Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 114, Issue 3, 2002, Pages 260-268

  Willcutt, Erik G ^a   Pennington, Bruce F ^b   Smith, Shelley D ^c   Cardon, Lon R ^d   Gayn, Javier ^d   Knopik, Valerie S ^e   Olson, Richard K ^a   Defries, John C ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF DENVER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ADMD; Comorbidity; Linkage; QTL; Reading disability

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CHILDHOOD DISEASE; CHROMOSOME 6P; COMORBIDITY; DATA ANALYSIS; DYSLEXIA; FEMALE; GENE LOCUS; GENE REPLICATION; GENETIC LINKAGE; GENETIC SELECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SCHOOL CHILD; SIBLING;

ANALYSIS OF VARIANCE; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHROMOSOMES, HUMAN, PAIR 6; DYSLEXIA; FAMILY HEALTH; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); MICROSATELLITE REPEATS; NUCLEAR FAMILY; QUANTITATIVE TRAIT, HERITABLE; TWINS, DIZYGOTIC;

EID: 0037041301     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.10205     Document Type: Article

References (82)

1. Extent and distribution of linkage disequilibrium in three genomic regions
2. Association of DSM-IV attention deficit hyperactivity disorder and monoamine pathway genes
3. Comorbidity of ADHD and reading disability among clinic referred children
4. Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit/hyperactivity disorder
5. Linkage study of catechol-O-methyltransferase and attention-deficit hyperactivity disorder
6. Family-genetic and psychosocial risk factors in DSM-III attention deficit disorder
7. Reading performance and general cognitive ability: A multivariate genetic analysis of twin data
8. The power of interval mapping of quantitative trait loci, using selected sib pairs
9. Association study designs for complex diseases
10. Quantitative trait locus for reading disability on chromosome 6
11. Quantitative trait locus for reading disability: A correction
12. Comorbidity in child psychopathology: Concepts, issues and research strategies
13. Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: Genetic and brain morphometric analyses
14. Association of attention deficit disorder and the dopamine transporter gene
15. Mapping susceptibility loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH, and DRD5 to affected children
16. Colorado reading project
17. Multiple regression analysis of twin data
18. Multiple regression analysis of twin data: Etiology of deviant scores versus individual differences
19. Genetics of specific reading disability
20. Open-field behavior in mice: Evidence for a major gene effect mediated by the visual system
21. Colorado learning disabilities research center
22. A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data
23. Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia twin study of adolescent behavioral development
24. Haplotype relative risk study of catachol-O-methyltransferase and attention deficit hyperactivity disorder (ADHD): Association of the high enzyme activity Val allele with ADHD impulsive - Hyperactive type
25. A new gene (DYX3) for dyslexia is located on chromosome 2
26. Evidence for the independent familial transmission of attention deficit hyperactivity disorder and learning disabilities: Results from a family genetic study
27. Dopamine D4 gene 7-repeat allele and attention-deficit hyperactivity disorder
28. Validity of DSM-IV subtypes of attention-deficit/hyperactivity disorder: A family study perspective
29. Attention deficit and reading achievement
30. A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia
31. A genome-wide screen for quantitative trait loci involved in developmental dyslexia in a large sample of sib pairs from the UK
32. The genetic basis of cognition
33. Multiple regression analysis of sib-pair data on reading to detect quantitative trait loci
34. Quantitative trait locus for specific language and reading deficits on chromosome 6p
35. Attention deficit disorder in reading disabled twins: Evidence for a genetic etiology
36. Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample
37. Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15
38. The chromosome 6p influences on different dyslexia-related cognitive processes: Further confirmation
39. Multipoint linkage analysis. A cautionary note
40. Development of a structured psychiatric interview for children: Agreement between child and parent on individual symptoms
41. A simple method for automated allele binning in microsatellite markers
42. Initial sequencing and analysis of the human genome
43. Complete multipoint sib pair analysis of qualitative and quantitative traits
44. DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents
45. Family-based tests of association in the presence of linkage
46. Attention-deficit hyperactivity disorder: A category or a continuum? A genetic analysis of a large-scale twin study
47. Reading disability and hyperactivity disorder: Evidence for a common genetic etiology
48. Systematic detection of errors in genetic linkage data
49. Another view of the "right" statistical measure of twin concordance
50. When assessing twin concordance, use the probandwise and not the pairwise rate
51. Complete sequence and gene map of a human major histocompatibility complex
52. Genetic effects on ADHD symptomatology in 7- to 13-year-old twins: Results from a telephone survey
53. Models of comorbidity for multifactorial disorders
54. Neuropsychological correlates of childhood attention-deficit/hyperactivity disorder: Explainable by comorbid disruptive behavior or reading problems?
55. Specific deficits in component reading and language skills: Genetic and environmental influences
56. Genes, environment, and the development of orthographic skills
57. Contrasting cognitive deficits in attention deficit hyperactivity disorder versus reading disability
58. Absence of significant linkage between phonological coding dyslexia and chromosome 6p23-21.3, as determined by use of quantitative-trait methods: Confirmation of qualitative analyses
59. Suggestive linkage of developmental dyslexia to chromosome 1p34-p36
60. Attention deficit hyperactivity disorder and executive dysfunction
61. Replication of linkage studies of complex traits: An examination of variation in location estimates
62. A comparison of behavioral and attentional functioning in children diagnosed as hyperactive or learning-disabled
63. Comorbidity: Meanings and mechanisms
64. Comorbidity between ADDH and learning disability: A review and report in a clinically referred sample
65. Specific reading disability: Identification of an inherited form through linkage analysis
66. Screening for multiple genes influencing dyslexia
67. Evidence for a genetic etiology in hyperactivity in children
68. Hyperactivity and spelling disability: Testing for shared genetic aetiology
69. Childhood hyperactivity scores are highly heritable and show sibling competition effects: Twin study evidence
70. QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice
71. Stability of genetic and environmental influences on reading performance at 7 and 12 years of age in the Colorado Adoption Project
72. Differential genetic etiology of reading disability as a function of IQ
73. Reliability, validity, and parent-child agreement studies of the diagnostic interview for children and adolescents (DICA)
74. Comorbidity of reading disability and attention-deficit/hyperactivity disorder: Differences by gender and subtype
75. Etiology of inattention and hyperactivity/impulsivity in a community sample of twins with learning difficulties
76. A twin study of the etiology of comorbidity between reading disability and attention-deficit/hyperactivity disorder
77. Validity of the DSM-IV subtypes of ADHD
78. A comparison of the cognitive deficits in reading disability and attention-deficit/hyperactivity disorder