Biomonitoring of rural workers exposed to a complex mixture of pesticides in the municipalities of Tianguá and Ubajara (Ceará state, Brazil): Genotoxic and cytogenetic studies

Environmental and Molecular Mutagenesis

Volumn 52, Issue 6, 2011, Pages 492-501

  Paiva, Jean C G ^a   Cabral, Igor O ^a   Soares, Bruno M ^a   Sombra, Carla M L ^a   Ferreira, José R O ^a   Moraes, Manoel O ^a   Cavalcanti, Bruno C ^a   Pessoa, Cláudia ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Biomonitoring; Chromosomal aberrations; Comet assay; Human lymphocytes; Pesticide exposure

Indexed keywords

AGRICULTURAL CHEMICAL; BENZIMIDAZOLE; CARBAMIC ACID; DITHIOCARBAMIC ACID; DNA; INORGANIC COMPOUND; ORGANOPHOSPHATE PESTICIDE; PESTICIDE; THIOCARBAMIC ACID; TRIAZOLE;

ADULT; AGRICULTURAL WORKER; BIOLOGICAL MONITORING; BLOOD SAMPLING; BRAZIL; CELL REGENERATION; COMET ASSAY; CONTROLLED STUDY; CYTOGENETICS; DNA DAMAGE; DNA STRAND BREAKAGE; GENOTOXICITY; HUMAN; MALE; MITOSIS; OCCUPATIONAL EXPOSURE; PERIPHERAL LYMPHOCYTE; REVIEW; RURAL POPULATION; STRUCTURAL CHROMOSOME ABERRATION;

ADOLESCENT; ADULT; AGED; BRAZIL; CHROMOSOME ABERRATIONS; COMET ASSAY; CYTOGENETICS; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; PESTICIDES; YOUNG ADULT;

EID: 79959977717     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20647     Document Type: Review

References (61)

1. Blair A, Zahm SH. 1995. Agricultural exposures and cancer. Environ Health Perspect 103( Suppl 8): 205-208.
2. Blair A, Sandler DP, Tarone R, Lubin J, Thomas K, Hoppin JA, Samanic C, Coble J, Kamel F, Knott C, Dosemeci M, Zahm SH, Lynch CF, Rothman N, Alavanja MC. 2005. Mortality among participants in the agricultural health study. Ann Epidemiol 15: 279-285.
3. Bolognesi C. 2003. Genotoxicity of pesticides: A review of human biomonitoring studies. Mutat Res 543: 251-272.
4. Bortoli GM, Azevedo MB, Silva LB. 2009. Cytogenetic biomonitoring of Brazilian workers exposed to pesticides: micronucleus analysis in buccal epithelial cells of soybean growers. Mutat Res 675: 1-4.
5. Bréga SM, Vassilieff I, Almeida A, Mercadante A, Bissacot D, Cury PR, Freire-Maia DV. 1998. Clinical, cytogenetic and toxicological studies in rural workers exposed to pesticides in Botucatu, São Paulo, Brazil. Cad. Saúde Pública, Rio de Janeiro, 14( Suppl. 3): 109-115.
6. Brogger A. 1982. The chromatid gap-a useful parameter in genotoxicology? Cytogenet Cell Genet 33: 14-19.
7. Calvert GM, Alarcon WA, Chelminski A, Crowley MS, Barrett R, Correa A, Higgins S, Leon HL, Correia J, Becker A, Allen RH, Evans E. 2007. Case report: three farmworkers who gave birth to infants with birth defects closely grouped in time and place-Florida and North Carolina, 2004-2005. Environ Health Perspect 115: 787-791.
8. Carbonell E, Valbuena A, Xamena N, Creus A, Marcos R. 1995. Temporary variations in chromosomal aberrations in a group of agricultural workers exposed to pesticides. Mutat Res 344: 127-134.
9. Carrano AV, Natarajan AT. 1988. International commission for protection against environmental mutagens and carcinogens. ICPEMC publication no. 14. Considerations for population monitoring using cytogenetic techniques. Mutat Res 204: 379-406.
10. Cavalcanti BC, Sombra CML, De Oliveira JHHL, Berlinck RGS, Morais MO, Pessoa C. 2008. Cytotoxicity and genotoxicity of ingenamine G isolated from the Brazilian marine sponge Pachychalina alcaloidifera. Comp Biochem Physiol C 147: 409-415.
11. Cavalcanti BC, Bezerra DP, Magalhães HIF, Moraes MO, Lima MAS, Silveira ER, Câmara CAG, Rao VS, Pessoa C, Costa-Lotufo LV. 2009. Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells. J Appl Toxicol 29: 560-568.
12. Chrisman JR, Koifman S, de Novaes Sarcinelli P, Moreira JC, Koifman RJ, Meyer A. 2009. Pesticide sales and adult male cancer mortality in Brazil. Int J Hyg Environ Health 212: 310-321.
13. Collins AR, Dusinska M, Franklin M, Somorovska M, Petrovska H, Duthie S, Fillion L, Panayiotidis M, Raslova K.Vaughan N. 1997. Comet assay in human biomonitoring studies: reliability, validation, and applications. Environ Mol Mutagen 30: 139-146.
14. Costa C, Silva S, Coelho P, Roma-Torres J, Teixeira JP, Mayan O. 2007. Micronucleus analysis in a Portuguese population exposed to pesticides: Preliminary survey. Int J Hyg Environ Health 210: 415-418.
15. Dahlhaus M, Almstadt E, Henschke P, Luttgert S, Apple KE. 1995. Induction of 8-hydroxy-2-deoxyguanosine and single-strand break in DNA of V79 cells by tetrachloro-p-hydroquinone. Mutat Res 329: 29-36.
16. Daniels JL, Olsha AR, Savitz DA. 1997. Pesticides and childhood cancers. Environ Health Perspect 105: 1068-1077.
17. Dearfield KL, McCarroll NE, Protzel A, Stack HF, Jackson MA, Waters MD. 1999. A survey of EPA/OPP and open literature on selected pesticide chemicals. II. Mutagenicity and carcinogenicity of selected chloroacetanilides and related compounds. Mutat Res 443: 183-221.
18. Ecobichon DJ. 2000. Our changing perspectives on benefit and risks of pesticides: A historical overview. NeuroToxicology 21: 211-218.
19. Ecobichon DJ. 2001. Pesticide use in developing countries. Toxicology 160: 27-33.
20. Ergene S, Celik A, Cavaş T, Kaya F. 2007. Genotoxic biomonitoring study of population residing in pesticide contaminated regions in Göksu Delta: Micronucleus, chromosomal aberrations and sister chromatid exchanges. Environ Int 33: 877-885.
21. Fairbairn DW, Olive PL, O'Neill KL. 1995. The comet assay: A comprehensive review. Mutat Res 339: 37-59.
22. Faria NMX, Fassa AG, Facchini LA. 2007. Pesticides poisoning in Brazil: the official notification system and challenges to conducting epidemiological studies. Cien Saude Colet 12: 25-38.
23. Garaj-Vrhovac V, Zeljezic D. 2000. Evaluation of DNA damage in workers occupationally exposed to pesticides using single-cell gel electrophoresis (SCGE) assay pesticide genotoxicity revealed by comet assay. Mutat Res 469: 279-285.
24. Gomez-Arroyo S, Diaz-Sanchez Y, Meneses-Perez MA, Villalobos-Pietrini R, De Leon-Rodriguez J. 2000. Cytogenetic biomonitoring in a Mexican floriculture worker group exposed to pesticides. Mutat Res 466: 117-124.
25. Guimarães AC, Antunes, LMG, Ribeiro HF, Dos Santos AKR, Cardoso PCS, De Lima PL, Seabra A D, Pontes TB, Pessoa C, Moraes MO, Cavalcanti BC, Sombra CML, Bahia MO, Burbano RR. 2010. Cytogenetic biomonitoring of inhabitants of a large uranium mineralization area: The municipalities of Monte Alegre, Prainha, and Alenquer, in the State of Pará, Brazil. Cell Biology and Toxicology 28:403-419.
26. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans (2002) vol. 1, 1971 to vol. 82.
27. Isidori M, Caterino E, Criscuolo E, Fatigati V, Liguori G, Parrella A. 2009. Antimutagenic and antigenotoxic effects of vegetable matrices on the activity of pesticides. Food Add Contam Part A Chem Anal Control Expo Risk Assess 26: 1049-1062.
28. Jacobsen PR, Christiansen S, Boberg J, Nellemann C, Hass U. 2010. Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats. Int J Androl 33: 434-442.
29. Jamil K, Das GP, Shaik AP, Dharmi SS, Murthy S. 2007. Epidemiological studies of pesticide exposed individuals and their clinical implications. Current Sci 92: 340-345.
30. Jobim PFC, Nunes LN, Giugliani R, Cruz IBM. 2010. Is there an association between cancer mortality and agrotoxics use? A contribution to the debate. Cien Saude Colet 15: 277-288.
31. Kaufman WK. 1989. Pathways of human cell post-replication repair. Carcinogenesis 10: 1-11.
32. King JS, Valgargel ER, Rufer JT, Phillips JW, Moran WF. 1993. Noncomplementary DNA double strand break rejoining in bacterial and human cells. Nucleic Acids Res 21: 1055-1059.
33. Klaude M, Erikson S, Nygren J, Ahnstrom G. 1996. The comet assay: Mechanisms and technical considerations. Mutat Res 363: 89-96.
34. Koifman S and Koifman RJ. 2003. Environment and cancer in Brazil: an overview from a public health perspective. Mutat Res 544: 305-311.
35. Koifman S, Koifman RJ, Meyer A. 2002. Human reproductive system disturbances and pesticide exposure in Brazil. Cad Saúde Pública Rio de Janeiro 18: 435-445.
36. Konradsen F. 2007. Acute pesticide poisoning: A global public health problem. Dan Med Bull 54: 58-59.
37. Koutros S, Alavanja MC, Lubin JH, Sandler DP, Hoppin JA, Lynch CF, Knott C, Blair A, Freeman LE. 2010. An update of cancer incidence in the Agricultural Health Study. J Occup Environ Med 52: 1098-1105.
38. Kumar LP, Panneerselvam N. 2008. Toxic effects of pesticides: A review on cytogenetic biomonitoring studies. Med Biol 15: 46-50.
39. Miyamae Y, Yamamoto M, Sasaki YF, Kobayashi H, Igarashi-Soga M, Shimoi K, Hayashi M. 1998. Evaluation of a tissue homogenization that isolates nuclei for the in vivo single cell gel electrophoresis (Comet) assay: A collaborative study by five laboratories. Mutat Res 418: 131-140.
40. Moller P, Knudsen LE, Loft S, Wallin H. 2000. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev 9: 1005-1015.
41. Moorhead PS, Nowell PC, Mellman WJ, Battips DM, Hungerford DA. 1960. Chromosome preparations of leukocytes cultured from human peripheral blood. Exp Cell Res 20: 613-616.
42. Moser VC. 2000. Dose response and time-course of neurobehavioral changes following oral chlorpyrifos in different ages. Neurotoxicol Teratol 22: 713-723.
43. Muniz JF, McCauley L, Scherer J, Lasarev M, Koshy M, Kow YW, Nazar-Stewart V, Kisby GE. 2008. Biomarkers of oxidative stress and DNA damage in agricultural workers: a pilot study. Toxicol Appl Pharmacol 227: 97-107.
44. Pacheco AO, Hackel C. 2002. Chromosome instability induced by agrochemicals among farm workers in Passo Fundo, Rio Grande do Sul, Brazil. Cad Saude Publ 18: 1675-1683.
45. Paz-y-Mino C, Bustamante G, Sanchez ME, Leone PE. 2002. Cytogenetic monitoring in a population occupationally exposed to pesticides in Ecuador. Environ Health Perspect 110: 1077-1080.
46. Paz-y-Mino C, Arevalo M, Sanchez ME, Leone PE. 2004. Chromosome and DNA damage analysis in individuals occupationally exposed to pesticides with relation to genetic polymorphism for CYP 1A1 gene in Ecuador. Mutat Res 562: 77-89.
47. Petrovská H, Dušinska M. 1999. Oxidative DNA damage in human cells induced by Paraquat. ATLA 27: 387-395.
48. Preston RJ, San Sebastian JR, McFee AF. 1987. The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents. Mutat Res 189: 175-183.
49. Remor AP, Totti CC, Moreira DA, Dutra GP, Heuser VD, Boeira JM. 2009. Occupational exposure of farm workers to pesticides: Biochemical parameters and evaluation of genotoxicity. Environ Int 35: 273-278.
50. Sailaja N, Chandrasekhar M, Rekhadevi PV, Mahboob M, Rahman MF, Vuyyuri SB, Danadevi K, Hussain SA, Grover P. 2006. Genotoxic evaluation of workers employed in pesticide production. Mutat Res 609: 74-80.
51. Savage JRK. 1976. Classification and relationship of induced chromosome structural changes. J Med Genet 13: 103-122.
52. Schinzel A, Schmid W. 1976. Lymphocyte chromosome studies in humans exposed to chemical mutagens. The validity of the method in 67 patients under cytostatic therapy. Mutat Res 40: 139-166.
53. Shah RG, Lagueux J, Kapur S, Levallois P, Ayotte P, Tremblay M, Zee J, Poirier GG. 1997. Determination of genotoxicity of the metabolites of pesticides guthion, sencor, lorox, reglone, daconil and admire by 32P-postlabeling. Mol Cell Biochem 169: 177-184.
54. Shaham J, Kaufman Z, Gurvich R, Levi Z. 2001. Frequency of sister-chromatid exchange among greenhouse farmers exposed to pesticides. Mutat Res 491: 71-80.
55. Silva J, Moraes CR, Heuser VD, Andrade VM, Silva FR, Kvitko K, Emmel V, Rohr P, Bordin DL, Andreazza AC, Salvador M, Henriques JAP, Erdtmann B. 2008. Evaluation of genetic damage in a Brazilian population occupationally exposed to pesticides and its correlation with polymorphisms in metabolizing genes. Mutagenesis 23: 415-422.
56. Singh NP, McCoy MT, Tice RR.Scheider EL. 1988. A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 175: 184-191.
57. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF. 2000. Single cell gel/Comet assay: Guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35: 206-221.
58. Van Maele-Fabry G, Willems JL. 2004. Prostate cancer among pesticide applicators: a meta-analysis. Int Arch Occup Environ Health 77: 559-570.
59. Webster LR, McKenzie GH, Moriarty HT. 2002. Organophosphate-based pesticides and genetic damage implicated in bladder cancer. Cancer Genet Cytogenet 133: 112-117.
60. Whitney KD, Seidler FJ, Slotkin TA. 1995. Developmental neurotoxicity of chlorpyrifos. Cellular mechanism. Toxicol Appl Pharmacol 134: 53-62.
61. Zeljezic D, Garaj-Vrhovac V. 2001. Chromosomal aberrations and single cell gel electrophoresis (comet) assay in the longitudinal risk assessment of occupational exposure to pesticides. Mutagenesis 16: 359-363.