Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample

Psychiatric Genetics

Volumn 18, Issue 6, 2008, Pages 310-312

  Ludwig, Kerstin U ^a   Schumacher, Johannes ^a   Schulte Körne, Gerd ^b   König, Inke R ^d   Warnke, Andreas ^e   Plume, Ellen ^e   Anthoni, Heidi ^g   Peyrard Janvid, Myriam ^g   Meng, Haiying ^h   Ziegler, Andreas ^d   Remschmidt, Helmut ^f   Kere, Juha ^g   Gruen, Jeffrey R ^h   Müller Myhsok, Bertram ^c   Nöthen, Markus M ^a   Hoffmann, Per ^a  

^a UNIVERSITY OF BONN   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f PHILIPPS UNIVERSITY MARBURG   (Germany)

^g KAROLINSKA INSTITUTE   (Sweden)

^h YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Doublecortin domain; Dyslexia susceptibility 2; Genetic association; Reading; Spelling

Indexed keywords

DOUBLECORTIN;

ARTICLE; CHROMOSOME 6P; DCDC 2 GENE; DNA POLYMORPHISM; DYSLEXIA; GENE; GENE DELETION; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; HUMAN; LEARNING DISORDER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SHORT TANDEM REPEAT;

CHROMOSOMES, HUMAN, PAIR 6; DYSLEXIA; GENE DELETION; GERMANY; HUMANS; INTRONS; LINKAGE DISEQUILIBRIUM; MICROSATELLITE REPEATS; MICROTUBULE-ASSOCIATED PROTEINS; POLYMORPHISM, GENETIC;

EID: 57149129848     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/YPG.0b013e3283063a78     Document Type: Article

References (9)

1. Cope N, Harold D, Hill G, Moskvina V, Stevenson J, Holmans P, et al. (2005). Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. Am J Hum Genet 76:581-591.
2. Deffenbacher KE, Kenyon JB, Hoover DM, Olson RK, Pennington BF, Defries JC, Smith SD (2004). Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses. Hum Genet 115:128-138.
3. Francks C, Paracchini S, Smith SD, Richardson AJ, Scerri TS, Cardon LR, et al. (2004). A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Am J Hum Genet 75:1046-1058.
4. Katusic SK, Colligan RC, Barbaresi WJ, Schaid DJ, Jacobsen SJ (2001). Incidence of reading disability in a population-based birth cohort, 1976-1982, Rochester, Minn. Mayo Clin Proc 76:1081-1092.
5. Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, et al. (2005). DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proc Natl Acad Sci U S A 102:17053-17058.
6. Schulte-Körne G, Deimel W, Müller K, Gutenbrunner C, Remschmidt H (1996). Familial aggregation of spelling disability. J Child Psychol Psychiatry 37:817-822.
7. Schumacher J, Anthoni H, Dahdouh F, König IR, Hillmer AM, Kluck N, et al. (2006). Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Am J Hum Genet 78:52-62.
8. Schumacher J, Hoffmann P, Schmael C, Schulte-Köme G, Nöthen MM (2007). Genetics of dyslexia: the evolving landscape. J Med Genet 44:289-297.
9. Shaywitz SE, Shaywitz BA, Fletcher JM, Escobar MD (1990). Prevalence of reading - disability in boys and girls - results of the Connecticut longitudinal study. JAMA 264:998-1002.