue 3, 2008, Pages 208-215

  Buxbaum, James ^a   Qian, Peiqing ^b   Allen, Paul M ^b   Peters, Marion G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute hepatitis; Antigen specific; Autoimmune hepatitis (AIH); Autoimmunity; Chronic hepatitis

Indexed keywords

OVALBUMIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL SURFACE; CELL TRANSFER; CONTROLLED STUDY; HEPATITIS; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIGENS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HEPATITIS, AUTOIMMUNE; HEPATOCYTES; LIVER; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OVALBUMIN;

EID: 56349136838     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2008.04.015     Document Type: Article

References (25)

1. Pinkert C.A., Ornitz D.M., Brinster R.L., and Palmiter R.D. An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev 1 (1987) 268-276
2. Kurts C., Heath W.R., Carbone F.R., Allison J., Miller J.F., and Kosaka H. Constitutive class I restricted exogenous presentation of self-antigens in vivo. J Exp Med 184 (1996) 923-930
3. + T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J Exp Med 186 (1997) 2057-2062
4. Batts K.P., and Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol 19 (1995) 1409-1417
5. Buxbaum J., Qian P., Khuu C., Shneider B.L., Daikh D.I., Gershwin M.E., et al. Novel model of antigen-specific induction of bile duct injury. Gastroenterology 131 (2006) 1899-1906
6. Mackay I.R., and Gershwin M.E. The nature of autoimmune disease. [Review] [46 refs]. Semin Liver Dis 17 (1997) 3-11
7. Kita H., Mackay I.R., Van De W.J., and Gershwin M.E. The lymphoid liver: considerations on pathways to autoimmune injury. Gastroenterology 120 (2001) 1485-1501
8. Tanaka A., Iwabuchi S., Takatori M., Ohno A., Yamada H., Hashimoto N., et al. Clonotypic analysis of T cells in patients with autoimmune and viral hepatitis. Hepatology 25 (1997) 1070-1076
9. Lohr H.F., Schlaak J.F., Gerken G., Fleischer B., Dienes H.P., and Meyer zum Buschenfelde K.H. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 14 (1994) 161-166
10. Hopf U., Meyer zum Buschenfelde K.H., and Freudenberg J. Liver-specific antigens of different species. II. Localization of a membrane antigen at cell surface of isolated hepatocytes. Clin Exp Immunol 16 (1974) 117-123
11. Peters M.G. Animal models of autoimmune liver disease. Immunol Cell Biol 80 (2002) 113-116
12. Lohse A.W., and Meyer zum Buschenfelde K.H. Remission of experimental autoimmune hepatitis is associated with antigen-specific and non-specific immunosuppression. Clin Exp Immunol 94 (1993) 163-167
13. Ogawa M., Mori Y., Mori T., Ueda S., Yoshida H., Kato I., et al. Adoptive transfer of experimental autoimmune hepatitis in mice-cellular interaction between donor and recipient mice. Clin Exp Immunol 73 (1988) 276-282
14. Araki K., Yamamoto H., and Fujimoto S. Studies on the pathogenesis of murine experimental autoimmune active hepatitis: sensitized T cell involvement in its induction. Clin Exp Immunol 67 (1987) 326-334
15. DeVoss J., Hou Y., Johannes K., Lu W., Liou G.I., Rinn J., et al. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med 203 (2006) 2727-2735
16. Vogel A., Liermann H., Harms A., Strassburg C.P., Manns M.P., and Obermayer-Straub P. Autoimmune regulator AIRE: evidence for genetic differences between autoimmune hepatitis and hepatitis as part of the autoimmune polyglandular syndrome type 1. Hepatology 33 (2001) 1047-1052
17. Jiang W., Anderson M.S., Bronson R., Mathis D., and Benoist C. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 202 (2005) 805-815
18. Guidotti L.G., Matzke B., Schaller H., and Chisari F.V. High-level hepatitis B virus replication in transgenic mice. J Virol 69 (1995) 6158-6169
19. Moriyama T., Guilhot S., Klopchin K., Moss B., Pinkert C.A., Palmiter R.D., et al. Immunobiology and pathogenesis of hepatocellular injury in XX hepatitis B virus transgenic mice. Science 248 (1990) 361-364
20. Ando K., Moriyama T., Guidotti L.G., Wirth S., Schreiber R.D., Schlicht H.J., et al. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J Exp Med 178 (1993) 1541-1554
21. Voehringer D., Blaser C., Grawitz A.B., Chisari F.V., Buerki K., and Pircher H. Break of T cell ignorance to a viral antigen in the liver induces hepatitis. J Immunol 165 (2000) 2415-2422
22. + T cells within the liver. J Immunol 166 (2001) 5430-5438
23. + T lymphocytes but fail to promote survival. Eur J Immunol 28 (1998) 221-236
24. Crispe I.N., Dao T., Klugewitz K., Mehal W.Z., and Metz D.P. The liver as a site of T cell apoptosis: graveyard, or killing field?. Immunol Rev 174 (2000) 47-62
25. + T cells by the normal liver. J Immunol 163 (1999) 3202-3210