Orientation of μ-conotoxin PIIIA in a sodium channel vestibule, based on voltage dependence of its binding

Molecular Pharmacology

Volumn 80, Issue 2, 2011, Pages 219-227

  McArthur, J R ^a,b   Singh, G ^a   O'Mara, M L ^b,c   McMaster, D ^a,b   Ostroumov, V ^a,b   Tieleman, D P ^a   French, Robert J ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLYCINE; LYSINE; MU CONOTOXIN PIIIA; SERINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TOXIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; ELECTRICITY; EXTRACELLULAR MATRIX; GENE MUTATION; MEMBRANE POTENTIAL; MOLECULAR DOCKING; NONHUMAN; POISSON DISTRIBUTION; PRIORITY JOURNAL; REDUCTION; STATIC ELECTRICITY; VESTIBULE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CONOTOXINS; ION CHANNEL GATING; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RATS; SARCOLEMMA; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 79960264030     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.071779     Document Type: Article

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