The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities

Journal of Molecular Medicine

Volumn 89, Issue 6, 2011, Pages 611-619

  Moncada Pazos, Angela ^a   Obaya, Alvaro J ^a   Viloria, Cristina G ^a   López Otín, Carlos ^a   Cal, Santiago ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

Arthritis; Biochemistry; Extracellular matrix; Inflammation

Indexed keywords

AGGRECAN; AGGRECANASE 1; AGGRECANASE 2; CURCUMIN; GENISTEIN; GLYCOSAMINOGLYCAN; GUGGULSTERONE; INTERLEUKIN 1ALPHA; LUTEOLIN; MATRIX METALLOPROTEINASE; NUTRACEUTICAL; PICEATANNOL; RESVERATROL; RETINOIC ACID; TRANSFERRIN;

ANIMAL TISSUE; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CELL DESTRUCTION; CHONDROPROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; MOUSE; NONHUMAN; PROTEIN SECRETION;

ADAM PROTEINS; AGGRECANS; ANIMALS; ARTHRITIS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; ENDOPEPTIDASES; EXTRACELLULAR MATRIX PROTEINS; GLYCOSAMINOGLYCANS; INTERLEUKIN-1ALPHA; LUTEOLIN; MATRIX METALLOPROTEINASES; METALLOPROTEASES; MICE; PROCOLLAGEN N-ENDOPEPTIDASE; TRETINOIN;

EID: 79959955193     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0741-7     Document Type: Article

References (35)

1. H Nagase M Kashiwagi 2003 Aggrecanases and cartilage matrix degradation Arthritis Res Ther 5 94 103 12718749 10.1186/ar630 1:CAS:528: DC%2BD3sXjt1aru7k%3D (Pubitemid 36849755)
2. DD Dean J Martel-Pelletier JP Pelletier DS Howell JF Woessner Jr 1989 Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage J Clin Invest 84 678 685 2760206 10.1172/JCI114215 1:CAS:528:DyaL1MXltlWqsrs%3D (Pubitemid 19197004)
3. EC Arner 2002 Aggrecanase-mediated cartilage degradation Curr Opin Pharmacol 2 322 329 12020478 10.1016/S1471-4892(02)00148-0 1:CAS:528: DC%2BD38XjvVKhs7o%3D (Pubitemid 34594376)
4. JD Sandy 2006 A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis Osteoarthritis Cartilage 14 95 100 16257242 10.1016/j.joca.2005. 09.004 1:STN:280:DC%2BD28%2FislOmtw%3D%3D (Pubitemid 43079305)
5. AJ Fosang CB Little 2008 Drug insight: aggrecanases as therapeutic targets for osteoarthritis Nat Clin Pract Rheumatol 4 420 427 18577998 10.1038/ncprheum0841 1:CAS:528:DC%2BD1cXptFSmsrY%3D
6. Z Zhou SS Apte R Soininen R Cao GY Baaklini RW Rauser J Wang Y Cao K Tryggvason 2000 Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I Proc Natl Acad Sci USA 97 4052 4057 10737763 10.1073/pnas.060037197 1:CAS:528:DC%2BD3cXislSgtLo%3D (Pubitemid 30226085)
7. C Colnot Z Thompson T Miclau Z Werb JA Helms 2003 Altered fracture repair in the absence of MMP9 Development 130 4123 4133 12874132 10.1242/dev.00559 1:CAS:528:DC%2BD3sXntFejs70%3D (Pubitemid 37063429)
8. H Stanton FM Rogerson CJ East SB Golub KE Lawlor CT Meeker CB Little K Last PJ Farmer IK Campbell, et al. 2005 ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro Nature 434 648 652 15800625 10.1038/nature03417 1:CAS:528:DC%2BD2MXislCmsrg%3D (Pubitemid 40488557)
9. M Colic K Pavelic 2000 Molecular mechanisms of anticancer activity of natural dietetic products J Mol Med 78 333 336 11001530 10.1007/s001090000121 1:CAS:528:DC%2BD3cXntV2gsr0%3D
10. MN Vankemmelbeke GC Jones C Fowles MZ Ilic CJ Handley AJ Day CG Knight JS Mort DJ Buttle 2003 Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters Eur J Biochem 270 2394 2403 12755694 10.1046/j.1432-1033.2003. 03607.x 1:CAS:528:DC%2BD3sXks1GktrY%3D (Pubitemid 36645357)
11. K Imada N Lin C Liu A Lu W Chen M Yano T Sato A Ito 2008 Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice Biochem Biophys Res Commun 373 181 185 18541144 10.1016/j.bbrc.2008.05.171 1:CAS:528: DC%2BD1cXotlWqu7w%3D
12. M Lopez-Lazaro 2009 Distribution and biological activities of the flavonoid luteolin Mini Rev Med Chem 9 31 59 19149659 10.2174/138955709787001712 1:CAS:528:DC%2BD1MXks1Srt7Y%3D
13. S Jang KW Kelley RW Johnson 2008 Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 Proc Natl Acad Sci USA 105 7534 7539 18490655 10.1073/pnas.0802865105 1:CAS:528: DC%2BD1cXmvFGju7c%3D (Pubitemid 351830053)
14. A Xagorari A Papapetropoulos A Mauromatis M Economou T Fotsis C Roussos 2001 Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages J Pharmacol Exp Ther 296 181 187 11123379 1:CAS:528:DC%2BD3MXosVeg (Pubitemid 32015077)
15. H Nagase 1995 Human stromelysins 1 and 2 Meth Enzymol 248 449 470 7674937 10.1016/0076-6879(95)48029-3 1:CAS:528:DyaK2MXptVShs7g%3D
16. C Gendron M Kashiwagi NH Lim JJ Enghild IB Thogersen C Hughes B Caterson H Nagase 2007 Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4 J Biol Chem 282 18294 18306 17430884 10.1074/jbc.M701523200 1:CAS:528:DC%2BD2sXmsVOksr4%3D (Pubitemid 47100219)
17. M Otero JJ Gomez Reino O Gualillo 2003 Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells Arthritis Rheum 48 404 409 12571850 10.1002/art.10811 1:CAS:528:DC%2BD3sXhslKkt78%3D (Pubitemid 36278009)
18. EC Arner MA Pratta JM Trzaskos CP Decicco MD Tortorella 1999 Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity J Biol Chem 274 6594 6601 10037754 10.1074/jbc.274.10.6594 1:CAS:528:DyaK1MXhs1Cisb0%3D (Pubitemid 29111077)
19. MK Majumdar R Askew S Schelling N Stedman T Blanchet B Hopkins EA Morris SS Glasson 2007 Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis Arthritis Rheum 56 3670 3674 17968948 10.1002/art.23027 1:CAS:528: DC%2BD2sXhsVSkt7jI (Pubitemid 350100701)
20. I Barbosa S Garcia V Barbier-Chassefiere JP Caruelle I Martelly D Papy-Garcia 2003 Improved and simple micro assay for sulfated glycosaminoglycans quantification in biological extracts and its use in skin and muscle tissue studies Glycobiology 13 647 653 12773478 10.1093/glycob/cwg082 1:CAS:528:DC%2BD3sXotFKrsLo%3D (Pubitemid 37220443)
21. D Khanna G Sethi KS Ahn MK Pandey AB Kunnumakkara B Sung A Aggarwal BB Aggarwal 2007 Natural products as a gold mine for arthritis treatment Curr Opin Pharmacol 7 344 351 17475558 10.1016/j.coph.2007.03.002 1:CAS:528: DC%2BD2sXlsF2nt7c%3D (Pubitemid 46731200)
22. JD Sandy PJ Neame RE Boynton CR Flannery 1991 Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain J Biol Chem 266 8683 8685 2026585 1:CAS:528: DyaK3MXktVGltLw%3D (Pubitemid 21906567)
23. CM Overall C Lopez-Otin 2002 Strategies for MMP inhibition in cancer: innovations for the post-trial era Nat Rev Cancer 2 657 672 12209155 10.1038/nrc884 1:CAS:528:DC%2BD38Xmslamsro%3D (Pubitemid 37328917)
24. C Lopez-Otin LH Palavalli Y Samuels 2009 Protective roles of matrix metalloproteinases: from mouse models to human cancer Cell Cycle 8 3657 3662 19844170 10.4161/cc.8.22.9956 1:CAS:528:DC%2BC3cXotlWrsL0%3D
25. C Lopez-Otin LM Matrisian 2007 Emerging roles of proteases in tumour suppression Nat Rev Cancer 7 800 808 17851543 10.1038/nrc2228 1:CAS:528:DC%2BD2sXhtVOnsr3I (Pubitemid 47463671)
26. A Moncada-Pazos AJ Obaya MF Fraga CG Viloria G Capella M Gausachs M Esteller C Lopez-Otin S Cal 2009 The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer J Cell Sci 122 2906 2913 19638407 10.1242/jcs.050468 1:CAS:528:DC%2BD1MXhtFOgsbzM
27. CG Viloria AJ Obaya A Moncada-Pazos M Llamazares A Astudillo G Capella S Cal C Lopez-Otin 2009 Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer Cancer Res 69 4926 4934 19458070 10.1158/0008-5472.CAN-08-4155 1:CAS:528:DC%2BD1MXmsFGks78%3D
28. H Nagase K Fushimi 2008 Elucidating the function of non catalytic domains of collagenases and aggrecanases Connect Tissue Res 49 169 174 18661336 10.1080/03008200802151698 1:CAS:528:DC%2BD1cXptVKltLs%3D
29. L Troeberg K Fushimi R Khokha H Emonard P Ghosh H Nagase 2008 Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases FASEB J 22 3515 3524 18632849 10.1096/fj.08-112680 1:CAS:528:DC%2BD1cXht1SqsrbM
30. P Patwari B Kurz JD Sandy AJ Grodzinsky 2000 Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage Arch Biochem Biophys 374 79 85 10640399 10.1006/abbi.1999.1538 1:CAS:528:DC%2BD3cXksl2ltw%3D%3D (Pubitemid 30084411)
31. JK Kim EK Shin JH Park YH Kim 2010 Antitumor and antimetastatic effects of licochalcone A in mouse models J Mol Med 88 829 838 20383690 10.1007/s00109-010-0625-2 1:CAS:528:DC%2BC3cXos1aisLw%3D
32. JL Lauer-Fields TP Spicer PS Chase M Cudic GD Burstein H Nagase P Hodder GB Fields 2008 Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate Anal Biochem 373 43 51 17949675 10.1016/j.ab.2007.09. 014 1:CAS:528:DC%2BD2sXhsVCks7%2FI (Pubitemid 350258635)
33. C Ende R Gebhardt 2004 Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids Planta Med 70 1006 1008 15490332 10.1055/s-2004-832630 1:CAS:528:DC%2BD2cXpsVWls70%3D (Pubitemid 39457814)
34. Y Hou J Wu Q Huang L Guo 2009 Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts Cell Biol Int 33 135 147 18992831 10.1016/j.cellbi.2008.10.005 1:CAS:528:DC%2BD1MXhtlSnu7c%3D
35. M Cudic GD Burstein GB Fields J Lauer-Fields 2009 Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates Chem Biol Drug Des 74 473 482 19793184 10.1111/j.1747-0285. 2009.00885.x 1:CAS:528:DC%2BD1MXhtlehu7vJ