Two modes of FEN1 binding to PCNA regulated by DNA

EMBO Journal

Volumn 19, Issue 14, 2000, Pages 3811-3821

  Gomes, Xavier V ^a   Burgers, Peter M J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA replication; FEN 1; PCNA; RAD27

Indexed keywords

CYCLINE; NUCLEASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA REPLICATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL;

EUKARYOTA;

EID: 0034679597     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.14.3811     Document Type: Article

References (50)

1. Amin, N.S. and Holm, C. (1996) In vivo analysis reveals that the interdomain region of the yeast proliferating cell nuclear antigen is important for DNA replication and DNA repair. Genetics, 144, 479-493.
2. Ayyagari, R., Impellizzeri, K.J., Yoder, B.L., Gary, S.L. and Burgers, P.M. (1995) A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair. Mol. Cell. Biol., 15, 4420-4429.
3. Bambara, R.A., Murante, R.S. and Henricksen, L.A. (1997) Enzymes and reactions at the eukaryotic DNA replication fork. J. Biol. Chem., 272, 4647-4650.
4. Burgers, P.M. and Gerik, K.J. (1998) Structure and processivity of two forms of Saccharomyces cerevisiae DNA polymerase δ. J. Biol. Chem., 273, 19756-19762.
5. Burgers, P.M.J. and Yoder, B.L. (1993) ATP-independent loading of the proliferating cell nuclear antigen requires DNA ends. J. Biol. Chem., 268, 19923-19936.
6. Chen, U., Chen, S., Saha, P. and Dutta, A. (1996) p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc. Natl Acad. Sci. USA, 93, 11597-11602.
7. Eissenberg, J.C, Ayyagari, R., Gomes, X.V. and Burgers, P. (1997) Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase δ and DNA polymerase ε. Mol. Cell. Biol., 17, 6367-6378.
8. Freudenreich, C.H., Kantrow, S.M. and Zakian, V.A. (1998) Expansion and length-dependent fragility of CTG repeats in yeast. Science, 279, 853-856.
9. Fukuda, K., Morioka, H., Imajou, S., Ikeda, S., Ohtsuka, E. and Tsurimoto, T. (1995) Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen. J. Biol. Chem., 270, 22527-22534.
10. Gary, R., Park, M.S., Nolan, J.P., Cornelius, H.L., Kozyreva, O.G., Tran, H.T., Lobachev, K.S., Resnick, M.A. and Gordenin, D.A. (1999) A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk. Mol. Cell. Biol., 19, 5373-5382.
11. Gerik, K.J., Gary, S.L. and Burgers, P.M. (1997) Overproduction and affinity purification of Saccharomyces cerevisiae replication factor C. J. Biol. Chem., 272, 1256-1262.
12. Gomes, X.V., Gary, S.L. and Burgers, P.M. (2000) Overproduction in E.coli and characterization of yeast replication factor C lacking the ligase-homology domain. J. Biol. Chem., 275, 14541-14549.
13. Gulbis, J.M., Kelman, Z., Hurwitz, J., O'Donnell, M. and Kuriyan, J. (1996) Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell, 87, 297-306.
14. Harrington, J.J. and Lieber, M.R. (1994) Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Genes Dev., 8, 1344-1355.
15. Henricksen, L.A., Umbricht, C.B. and Wold, M.S. (1994) Recombinant replication protein A: expression, complex formation and functional characterization [published erratum appears in J. Biol. Chem. 1994, 269, 16519]. J. Biol. Chem., 269, 11121-11132.
16. Henricksen, L.A., Umbricht, C.B. and Wold, M.S. (1994) Recombinant replication protein A: expression, complex formation and functional characterization [published erratum appears in J. Biol. Chem. 1994, 269, 16519]. J. Biol. Chem., 269, 11121-11132.
17. Hosfield, D.J., Mol, C.D., Shen, B. and Tainer, J.A. (1998) Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Cell, 95, 135-146.
18. Johnson, R.E., Kovvali, G.K., Prakash, L. and Prakash, S. (1995) Requirement of the yeast RTH1 5′ to 3′ exonuclease for the stability of simple repetitive DNA. Science, 269, 238-240.
19. Johnson, R.E., Kovvali, G.K., Guzder, S.N., Amin, N.S., Holm, C., Habraken, Y., Sung, P., Prakash, L. and Prakash, S. (1996) Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair. J. Biol. Chem., 271, 27987-27990.
20. Johnson, R.E., Kovvali, G.K., Prakash, L. and Prakash, S. (1998) Role of yeast Rth1 nuclease and its homologs in mutation avoidance. DNA repair and DNA replication. Curr. Genet., 34, 21-29.
21. Jonsson, Z.O., Hindges, R. and Hubscher, U. (1998) Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen. EMBO J., 17, 2412-2425.
22. Kim, K., Biade, S. and Matsumoto, Y. (1998) Involvement of flap endonuclease 1 in base excision DNA repair. J. Biol. Chem., 273, 8842-8848.
23. Klungland, A. and Lindahl, T. (1997) Second pathway for completion of human DNA base excision-repair - reconstitution with purified proteins and requirement for DNase IV (fen1). EMBO J., 16, 3341-3348.
24. Kokoska, R.J., Stefanovic, L., Tran, H.T., Resnick, M.A., Gordenin, D.A. and Petes, T.D. (1998) Destabilization of yeast micro-and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase δ (pol3-t). Mol. Cell. Biol., 18, 2779-2788.
25. Krishna, T.S., Kong, X.-P., Gary, S., Burgers, P.M. and Kuriyan, J, (1994) Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell, 79, 1233-1243.
26. Li, X., Li, J., Harrington, J., Lieber, M.R. and Burgers, P.M. (1995) Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by PCNA. J. Biol. Chem., 270, 22109-22112.
27. Montecucco, A. et al. (1998) DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories. EMBO J., 17, 3786-3795.
28. Nakanishi, M., Robetorye, R.S., Pereira, S.O. and Smith, J.R. (1995) The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition. J. Biol. Chem., 270, 17060-17063.
29. Oku, T., Ikeda, S., Sasaki, H., Fukuda, K., Morioka, H., Ohtsuka, E., Yoshikawa, H. and Tsurimoto, T. (1998) Functional sites of human PCNA which interact with p21 (Cip1/Waf1), DNA polymerase δ and replication factor C. Genes Cells, 3, 357-369.
30. Parenteau, J. and Wellinger, R.J. (1999) Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27. Mol. Cell. Biol., 19, 4143-4152.
31. Prelich, G., Kostura, M., Marshak, D.R., Mathews, M.B. and Stillman, B. (1987) The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro. Nature, 326, 471-475.
32. Reagan, M.S., Pittenger, C., Siede, W. and Friedberg, E.C. (1995) Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene. J. Bacteriol., 177, 364-371.
33. Reynolds, N., Warbrick, E., Fantes, P.A. and MacNeill, S.A. (2000) Essential interaction between the fission yeast DNA polymerase δ subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif. EMBO J., 19, 1108-1118.
34. Schweitzer, J.K. and Livingston, D.M. (1998) Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation. Hum. Mol. Genet., 7, 69-74.
35. Sommers, C.H., Miller, E.J., Dujon, B., Prakash, S. and Prakash, L. (1995) Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5′-to 3′-exonuclease required for lagging strand DNA synthesis in reconstituted systems. J. Biol. Chem., 270, 4193-4196.
36. Symington, L.S. (1998) Homologous recombination is required for the viability of rad27 mutants. Nucleic Acids Res., 26, 5589-5595.
37. Tan, C.K., Castillo, C., So, A.G. and Downey, K.M. (1986) An auxiliary protein for DNA polymerase δ from fetal calf thymus. J. Biol. Chem., 261, 12310-12316.
38. Tishkoff, D.X., Boerger, A.L., Bertrand, P., Filosi, N., Gaida, G.M., Kane, M.F. and Kolodner, R.D. (1997a) Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2. Proc. Natl Acad. Sci. USA, 94, 7487-7492.
39. Tishkoff, D.X., Filosi, N., Gaida, G.M. and Kolodner, R.D. (1997b) A novel mutation avoidance mechanism dependent on S.cerevisiae RAD27 is distinct from DNA mismatch repair. Cell, 88, 253-263.
40. Tom, S., Henricksen, L.A. and Bambara, R.A. (2000) Mechanism whereby proliferating cell nuclear antigen stimulates Flap endonuclease I. J. Biol. Chem., 275, 10498-10505.
41. Tsurimoto, T. (1999) PCNA binding proteins. From. Biosci., 4, 849-858.
42. Waga.S., Hannon, G.J., Beach, D. and Stillman, B. (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature, 369, 574-578.
43. Waga, S. and Stillman, B. (1998) Cyclin-dependent kinase inhibitor p21 modulates the DNA primer-template recognition complex. Mol. Cell. Biol., 18, 4177-4187.
44. Warbrick, E. (1998) PCNA binding through a conserved motif. BioEssays, 20, 195-199.
45. Warbrick, E., Lane, D.P., Glover, D.M. and Cox, L.S. (1995) A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen. Curr. Biol., 5, 275-282.
46. Warbrick, E., Lane, D.P., Glover, D.M. and Cox, L.S. (1997) Homologous regions of fen1 and p21(cip1) compete for binding to the same site on PCNA-a potential mechanism to co-ordinate DNA replication and repair. Oncogene, 14, 2313-2321.
47. Wu, X., Li, J., Li, X., Hsieh, C.L., Burgers, P.M. and Lieber, M.R. (1996) Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA. Nucleic Acids Res., 24, 2036-2043.
48. Wu, X., Wilson, T.E. and Lieber, M.R. (1999) A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events. Proc. Natl Acad. Sci. USA, 96, 1303-1308.
49. Zhang, P., Sun, Y., Hsu, H., Zhang, L., Zhang, Y. and Lee, M.Y. (1998) The interdomain connector loop of human PCNA is involved in a direct interaction with human polymerase δ. J. Biol. Chem., 273, 713-719.
50. Zhang, P., Mo, J.Y., Perez, A., Leon, A., Liu, L., Mazloum, N., Xu, H. and Lee, M.Y. (1999) Direct interaction of proliferating cell nuclear antigen with the p125 catalytic subunit of mammalian DNA polymerase δ. J. Biol. Chem., 274, 26647-26653.