Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth

Molecular and Cellular Biochemistry

Volumn 333, Issue 1-2, 2010, Pages 159-167

  Zhu, Dan ^a   Hensel, Jennifer ^a   Hilgraf, Robert ^a   Abbasian, Mahan ^a   Pornillos, Owen ^a,b   Deyanat Yazdi, Gordafaried ^a   Hua, Xuequn Helen ^a,c   Cox, Sarah ^a,d  

^a CELGENE CORPORATION   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c Ambit Biosciences   (United States)

^d GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Cell growth inhibition; CK2; Crystallography; HTS; Small molecule inhibitor

Indexed keywords

CASEIN KINASE II; CASEIN KINASE II INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL STRAIN HCT116; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; PROTEIN EXPRESSION;

CASEIN KINASE II; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; SMALL MOLECULE LIBRARIES;

ZEA MAYS;

EID: 73449138209     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0216-0     Document Type: Article

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