Concerted action of exonuclease and gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG) n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragments

Journal of Biological Chemistry

Volumn 282, Issue 6, 2007, Pages 3465-3477

  Singh, Purnima ^a   Zheng, Li ^a   Chavez, Valerie ^a   Qiu, Junzhuan ^a   Shen, Binghui ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE ACTIVITIES; TRINUCLEOTIDE REPEAT (TNR); TRIPLET REPEAT SEQUENCES;

DNA; GENES; GENETIC ALGORITHMS; YEAST;

BIOMEDICAL ENGINEERING;

ENDONUCLEASE; EXONUCLEASE; FLAP ENDONUCLEASE; OKAZAKI FRAGMENT; TRINUCLEOTIDE; ALANINE; DNA; EXODEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE I; FUNGAL DNA; GLUTAMIC ACID; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HETERODUPLEX; OKAZAKI FRAGMENTS; RAD27 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME STRUCTURE; IN VIVO STUDY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRINUCLEOTIDE REPEAT; YEAST; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

ALANINE; DNA; DNA, FUNGAL; EXODEOXYRIBONUCLEASES; FLAP ENDONUCLEASES; GLUTAMIC ACID; GTPASE-ACTIVATING PROTEINS; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; TRINUCLEOTIDE REPEATS;

EID: 33947528624     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606582200     Document Type: Article

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