Regulation of local translation at the synapse by BDNF

Progress in Neurobiology

Volumn 92, Issue 4, 2010, Pages 505-516

  Santos, Ana Rita ^a   Comprido, Diogo ^a   Duarte, Carlos B ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

BDNF; Local translation; MRNA trafficking; RNA granules; RNA targeting; RNA binding proteins; Synaptic regulation

Indexed keywords

AMPA RECEPTOR; BRAIN DERIVED GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; COFILIN; F ACTIN; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

BRAIN REGION; DENDRITE; DEPOLARIZATION; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; MICROARRAY ANALYSIS; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SYNAPSE; SYNAPTIC MEMBRANE; TRANSCRIPTION INITIATION;

ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DENDRITES; GENE EXPRESSION REGULATION; MODELS, BIOLOGICAL; NEURONAL PLASTICITY; NEURONS; RECEPTOR, TRKB; RNA, MESSENGER; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 77956664066     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2010.08.004     Document Type: Review

References (149)

1. Aakalu G., Smith W.B., Nguyen N., Jiang C., Schuman E.M. Dynamic visualization of local protein synthesis in hippocampal neurons. Neuron 2001, 30:489-502.
2. Aicardi G., Argilli E., Cappello S., Santi S., Riccio M., Thoenen H., Canossa M. Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA 2004, 101:15788-15792.
3. Alder J., Thakker-Varia S., Crozier R.A., Shaheen A., Plummer M.R., Black I.B. Early presynaptic and late postsynaptic components contribute independently to brain-derived neurotrophic factor-induced synaptic plasticity. J. Neurosci. 2005, 25:3080-3085.
4. An J.J., Gharami K., Liao G.Y., Woo N.H., Lau A.G., Vanevski F., Torre E.R., Jones K.R., Feng Y., Lu B., Xu B. Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell 2008, 134:175-187.
5. Bagni C., Greenough W.T. From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat. Rev. Neurosci. 2005, 6:376-387.
6. Bakker C., Verheij C., Willemsen R., van der Helm R., Oerlemans F., Vermey M., Bygrave A., Hoogeveen A., Oostra B. Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium. Cell 1994, 78:23-33.
7. Banerjee S., Neveu P., Kosik K.S. A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation. Neuron 2009, 64:871-884.
8. Bassell G.J., Warren S.T. Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron 2008, 60:201-214.
9. Bramham C.R., Alme M.N., Bittins M., Kuipers S.D., Nair R.R., Pai B., Panja D., Schubert M., Soule J., Tiron A., Wibrand K. The Arc of synaptic memory. Exp. Brain Res. 2010, 200:125-140.
10. Bramham C.R., Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog. Neurobiol. 2005, 76:99-125.
11. Burgin K.E., Waxham M.N., Rickling S., Westgate S.A., Mobley W.C., Kelly P.T. In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain. J. Neurosci. 1990, 10:1788-1798.
12. Caldeira M.V., Melo C.V., Pereira D.B., Carvalho R., Correia S.S., Backos D.S., Carvalho A.L., Esteban J.A., Duarte C.B. Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons. J. Biol. Chem. 2007, 282:12619-12628.
13. Caldeira M.V., Melo C.V., Pereira D.B., Carvalho R.F., Carvalho A.L., Duarte C.B. BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons. Mol. Cell. Neurosci. 2007, 35:208-219.
14. Carvalho A.L., Caldeira M.V., Santos S.D., Duarte C.B. Role of the brain-derived neurotrophic factor at glutamatergic synapses. Br. J. Pharmacol. 2008, 153(Suppl. 1):S310-S324.
15. Chen G., Kolbeck R., Barde Y.A., Bonhoeffer T., Kossel A. Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation. J. Neurosci. 1999, 19:7983-7990.
16. Costa-Mattioli M., Sossin W.S., Klann E., Sonenberg N. Translational control of long-lasting synaptic plasticity and memory. Neuron 2009, 61:10-26.
17. Cougot N., Bhattacharyya S.N., Tapia-Arancibia L., Bordonne R., Filipowicz W., Bertrand E., Rage F. Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation. J. Neurosci. 2008, 28:13793-13804.
18. Cowansage K.K., LeDoux J.E., Monfils M.H. Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Curr. Mol. Pharmacol. 2010, 3:12-29.
19. Davis M. Neurobiology of fear responses: the role of the amygdala. J. Neuropsychiatry Clin. Neurosci. 1997, 9:382-402.
20. Dong C., Upadhya S.C., Ding L., Smith T.K., Hegde A.N. Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation. Learn. Mem. 2008, 15:335-347.
21. Eberwine J., Belt B., Kacharmina J.E., Miyashiro K. Analysis of subcellularly localized mRNAs using in situ hybridization, mRNA amplification, and expression profiling. Neurochem. Res. 2002, 27:1065-1077.
22. Edbauer D., Neilson J.R., Foster K.A., Wang C.F., Seeburg D.P., Batterton M.N., Tada T., Dolan B.M., Sharp P.A., Sheng M. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 2010, 65:373-384.
23. Fendt M., Fanselow M.S. The neuroanatomical and neurochemical basis of conditioned fear. Neurosci. Biobehav. Rev. 1999, 23:743-760.
24. Figurov A., Pozzo-Miller L.D., Olafsson P., Wang T., Lu B. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 1996, 381:706-709.
25. Fiore R., Khudayberdiev S., Christensen M., Siegel G., Flavell S.W., Kim T.K., Greenberg M.E., Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J. 2009, 28:697-710.
26. Fonseca R., Vabulas R.M., Hartl F.U., Bonhoeffer T., Nagerl U.V. A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron 2006, 52:239-245.
27. Gartner A., Polnau D.G., Staiger V., Sciarretta C., Minichiello L., Thoenen H., Bonhoeffer T., Korte M. Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling. J. Neurosci. 2006, 26:3496-3504.
28. Gartner A., Staiger V. Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns. Proc. Natl. Acad. Sci. USA 2002, 99:6386-6391.
29. Gazzaley A.H., Benson D.L., Huntley G.W., Morrison J.H. Differential subcellular regulation of NMDAR1 protein and mRNA in dendrites of dentate gyrus granule cells after perforant path transection. J. Neurosci. 1997, 17:2006-2017.
30. Graham D.L., Edwards S., Bachtell R.K., DiLeone R.J., Rios M., Self D.W. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat. Neurosci. 2007, 10:1029-1037.
31. Graham D.L., Krishnan V., Larson E.B., Graham A., Edwards S., Bachtell R.K., Simmons D., Gent L.M., Berton O., Bolanos C.A., DiLeone R.J., Parada L.F., Nestler E.J., Self D.W. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol. Psychiatry 2009, 65:696-701.
32. Gruart A., Sciarretta C., Valenzuela-Harrington M., Delgado-Garcia J.M., Minichiello L. Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice. Learn. Mem. 2007, 14:54-62.
33. Hartmann M., Heumann R., Lessmann V. Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. EMBO J. 2001, 20:5887-5897.
34. Herbert T.P., Proud C.G. Regulation of translation elongation and the cotranslationa protein target pathway. Translational Control in Biology and Medicine 2007, 601-624. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. M.B. Mathews, N. Sonenberg, J.W.B. Hershey (Eds.).
35. Huang F., Chotiner J.K., Steward O. Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites. J. Neurosci. 2007, 27:9054-9067.
36. Huang Y.Y., Zakharenko S.S., Schoch S., Kaeser P.S., Janz R., Sudhof T.C., Siegelbaum S.A., Kandel E.R. Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proc. Natl. Acad. Sci. USA 2005, 102:9365-9370.
37. Iacoangeli A., Rozhdestvensky T.S., Dolzhanskaya N., Tournier B., Schutt J., Brosius J., Denman R.B., Khandjian E.W., Kindler S., Tiedge H. On BC1 RNA and the fragile X mental retardation protein. Proc. Natl. Acad. Sci. USA 2008, 105:734-739.
38. Inamura N., Nawa H., Takei N. Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling. J. Neurochem. 2005, 95:1438-1445.
39. Ji Y., Lu Y., Yang F., Shen W., Tang T.T., Feng L., Duan S., Lu B. Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nat. Neurosci. 2010, 13:302-309.
40. John B., Enright A.J., Aravin A., Tuschl T., Sander C., Marks D.S. Human MicroRNA targets. PLoS Biol. 2004, 2:e363.
41. Jourdi H., Hsu Y.T., Zhou M., Qin Q., Bi X., Baudry M. Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation. J. Neurosci. 2009, 29:8688-8697.
42. Jovanovic J.N., Czernik A.J., Fienberg A.A., Greengard P., Sihra T.S. Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat. Neurosci. 2000, 3:323-329.
43. Kang H., Schuman E.M. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 1995, 267:1658-1662.
44. Kang H., Schuman E.M. A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science 1996, 273:1402-1406.
45. Kang H., Welcher A.A., Shelton D., Schuman E.M. Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation. Neuron 1997, 19:653-664.
46. Kanhema T., Dagestad G., Panja D., Tiron A., Messaoudi E., Havik B., Ying S.W., Nairn A.C., Sonenberg N., Bramham C.R. Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. J. Neurochem. 2006, 99:1328-1337.
47. Kelleher R.J., Govindarajan A., Jung H.Y., Kang H., Tonegawa S. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 2004, 116:467-479.
48. Kolarow R., Brigadski T., Lessmann V. Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium calmodulin kinase II signaling and proceeds via delayed fusion pore opening. J. Neurosci. 2007, 27:10350-10364.
49. Konecna A., Heraud J.E., Schoderboeck L., Raposo A.A., Kiebler M.A. What are the roles of microRNAs at the mammalian synapse?. Neurosci. Lett. 2009, 466:63-68.
50. Korte M., Carroll P., Wolf E., Brem G., Thoenen H., Bonhoeffer T. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA 1995, 92:8856-8860.
51. Korte M., Griesbeck O., Gravel C., Carroll P., Staiger V., Thoenen H., Bonhoeffer T. Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice. Proc. Natl. Acad. Sci. USA 1996, 93:12547-12552.
52. Korte M., Kang H., Bonhoeffer T., Schuman E. A role for BDNF in the late-phase of hippocampal long-term potentiation. Neuropharmacology 1998, 37:553-559.
53. Korte M., Staiger V., Griesbeck O., Thoenen H., Bonhoeffer T. The involvement of brain-derived neurotrophic factor in hippocampal long-term potentiation revealed by gene targeting experiments. J. Physiol. Paris 1996, 90:157-164.
54. Kovalchuk Y., Hanse E., Kafitz K.W., Konnerth A. Postsynaptic induction of BDNF-mediated long-term potentiation. Science 2002, 295:1729-1734.
55. Kuczewski N., Porcher C., Lessmann V., Medina I., Gaiarsa J.L. Activity-dependent dendritic release of BDNF and biological consequences. Mol. Neurobiol. 2009, 39:37-49.
56. Kye M.J., Liu T., Levy S.F., Xu N.L., Groves B.B., Bonneau R., Lao K., Kosik K.S. Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. RNA 2007, 13:1224-1234.
57. Lessmann V., Brigadski T. Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update. Neurosci. Res. 2009, 65:11-22.
58. Lessmann V., Heumann R. Modulation of unitary glutamatergic synapses by neurotrophin-4/5 or brain-derived neurotrophic factor in hippocampal microcultures: presynaptic enhancement depends on pre-established paired-pulse facilitation. Neuroscience 1998, 86:399-413.
59. Levine E.S., Crozier R.A., Black I.B., Plummer M.R. Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity. Proc. Natl. Acad. Sci. USA 1998, 95:10235-10239.
60. Levine E.S., Dreyfus C.F., Black I.B., Plummer M.R. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc. Natl. Acad. Sci. USA 1995, 92:8074-8077.
61. Levine E.S., Kolb J.E. Brain-derived neurotrophic factor increases activity of NR2B-containing N-methyl-D-aspartate receptors in excised patches from hippocampal neurons. J. Neurosci. Res. 2000, 62:357-362.
62. Li W., Keifer J. BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK. Neurobiol. Learn. Mem. 2009, 91:243-249.
63. Li Y.X., Zhang Y., Lester H.A., Schuman E.M., Davidson N. Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons. J. Neurosci. 1998, 18:10231-10240.
64. Liao L., Pilotte J., Xu T., Wong C.C., Edelman G.M., Vanderklish P., Yates J.R. BDNF induces widespread changes in synaptic protein content and up-regulates components of the translation machinery: an analysis using high-throughput proteomics. J. Proteome Res. 2007, 6:1059-1071.
65. Lin C.H., Yeh S.H., Lu K.T., Leu T.H., Chang W.C., Gean P.W. A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron 2001, 31:841-851.
66. Lin S.Y., Wu K., Levine E.S., Mount H.T., Suen P.C., Black I.B. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain Res. Mol. Brain Res. 1998, 55:20-27.
67. Lohof A.M., Ip N.Y., Poo M.M. Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature 1993, 363:350-353.
68. Lu Y., Christian K., Lu B. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?. Neurobiol. Learn. Mem. 2008, 89:312-323.
69. Magby J.P., Bi C., Chen Z.Y., Lee F.S., Plummer M.R. Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor. J. Neurosci. 2006, 26:13531-13536.
70. Malenka R.C., Bear M.F. LTP and LTD: an embarrassment of riches. Neuron 2004, 44:5-21.
71. Manadas B., Santos A.R., Szabadfi K., Gomes J.R., Garbis S.D., Fountoulakis M., Duarte C.B. BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: protein levels and dendritic mRNA. J. Proteome Res. 2009, 8:4536-4552.
72. Marin-Padilla M. Structural abnormalities of the cerebral cortex in human chromosomal aberrations: a Golgi study. Brain Res. 1972, 44:625-629.
73. Matsumoto T., Rauskolb S., Polack M., Klose J., Kolbeck R., Korte M., Barde Y.A. Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat. Neurosci. 2008, 11:131-133.
74. Matsuzaki M., Honkura N., Ellis-Davies G.C., Kasai H. Structural basis of long-term potentiation in single dendritic spines. Nature 2004, 429:761-766.
75. McGinty J.F., Whitfield T.W., Berglind W.J. Brain-derived neurotrophic factor and cocaine addiction. Brain Res. 2010, 1314:183-193.
76. McKernan M.G., Shinnick-Gallagher P. Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature 1997, 390:607-611.
77. Meng Y., Zhang Y., Tregoubov V., Janus C., Cruz L., Jackson M., Lu W.Y., MacDonald J.F., Wang J.Y., Falls D.L., Jia Z. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 2002, 35:121-133.
78. Messaoudi E., Bardsen K., Srebro B., Bramham C.R. Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus. J. Neurophysiol. 1998, 79:496-499.
79. Messaoudi E., Kanhema T., Soule J., Tiron A., Dagyte G., da Silva B., Bramham C.R. Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. J. Neurosci. 2007, 27:10445-10455.
80. Messaoudi E., Ying S.W., Kanhema T., Croll S.D., Bramham C.R. Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. J. Neurosci. 2002, 22:7453-7461.
81. Minichiello L. TrkB signalling pathways in LTP and learning. Nat. Rev. Neurosci. 2009, 10:850-860.
82. Minichiello L., Calella A.M., Medina D.L., Bonhoeffer T., Klein R., Korte M. Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron 2002, 36:121-137.
83. Minichiello L., Korte M., Wolfer D., Kuhn R., Unsicker K., Cestari V., Rossi-Arnaud C., Lipp H.P., Bonhoeffer T., Klein R. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 1999, 24:401-414.
84. Musumeci G., Sciarretta C., Rodriguez-Moreno A., Al Banchaabouchi M., Negrete-Diaz V., Costanzi M., Berno V., Egorov A.V., von Bohlen Und Halbach O., Cestari V., Delgado-Garcia J.M., Minichiello L. TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites. J. Neurosci. 2009, 29:10131-10143.
85. Nagappan G., Zaitsev E., Senatorov V.V., Yang J., Hempstead B.L., Lu B. Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proc. Natl. Acad. Sci. USA 2009, 106:1267-1272.
86. Nairn A.C., Palfrey H.C. Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2. J. Biol. Chem. 1987, 262:17299-17303.
87. Nakata H., Nakamura S. Brain-derived neurotrophic factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signaling. FEBS Lett. 2007, 581:2047-2054.
88. Napoli I., Mercaldo V., Boyl P.P., Eleuteri B., Zalfa F., De Rubeis S., Di Marino D., Mohr E., Massimi M., Falconi M., Witke W., Costa-Mattioli M., Sonenberg N., Achsel T., Bagni C. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 2008, 134:1042-1054.
89. Nomoto H., Takaiwa M., Mouri A., Furukawa S. Pro-region of neurotrophins determines the processing efficiency. Biochem. Biophys. Res. Commun. 2007, 356:919-924.
90. Ou L.C., Gean P.W. Regulation of amygdala-dependent learning by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol-3-kinase. Neuropsychopharmacology 2006, 31:287-296.
91. Ou L.C., Yeh S.H., Gean P.W. Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory. Neurobiol. Learn. Mem. 2010, 93:372-382.
92. Pang P.T., Teng H.K., Zaitsev E., Woo N.T., Sakata K., Zhen S., Teng K.K., Yung W.H., Hempstead B.L., Lu B. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 2004, 306:487-491.
93. Pascual M., Climent E., Guerri C. BDNF induces glutamate release in cerebrocortical nerve terminals and in cortical astrocytes. Neuroreport 2001, 12:2673-2677.
94. Patterson S.L., Abel T., Deuel T.A., Martin K.C., Rose J.C., Kandel E.R. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 1996, 16:1137-1145.
95. Pereira D.B., Rebola N., Rodrigues R.J., Cunha R.A., Carvalho A.P., Duarte C.B. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. J. Neurosci. Res. 2006, 83:832-844.
96. Plath N., Ohana O., Dammermann B., Errington M.L., Schmitz D., Gross C., Mao X., Engelsberg A., Mahlke C., Welzl H., Kobalz U., Stawrakakis A., Fernandez E., Waltereit R., Bick-Sander A., Therstappen E., Cooke S.F., Blanquet V., Wurst W., Salmen B., Bosl M.R., Lipp H.P., Grant S.G., Bliss T.V., Wolfer D.P., Kuhl D. Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron 2006, 52:437-444.
97. Poon M.M., Choi S.H., Jamieson C.A., Geschwind D.H., Martin K.C. Identification of process-localized mRNAs from cultured rodent hippocampal neurons. J. Neurosci. 2006, 26:13390-13399.
98. Pozzo-Miller L.D., Gottschalk W., Zhang L., McDermott K., Du J., Gopalakrishnan R., Oho C., Sheng Z.H., Lu B. Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J. Neurosci. 1999, 19:4972-4983.
99. Purpura D.P. Dendritic spine "dysgenesis" and mental retardation. Science 1974, 186:1126-1128.
100. Rattiner L.M., Davis M., French C.T., Ressler K.J. Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning. J. Neurosci. 2004, 24:4796-4806.
101. Rattiner L.M., Davis M., Ressler K.J. Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning. Learn. Mem. 2004, 11:727-731.
102. Remenyi J., Hunter C.J., Cole C., Ando H., Impey S., Monk C.E., Martin K.J., Barton G.J., Hutvagner G., Arthur J.S. Regulation of the miR-212/132 locus by MSK and CREB in response to neurotrophins. Biochem. J. 2010, 428:281-291.
103. Rex C.S., Lin C.Y., Kramar E.A., Chen L.Y., Gall C.M., Lynch G. Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. J. Neurosci. 2007, 27:3017-3029.
104. Rhoads R.E. Signal transduction pathways that regulate eukaryotic protein synthesis. J. Biol. Chem. 1999, 274:30337-30340.
105. Richter E.K.a.J.D. Translational Control of Synaptic Plasticity and Learning and Memory 2007, Cold Spring Harbor Laboratory Press.
106. Righi M., Tongiorgi E., Cattaneo A. Brain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 kinase-dependent pathway. J. Neurosci. 2000, 20:3165-3174.
107. Rogan M.T., Staubli U.V., LeDoux J.E. Fear conditioning induces associative long-term potentiation in the amygdala. Nature 1997, 390:604-607.
108. Russo S.J., Mazei-Robison M.S., Ables J.L., Nestler E.J. Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 2009, 56(Suppl. 1):73-82.
109. Ryazanov A.G., Shestakova E.A., Natapov P.G. Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation. Nature 1988, 334:170-173.
110. Santi S., Cappello S., Riccio M., Bergami M., Aicardi G., Schenk U., Matteoli M., Canossa M. Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. EMBO J. 2006, 25:4372-4380.
111. Schinder A.F., Berninger B., Poo M. Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation. Neuron 2000, 25:151-163.
112. Schratt G. microRNAs at the synapse. Nat. Rev. Neurosci. 2009, 10:842-849.
113. Schratt G.M., Nigh E.A., Chen W.G., Hu L., Greenberg M.E. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development. J. Neurosci. 2004, 24:7366-7377.
114. Schratt G.M., Tuebing F., Nigh E.A., Kane C.G., Sabatini M.E., Kiebler M., Greenberg M.E. A brain-specific microRNA regulates dendritic spine development. Nature 2006, 439:283-289.
115. Schutt J., Falley K., Richter D., Kreienkamp H.J., Kindler S. Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. J. Biol. Chem. 2009, 284:25479-25487.
116. Sebeo J., Hsiao K., Bozdagi O., Dumitriu D., Ge Y., Zhou Q., Benson D.L. Requirement for protein synthesis at developing synapses. J. Neurosci. 2009, 29:9778-9793.
117. Shahbazian D., Roux P.P., Mieulet V., Cohen M.S., Raught B., Taunton J., Hershey J.W., Blenis J., Pende M., Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 2006, 25:2781-2791.
118. Shiina N., Shinkura K., Tokunaga M. A novel RNA-binding protein in neuronal RNA granules: regulatory machinery for local translation. J. Neurosci. 2005, 25:4420-4434.
119. Shiraishi-Yamaguchi Y., Furuichi T. The Homer family proteins. Genome Biol. 2007, 8:206.
120. Simsek-Duran F., Lonart G. The role of RIM1alpha in BDNF-enhanced glutamate release. Neuropharmacology 2008, 55:27-34.
121. Steward O., Levy W.B. Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus. J. Neurosci. 1982, 2:284-291.
122. Steward O., Schuman E.M. Protein synthesis at synaptic sites on dendrites. Annu. Rev. Neurosci. 2001, 24:299-325.
123. Steward O., Schuman E.M. Compartmentalized synthesis and degradation of proteins in neurons. Neuron 2003, 40:347-359.
124. Steward O., Wallace C.S., Lyford G.L., Worley P.F. Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. Neuron 1998, 21:741-751.
125. Suen P.C., Wu K., Levine E.S., Mount H.T., Xu J.L., Lin S.Y., Black I.B. Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1. Proc. Natl. Acad. Sci. USA 1997, 94:8191-8195.
126. Sutton M.A., Taylor A.M., Ito H.T., Pham A., Schuman E.M. Postsynaptic decoding of neural activity: eEF2 as a biochemical sensor coupling miniature synaptic transmission to local protein synthesis. Neuron 2007, 55:648-661.
127. Takei N., Inamura N., Kawamura M., Namba H., Hara K., Yonezawa K., Nawa H. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. J. Neurosci. 2004, 24:9760-9769.
128. Takei N., Kawamura M., Hara K., Yonezawa K., Nawa H. Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin. J. Biol. Chem. 2001, 276:42818-42825.
129. Takei N., Kawamura M., Ishizuka Y., Kakiya N., Inamura N., Namba H., Nawa H. Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons. J. Biol. Chem. 2009, 284:26340-26348.
130. Tanaka J., Horiike Y., Matsuzaki M., Miyazaki T., Ellis-Davies G.C., Kasai H. Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science 2008, 319:1683-1687.
131. Tang S.J., Reis G., Kang H., Gingras A.C., Sonenberg N., Schuman E.M. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc. Natl. Acad. Sci. USA 2002, 99:467-472.
132. Tartaglia N., Du J., Tyler W.J., Neale E., Pozzo-Miller L., Lu B. Protein synthesis-dependent and -independent regulation of hippocampal synapses by brain-derived neurotrophic factor. J. Biol. Chem. 2001, 276:37585-37593.
133. Thakker-Varia S., Alder J., Crozier R.A., Plummer M.R., Black I.B. Rab3A is required for brain-derived neurotrophic factor-induced synaptic plasticity: transcriptional analysis at the population and single-cell levels. J. Neurosci. 2001, 21:6782-6790.
134. Tongiorgi E., Armellin M., Giulianini P.G., Bregola G., Zucchini S., Paradiso B., Steward O., Cattaneo A., Simonato M. Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J. Neurosci. 2004, 24:6842-6852.
135. Tongiorgi E., Baj G. Functions and mechanisms of BDNF mRNA trafficking. Novartis Found. Symp. 2008, 289:136-147. discussion 147-151, 193-135.
136. Tongiorgi E., Righi M., Cattaneo A. Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons. J. Neurosci. 1997, 17:9492-9505.
137. Troca-Marin J.A., Alves-Sampaio A., Tejedor F.J., Montesinos M.L. Local translation of dendritic RhoA revealed by an improved synaptoneurosome preparation. Mol. Cell. Neurosci. 2010, 43:308-314.
138. Tyler W.J., Pozzo-Miller L.D. BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapses. J. Neurosci. 2001, 21:4249-4258.
139. Tyler W.J., Zhang X.L., Hartman K., Winterer J., Muller W., Stanton P.K., Pozzo-Miller L. BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses. J. Physiol. 2006, 574:787-803.
140. Verpelli C., Piccoli G., Zanchi A., Gardoni F., Huang K., Brambilla D., Di Luca M., Battaglioli E., Sala C. Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. J. Neurosci. 2010, 30:5830-5842.
141. Vessey J.P., Schoderboeck L., Gingl E., Luzi E., Riefler J., Di Leva F., Karra D., Thomas S., Kiebler M.A., Macchi P. Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function. Proc. Natl. Acad. Sci. USA 2010, 107:3222-3227.
142. Vo N., Klein M.E., Varlamova O., Keller D.M., Yamamoto T., Goodman R.H., Impey S. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. USA 2005, 102:16426-16431.
143. Woo N.H., Teng H.K., Siao C.J., Chiaruttini C., Pang P.T., Milner T.A., Hempstead B.L., Lu B. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat. Neurosci. 2005, 8:1069-1077.
144. Xu B., Gottschalk W., Chow A., Wilson R.I., Schnell E., Zang K., Wang D., Nicoll R.A., Lu B., Reichardt L.F. The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB. J. Neurosci. 2000, 20:6888-6897.
145. Yin Y., Edelman G.M., Vanderklish P.W. The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes. Proc. Natl. Acad. Sci. USA 2002, 99:2368-2373.
146. Ying S.W., Futter M., Rosenblum K., Webber M.J., Hunt S.P., Bliss T.V., Bramham C.R. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J. Neurosci. 2002, 22:1532-1540.
147. Zadran S., Jourdi H., Rostamiani K., Qin Q., Bi X., Baudry M. Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation. J. Neurosci. 2010, 30:1086-1095.
148. Zakharenko S.S., Patterson S.L., Dragatsis I., Zeitlin S.O., Siegelbaum S.A., Kandel E.R., Morozov A. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron 2003, 39:975-990.
149. Zhong J., Zhang T., Bloch L.M. Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons. BMC Neurosci. 2006, 7:17.