DCDC2, KIAA0319 and CMIP are associated with reading-related traits

Biological Psychiatry

Volumn 70, Issue 3, 2011, Pages 237-245

  Scerri, Tom S ^a   Morris, Andrew P ^a   Buckingham, Lyn Louise ^a   Newbury, Dianne F ^a   Miller, Laura L ^b   Monaco, Anthony P ^a   Bishop, Dorothy V M ^c   Paracchini, Silvia ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

ALSPAC; association study; dyslexia; language; reading abilities; specific language impairment (SLI)

Indexed keywords

ARTICLE; ATP2C2 GENE; CHILD; CMIP GENE; COGNITION; COGNITIVE DEFECT; COMORBIDITY; DCDC2 GENE; DYSLEXIA; GENE; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; KIAA0319 GENE; LANGUAGE DISABILITY; MAJOR CLINICAL STUDY; MRPL19 GENE; PHENOTYPE; PRIORITY JOURNAL; READING; SPELLING; UNITED KINGDOM;

ADOLESCENT; CARRIER PROTEINS; CASE-CONTROL STUDIES; COGNITION; COMORBIDITY; DYSLEXIA; ENGLAND; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; LANGUAGE; LANGUAGE DISORDERS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; PREVALENCE; READING;

EID: 79960220393     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.02.005     Document Type: Article

References (75)

1. B.F. Pennington, and D.V. Bishop Relations among speech, language, and reading disorders Annu Rev Psychol 60 2009 283 306
2. J.G. Barry, I. Yasin, and D.V. Bishop Heritable risk factors associated with language impairments Genes Brain Behav 6 2007 66 76 (Pubitemid 46090334)
3. S.E. Fisher, and J.C. DeFries Developmental dyslexia: Genetic dissection of a complex cognitive trait Nat Rev Neurosci 3 2002 767 780 (Pubitemid 135706688)
4. M. Snowling, D.V. Bishop, and S.E. Stothard Is preschool language impairment a risk factor for dyslexia in adolescence? J Child Psychol Psychiatry 41 2000 587 600 (Pubitemid 30461899)
5. G.M. McArthur, J.H. Hogben, V.T. Edwards, S.M. Heath, and E.D. Mengler On the "specifics" of specific reading disability and specific language impairment J Child Psychol Psychiatry 41 2000 869 874
6. L. Burd, M.G. Klug, M.J. Coumbe, and J. Kerbeshian Children and adolescents with attention deficit-hyperactivity disorder: 1 Prevalence and cost of care J Child Neurol 18 2003 555 561 (Pubitemid 37098632)
7. B.F. Pennington From single to multiple deficit models of developmental disorders Cognition 101 2006 385 413 (Pubitemid 44233557)
8. J.H. Beitchman, R. Nair, M. Clegg, B. Ferguson, and P.G. Patel Prevalence of Psychiatric Disorders in Children with Speech and Language Disorders J Am Academy Child Psychiatry 25 1986 528 535 (Pubitemid 16089399)
9. T.S. Scerri, and G. Schulte-Korne Genetics of developmental dyslexia Eur Child Adolesc Psychiatry 19 2010 179 197
10. D.F. Newbury, S.E. Fisher, and A.P. Monaco Recent advances in the genetics of language impairment Genome Med 2 2010 6
11. S. Paracchini, T. Scerri, and A.P. Monaco The genetic lexicon of dyslexia Annu Rev Genomics Hum Genet 8 2007 57 79
12. K. Hannula-Jouppi, N. Kaminen-Ahola, M. Taipale, R. Eklund, J. Nopola-Hemmi, H. Kaariainen, and J. Kere The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia PLoS Genet 1 2005 e50
13. M. Taipale, N. Kaminen, J. Nopola-Hemmi, T. Haltia, B. Myllyluoma, and H. Lyytinen A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain Proc Natl Acad Sci U S A 100 2003 11553 11558 (Pubitemid 37205974)
14. Z. Brkanac, N.H. Chapman, M.M. Matsushita, L. Chun, K. Nielsen, and E. Cochrane Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia Am J Med Genet B Neuropsychiatr Genet 144B 2007 556 560 (Pubitemid 46983168)
15. F. Dahdouh, H. Anthoni, I. Tapia-Paez, M. Peyrard-Janvid, G. Schulte-Korne, and A. Warnke Further evidence for DYX1C1 as a susceptibility factor for dyslexia Psychiatr Genet 19 2009 59 63
16. T.S. Scerri, S.E. Fisher, C. Francks, I.L. MacPhie, S. Paracchini, and A.J. Richardson Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK J Med Genet 41 2004 853 857 (Pubitemid 39524313)
17. K.G. Wigg, J.M. Couto, Y. Feng, B. Anderson, T.D. Cate-Carter, and F. Macciardi Support for EKN1 as the susceptibility locus for dyslexia on 15q21 Mol Psychiatry 9 2004 1111 1121 (Pubitemid 40065456)
18. C. Marino, A. Citterio, R. Giorda, A. Facoetti, G. Menozzi, and L. Vanzin Association of short-term memory with a variant within DYX1C1 in developmental dyslexia Genes Brain Behav 6 2007 640 646 (Pubitemid 47476184)
19. N.A. Cope, G. Hill, M. van den Bree, D. Harold, V. Moskvina, and E.K. Green No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia Mol Psychiatry 10 2005 237 238 (Pubitemid 40432677)
20. G. Bellini, C. Bravaccio, F. Calamoneri, M. Donatella Cocuzza, P. Fiorillo, and A. Gagliano No evidence for association between dyslexia and DYX1C1 functional variants in a group of children and adolescents from southern Italy J Mol Neurosci 27 2005 311 314 (Pubitemid 41572678)
21. H. Meng, K. Hager, M. Held, G.P. Page, R.K. Olson, and B.F. Pennington TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort Hum Genet 118 2005 87 90
22. S. Paracchini, Q.W. Ang, F.J. Stanley, A.P. Monaco, C.E. Pennell, and A.J. Whitehouse Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population Genes Brain Behav 10 2011 158 165
23. D. Harold, S. Paracchini, T. Scerri, M. Dennis, N. Cope, and G. Hill Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia Mol Psychiatry 11 2006 1085 1091 1061 (Pubitemid 44863433)
24. N. Cope, D. Harold, G. Hill, V. Moskvina, J. Stevenson, and P. Holmans Strong evidence that KIAA0319 on chromosome 6p Is a Susceptibility Gene for Developmental Dyslexia Am J Hum Genet 76 2005 581 591 (Pubitemid 40432166)
25. K.E. Deffenbacher, J.B. Kenyon, D.M. Hoover, R.K. Olson, B.F. Pennington, J.C. DeFries, and S.D. Smith Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: Linkage and association analyses Hum Genet 115 2004 128 138 (Pubitemid 39010927)
26. C. Francks, S. Paracchini, S.D. Smith, A.J. Richardson, T.S. Scerri, and L.R. Cardon A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States Am J Hum Genet 75 2004 1046 1058 (Pubitemid 39532073)
27. D.E. Kaplan, J. Gayan, J. Ahn, T.W. Won, D. Pauls, and R.K. Olson Evidence for linkage and association with reading disability on 6p21.3-22 Am J Hum Genet 70 2002 1287 1298 (Pubitemid 34450578)
28. S. Paracchini, A. Thomas, S. Castro, C. Lai, M. Paramasivam, and Y. Wang The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration Hum Mol Genet 15 2006 1659 1666 (Pubitemid 43904832)
29. M.Y. Dennis, S. Paracchini, T.S. Scerri, L. Prokunina-Olsson, J.C. Knight, and R. Wade-Martins A common variant associated with dyslexia reduces expression of the KIAA0319 gene PLoS Genet 5 2009 e1000436
30. H. Meng, S.D. Smith, K. Hager, M. Held, J. Liu, and R.K. Olson DCDC2 is associated with reading disability and modulates neuronal development in the brain Proceedings of the Natl Academy Sci U S A 102 2005 17053 17058 (Pubitemid 41692682)
31. J. Schumacher, H. Anthoni, F. Dahdouh, I.R. Konig, A.M. Hillmer, and N. Kluck Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia Am J Hum Genet 78 2006 52 62 (Pubitemid 41833159)
32. A. Wilcke, J. Weissfuss, H. Kirsten, G. Wolfram, J. Boltze, and P. Ahnert The role of gene DCDC2 in German dyslexics Ann Dyslexia 59 2009 1 11
33. K.U. Ludwig, J. Schumacher, G. Schulte-Korne, I.R. Konig, A. Warnke, and E. Plume Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample Psychiatr Genet 18 2008 310 312
34. D. Czamara, J. Bruder, J. Becker, J. Bartling, P. Hoffmann, and K.U. Ludwig Association of a rare variant with mismatch negativity in a region between KIAA0319 and DCDC2 in dyslexia Behav Genet 41 2011 110 119
35. H. Anthoni, M. Zucchelli, H. Matsson, B. Muller-Myhsok, I. Fransson, and J. Schumacher A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia Hum Mol Genet 16 2007 667 677 (Pubitemid 46585666)
36. D.F. Newbury, L. Winchester, L. Addis, S. Paracchini, L.L. Buckingham, and A. Clark CMIP and ATP2C2 modulate phonological short-term memory in language impairment Am J Hum Genet 85 2009 264 272
37. SLI Consortium (SLIC) Highly significant linkage to the SLI1 locus in an expanded sample of individuals affected by specific language impairment Am J Hum Genet 74 2004 1225 1238
38. J. Golding, M. Pembrey, and R. Jones ALSPACThe Avon Longitudinal Study of Parents and Children I. Study methodology Paediatr Perinat Epidemiol 15 2001 74 87 (Pubitemid 32155760)
39. S.C. Vernes, D.F. Newbury, B.S. Abrahams, L. Winchester, J. Nicod, and M. Groszer A functional genetic link between distinct developmental language disorders N Engl J Med 359 2008 2337 2345
40. C.S. Lai, S.E. Fisher, J.A. Hurst, F. Vargha-Khadem, and A.P. Monaco A forkhead-domain gene is mutated in a severe speech and language disorder Nature 413 2001 519 523 (Pubitemid 32938749)
41. S. Paracchini, C.D. Steer, L.L. Buckingham, A.P. Morris, S. Ring, and T. Scerri Association of the KIAA0319 dyslexia susceptibility gene with reading skills in the general population Am J Psychiatry 165 2008 1576 1584
42. M. Luciano, P.A. Lind, D.L. Duffy, A. Castles, M.J. Wright, and G.W. Montgomery A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability Biol Psychiatry 62 2007 811 817 (Pubitemid 47374651)
43. P.A. Lind, M. Luciano, M.J. Wright, G.W. Montgomery, N.G. Martin, and T.C. Bates Dyslexia and DCDC2: Normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample Eur J Hum Genet 18 2010 668 673
44. T.C. Bates, P.A. Lind, M. Luciano, G.W. Montgomery, N.G. Martin, and M.J. Wright Dyslexia and DYX1C1: Deficits in reading and spelling associated with a missense mutation Mol Psychiatry 15 2009 1190 1196
45. S.E. Shaywitz Dyslexia N Engl J Med 338 1998 307 312 (Pubitemid 28065336)
46. D.V. Bishop, T. North, and C. Donlan Nonword repetition as a behavioural marker for inherited language impairment: Evidence from a twin study J Child Psychol Psychiatry 37 1996 391 403 (Pubitemid 26146032)
47. D.V. Bishop, G. Laws, C. Adams, and C.F. Norbury High heritability of speech and language impairments in 6-year-old twins demonstrated using parent and teacher report Behav Genet 36 2006 173 184 (Pubitemid 43673560)
48. D.V. Bishop, and M.E. Hayiou-Thomas Heritability of specific language impairment depends on diagnostic criteria Genes Brain Behav 7 2008 365 372 (Pubitemid 351490241)
49. D.V. Bishop, and D. McDonald Identifying language impairment in children: Combining language test scores with parental report Int J Lang Commun Disord 44 2009 600 615
50. D.V. Bishop, and M.J. Snowling Developmental dyslexia and specific language impairment: Same or different? Psychol Bull 130 2004 858 886 (Pubitemid 39508392)
51. M.L. Rice, S.D. Smith, and J. Gayan Convergent genetic linkage and associations to language, speech and reading measures in families of probands with specific language Impairment J Neurodev Disord 1 2009 264 282
52. D.F. Newbury, S. Paracchini, T.S. Scerri, L. Winchester, L. Addis, and J. Walter Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects Behav Genet 41 2011 90 104
53. C. Marino, S. Mascheretti, V. Riva, F. Cattaneo, C. Rigoletto, and M. Rusconi Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia Behav Genet 41 2011 67 76
54. E.G. Willcutt, B.F. Pennington, S.D. Smith, L.R. Cardon, J. Gayan, and V.S. Knopik Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder Am J Med Genet 114 2002 260 268 (Pubitemid 34258848)
55. J.M. Couto, L. Gomez, K. Wigg, A. Ickowicz, T. Pathare, and M. Malone Association of attention-deficit/hyperactivity disorder with a candidate region for reading disabilities on chromosome 6p Biol Psychiatry 66 2009 368 375
56. K.P. Lesch, N. Timmesfeld, T.J. Renner, R. Halperin, C. Roser, and T.T. Nguyen Molecular genetics of adult ADHD: Converging evidence from genome-wide association and extended pedigree linkage studies J Neural Transm 115 2008 1573 1585
57. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, and D. Bender PLINK: A tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 2007 559 575 (Pubitemid 47330214)
58. M.J. Snowling, V. Muter, and J. Carroll Children at family risk of dyslexia: A follow-up in early adolescence J Child Psychol Psychiatry 48 2007 609 618 (Pubitemid 46902331)
59. G. Polanczyk, M.S. de Lima, B.L. Horta, J. Biederman, and L.A. Rohde The worldwide prevalence of ADHD: A systematic review and metaregression analysis Am J Psychiatry 164 2007 942 948 (Pubitemid 46972911)
60. D. Wolke, A. Waylen, M. Samara, C. Steer, R. Goodman, T. Ford, and K. Lamberts Selective drop-out in longitudinal studies and non-biased prediction of behaviour disorders Br J Psychiatry 195 2009 249 256
61. D.V. Bishop Genetic influences on language impairment and literacy problems in children: Same or different? J Child Psychol Psychiatry 42 2001 189 198 (Pubitemid 32233119)
62. I.L. Zimmerman, V.G. Steiner, and R.E. Pond Preschool Language Scale3 1992 Psychological Corporation San Antonio, TX
63. W.E.H. Semel Em, and W. Secord Clinical Evaluation of Language FundamentalsRevised 1992 Psychological Corporation San Antonio, TX
64. A.M. Galaburda, J. LoTurco, F. Ramus, R.H. Fitch, and G.D. Rosen From genes to behavior in developmental dyslexia Nat Neurosci 9 2006 1213 1217 (Pubitemid 44462637)
65. M.F. McManus, and J.A. Golden Neuronal migration in developmental disorders J Child Neurol 20 2005 280 286 (Pubitemid 40766984)
66. A.M. Galaburda, G.F. Sherman, G.D. Rosen, F. Aboitiz, and N. Geschwind Developmental dyslexia: Four consecutive patients with cortical anomalies Ann Neurol 18 1985 222 233 (Pubitemid 15004894)
67. J. Rust, S. Golombok, and G. Trickey WORD: Wechsler Objective Reading Dimensional Manual 1993 Psychological Corporation Sidcup, UK
68. T. Nunes, P. Bryant, and J. Olsson Learning morphological and phonological spelling rules: An intervention study Sci Stud Reading 7 2003 298 307
69. J. Rosner, and D.P. Simon The auditory analysis test: An initial report J Learn Disabilities 4 1971 40 48
70. R. Case, D.M. Kurland, and J. Goldberg Operational efficiency and the growth of short-term memory span J Exp Child Psychol 33 1982 386 404
71. J. Rust WOLD Wechsler Objective Language Dimensions Manual 1996 Psychological Corporation London UK
72. S.E. Gathercole, C.S. Willis, A.D. Baddeley, and H. Emslie The Children's Test of Nonword Repetition: A test of phonological working memory Memory 2 1994 103 127
73. D.V. Bishop Development of the Children's Communication Checklist CCC: A method for assessing qualitative aspects of communicative impairment in children J Child Psychol Psychiatry 39 1998 879 891 (Pubitemid 28423260)
74. R. Goodman, T. Ford, H. Richards, R. Gatward, and H. Meltzer The development and well-being assessment: Description and initial validation of an integrated assessment of child and adolescent psychopathology J Child Psychol Psychiatry 41 2000 645 655 (Pubitemid 30461904)
75. D. Wechsler, S. Golombok, and J. Rust WISC-IIIUK: Wechsler Intelligence Scale for Children 1992 Psycological Corporation Sidcup, UK