메뉴 건너뛰기




Volumn 16, Issue 3, 2011, Pages 441-458

Emerging therapies in metastatic bone pain

Author keywords

bone metastases; cancer; cathepsin K; CXCR4; pain; RANKL; skeletal related events; Src; targeted therapy; Wnt

Indexed keywords

(5 TERT BUTYL 2,3 DIHYDRO 1H INDEN 1 YL) 3 (1H INDAZOL 4 YL)UREA; 4 [3 (TRIFLUOROMETHYL) 2 PYRIDINYL] N [5 (TRIFLUOROMETHYL) 2 PYRIDINYL] 1 PIPERAZINECARBOXAMIDE; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; ALENDRONIC ACID; AMGN 0007; ANALGESIC AGENT; ARRY 470; ATRASENTAN; BETA CATENIN; BISPHOSPHONIC ACID DERIVATIVE; CANNABINOID RECEPTOR; CATHEPSIN K; CHEMOKINE RECEPTOR CXCR4; CLODRONIC ACID; CORTICOSTEROID; DASATINIB; DENOSUMAB; DEXAMETHASONE; ENDOTHELIN A RECEPTOR; GABAPENTIN; IBANDRONIC ACID; KX 2391; NERVE GROWTH FACTOR; ODANACATIB; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; PROTEIN TYROSINE KINASE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; RISEDRONIC ACID; SARACATINIB; SCLEROSTIN; SOTATERCEPT; TANEZUMAB; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 1; WAY 262611; WNT PROTEIN; ZIBOTENTAN; ZOLEDRONIC ACID;

EID: 79959932437     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2011.576668     Document Type: Review
Times cited : (17)

References (150)
  • 1
    • 0032813617 scopus 로고    scopus 로고
    • A working group of the IAPS task force on cancer pain: An international survey of cancer pain characteristics and syndromes
    • Caraceni A, Portenoy PK. A working group of the IAPS task force on cancer pain: An international survey of cancer pain characteristics and syndromes. Pain 1999;16:263-74
    • (1999) Pain , vol.16 , pp. 263-274
    • Caraceni, A.1    Portenoy, P.K.2
  • 2
    • 0028912142 scopus 로고
    • The systemic treatment of bone metastases
    • Houston SJ, Rubens RD. The systemic treatment of bone metastases. Clin Orthop Relat Res 1995;312:539-42
    • (1995) Clin Orthop Relat Res , vol.312 , pp. 539-542
    • Houston, S.J.1    Rubens, R.D.2
  • 3
    • 34250009724 scopus 로고    scopus 로고
    • Management of painful bone metastases
    • Mercadante S, Fulfaro F. Management of painful bone metastases. Curr Opin Oncol 2007;19:308-14
    • (2007) Curr Opin Oncol , vol.19 , pp. 308-314
    • Mercadante, S.1    Fulfaro, F.2
  • 4
    • 34249028508 scopus 로고    scopus 로고
    • Pain management in hospitalized cancer patients: A systematic review
    • Goldberg G, Morrison R. Pain management in hospitalized cancer patients: A systematic review. J Clin Oncol 2007;25:1792-801
    • (2007) J Clin Oncol , vol.25 , pp. 1792-1801
    • Goldberg, G.1    Morrison, R.2
  • 5
    • 0346098113 scopus 로고    scopus 로고
    • Pain management in cancer patients with bone metastases remains a challenge
    • Yau V, Chow E, Davis L, et al. Pain management in cancer patients with bone metastases remains a challenge. J Pain Symptom Manage 2004;27:1-3
    • (2004) J Pain Symptom Manage , vol.27 , pp. 1-3
    • Yau, V.1    Chow, E.2    Davis, L.3
  • 7
    • 33646789784 scopus 로고    scopus 로고
    • COX-2 inhibitors: Pharmacological data and adverse effects
    • Mattia C, Coluzzi F. COX-2 inhibitors: Pharmacological data and adverse effects. Minerva Anestesiol 2005;71:461-70
    • (2005) Minerva Anestesiol , vol.71 , pp. 461-470
    • Mattia, C.1    Coluzzi, F.2
  • 8
    • 37349059237 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs, cyclooxygenase-2 and the bone healing process
    • Vuolteenaho K, Moilanen T, Moilanen E. Non-steroidal anti-inflammatory drugs, cyclooxygenase-2 and the bone healing process. Basic Clin Pharmacol Toxicol 2008;102:10-14
    • (2008) Basic Clin Pharmacol Toxicol , vol.102 , pp. 10-14
    • Vuolteenaho, K.1    Moilanen, T.2    Moilanen, E.3
  • 9
    • 61849123196 scopus 로고    scopus 로고
    • Oral opioids for chronic non-cancer pain: Higher prevalence of hypogonadism in men than in women
    • Fraser LA, Morrison D, Morley-Forster P, et al. Oral opioids for chronic non-cancer pain: Higher prevalence of hypogonadism in men than in women. Exp Clin Endocrinol Diabetes 2009;117:38-43
    • (2009) Exp Clin Endocrinol Diabetes , vol.117 , pp. 38-43
    • Fraser, L.A.1    Morrison, D.2    Morley-Forster, P.3
  • 10
    • 77954085188 scopus 로고    scopus 로고
    • Pre-treatment with capsaicin in a rat osteoarthritis model reduces the symptoms of pain and bone damage induced by monosodium iodoacetate
    • Kalff KM, El Mouedden M, van Egmond J, et al. Pre-treatment with capsaicin in a rat osteoarthritis model reduces the symptoms of pain and bone damage induced by monosodium iodoacetate. Eur J Pharmacol 2010;641:108-13
    • (2010) Eur J Pharmacol , vol.641 , pp. 108-113
    • Kalff, K.M.1    El Mouedden, M.2    Van Egmond, J.3
  • 11
    • 0033972908 scopus 로고    scopus 로고
    • Oral biphosphonates: A review of clinical use in patients with bone metastases
    • Major PP, Lipton A, Berenson J, et al. Oral biphosphonates: A review of clinical use in patients with bone metastases. Cancer 2000;88:6-14
    • (2000) Cancer , vol.88 , pp. 6-14
    • Major, P.P.1    Lipton, A.2    Berenson, J.3
  • 12
    • 75149164059 scopus 로고    scopus 로고
    • Emerging therapeutic targets in breast cancer bone metastasis
    • This review is a milestone for understanding the mechanisms underlying the newer proposed therapeutic targets in bone metastatic breast cancer
    • Rose NAA, Siegel PM. Emerging therapeutic targets in breast cancer bone metastasis. Future Oncol 2010;6:55-74 This review is a milestone for understanding the mechanisms underlying the newer proposed therapeutic targets in bone metastatic breast cancer.
    • (2010) Future Oncol , vol.6 , pp. 55-74
    • Rose, N.A.A.1    Siegel, P.M.2
  • 13
    • 0037115425 scopus 로고    scopus 로고
    • Simultaneous reduction in cancer pain, bone destruction, and tumor grwth by selective inhibition of cyclooxygenase-2
    • Sabino MA, Ghilardi JR, Jongen JL, et al. Simultaneous reduction in cancer pain, bone destruction, and tumor grwth by selective inhibition of cyclooxygenase-2. Cancer Res 2002;62:7343-9
    • (2002) Cancer Res , vol.62 , pp. 7343-7349
    • Sabino, M.A.1    Ghilardi, J.R.2    Jongen, J.L.3
  • 14
    • 70349332588 scopus 로고    scopus 로고
    • Controversial effects of non-steroidal anti-inflammatory drugs on bone: A review
    • Salari P, Abdollahi M. Controversial effects of non-steroidal anti-inflammatory drugs on bone: A review. Inflamm Allergy Drug Targets 2009;8:169-75
    • (2009) Inflamm Allergy Drug Targets , vol.8 , pp. 169-175
    • Salari, P.1    Abdollahi, M.2
  • 15
    • 33645106396 scopus 로고    scopus 로고
    • Low morphine doses in opioid-naive cancer patients with pain
    • Mercadante S, Porzio G, Ferrera P, et al. Low morphine doses in opioid-naive cancer patients with pain. J Pain Symptom Manage 2006;31:242-7
    • (2006) J Pain Symptom Manage , vol.31 , pp. 242-247
    • Mercadante, S.1    Porzio, G.2    Ferrera, P.3
  • 16
    • 52449130336 scopus 로고    scopus 로고
    • Paracetamol/Tramadol association: The easy solution for mild-moderate pain
    • Mattia C, Coluzzi F, Sarzi Puttini P, et al. Paracetamol/Tramadol association: The easy solution for mild-moderate pain. Minerva Med 2008;99:369-90
    • (2008) Minerva Med , vol.99 , pp. 369-390
    • Mattia, C.1    Coluzzi, F.2    Sarzi Puttini, P.3
  • 17
    • 0036468726 scopus 로고    scopus 로고
    • Steering Committee of the European Association for Palliative Care (EAPC) Research Network. Episodic (breakthrough) pain: Consensus conference of an expert working group of the european association for palliative care
    • Mercadante S, Radbruch L, Caraceni A, et al. Steering Committee of the European Association for Palliative Care (EAPC) Research Network. Episodic (breakthrough) pain: Consensus conference of an expert working group of the European Association for Palliative Care. Cancer 2002;94:832-9
    • (2002) Cancer , vol.94 , pp. 832-839
    • Mercadante, S.1    Radbruch, L.2    Caraceni, A.3
  • 18
    • 33847154665 scopus 로고    scopus 로고
    • Absolute and relative bioavailability of fentanyl buccal tablet and oral transmucosal fentanyl citrate
    • Darwish M, Kirby M, Robertson P, et al. Absolute and relative bioavailability of fentanyl buccal tablet and oral transmucosal fentanyl citrate. J Clin Pharmacol 2007;47:343-50
    • (2007) J Clin Pharmacol , vol.47 , pp. 343-350
    • Darwish, M.1    Kirby, M.2    Robertson, P.3
  • 19
    • 78651385205 scopus 로고    scopus 로고
    • Make a CHANGE: Optimising communication and pain management decisions
    • Muller-Schwefe G, Jaksch W, Morlion B, et al. Make a CHANGE: Optimising communication and pain management decisions. Curr Med Res Opin 2011;27:481-8
    • (2011) Curr Med Res Opin , vol.27 , pp. 481-488
    • Muller-Schwefe, G.1    Jaksch, W.2    Morlion, B.3
  • 20
    • 70349386728 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I
    • Zhou SF. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet 2009;48:689-723
    • (2009) Clin Pharmacokinet , vol.48 , pp. 689-723
    • Zhou, S.F.1
  • 21
    • 77956307067 scopus 로고    scopus 로고
    • Risk of injury associated with opioid use in older adults
    • Buckeridge D, Huang A, Hanley J, et al. Risk of injury associated with opioid use in older adults. J Am Geriatr Soc 2010;58:1664-70
    • (2010) J Am Geriatr Soc , vol.58 , pp. 1664-1670
    • Buckeridge, D.1    Huang, A.2    Hanley, J.3
  • 22
    • 0033765891 scopus 로고    scopus 로고
    • Expression of opioid receptors in osteoblast-like MG-63 cells, and effects of different opioid agonists on alkaline phosphatase and osteocalcin secretion by these cells
    • Perez-Castrillon JL, Olmos JM, Gomez JJ, et al. Expression of opioid receptors in osteoblast-like MG-63 cells, and effects of different opioid agonists on alkaline phosphatase and osteocalcin secretion by these cells. Neuroendocrinology 2000;72:187-94
    • (2000) Neuroendocrinology , vol.72 , pp. 187-194
    • Perez-Castrillon, J.L.1    Olmos, J.M.2    Gomez, J.J.3
  • 24
    • 51349116134 scopus 로고    scopus 로고
    • Evidence-based standards for cancer pain management
    • Dy SM, Asch SM, Maeim A, et al. Evidence-based standards for cancer pain management. J Clin Oncol 2008;26:3879-85
    • (2008) J Clin Oncol , vol.26 , pp. 3879-3885
    • Dy, S.M.1    Asch, S.M.2    Maeim, A.3
  • 26
    • 43649093122 scopus 로고    scopus 로고
    • Challenges in cancer pain management-bone pain
    • Colvin L, Fallon M. Challenges in cancer pain management-bone pain. Eur J Cancer 2008;44:1083-90
    • (2008) Eur J Cancer , vol.44 , pp. 1083-1090
    • Colvin, L.1    Fallon, M.2
  • 27
    • 0642285455 scopus 로고    scopus 로고
    • Antidepressants in chronic neuropathic pain
    • Mattia C, Coluzzi F. Antidepressants in chronic neuropathic pain. Mini Rev Med Chem 2003;3:773-84
    • (2003) Mini Rev Med Chem , vol.3 , pp. 773-784
    • Mattia, C.1    Coluzzi, F.2
  • 29
    • 34447648338 scopus 로고    scopus 로고
    • Gabapentin and an opioid combination versus opioid alone for the management of neuropathic cancer pain: A randomized open trial
    • Keskinbora K, Pekel AF, Aydinli I. Gabapentin and an opioid combination versus opioid alone for the management of neuropathic cancer pain: A randomized open trial. J Pain Symptom Manage 2007;34:183-9
    • (2007) J Pain Symptom Manage , vol.34 , pp. 183-189
    • Keskinbora, K.1    Pekel, A.F.2    Aydinli, I.3
  • 30
    • 0034844861 scopus 로고    scopus 로고
    • Should biphosphonates be the treatment of choice for metastatic bone disease?
    • Coleman RE. Should biphosphonates be the treatment of choice for metastatic bone disease? Semin Oncol 2001;28(4 Suppl 11):35-41
    • (2001) Semin Oncol , vol.28 , Issue.4 SUPPL. 11 , pp. 35-41
    • Coleman, R.E.1
  • 31
    • 66949136282 scopus 로고    scopus 로고
    • Efficacy of clodronate, pamidronate, and zoledronate in reducing morbidity and mortality in cancer patients with bone metastasis: A meta-analysis of randomized clinical trials
    • Machado M, Cruz LS, Tannus G, et al. Efficacy of clodronate, pamidronate, and zoledronate in reducing morbidity and mortality in cancer patients with bone metastasis: A meta-analysis of randomized clinical trials. Clin Ther 2009;31:962-79
    • (2009) Clin Ther , vol.31 , pp. 962-979
    • Machado, M.1    Cruz, L.S.2    Tannus, G.3
  • 32
    • 79952111427 scopus 로고    scopus 로고
    • Implications of bone metastases and the benefits of bone-targeted therapy
    • Lipton A. Implications of bone metastases and the benefits of bone-targeted therapy. Semin Oncol 2010;37(Suppl 2):S15-29
    • (2010) Semin Oncol , vol.37 , Issue.SUPPL. 2
    • Lipton, A.1
  • 33
    • 33947610096 scopus 로고    scopus 로고
    • Managing metastatic bone pain: The role of biphosphonates
    • Gralow J, Tripathy D. Managing metastatic bone pain: The role of biphosphonates. J Pain Symptom Manage 2007;33:462-72
    • (2007) J Pain Symptom Manage , vol.33 , pp. 462-472
    • Gralow, J.1    Tripathy, D.2
  • 34
    • 17444435152 scopus 로고    scopus 로고
    • Double-blinded controlled study comparing clodronate versus placebo in patients with breast cancer bone metastases
    • Tubiana-Hulin M, Beuzeboc P, Mauriac L, et al. Double-blinded controlled study comparing clodronate versus placebo in patients with breast cancer bone metastases. Bull Cancer 2001;88:701-7
    • (2001) Bull Cancer , vol.88 , pp. 701-707
    • Tubiana-Hulin, M.1    Beuzeboc, P.2    Mauriac, L.3
  • 35
    • 0030955855 scopus 로고    scopus 로고
    • A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain
    • Ernst DS, Brasher P, Hagen N, et al. A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain. J Pain Symptom Manage 1997;13:319-26
    • (1997) J Pain Symptom Manage , vol.13 , pp. 319-326
    • Ernst, D.S.1    Brasher, P.2    Hagen, N.3
  • 36
    • 13144294096 scopus 로고    scopus 로고
    • A double blind randomized study of oral clodronate in the treatment of bone metastases from tumors poorly responsive to chemotherapy
    • Piga A, Bracci R, Ferretti B, et al. A double blind randomized study of oral clodronate in the treatment of bone metastases from tumors poorly responsive to chemotherapy. J Exp Clin Cancer Res 1998;17:213-17
    • (1998) J Exp Clin Cancer Res , vol.17 , pp. 213-217
    • Piga, A.1    Bracci, R.2    Ferretti, B.3
  • 37
    • 0029782630 scopus 로고    scopus 로고
    • Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: Results from a multinational randomized controlled trial. The Aredia Multinational Cooperative Group
    • Conte PF, Latreille J, Mauriac L, et al. Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: Results from a multinational randomized controlled trial. The Aredia Multinational Cooperative Group. J Clin Oncol 1996;14:2552-9
    • (1996) J Clin Oncol , vol.14 , pp. 2552-2559
    • Conte, P.F.1    Latreille, J.2    Mauriac, L.3
  • 38
    • 0033429593 scopus 로고    scopus 로고
    • Efficacy of pamidronate in breast cancer with bone metastases: A randomized, double-blind placebo-controlled multicenter study
    • Hultborn R, Gundersen S, Ryden S, et al. Efficacy of pamidronate in breast cancer with bone metastases: A randomized, double-blind placebo-controlled multicenter study. Anticancer Res 1999;19:3383-92
    • (1999) Anticancer Res , vol.19 , pp. 3383-3392
    • Hultborn, R.1    Gundersen, S.2    Ryden, S.3
  • 39
    • 0642337996 scopus 로고    scopus 로고
    • Combined analysis of two multicenter, randomized, placebo- controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer
    • Small EJ, Smith MR, Seaman JJ, et al. Combined analysis of two multicenter, randomized, placebo- controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer. J Clin Oncol 2003;21:4277-84
    • (2003) J Clin Oncol , vol.21 , pp. 4277-4284
    • Small, E.J.1    Smith, M.R.2    Seaman, J.J.3
  • 40
    • 0031810467 scopus 로고    scopus 로고
    • Failure of oral pamidronate to reduce skeletal morbidity in multiple myeloma: A double-blind placebo-controlled trial. Danish-Swedish Co-operative Study Group
    • Brincker H, Westin J, Abildgaard N, et al. Failure of oral pamidronate to reduce skeletal morbidity in multiple myeloma: A double-blind placebo-controlled trial. Danish-Swedish Co-operative Study Group. Br J Haematol 1998;101:280-6
    • (1998) Br J Haematol , vol.101 , pp. 280-286
    • Brincker, H.1    Westin, J.2    Abildgaard, N.3
  • 41
    • 20644449488 scopus 로고    scopus 로고
    • Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial
    • Kohno N, Aogi K, Minami H, et al. Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial. J Clin Oncol 2005;23:3314-21
    • (2005) J Clin Oncol , vol.23 , pp. 3314-3321
    • Kohno, N.1    Aogi, K.2    Minami, H.3
  • 42
    • 2942518111 scopus 로고    scopus 로고
    • Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer
    • Saad F, Gleason DM, Murray R, et al. Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst 2004;96:879-82
    • (2004) J Natl Cancer Inst , vol.96 , pp. 879-882
    • Saad, F.1    Gleason, D.M.2    Murray, R.3
  • 43
    • 68549096058 scopus 로고    scopus 로고
    • The impact of zoledronic acid therapy in survival of lung cancer patients with bone metastasis
    • Zarogoulidis K, Boutsikou E, Zarogoulidis P, et al. The impact of zoledronic acid therapy in survival of lung cancer patients with bone metastasis. Int J Cancer 2009;125:1705-9
    • (2009) Int J Cancer , vol.125 , pp. 1705-1709
    • Zarogoulidis, K.1    Boutsikou, E.2    Zarogoulidis, P.3
  • 44
    • 70350502817 scopus 로고    scopus 로고
    • Efficacy of ibadronate for the treatment of skeletal events in patients with metastatic breast cancer
    • Heras P, Kritikos K, Hatzopoulos A, et al. Efficacy of ibadronate for the treatment of skeletal events in patients with metastatic breast cancer. Eur J Cancer Care 2009;18:653-6
    • (2009) Eur J Cancer Care , vol.18 , pp. 653-656
    • Heras, P.1    Kritikos, K.2    Hatzopoulos, A.3
  • 45
    • 73849148160 scopus 로고    scopus 로고
    • Longitudinal cohort study of risk factors in cancer patients of biphosphonate-related osteonecrosis of the jaw
    • Vahtsevanos K, Kyrgidis A, Verrou E, et al. Longitudinal cohort study of risk factors in cancer patients of biphosphonate-related osteonecrosis of the jaw. J Clin Oncol 2009;27:5356-62
    • (2009) J Clin Oncol , vol.27 , pp. 5356-5362
    • Vahtsevanos, K.1    Kyrgidis, A.2    Verrou, E.3
  • 46
    • 39049178118 scopus 로고    scopus 로고
    • Analgesic activity of high-dose intravenous calcitonin in cancer patients with bone metastases
    • Tsavaris N, Kopterides P, Kosmas C, et al. Analgesic activity of high-dose intravenous calcitonin in cancer patients with bone metastases. Oncol Rep 2006;16:871-5
    • (2006) Oncol Rep , vol.16 , pp. 871-875
    • Tsavaris, N.1    Kopterides, P.2    Kosmas, C.3
  • 48
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Roodman GD. Mechanisms of bone metastasis. N Engl J Med 2004;350:1655-64
    • (2004) N Engl J Med , vol.350 , pp. 1655-1664
    • Roodman, G.D.1
  • 49
    • 84855733681 scopus 로고    scopus 로고
    • Available from:, Accessed January
    • Available from: Http://apps.nccd.cdc.gov [Accessed January 2011]
    • (2011)
  • 50
    • 34249087771 scopus 로고    scopus 로고
    • Economic burden of metastatic bone disease in the U.S
    • Schulman KL, Kohles J. Economic burden of metastatic bone disease in the U.S. Cancer 2007;109:2334-42
    • (2007) Cancer , vol.109 , pp. 2334-2342
    • Schulman, K.L.1    Kohles, J.2
  • 51
    • 77957344022 scopus 로고    scopus 로고
    • Economic/societal burden of metastatic breast cancer: A US perspective
    • Allen JM. Economic/societal burden of metastatic breast cancer: A US perspective. Am J Manag Care 2010;16:697-704
    • (2010) Am J Manag Care , vol.16 , pp. 697-704
    • Allen, J.M.1
  • 52
    • 43949146650 scopus 로고    scopus 로고
    • The cost of treating skeletal-related events in patients with prostate cancer
    • Lage MJ, Barber BL, Harrison DJ, et al. The cost of treating skeletal-related events in patients with prostate cancer. Am J Manag Care 2008;14:317-22
    • (2008) Am J Manag Care , vol.14 , pp. 317-322
    • Lage, M.J.1    Barber, B.L.2    Harrison, D.J.3
  • 53
    • 33747887309 scopus 로고    scopus 로고
    • Bone biology and the pathogenesis of osteoporosis
    • Russell RG, Espina B, Hulley P. Bone biology and the pathogenesis of osteoporosis. Curr Opin Rheumatol 2006;18(Suppl 1):S3-10
    • (2006) Curr Opin Rheumatol , vol.18 , Issue.SUPPL. 1
    • Russell, R.G.1    Espina, B.2    Hulley, P.3
  • 55
    • 31044432767 scopus 로고    scopus 로고
    • Pathogenesis of osteoporosis: Concepts, conflicts, and prospects
    • Raisz LG. Pathogenesis of osteoporosis: Concepts, conflicts, and prospects. J Clin Invest 2005;115:3318-25
    • (2005) J Clin Invest , vol.115 , pp. 3318-3325
    • Raisz, L.G.1
  • 56
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev 1989;8:98-101
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 57
    • 79952111472 scopus 로고    scopus 로고
    • Examining the metastatic niche: Targeting the microenvironment
    • This is a comprehensive review of the physiology of bone remodeling and molecular mechanisms involved in bone metastases
    • Guise T. Examining the metastatic niche: Targeting the microenvironment. Semin Oncol 2010;37(Suppl 2):S2-14 This is a comprehensive review of the physiology of bone remodeling and molecular mechanisms involved in bone metastases.
    • (2010) Semin Oncol , vol.37 , Issue.SUPPL. 2
    • Guise, T.1
  • 58
    • 19644378914 scopus 로고    scopus 로고
    • Mechanisms of cancer metastasis to the bone
    • Yin JJ, Pollock CB, Kelly K. Mechanisms of cancer metastasis to the bone. Cell Res 2005;15:57-62
    • (2005) Cell Res , vol.15 , pp. 57-62
    • Yin, J.J.1    Pollock, C.B.2    Kelly, K.3
  • 59
    • 78650304106 scopus 로고    scopus 로고
    • Advances in the biology of bone metastasis: How the skeleton affects tumor behavior
    • Sterling JA, Edwards JR, Martin TJ, et al. Advances in the biology of bone metastasis: How the skeleton affects tumor behavior. Bone 2011;48:6-15
    • (2011) Bone , vol.48 , pp. 6-15
    • Sterling, J.A.1    Edwards, J.R.2    Martin, T.J.3
  • 60
    • 63049121364 scopus 로고    scopus 로고
    • The metastatic niche: Adapting the foreign soil
    • Psaila B, Lyden D. The metastatic niche: Adapting the foreign soil. Nat Rev Cancer 2009;9:285-93
    • (2009) Nat Rev Cancer , vol.9 , pp. 285-293
    • Psaila, B.1    Lyden, D.2
  • 61
    • 77954597727 scopus 로고    scopus 로고
    • Bone cancer pain
    • In this paper, there is a clear explanation of possible pathogenetic mechanisms at the basis of pain from bone metastases
    • Jimenez-Andrade JM, Mantyh WG, Bloom AP, et al. Bone cancer pain. Ann NY Acad Sci 2010;1198:173-81 In this paper, there is a clear explanation of possible pathogenetic mechanisms at the basis of pain from bone metastases.
    • (2010) Ann NY Acad Sci , vol.1198 , pp. 173-181
    • Jimenez-Andrade, J.M.1    Mantyh, W.G.2    Bloom, A.P.3
  • 62
    • 33748165207 scopus 로고    scopus 로고
    • Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer
    • Halvorson KG, Sevcik MA, Ghilardi JR, et al. Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer. Clin J Pain 2006;22:587-600
    • (2006) Clin J Pain , vol.22 , pp. 587-600
    • Halvorson, K.G.1    Sevcik, M.A.2    Ghilardi, J.R.3
  • 64
    • 69249087342 scopus 로고    scopus 로고
    • Osteoprotegerin production by breast cancer cells is suppressed by dexamethasone and confers resistance against TRAIL-induced apoptosis
    • Rachner TD, Benad P, Rauner M, et al. Osteoprotegerin production by breast cancer cells is suppressed by dexamethasone and confers resistance against TRAIL-induced apoptosis. J Cell Biochem 2009;108:106-16
    • (2009) J Cell Biochem , vol.108 , pp. 106-116
    • Rachner, T.D.1    Benad, P.2    Rauner, M.3
  • 65
    • 38749106994 scopus 로고    scopus 로고
    • RANK ligand as a therapeutic target for bone metastases and multiple myeloma
    • Roodman GD, Dougall WC. RANK ligand as a therapeutic target for bone metastases and multiple myeloma. Cancer Treat Rev 2008;34:92-101
    • (2008) Cancer Treat Rev , vol.34 , pp. 92-101
    • Roodman, G.D.1    Dougall, W.C.2
  • 66
    • 0035872471 scopus 로고    scopus 로고
    • Osteoprotegerin diminishes advanced bone cancer pain
    • Luger NM, Honore P, Sabino MA, et al. Osteoprotegerin diminishes advanced bone cancer pain. Cancer Res 2001;61:4038-47
    • (2001) Cancer Res , vol.61 , pp. 4038-4047
    • Luger, N.M.1    Honore, P.2    Sabino, M.A.3
  • 67
    • 59049085396 scopus 로고    scopus 로고
    • Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption
    • Wilson SR, Peters C, Saftig P, et al. Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem 2009;284:2584-92
    • (2009) J Biol Chem , vol.284 , pp. 2584-2592
    • Wilson, S.R.1    Peters, C.2    Saftig, P.3
  • 68
    • 65549147617 scopus 로고    scopus 로고
    • Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women
    • Ruckle J, Jacobs M, Kramer W, et al. Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women. J Bone Miner Res 2009;24:744-52
    • (2009) J Bone Miner Res , vol.24 , pp. 744-752
    • Ruckle, J.1    Jacobs, M.2    Kramer, W.3
  • 69
    • 77956042544 scopus 로고    scopus 로고
    • SRC: A century of science brought to the clinic
    • Aleshin A, Finn RS. SRC: A century of science brought to the clinic. Neoplasia 2010;12:599-607
    • (2010) Neoplasia , vol.12 , pp. 599-607
    • Aleshin, A.1    Finn, R.S.2
  • 70
    • 20144388553 scopus 로고    scopus 로고
    • Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization
    • Sevcik MA, Ghilardi JR, Peters CM, et al. Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain 2005;115:128-41
    • (2005) Pain , vol.115 , pp. 128-141
    • Sevcik, M.A.1    Ghilardi, J.R.2    Peters, C.M.3
  • 71
    • 27144433512 scopus 로고    scopus 로고
    • A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone
    • Halvorson KG, Kubota K, Sevcik MA, et al. A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone. Cancer Res 2005;65:9426-35
    • (2005) Cancer Res , vol.65 , pp. 9426-9435
    • Halvorson, K.G.1    Kubota, K.2    Sevcik, M.A.3
  • 72
    • 39849091784 scopus 로고    scopus 로고
    • Endothelin-1-induced pain and hyperalgesia: A review of pathophysiology, clinical manifestations and future therapeutic options
    • Hans G, Deseure K, Adriaensen H. Endothelin-1-induced pain and hyperalgesia: A review of pathophysiology, clinical manifestations and future therapeutic options. Neuropeptides 2008;42:119-32
    • (2008) Neuropeptides , vol.42 , pp. 119-132
    • Hans, G.1    Deseure, K.2    Adriaensen, H.3
  • 73
    • 0346837985 scopus 로고    scopus 로고
    • A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body JJ, Greipp P, Coleman RE, et al. A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 2003;97(3 Suppl):887-92
    • (2003) Cancer , vol.97 , Issue.3 SUPPL. , pp. 887-892
    • Body, J.J.1    Greipp, P.2    Coleman, R.E.3
  • 74
    • 4043138669 scopus 로고    scopus 로고
    • Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis
    • Neville-Webbe HL, Cross NA, Eaton CL, et al. Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis. Breast Cancer Res Treat 2004;86:269-79
    • (2004) Breast Cancer Res Treat , vol.86 , pp. 269-279
    • Neville-Webbe, H.L.1    Cross, N.A.2    Eaton, C.L.3
  • 75
    • 75349090418 scopus 로고    scopus 로고
    • Regulation of osteoprotegerin pro- or anti-tumoral activity by bone tumor microenvironment
    • Lamoureux F, Moriceau G, Picarda G, et al. Regulation of osteoprotegerin pro- or anti-tumoral activity by bone tumor microenvironment. Biochim Biophys Acta 2010;1805:17-24
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 17-24
    • Lamoureux, F.1    Moriceau, G.2    Picarda, G.3
  • 76
    • 33751167602 scopus 로고    scopus 로고
    • Novel approaches in the management of myeloma-related skeletal complications
    • Reddy GK, Mughal TI, Roodman GD. Novel approaches in the management of myeloma-related skeletal complications. Support Cancer Ther 2006;4:15-18
    • (2006) Support Cancer Ther , vol.4 , pp. 15-18
    • Reddy, G.K.1    Mughal, T.I.2    Roodman, G.D.3
  • 77
    • 77956246270 scopus 로고    scopus 로고
    • Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL
    • Pierroz DD, Bonnet N, Baldock PA, et al. Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL. J Biol Chem 2010;285:28164-73
    • (2010) J Biol Chem , vol.285 , pp. 28164-28173
    • Pierroz, D.D.1    Bonnet, N.2    Baldock, P.A.3
  • 78
    • 45149124792 scopus 로고    scopus 로고
    • Effects of denosumab on bone mineral density and bone turnover in postmenopausal women
    • Bone HG, Bolognese MA, Yuen CK, et al. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. J Clin Endocrinol Metab 2008;93:2149-57
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2149-2157
    • Bone, H.G.1    Bolognese, M.A.2    Yuen, C.K.3
  • 79
    • 69049083492 scopus 로고    scopus 로고
    • FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    • Cummings SR, San Martin J, McClung MR, et al. FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009;361:756-65
    • (2009) N Engl J Med , vol.361 , pp. 756-765
    • Cummings, S.R.1    San Martin, J.2    McClung, M.R.3
  • 80
    • 78650314607 scopus 로고    scopus 로고
    • Comparison of the effect of denosumab and alendronate on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, phase 3 trial
    • Brown JP, Prince RL, Deal C, et al. Comparison of the effect of denosumab and alendronate on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, phase 3 trial. J Bone Miner Res 2009;14:1-34
    • (2009) J Bone Miner Res , vol.14 , pp. 1-34
    • Brown, J.P.1    Prince, R.L.2    Deal, C.3
  • 81
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body JJ, Facon T, Coleman RE, et al. A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res 2006;12:1221-8
    • (2006) Clin Cancer Res , vol.12 , pp. 1221-1228
    • Body, J.J.1    Facon, T.2    Coleman, R.E.3
  • 82
    • 77649267690 scopus 로고    scopus 로고
    • Role of targeted therapy in the treatment of advanced prostate cancer
    • Fizazi K, Sternberg CN, Fitzpatrick JM, et al. Role of targeted therapy in the treatment of advanced prostate cancer. BJU Int 2010;105:748-67
    • (2010) BJU Int , vol.105 , pp. 748-767
    • Fizazi, K.1    Sternberg, C.N.2    Fitzpatrick, J.M.3
  • 83
    • 79952761418 scopus 로고    scopus 로고
    • Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
    • [Epub ahead of print]
    • Henry DH, Costa L, Goldwasser F, et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol 2011. [Epub ahead of print]
    • (2011) J Clin Oncol
    • Henry, D.H.1    Costa, L.2    Goldwasser, F.3
  • 85
    • 67651180563 scopus 로고    scopus 로고
    • Effect of the Cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: Two double-blind, randomized, placebo-controlled Phase I studies
    • Stoch SA, Zajic S, Stone J, et al. Effect of the Cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: Two double-blind, randomized, placebo-controlled Phase I studies. Clin Pharmacol Ther 2009;86:175-82
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 175-182
    • Stoch, S.A.1    Zajic, S.2    Stone, J.3
  • 86
    • 79952278967 scopus 로고    scopus 로고
    • The Cathepsin K inhibitor odanacatib suppresses one resorption in women with breast cancer and established bone metastases: Results of a 4-week, double-blind, randomized, controlled trial
    • Jensen AB, Wynne C, Ramirez G, et al. The Cathepsin K inhibitor odanacatib suppresses one resorption in women with breast cancer and established bone metastases: Results of a 4-week, double-blind, randomized, controlled trial. Clin Breast Cancer 2010;10:452-8
    • (2010) Clin Breast Cancer , vol.10 , pp. 452-458
    • Jensen, A.B.1    Wynne, C.2    Ramirez, G.3
  • 87
    • 84855722136 scopus 로고    scopus 로고
    • Accessed January
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT00747123
    • (2011)
  • 88
    • 84855733680 scopus 로고    scopus 로고
    • Available from:, Accessed January
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT01074138
    • (2011)
  • 89
    • 84855745453 scopus 로고    scopus 로고
    • Available from: Accessed January, NCT00566618, NCT00936975
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT00410813, NCT00566618, NCT00936975
    • (2011)
  • 90
    • 84855745451 scopus 로고    scopus 로고
    • Available from: Accessed January, NCT01144481
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT00558272, NCT01144481
    • (2011)
  • 91
    • 84855720633 scopus 로고    scopus 로고
    • Available from:, Accessed January, NCT00830180
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT00545129; NCT00830180
    • (2011)
  • 92
    • 35648968713 scopus 로고    scopus 로고
    • A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
    • Atrasentan Phase III Study Group Institutions
    • Carducci MA, Saad F, Abrahamsson PA, et al. Atrasentan Phase III Study Group Institutions. A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer 2007;110:1959-66
    • (2007) Cancer , vol.110 , pp. 1959-1966
    • Carducci, M.A.1    Saad, F.2    Abrahamsson, P.A.3
  • 93
    • 55549112219 scopus 로고    scopus 로고
    • Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer
    • Atrasentan Phase 3 Study Group.
    • Nelson JB, Love W, Chin JL, et al. Atrasentan Phase 3 Study Group. Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer. Cancer 2008;113:2478-87
    • (2008) Cancer , vol.113 , pp. 2478-2487
    • Nelson, J.B.1    Love, W.2    Chin, J.L.3
  • 94
    • 58149143013 scopus 로고    scopus 로고
    • A phase I-II study of docetaxel and atrasentan in men with castration-resistant metastatic prostate cancer
    • Armstrong AJ, Creel P, Turnbull J, et al. A phase I-II study of docetaxel and atrasentan in men with castration-resistant metastatic prostate cancer. Clin Cancer Res 2008;14:6270-6
    • (2008) Clin Cancer Res , vol.14 , pp. 6270-6276
    • Armstrong, A.J.1    Creel, P.2    Turnbull, J.3
  • 95
    • 84855745452 scopus 로고    scopus 로고
    • Available from: Accessed January
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT00134056
    • (2011)
  • 96
    • 51449109131 scopus 로고    scopus 로고
    • ZD4054: A specific endothelin A receptor antagonist with promising activity in metastatic castration-resistant prostate cancer
    • Warren R, Liu G. ZD4054: A specific endothelin A receptor antagonist with promising activity in metastatic castration-resistant prostate cancer. Expert Opin Investig Drugs 2008;17:1237-45
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1237-1245
    • Warren, R.1    Liu, G.2
  • 97
    • 0028333046 scopus 로고
    • Clearance of circulating endothelin-1 by ETB receptors in rats
    • Fukuroda T, Fujikawa T, Ozaki S, et al. Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem Biophys Res Commun 1994;199:1461-5
    • (1994) Biochem Biophys Res Commun , vol.199 , pp. 1461-1465
    • Fukuroda, T.1    Fujikawa, T.2    Ozaki, S.3
  • 98
    • 62649134676 scopus 로고    scopus 로고
    • Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: A double-blind, placebo-controlled, randomised, phase 2 trial
    • James ND, Caty A, Borre M, et al. Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: A double-blind, placebo-controlled, randomised, phase 2 trial. Eur Urol 2009;55:1112-23
    • (2009) Eur Urol , vol.55 , pp. 1112-1123
    • James, N.D.1    Caty, A.2    Borre, M.3
  • 99
    • 77956634017 scopus 로고    scopus 로고
    • Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration-resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: A double-blind, placebo-controlled, randomized Phase II trial
    • James ND, Caty A, Payne H, et al. Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration-resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: A double-blind, placebo-controlled, randomized Phase II trial. BJU Int 2010;106:966-73
    • BJU Int , vol.2010 , Issue.106 , pp. 966-973
    • James, N.D.1    Caty, A.2    Payne, H.3
  • 100
    • 79151468942 scopus 로고    scopus 로고
    • A phase I study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancer
    • Schelman WR, Liu G, Wilding G, et al. A phase I study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancer. Invest New Drugs 2011;29:118-25
    • (2011) Invest New Drugs , vol.29 , pp. 118-125
    • Schelman, W.R.1    Liu, G.2    Wilding, G.3
  • 101
    • 84855733678 scopus 로고    scopus 로고
    • Available from: Accessed January
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT00617669
    • (2011)
  • 102
    • 80051998884 scopus 로고    scopus 로고
    • A phase II, randomized, multicenter study to assess the efficacy, safety, and tolerability of zibotentan (ZD4054) in combination with pemetrexed in patients with advanced non-small cell lung cancer
    • [Epub ahead of print]
    • Chouaid C, Nathan F, Pemberton K, et al. A phase II, randomized, multicenter study to assess the efficacy, safety, and tolerability of zibotentan (ZD4054) in combination with pemetrexed in patients with advanced non-small cell lung cancer. Cancer Chemother Pharmacol 2010. [Epub ahead of print]
    • (2010) Cancer Chemother Pharmacol
    • Chouaid, C.1    Nathan, F.2    Pemberton, K.3
  • 103
    • 84855733679 scopus 로고    scopus 로고
    • Available from:, Accessed January, NCT01134497; NCT00929162
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT01205711; NCT01134497; NCT00929162
    • (2011)
  • 104
    • 25444479744 scopus 로고    scopus 로고
    • Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
    • Kang Y, He W, Tulley S, et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA 2005;102:13909-14
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13909-13914
    • Kang, Y.1    He, W.2    Tulley, S.3
  • 105
    • 84855720631 scopus 로고    scopus 로고
    • Available from:, Accessed January, NCT00761280; NCT00431561
    • Available from: Http://clinicaltrials.gov. [Accessed January 2011]. NCT00844064; NCT00761280; NCT00431561
    • (2011)
  • 106
    • 67650992011 scopus 로고    scopus 로고
    • A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer
    • Huang EH, Singh B, Cristofanilli M, et al. A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res 2009;155:231-6
    • (2009) J Surg Res , vol.155 , pp. 231-236
    • Huang, E.H.1    Singh, B.2    Cristofanilli, M.3
  • 107
    • 64849102577 scopus 로고    scopus 로고
    • Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone
    • Richert MM, Vaidya KS, Mills CN, et al. Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone. Oncol Rep 2009;21:761-7
    • (2009) Oncol Rep , vol.21 , pp. 761-767
    • Richert, M.M.1    Vaidya, K.S.2    Mills, C.N.3
  • 108
    • 79956147407 scopus 로고    scopus 로고
    • CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model
    • [Epub ahead of print]
    • Hassan S, Buchanan M, Jahan K, et al. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer 2010. [Epub ahead of print]
    • (2010) Int J Cancer
    • Hassan, S.1    Buchanan, M.2    Jahan, K.3
  • 109
    • 67651226970 scopus 로고    scopus 로고
    • New agents for mobilizing peripheral blood stem cells
    • Greinix HT, Worel N. New agents for mobilizing peripheral blood stem cells. Transfus Apheresis Sci 2009;41:67-71
    • (2009) Transfus Apheresis Sci , vol.41 , pp. 67-71
    • Greinix, H.T.1    Worel, N.2
  • 110
    • 74549129414 scopus 로고    scopus 로고
    • Plerixafor for stem cell mobilization in patients with non-Hodgkin's lymphoma and multiple myeloma
    • Choi HY, Yong CS, Yoo BK. Plerixafor for stem cell mobilization in patients with non-Hodgkin's lymphoma and multiple myeloma. Ann Pharmacother 2010;44:117-26
    • (2010) Ann Pharmacother , vol.44 , pp. 117-126
    • Choi, H.Y.1    Yong, C.S.2    Yoo, B.K.3
  • 112
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • This historic paper is a milestone in understanding the role of capsaicin receptors in pain pathway
    • Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 1997;389:816-24 This historic paper is a milestone in understanding the role of capsaicin receptors in pain pathway.
    • (1997) Nature , vol.389 , pp. 816-824
    • Caterina, M.J.1    Schumacher, M.A.2    Tominaga, M.3
  • 113
    • 20144388484 scopus 로고    scopus 로고
    • Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain
    • Ghilardi JR, Rohrich H, Lindsay TH, et al. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci 2005;25:3126-31
    • (2005) J Neurosci , vol.25 , pp. 3126-3131
    • Ghilardi, J.R.1    Rohrich, H.2    Lindsay, T.H.3
  • 114
    • 58449106224 scopus 로고    scopus 로고
    • SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain
    • Niiyama Y, Kawamata T, Yamamoto J, et al. SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain. Br J Anaesth 2009;102:251-8
    • (2009) Br J Anaesth , vol.102 , pp. 251-258
    • Niiyama, Y.1    Kawamata, T.2    Yamamoto, J.3
  • 116
    • 60049089359 scopus 로고    scopus 로고
    • Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia
    • Honore P, Chandran P, Hernandez G, et al. Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. Pain 2009;142:27-35
    • (2009) Pain , vol.142 , pp. 27-35
    • Honore, P.1    Chandran, P.2    Hernandez, G.3
  • 117
    • 58149107126 scopus 로고    scopus 로고
    • Clinical development of TRPV1 antagonists: Targeting a pivotal point in the pain pathway
    • Gunthorpe MJ, Chizh BA. Clinical development of TRPV1 antagonists: Targeting a pivotal point in the pain pathway. Drug Discov Today 2009;14:56-67
    • (2009) Drug Discov Today , vol.14 , pp. 56-67
    • Gunthorpe, M.J.1    Chizh, B.A.2
  • 118
    • 33749013892 scopus 로고    scopus 로고
    • A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation
    • Klionsky L, Tamir R, Holzinger B, et al. A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation. J Pharmacol Exp Ther 2006;319:192-8
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 192-198
    • Klionsky, L.1    Tamir, R.2    Holzinger, B.3
  • 119
    • 78649756871 scopus 로고    scopus 로고
    • Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain
    • Ghilardi JR, Freeman KT, Jimenez-Andrade JM, et al. Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain. Mol Pain 2010;6:87
    • (2010) Mol Pain , vol.6 , pp. 87
    • Ghilardi, J.R.1    Freeman, K.T.2    Jimenez-Andrade, J.M.3
  • 120
    • 78650983503 scopus 로고    scopus 로고
    • Sustained blockade of neurotrophin receptor TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers
    • Ghilardi JR, Freeman KT, Jimenez-Andrade JM, et al. Sustained blockade of neurotrophin receptor TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers. Bone 2011;48:389-98
    • (2011) Bone , vol.48 , pp. 389-398
    • Ghilardi, J.R.1    Freeman, K.T.2    Jimenez-Andrade, J.M.3
  • 121
    • 77952663261 scopus 로고    scopus 로고
    • Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain
    • Curto-Reyes V, Llames S, Hidalgo A, et al. Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain. Br J Pharmacol 2010;160:561-73
    • (2010) Br J Pharmacol , vol.160 , pp. 561-573
    • Curto-Reyes, V.1    Llames, S.2    Hidalgo, A.3
  • 122
    • 77951238358 scopus 로고    scopus 로고
    • A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss
    • Lozano-Ondoua AN, Wright C, Vardanyan A, et al. A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. Life Sci 2010;86:646-53
    • (2010) Life Sci , vol.86 , pp. 646-653
    • Lozano-Ondoua, A.N.1    Wright, C.2    Vardanyan, A.3
  • 123
    • 0034814279 scopus 로고    scopus 로고
    • Osteoclast inhibitory peptide 2 inhibits osteoclast formation via its C-terminal fragment
    • Choi SJ, Kurihara N, Oba Y, et al. Osteoclast inhibitory peptide 2 inhibits osteoclast formation via its C-terminal fragment. J Bone Miner Res 2001;16:1804-11
    • (2001) J Bone Miner Res , vol.16 , pp. 1804-1811
    • Choi, S.J.1    Kurihara, N.2    Oba, Y.3
  • 124
    • 73649088338 scopus 로고    scopus 로고
    • Wnts, bone and cancer
    • Thomas DM. Wnts, bone and cancer. J Pathol 2010;220:1-4
    • (2010) J Pathol , vol.220 , pp. 1-4
    • Thomas, D.M.1
  • 125
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 126
    • 33646808104 scopus 로고    scopus 로고
    • Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro
    • Spencer GJ, Utting JC, Etheridge SL, et al. Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro. J Cell Sci 2006;119:1283-96
    • (2006) J Cell Sci , vol.119 , pp. 1283-1296
    • Spencer, G.J.1    Utting, J.C.2    Etheridge, S.L.3
  • 127
    • 14744275847 scopus 로고    scopus 로고
    • Regulation of osteoblastogenesis and bone mass by Wnt10b
    • Bennett CN, Longo KA, Wright WS, et al. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci USA 2005;102:3324-9
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 3324-3329
    • Bennett, C.N.1    Longo, K.A.2    Wright, W.S.3
  • 128
    • 40149103353 scopus 로고    scopus 로고
    • Dkk-1 inhibition increases bone mineral density in rodents
    • Grisanti M, Nju QT, Fan W, et al. Dkk-1 inhibition increases bone mineral density in rodents. J Bone Miner Res 2006;21:S25
    • (2006) J Bone Miner Res , vol.21
    • Grisanti, M.1    Nju, Q.T.2    Fan, W.3
  • 129
    • 67349126564 scopus 로고    scopus 로고
    • A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
    • Bodine PVN, Stauffer B, Ponce-de- Leon H, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 2009;44:1063-8
    • (2009) Bone , vol.44 , pp. 1063-1068
    • Bodine, P.V.N.1    Stauffer, B.2    Ponce-De-Leon, H.3
  • 130
    • 70949108320 scopus 로고    scopus 로고
    • (1-(4-(Naphthalen-2- yl) pyrimidin-2-yl)piperidin-4 yl) methanamine: A wingless beta-catenin agonist that increases bone formation rate
    • Pelletier JC, Lundquist JT IV, Gilbert AM, et al. (1-(4-(Naphthalen-2- yl)pyrimidin-2-yl)piperidin-4 yl) methanamine: A wingless beta-catenin agonist that increases bone formation rate. J Med Chem 2009;52:6962-5
    • (2009) J Med Chem , vol.52 , pp. 6962-6965
    • Pelletier, J.C.1    Lundquist, J.T.I.V.2    Gilbert, A.M.3
  • 131
    • 16844364003 scopus 로고    scopus 로고
    • A small-molecule agonist of the Wnt signaling pathway
    • Liu J, Wu X, Mitchell B, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed 2005;44:1987-90
    • (2005) Angew Chem Int Ed , vol.44 , pp. 1987-1990
    • Liu, J.1    Wu, X.2    Mitchell, B.3
  • 132
    • 28444438846 scopus 로고    scopus 로고
    • Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
    • Clement-Lacroix P, Ai M, Morvan F, et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci USA 2005;102:17406-111
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17406-17111
    • Clement-Lacroix, P.1    Ai, M.2    Morvan, F.3
  • 134
    • 33645006198 scopus 로고    scopus 로고
    • Role of Wnts in prostate cancer bone metastases
    • Hall CL, Kang S, MacDougald OA, et al. Role of Wnts in prostate cancer bone metastases. J Cell Biochem 2006;97:661-72
    • (2006) J Cell Biochem , vol.97 , pp. 661-672
    • Hall, C.L.1    Kang, S.2    MacDougald, O.A.3
  • 135
    • 24744439747 scopus 로고    scopus 로고
    • Prostate cancer cells promote osteoblastic bone metastases through Wnts
    • Hall CL, Bafico A, Dai J, et al. Prostate cancer cells promote osteoblastic bone metastases through Wnts. Cancer Res 2005;65:7554-60
    • (2005) Cancer Res , vol.65 , pp. 7554-7560
    • Hall, C.L.1    Bafico, A.2    Dai, J.3
  • 136
    • 47249149740 scopus 로고    scopus 로고
    • Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases
    • Bu G, Lu W, Liu CC, et al. Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases. Int J Cancer 2008;123:1034-42
    • (2008) Int J Cancer , vol.123 , pp. 1034-1042
    • Bu, G.1    Lu, W.2    Liu, C.C.3
  • 137
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-94
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 139
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • Yaccoby S, Ling W, Zhan F, et al. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 2007;109:2106-11
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3
  • 140
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T, et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 2009;114:371-9
    • (2009) Blood , vol.114 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 141
    • 61849137831 scopus 로고    scopus 로고
    • Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma
    • Heath DJ, Chantry AD, Buckle CH, et al. Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma. J Bone Miner Res 2009;24:425-36
    • (2009) J Bone Miner Res , vol.24 , pp. 425-436
    • Heath, D.J.1    Chantry, A.D.2    Buckle, C.H.3
  • 142
    • 0035089781 scopus 로고    scopus 로고
    • Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
    • Brunkow ME, Gardner JC, Van Ness J, et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet 2001;68:577-89
    • (2001) Am J Hum Genet , vol.68 , pp. 577-589
    • Brunkow, M.E.1    Gardner, J.C.2    Van Ness, J.3
  • 143
    • 28744432803 scopus 로고    scopus 로고
    • Bone mineral density in sclerosteosis; affected individuals and gene carriers
    • Gardner JC, van Bezooijen RL, Mervis B, et al. Bone mineral density in sclerosteosis; affected individuals and gene carriers. J Clin Endocrinol Metab 2005;90:6392-5
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6392-6395
    • Gardner, J.C.1    Van Bezooijen, R.L.2    Mervis, B.3
  • 145
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • Li X, Ominsky MS, Niu QT, et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 2008;23:860-9
    • (2008) J Bone Miner Res , vol.23 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.T.3
  • 146
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • Li X, Ominsky MS, Warmington KS, et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res 2009;24:578-88
    • (2009) J Bone Miner Res , vol.24 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3
  • 147
    • 78650958526 scopus 로고    scopus 로고
    • Singledose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    • Padhi D, Jang G, Stouch B, et al. Singledose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res 2011;26:19-26
    • (2011) J Bone Miner Res , vol.26 , pp. 19-26
    • Padhi, D.1    Jang, G.2    Stouch, B.3
  • 148
    • 84855733674 scopus 로고    scopus 로고
    • Available from:, Accessed March
    • Available from: Http://clinicaltrials.gov. [Accessed March 2011]. NCT00896532
    • (2011)
  • 149
    • 84855733675 scopus 로고    scopus 로고
    • Available from:, Accessed March, NCT00907296
    • Available from: Http://clinicaltrials.gov [Accessed March 2011]. NCT01081678; NCT00907296
    • (2011)
  • 150


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.