To BDNF or not to BDNF: That is the epileptic hippocampus

Neuroscientist

Volumn 11, Issue 4, 2005, Pages 282-287

  Koyama, Ryuta ^a   Ikegaya, Yuji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

BDNF; Dentate gyrus; Epilepsy; Hippocampus; Mossy fiber; NPY

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMATE DECARBOXYLASE; KAINIC ACID; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; DENTATE GYRUS; EPILEPSY; EPILEPTOGENESIS; HIPPOCAMPUS; HUMAN; MOSSY FIBER; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEIZURE; TEMPORAL LOBE EPILEPSY; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRAIN-DERIVED NEUROTROPHIC FACTOR; EPILEPSY; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; HUMANS; MODELS, NEUROLOGICAL; NEUROPEPTIDE Y;

EID: 22844445346     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/1073858405278266     Document Type: Review

References (32)

1. Croll SD, Suri C, Compton DL, Simmons MV, Yancopoulos GD, Lindsay RM, and others. 1999. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 93:1491-506.
2. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, and others. 2003. The BDNF va166met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-69.
3. Erickson JC, Clegg KE, Palmiter RD. 1996. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415-21.
4. Grunewald R. 2002. Childhood seizures and their consequences for the hippocampus. Brain 125:1935-6.
5. He XP, Kotloski R, Nef S, Luikart BW, Parada LF, McNamara JO. 2004. Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron 43:31-42.
6. Kang H, Schuman EM. 1995. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267:1658-62.
7. Kim YH, Rhyu IJ, Park KW, Eun BL, Kim YI, Rha HK, and others. 2001. The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures. Neuroreport 12:3243-6.
8. Koyama R, Ikegaya Y. 2004. Mossy fiber sprouting as a potential therapeutic target for epilepsy. Curr Neurovasc Res 1:3-10.
9. Koyama R, Yamada MK, Fujisawa S, Katoh-Semba R, Matsuki N, Ikegaya Y. 2004. Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus. J Neurosci 24:7215-24.
10. Lahteinen S, Pitkanen A, Koponen E, Saarelainen T, Castren E. 2003. Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling. Neuroscience 122:1081-92.
11. Levine ES, Dreyfus CF, Black IB, Plummer MR. 1995. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc Natl Acad Sci U S A 92:8074-7.
12. Marty S, Wehrle R, Sotelo C. 2000. Neuronal activity and brain-derived neurotrophic factor regulate the density of inhibitory synapses in organotypic slice cultures of postnatal hippocampus. J Neurosci 20:8087-95.
13. Murray KD, Isackson PJ, Eskin TA, King MA, Montesinos SP, Abraham LA, and others. 2000. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. J Comp Neurol 418:411-22.
14. Nadler JV 2003. The recurrent mossy fiber pathway of the epileptic brain. Neurochem Res 28:1649-58.
15. Palma E, Torchia G, Limatola C, Trettel F, Arcella A, Cantore G, and others. 2005. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proc Natl Acad Sci USA 102:1667-72.
16. Ramirez M, Gutierrez R. 2001. Activity-dependent expression of GAD67 in the granule cells of the rat hippocampus. Brain Res 917:139-46.
17. Reibel S, Benmaamar R, Le BT, Larmet Y, Kalra SP, Marescaux C, and others. 2003. Neuropeptide Y delays hippocampal kindling in the rat. Hippocampus 13:557-60.
18. Reibel S, Larmet Y, Le BT, Carnahan J, Marcscaux C, Depaulis A. 2000a. Brain-derived neurotrophic factor delays hippocampal kindling in the rat. Neuroscience 100:777-88.
19. Reibel S, Vivien-Roels B, Le BT, Larmet Y, Carnahan J, Marescaux C, and others. 2000b. Overexpression of neuropeptide Y induced by brain-derived neurotrophic factor in the rat hippocampus is long lasting. Eur J Neurosci 12:595-605.
20. Rudge JS, Mather PE, Pasnikowski EM, Cai N, Corcoran T, Acheson A, and others. 1998. Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective. Exp Neurol 149:398-410.
21. Scharfman HE. 1997. Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor. J Neurophysiol 78:1082-95.
22. Scharfman HE, Goodman JH, Sollas AL. 1999. Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. J Neurosci 19:5619-31.
23. Scharfman HE, Goodman JH, Sollas AL, Croll SD. 2002. Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. Exp Neurol 174:201-14.
24. Takahashi M, Hayashi S, Kakita A, Wakabayashi K, Fukuda M, Kameyama S, and others. 1999. Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y. Brain Res 818:579-82.
25. Tanaka T, Saito H, Matsuki N. 1997, Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus. J Neurosci 17:2959-66.
26. Tu B, Timofeeva O, Jiao Y, Nadler JV 2005. Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain. J Neurosci 25:1718-29.
27. Vaidya VA, Siuciak JA, Du F, Duman RS. 1999. Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures. Neuroscience 89:157-66.
28. Vezzani A, Ravizza T, Moneta D, Conti M, Borroni A, Rizzi M, and others. 1999. Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions: temporal evolution of changes as compared to neuropeptide Y Neuroscience 90:1445-61.
29. Wieser H-G, Engel J Jr, Williamson PD, Babb TL, Gloor P. 1993. Surgically remedial temporal lobe syndromes. In: Engel J Jr, editor. Surgical treatment of the epilepsies. New York: Raven, p 49-63.
30. Wyneken U, Marengo JJ, Villanueva S, Soto D, Sandoval R, Gundelfinger ED, and others. 2003. Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities. Epilepsia 44:243-6.
31. Yamada MK, Nakanishi K, Ohba S, Nakamura T, Ikegaya Y, Nishiyama N, and others. 2002. Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons. J Neurosci 22:7580-5.
32. Zhu WJ, Roper SN. 2001. Brain-derived neurotrophic factor enhances fast excitatory synaptic transmission in human epileptic dentate gyrus. Ann Neurol 50:188-94.