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Volumn 4, Issue 1, 2006, Pages 15-18

Novel approaches in the management of myeloma-related skeletal complications

Author keywords

Denosumab; Interteukin 3; Macrophage inflammatory protein 1 ; Osteoprotegerin; RANK; RANKL; Wnt signaling pathway

Indexed keywords

AMG 162; ANALGESIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR 1; CHEMOKINE RECEPTOR 5; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 3; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; TELOPEPTIDE; UNCLASSIFIED DRUG; WNT PROTEIN; ZOLEDRONIC ACID;

EID: 33751167602     PISSN: 15432912     EISSN: None     Source Type: Journal    
DOI: 10.3816/SCT.2006.n.026     Document Type: Review
Times cited : (7)

References (24)
  • 1
    • 33745508154 scopus 로고    scopus 로고
    • Role of the microenvironment in multiple myeloma bone disease
    • Huston A, Roodman GD. Role of the microenvironment in multiple myeloma bone disease. Future Oncol 2006; 2:371-378.
    • (2006) Future Oncol , vol.2 , pp. 371-378
    • Huston, A.1    Roodman, G.D.2
  • 3
    • 33751193178 scopus 로고    scopus 로고
    • Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition
    • Epub ahead of print
    • Giuliani N, Rizzoli V, Roodman GD. Multiple myeloma bone disease: pathophysiology of osteoblast inhibition. Blood 2006 [Epub ahead of print].
    • (2006) Blood
    • Giuliani, N.1    Rizzoli, V.2    Roodman, G.D.3
  • 4
    • 23844551832 scopus 로고    scopus 로고
    • Myeloma bone disease: Pathophysiology and management
    • Terpos E, Dimopoulos MA. Myeloma bone disease: pathophysiology and management. Ann Oncol 2005; 16:1223-1231.
    • (2005) Ann Oncol , vol.16 , pp. 1223-1231
    • Terpos, E.1    Dimopoulos, M.A.2
  • 6
    • 33746375016 scopus 로고    scopus 로고
    • Myeloma bone disease and treatment options
    • Yeh HS, Berenson JR. Myeloma bone disease and treatment options. Eur J Cancer 2006; 42:1554-1563.
    • (2006) Eur J Cancer , vol.42 , pp. 1554-1563
    • Yeh, H.S.1    Berenson, J.R.2
  • 7
    • 33746855407 scopus 로고    scopus 로고
    • Mayo clinic consensus statement for the use of bisphosphonates in multiple myeloma
    • Lacy MQ, Dispenzieri A, Gertz MA, et al. Mayo clinic consensus statement for the use of bisphosphonates in multiple myeloma. Mayo Clin Proc 2006; 81:1047-1053.
    • (2006) Mayo Clin Proc , vol.81 , pp. 1047-1053
    • Lacy, M.Q.1    Dispenzieri, A.2    Gertz, M.A.3
  • 8
    • 33646444443 scopus 로고    scopus 로고
    • Bisphosphonates for malignancy-related bone disease: Current status, future developments
    • 2006
    • Body JJ. Bisphosphonates for malignancy-related bone disease: current status, future developments. Support Care Cancer 2006; 14:408-418. 2006.
    • (2006) Support Care Cancer , vol.14 , pp. 408-418
    • Body, J.J.1
  • 9
    • 4444257291 scopus 로고    scopus 로고
    • RANKL/RANK/OPG: New therapeutic targets in bone tumours and associated osteolysis
    • Wittrant Y, Theoleyre S, Chipoy C, et al. RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis. Biochim Biophys Acta 2004; 1704:49-57.
    • (2004) Biochim Biophys Acta , vol.1704 , pp. 49-57
    • Wittrant, Y.1    Theoleyre, S.2    Chipoy, C.3
  • 10
    • 1642432081 scopus 로고    scopus 로고
    • IL-6, RANKL, TNF-alpha/IL-1: Interrelations in bone resorption pathophysiology
    • Kwan Tat S, Padrines M, Theoleyre S, et al. IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev 2004; 15:49-60.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 49-60
    • Kwan Tat, S.1    Padrines, M.2    Theoleyre, S.3
  • 11
    • 27744529640 scopus 로고    scopus 로고
    • Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength
    • Kostenuik PJ. Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr Opin Pharmacol 2005; 5:618-625.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 618-625
    • Kostenuik, P.J.1
  • 12
    • 85030595793 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) and pharmacodynamics (PD) of AMG 162, a fully human monoclonal antibody to receptor activator of NF kappa B ligand (RANKL), following a single subcutaneous dose to patients with cancer-related bone lesions
    • Abstract #8106
    • Peterson MC, Martin SW, Stouch B, et al. Pharmacokinetics (PK) and pharmacodynamics (PD) of AMG 162, a fully human monoclonal antibody to receptor activator of NF kappa B ligand (RANKL), following a single subcutaneous dose to patients with cancer-related bone lesions. Proc Am Soc Clin Oncol 2004; 23:751 (Abstract #8106).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 751
    • Peterson, M.C.1    Martin, S.W.2    Stouch, B.3
  • 13
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body JJ, Facon T, Coleman RE, et al. A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res 2006; 12:1221-1228.
    • (2006) Clin Cancer Res , vol.12 , pp. 1221-1228
    • Body, J.J.1    Facon, T.2    Coleman, R.E.3
  • 15
    • 33845307669 scopus 로고    scopus 로고
    • A randomized trial of denosumab (AMG 162) versus intravenous (IV) bisphosphonates (BP) in cancer patients (pts) with bone metastases (BM) on established IV BP and evidence of elevated bone resorption
    • Abstract #8562
    • Suarez T, Fizazi K, Rahim Y, et al. A randomized trial of denosumab (AMG 162) versus intravenous (IV) bisphosphonates (BP) in cancer patients (pts) with bone metastases (BM) on established IV BP and evidence of elevated bone resorption. J Clin Oncol 2006; 24(18 suppl):483s (Abstract #8562).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Suarez, T.1    Fizazi, K.2    Rahim, Y.3
  • 17
    • 13844317079 scopus 로고    scopus 로고
    • MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells
    • Oba Y, Lee JW, Ehrlich LA, et al. MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells. Exp Hematol 2005; 33:272-278.
    • (2005) Exp Hematol , vol.33 , pp. 272-278
    • Oba, Y.1    Lee, J.W.2    Ehrlich, L.A.3
  • 18
    • 0035664488 scopus 로고    scopus 로고
    • Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease
    • Choi SJ, Oba Y, Gazitt Y, et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 2001; 108:1833-1841.
    • (2001) J Clin Invest , vol.108 , pp. 1833-1841
    • Choi, S.J.1    Oba, Y.2    Gazitt, Y.3
  • 19
    • 0037105599 scopus 로고    scopus 로고
    • Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma
    • Abe M, Hiura K, Wilde J, et al. Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma. Blood 2002; 100:2195-2202.
    • (2002) Blood , vol.100 , pp. 2195-2202
    • Abe, M.1    Hiura, K.2    Wilde, J.3
  • 20
    • 1542313900 scopus 로고    scopus 로고
    • IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells
    • Lee JW, Chung HY, Ehrlich LA, et al. IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells. Blood 2004; 103:2308-2315.
    • (2004) Blood , vol.103 , pp. 2308-2315
    • Lee, J.W.1    Chung, H.Y.2    Ehrlich, L.A.3
  • 21
    • 23744507989 scopus 로고    scopus 로고
    • IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma
    • Ehrlich LA, Chung HY, Ghobrial I, et al. IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma. Blood 2005; 106:1407-1414.
    • (2005) Blood , vol.106 , pp. 1407-1414
    • Ehrlich, L.A.1    Chung, H.Y.2    Ghobrial, I.3
  • 22
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • Westendorf JJ, Kahler RA, Schroeder TM. Wnt signaling in osteoblasts and bone diseases. Gene 2004; 341:19-39.
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 23
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003; 349:2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 24
    • 27644473781 scopus 로고    scopus 로고
    • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
    • Oshima T, Abe M, Asano J, et al. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood 2005; 106:3160-3165.
    • (2005) Blood , vol.106 , pp. 3160-3165
    • Oshima, T.1    Abe, M.2    Asano, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.