Enhancement of preneoplastic lesion yield by Chios Mastic Gum in a rat liver medium-term carcinogenesis bioassay

Toxicology and Applied Pharmacology

Volumn 234, Issue 1, 2009, Pages 135-142

  Doi, Kenichiro ^a   Wei, Min ^a   Kitano, Mitsuaki ^a   Uematsu, Naomi ^a   Inoue, Masayo ^a   Wanibuchi, Hideki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chios Mastic Gum; GST P foci; Ito test; Rat liver carcinogenesis

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CHIOS MASTIC GUM; CYTOCHROME P450 1A1; CYTOCHROME P450 3A; CYTOCHROME P450 4B1; DIETHYLNITROSAMINE; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE TRANSFERASE A2; GLUTATHIONE TRANSFERASE P1; HEME OXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; PISTACIA LENTISCUS EXTRACT; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN B;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOASSAY; BLOOD CHEMISTRY; CANCER PREVENTION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DETOXIFICATION; DIETARY INTAKE; DOSE RESPONSE; FLUID INTAKE; GENE EXPRESSION; GENE FUNCTION; HEMATOLOGICAL PARAMETERS; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER PROTECTION; LIVER WEIGHT; MALE; NONHUMAN; PARTIAL HEPATECTOMY; RAT; REAL TIME POLYMERASE CHAIN REACTION; XENOBIOTIC METABOLISM;

ANIMALS; CARCINOGENICITY TESTS; DEOXYGUANOSINE; DIETHYLNITROSAMINE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUTATHIONE S-TRANSFERASE PI; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MEDITERRANEAN REGION; ORGAN SIZE; PISTACIA; POLYMERASE CHAIN REACTION; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; RESINS, PLANT;

PISTACIA LENTISCUS; RATTUS;

EID: 57149120751     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.10.001     Document Type: Article

References (49)

1. Aksoy A., Duran N., and Koksal F. In vitro and in vivo antimicrobial effects of mastic chewing gum against Streptococcus mutans and mutans streptococci. Arch. Oral Biol. 51 (2006) 476-481
2. Aksoy A., Duran N., Toroglu S., and Koksal F. Short-term effect of mastic gum on salivary concentrations of carcinogenic bacteria in orthodontic patients. Angle Orthod. 77 (2007) 124-128
3. Al-Habbal M.J., Al-Habbal Z., and Huwez F.U. A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer. Clin. Exp. Pharmacol. Physiol. 11 (1984) 541-544
4. Al-Said M.S., Ageel A.M., Parmar N.S., and Tariq M. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J. Ethnopharmacol. 15 (1986) 271-278
5. Andrikopoulos N.K., Kaliora A.C., Assimopoulou A.N., and Papapeorgiou V.P. Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation. Phytother. Res. 17 (2003) 501-507
6. Anzenbacher P., and Anzenbacherová E. Cytochromes P450 and metabolism of xenobiotics. Cell. Mol. Life Sci. 58 (2001) 737-747
7. Balan K.V., Demetzos C., Prince J., Dimas K., Cladaras M., Han Z., Wyche J.H., and Pantazis P. Induction of apoptosis in human colon cancer HCT116 cells treated with an extract of the plant product, Chios mastic gum. In vivo 19 (2005) 93-102
8. Bebb J.R., Bailey-Flitter N., Ala'Aldeen D., and Atherton J.C. Mastic gum has no effect on Helicobacter pylori load in vivo. J. Antimicrob. Chemother. 52 (2003) 522-523
9. Choudhary S., Xiao T., Vergara L.A., Srivastava S., Nees D., Piatigorsky J., and Ansari N.H. Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Invest. Ophthalmol. Vis. Sci. 46 (2005) 259-267
10. Cohen S.M., and Ellwein L.B. Cell proliferation in carcinogenesis. Science 249 (1990) 1007-1011
11. Dedoussis G.V., Kaliora A.C., Psarras S., Chiou A., Mylona A., Papadopoulos N.G., and Andrikopoulos N.K. Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 mRNA expression. Atherosclerosis 174 (2004) 293-303
12. Doi K., Hagihara A., Wei M., Yunoki T., Fukushima S., and Wanibuchi H. Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine initiation-promotion model. Oncology 73 (2007) 252-260
13. Emi Y., Ikushiro S., and Iyanagi T. Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. J. Biol. Chem. 271 (1996) 3952-3958
14. Fukushima S., Kinoshita A., Puatanachokchai R., Kushida M., Wanibuchi H., and Morimura K. Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. Carcinogenesis 26 (2005) 1835-1845
15. Gong P., Hu B., and Cederbaum A.I. Diallyl sulfide induces heme oxygenase-1 through MAPK pathway. Arch. Biochem. Biophys. 432 (2004) 252-260
16. He M.L., Yuan H.Q., Jiang A.L., Gong A.Y., Chen W.W., Zhang P.J., Young C.Y., and Zhang J.Y. Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells. Cancer 106 (2006) 2547-2555
17. Huwez F.U., Thirlwell D., Cockayne A., and Ala'Aldeen D.A. Mastic gum kills Helicobacter pylori. N. Engl. J. Med. 339 (1998) 1946
18. Ichihara T., Wanibuchi H., Lee C.C., Nakajima K., Yano Y., Taniyama T., Otani S., Shimizu Y., and Fukushima S. Lack of inhibitory effects of the Ju-myo protein on development of glutathione S-transferase placental form-positive foci in the male F344 rat liver. J. Toxicol. Sci. 24 (1999) 27-31
19. Imaida K., and Fukushima S. Initiation-promotion model for assessment of carcinogenicity: medium-term liver bioassay in rats for rapid detection of carcinogenic agents. J. Toxicol. Sci. 21 (1996) 483-487
20. Imaoka S., Yoneda Y., Matsuda T., Degawa M., Fukushima S., and Funae Y. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. Biochem. Pharmacol. 54 (1997) 677-683
21. Ito N., Tsuda H., Tatematsu M., Inoue T., Tagawa Y., Aoki T., Uwagawa S., Kagawa M., Ogiso T., Masui T., Imaida K., Fukushima S., and Asamoto M. Enhancing effects of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in the rats an approach for a new median-term bioassay system. Carcinogenesis 9 (1988) 387-394
22. Janakat S., and Al-Merie H. Evaluation of hepatoprotective effect of Pistacia lentiscus, Phillyrea latifolia and Nicotiana glauca. J. Ethnopharmacol. 83 (2002) 135-138
23. Kaliora A.C., Stathopoulou M.G., Triantafillidis J.K., Dedoussis G.V., and Andrikopoulos N.K. Chios mastic treatment of patients with active Crohn's disease. World J. Gastroenterol. 13 (2007) 748-753
24. Kang J.S., Wanibuchi H., Salim E.I., Kinoshita A., and Fukushima S. Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 rats. Food Chem. Toxicol. 45 (2007) 494-501
25. Koutsoudaki C., Krsek M., and Rodger A. Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus var. chia. J. Agric. Food Chem. 53 (2005) 7681-7685
26. Kushida M., Sukata T., Uwagawa S., Ozaki K., Kinoshita A., Wanibuchi H., Morimura K., Okuno Y., and Fukushima S. Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms. Toxicol. Appl. Pharmacol. 208 (2005) 285-294
27. Lewis R.W., Billington R., Debryune E., Gamer A., Lang B., and Carpanini F. Recognition of adverse and nonadverse effects in toxicity studies. Toxicol. Pathol. 30 (2002) 66-74
28. Loughlin M.F., Ala'Aldeen D.A., and Jenks P.J. Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice. J. Antimicrob. Chemother. 51 (2003) 367-371
29. Loutrari H., Magkouta S., Pyriochou A., Koika V., Kolisis F.N., Papapetropoulos A., and Roussos C. Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. Nutr. Cancer 55 (2006) 86-93
30. Magiatis P., Melliou E., Skaltsounis A.L., Chinou I.B., and Mitaku S. Chemical composition and antimicrobial activity of the essential oils of Pistacia lentiscus var. chia. Planta Med. 65 (1999) 749-752
31. McFadyen M.C.E., Melvin W.T., and Murray G.I. Cytochrome P450 enzymes: novel options for cancer therapeutics. Mol. Cancer Ther. 3 (2004) 363-371
32. Min Y., Adachi Y., Yamamoto H., Imsumran A., Arimura Y., Endo T., Hinoda Y., Lee C.T., Nadaf S., Carbone D.P., and Imai K. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumor growth in human gastric cancer xenografts. Gut 54 (2005) 591-600
33. Nakae D., Mizumoto Y., Kobayashi E., Noguchi O., and Konishi Y. Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue. Cancer Lett. 97 (1995) 233-239
34. Otoshi T., Iwata H., Takada N., Nishikawa Y., Morii H., and Fukushima S. 22-Oxa-1,25(OH)2vitamin D3, a synthetic analogue of vitamin D3, has no promoting activity in a rat liver median-term bioassay. Cancer Lett. 83 (1994) 69-74
35. Pappas P., Stephanou P., Karamanakos P., Vasiliou V., and Marselos M. Phenobarbital inducibility and differences in protein expression of an animal model. Chem. Biol. Interact. (2001) 130-132 275-283
36. Park E.Y., Cho I.J., and Kim S.G. Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-γ and retinoid X receptor heterodimer. Cancer Res. 64 (2004) 3701-3713
37. Puatanachokchai R., Morimura K., Wanibuchi H., Oka M., Kinoshita A., Fukui M., Yamaguchi S., Funae Y., and Fukushima S. Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with a possible role for hepatic detoxifying enzymes. Cancer Lett. 240 (2006) 102-113
38. Ruch R.J., and Sigler K. Growth inhibition of rat liver epithelial tumor cells by monoterpenes does not involve Ras plasma membrane association. Carcinogenosis 15 (1994) 787-789
39. Satoh K., and Hatayama I. Anomalous elevation of glutathione S-transferase P-form (GST-P) in the elementary process of epigenetic initiation of chemical hepatocarcinogenesis in rats. Carcinogenesis 23 (2002) 1193-1198
40. Singh A., Rangasamy T., Thimmulappa R.K., Lee H., Osburn W.O., Brigelius-Flohe R., Kensler T.W., Yamamoto M., and Biswal S. Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am. J. Respir. Cell Mol. Biol. 35 (2006) 639-650
41. Singhal R., Shankar K., Badger T.M., and Ronis M.J. Estrogenic status modulates aryl hydrocarbon receptor-mediated hepatic gene expression and carcinogenicity. Carcinigenesis 29 (2008) 227-236
42. Stoeltzing O., Liu W., Reinmuth N., Fan F., Parikh A.A., Bucana C.D., Evans D.B., Semenza G.L., and Ellis L.M. Regulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am. J. Pathol. 163 (2003) 1001-1011
43. Stoltz C., Vachon M.H., Trottier E., Dubois S., Paquet Y., and Anderson A. The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. J. Biol. Chem. 273 (1998) 8528-8536
44. Sukata T., Uwagawa S., Ozaki K., Ogawa M., Nishikawa T., Iwai S., Kinoshita A., Wanibuchi H., Imaoka S., Funae Y., Okuno Y., and Fukushima S. Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane carcinogenesis suggests the possibility of a hormetic effect. Int. J. Cancer 99 (2002) 112-118
45. Suzuki S., Asamoto M., Tsujimura K., and Shirai T. Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue. Carcinogenesis 25 (2004) 439-443
46. Takahashi K., Fukazawa M., Motohira H., Ochiai K., Nishikawa H., and Miyata T. A pilot study on antiplaque effects of mastic chewing gum in the oral cavity. J. Periodontol. 74 (2003) 501-505
47. Triantafyllou A., Chaviaras N., Sergentanis T.N., Protopapa E., and Tsaknis J. Chios mastic gum modulates serum biochemical parameters in a human population. J. Ethnopharmacol. 111 (2007) 43-49
48. Wakelin S.H. Allergic contact dermatitis from mastic in compound mastic paint. Contact Dermatitis 45 (2001) 118
49. Williams G.M., and Iatropoulos M.J. Alterations of liver cell function and proliferation: differentiation between adaptation and toxicity. Toxicol. Pathol. 30 (2002) 41-53