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Volumn 39, Issue 2, 2011, Pages 443-451

Suppression of DNA-PKcs and Ku80 individually and in combination: Different effects of radiobiology in HeLa cells

Author keywords

Cell cycle; DNA PK; Ku80; LY294002; Radiosensitivity

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DNA DEPENDENT PROTEIN KINASE; PROTEIN KU80; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 79959977722     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1041     Document Type: Article
Times cited : (7)

References (38)
  • 1
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH: Genome maintenance mechanisms for preventing cancer. Nature 411: 366-374, 2001.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 2
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • DOI 10.1038/35056049
    • van Gent DC, Hoeijmakers JH and Kanaar R: Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2: 196-206, 2001. (Pubitemid 33674018)
    • (2001) Nature Reviews Genetics , vol.2 , Issue.3 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.J.2    Kanaar, R.3
  • 4
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber MR: The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79: 181-211, 2010.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 7
    • 0034141562 scopus 로고    scopus 로고
    • The controlling role of ATM in homologous recombinational repair of DNA damage
    • Morrison C, Sonoda E, Takao N, Shinohara A, Yamamoto K and Takeda S: The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J 19: 463-472, 2000.
    • (2000) EMBO J , vol.19 , pp. 463-472
    • Morrison, C.1    Sonoda, E.2    Takao, N.3    Shinohara, A.4    Yamamoto, K.5    Takeda, S.6
  • 8
    • 77956401853 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?
    • Hill R and Lee PW: The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet? Cell Cycle 9: 3460-3469, 2010.
    • (2010) Cell Cycle , vol.9 , pp. 3460-3469
    • Hill, R.1    Lee, P.W.2
  • 9
    • 70350088548 scopus 로고    scopus 로고
    • Mechanisms of double-strand break repair in somatic mammalian cells
    • Hartlerode AJ and Scully R: Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J 423: 157-168, 2009
    • (2009) Biochem J , vol.423 , pp. 157-168
    • Hartlerode, A.J.1    Scully, R.2
  • 10
    • 77952583540 scopus 로고    scopus 로고
    • Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair
    • Pawelczak KS and Turchi JJ: Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair. DNA Repair 9: 670-677, 2010.
    • (2010) DNA Repair , vol.9 , pp. 670-677
    • Pawelczak, K.S.1    Turchi, J.J.2
  • 11
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    • Mahaney BL, Meek K and Lees-Miller SP: Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J 417: 639-650, 2009
    • (2009) Biochem J , vol.417 , pp. 639-650
    • Mahaney, B.L.1    Meek, K.2    Lees-Miller, S.P.3
  • 12
    • 50249154761 scopus 로고    scopus 로고
    • Role and regulation of human XRCC4-like factor/cernunnos
    • Dahm K: Role and regulation of human XRCC4-like factor/cernunnos. J Cell Biochem 104: 1534-1540, 2008.
    • (2008) J Cell Biochem , vol.104 , pp. 1534-1540
    • Dahm, K.1
  • 13
    • 33646160992 scopus 로고    scopus 로고
    • The biology of Ku and its potential oncogenic role in cancer
    • Gullo C, Au M, Feng G and Teoh G: The biology of Ku and its potential oncogenic role in cancer. Biochim Biophys Acta 1765: 223-234, 2006.
    • (2006) Biochim Biophys Acta , vol.1765 , pp. 223-234
    • Gullo, C.1    Au, M.2    Feng, G.3    Teoh, G.4
  • 14
    • 33744530828 scopus 로고    scopus 로고
    • The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy
    • DOI 10.1016/j.patbio.2006.01.012, PII S0369811406000162
    • Salles B, Calsou P, Frit P and Muller C: The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy. Pathol Biol 54: 185-193, 2006. (Pubitemid 43815658)
    • (2006) Pathologie Biologie , vol.54 , Issue.4 , pp. 185-193
    • Salles, B.1    Calsou, P.2    Frit, P.3    Muller, C.4
  • 15
    • 25444499420 scopus 로고    scopus 로고
    • Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles
    • DOI 10.1667/RR3366.1
    • Zhang Q, Williams ES, Askin KF, Peng Y, Bedford JS, Liber HL and Bailey SM: Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles. Radiat Res 164: 497-504, 2005 (Pubitemid 41368925)
    • (2005) Radiation Research , vol.164 , Issue.4 II , pp. 497-504
    • Zhang, Q.1    Williams, E.S.2    Askin, K.F.3    Peng, Y.4    Bedford, J.S.5    Liber, H.L.6    Bailey, S.M.7
  • 16
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • DOI 10.1038/35078107
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K and Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498, 2001. (Pubitemid 32494397)
    • (2001) Nature , vol.411 , Issue.6836 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 17
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • DOI 10.1126/science.1068999
    • Brummelkamp TR, Bernards R and Agami R: A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553, 2002. (Pubitemid 34408678)
    • (2002) Science , vol.296 , Issue.5567 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 18
    • 0029156599 scopus 로고
    • DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
    • Hartley KO, Gell D, Smith GC, et al: DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82: 849-856, 1995.
    • (1995) Cell , vol.82 , pp. 849-856
    • Hartley, K.O.1    Gell, D.2    Smith, G.C.3
  • 19
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos CJ, Matter WF, Hui KY and Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269: 5241-5248, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 21
    • 0141757504 scopus 로고    scopus 로고
    • P53 and radiation responses
    • DOI 10.1038/sj.onc.1206677
    • Fei P and El-Deiry WS: p53 and radiation responses. Oncogene 22: 5774-5783, 2003. (Pubitemid 37176699)
    • (2003) Oncogene , vol.22 , Issue.37 REV. ISS. 3 , pp. 5774-5783
    • Fei, P.1    El-Deiry, W.S.2
  • 22
    • 0037108857 scopus 로고    scopus 로고
    • An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents
    • Belenkov AI, Paiement JP, Panasci LC, Monia BP and Chow TY: An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents. Cancer Res 62: 5888-5896, 2002. (Pubitemid 35204750)
    • (2002) Cancer Research , vol.62 , Issue.20 , pp. 5888-5896
    • Belenkov, A.I.1    Paiement, J.-P.2    Panasci, L.C.3    Monia, B.P.4    Chow, T.Y.K.5
  • 23
    • 54449093293 scopus 로고    scopus 로고
    • Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: The example of adipogenesis
    • Meulle A, Salles B, Daviaud D, Valet P and Muller C: Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis. PLoS One 3: E3345, 2008.
    • (2008) PLoS One , vol.3
    • Meulle, A.1    Salles, B.2    Daviaud, D.3    Valet, P.4    Muller, C.5
  • 24
    • 0028897304 scopus 로고
    • DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair
    • Finnie NJ Gottlieb TM, Blunt T, Jeggo PA and Jackson SP: DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci USA 92: 320-324, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 320-324
    • Finnie, N.J.1    Gottlieb, T.M.2    Blunt, T.3    Jeggo, P.A.4    Jackson, S.P.5
  • 25
    • 0033560796 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase
    • Smith GCM and Jackson SP: The DNA-dependent protein kinase. Genes Dev 13: 916-934, 1999. (Pubitemid 29200976)
    • (1999) Genes and Development , vol.13 , Issue.8 , pp. 916-934
    • Smith, G.C.M.1    Jackson, S.P.2
  • 26
    • 0040077747 scopus 로고    scopus 로고
    • Dimerization, translocation and localization of Ku70 and Ku80 proteins
    • Koike M: Dimerization, translocation and localization of Ku70 and Ku80 proteins. J Radiat Res 43: 223-236, 2002.
    • (2002) J Radiat Res , vol.43 , pp. 223-236
    • Koike, M.1
  • 27
    • 0031708232 scopus 로고    scopus 로고
    • Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini
    • West RB, Yaneva M and Lieber MR: Productive and non-productive complexes of Ku and DNA-dependent protein kinase at DNA termini. Mol Cell Biol 18: 5908-5920, 1998. (Pubitemid 28450542)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.10 , pp. 5908-5920
    • West, R.B.1    Yaneva, M.2    Lieber, M.R.3
  • 29
    • 0035893363 scopus 로고    scopus 로고
    • Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    • DOI 10.1101/gad.946401
    • Pierce AJ, Hu P, Han M, Ellis N and Jasin M: Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 15: 3237-3242, 2001. (Pubitemid 34008189)
    • (2001) Genes and Development , vol.15 , Issue.24 , pp. 3237-3242
    • Pierce, A.J.1    Hu, P.2    Han, M.3    Ellis, N.4    Jasin, M.5
  • 31
    • 0142025259 scopus 로고    scopus 로고
    • Interactive Competition Between Homologous Recombination and Non-Homologous End Joining
    • Allen C, Halbrook J and Nickoloff JA: Interactive competition between homologous recombination and non-homologous end joining. Mol Cancer Res 1: 913-920, 2003. (Pubitemid 37288709)
    • (2003) Molecular Cancer Research , vol.1 , Issue.12 , pp. 913-920
    • Allen, C.1    Halbrook, J.2    Nickoloff, J.A.3
  • 32
    • 0036864626 scopus 로고    scopus 로고
    • Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination
    • DOI 10.1016/S1097-2765(02)00705-0
    • Frank-Vaillant M and Marcand S: Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol Cell 10: 1189-1199, 2002. (Pubitemid 35453835)
    • (2002) Molecular Cell , vol.10 , Issue.5 , pp. 1189-1199
    • Frank-Vaillant, M.1    Marcand, S.2
  • 33
    • 0036682122 scopus 로고    scopus 로고
    • An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells
    • Delacote F, Han M, Stamato TD, Jasin M and Lopez BS: An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res 30: 3454-3463, 2002. (Pubitemid 34851217)
    • (2002) Nucleic Acids Research , vol.30 , Issue.15 , pp. 3454-3463
    • Delacote, F.1    Han, M.2    Stamato, T.D.3    Jasin, M.4    Lopez, B.S.5
  • 34
    • 0028307190 scopus 로고
    • The molecular basis for cell cycle delays following ionizing radiation: A review
    • DOI 10.1016/0167-8140(94)90408-1
    • Maity A, McKenna WG and Muschel RJ: The molecular basis for cell cycle delays following ionizing radiation: a review. Radiother Oncol 31: 1-13, 1994. (Pubitemid 24167585)
    • (1994) Radiotherapy and Oncology , vol.31 , Issue.1 , pp. 1-13
    • Maity, A.1
  • 35
    • 0037068770 scopus 로고    scopus 로고
    • Ku affects the ATM-dependent S phase checkpoint following ionizing radiation
    • Zhou XY, Wang X, Wang H, Chen DJ Li GC, Iliakis G and Wang Y: Ku affects the ATM-dependent S phase checkpoint following ionizing radiation. Oncogene 21: 6377-6381, 2002.
    • (2002) Oncogene , vol.21 , pp. 6377-6381
    • Zhou, X.Y.1    Wang, X.2    Wang, H.3    Chen, D.J.4    Li, G.C.5    Iliakis, G.6    Wang, Y.7
  • 36
    • 0036146085 scopus 로고    scopus 로고
    • 2/M checkpoints are induced by ionizing irradiation
    • DOI 10.1128/MCB.22.4.1049-1059.2002
    • Xu B, Kim ST and Kastan MB: Two molecularly distinct G2/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 22: 1049-1059, 2002. (Pubitemid 34094842)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.4 , pp. 1049-1059
    • Xu, B.1    Kim, S.-T.2    Lim, D.-S.3    Kastan, M.B.4
  • 38
    • 0030814125 scopus 로고    scopus 로고
    • 2-M delay
    • Rosenzweig KE, Youmell MB, Palayoor ST and Price BD: Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res 3: 1149-1156, 1997. (Pubitemid 27319761)
    • (1997) Clinical Cancer Research , vol.3 , Issue.7 , pp. 1149-1156
    • Rosenzweig, K.E.1    Youmell, M.B.2    Palayoor, S.T.3    Price, B.D.4


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