-
1
-
-
44649152966
-
Remodeling and skeletal fragility
-
R Heaney 2003 Remodeling and skeletal fragility Osteoporos Int 14 Suppl 5 S12 S15
-
(2003)
Osteoporos Int
, vol.14
, Issue.SUPPL. 5
-
-
Heaney, R.1
-
2
-
-
52449126861
-
Model structure and control of bone remodeling: A theoretical study
-
1:CAS:528:DC%2BD1cXosVOit74%3D 10.1016/j.bone.2008.03.025 18514606
-
P Pivonka J Zimak DW Smith 2008 Model structure and control of bone remodeling: a theoretical study Bone 43 249 263 1:CAS:528:DC%2BD1cXosVOit74%3D 10.1016/j.bone.2008.03.025 18514606
-
(2008)
Bone
, vol.43
, pp. 249-263
-
-
Pivonka, P.1
Zimak, J.2
Smith, D.W.3
-
3
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
DOI 10.1016/S0092-8674(00)81569-X
-
DL Lacey E Timms HL Tan, et al. 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 93 165 176 1:CAS:528:DyaK1cXivVyhtrg%3D 10.1016/S0092-8674(00)81569-X 9568710 (Pubitemid 28180851)
-
(1998)
Cell
, vol.93
, Issue.2
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.-L.3
Kelley, M.J.4
Dunstan, C.R.5
Burgess, T.6
Elliott, R.7
Colombero, A.8
Elliott, G.9
Scully, S.10
Hsu, H.11
Sullivan, J.12
Hawkins, N.13
Davy, E.14
Capparelli, C.15
Eli, A.16
Qian, Y.-X.17
Kaufman, S.18
Sarosi, I.19
Shalhoub, V.20
Senaldi, G.21
Guo, J.22
Delaney, J.23
Boyle, W.J.24
more..
-
4
-
-
13044316551
-
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
-
DOI 10.1073/pnas.96.7.3540
-
H Hsu DL Lacey CR Dunstan, et al. 1999 Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand Proc Natl Acad Sci USA 96 3540 3545 1:CAS:528: DyaK1MXjslCitL8%3D 10.1073/pnas.96.7.3540 10097072 (Pubitemid 29168945)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.7
, pp. 3540-3545
-
-
Hsu, H.1
Lacey, D.L.2
Dunstan, C.R.3
Solovyev, I.4
Colombero, A.5
Timms, E.6
Tan, H.-L.7
Elliott, G.8
Kelley, M.J.9
Sarosi, I.10
Wang, L.11
Xia, X.-Z.12
Elliott, R.13
Chiu, L.14
Black, T.15
Scully, S.16
Capparelli, C.17
Morony, S.18
Shimamoto, G.19
Bass, M.B.20
Boyle, W.J.21
more..
-
5
-
-
12944262423
-
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
-
DOI 10.1073/pnas.97.4.1566
-
J Li I Sarosi XQ Yan, et al. 2000 RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism Proc Natl Acad Sci USA 97 1566 1571 1:CAS:528:DC%2BD3cXhsFCrsL4%3D 10.1073/pnas.97.4.1566 10677500 (Pubitemid 30118482)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.4
, pp. 1566-1571
-
-
Li, J.1
Sarosi, I.2
Yan, X.-Q.3
Morony, S.4
Capparelli, C.5
Tan, H.-L.6
McCabe, S.7
Elliott, R.8
Scully, S.9
Van, G.10
Kaufman, S.11
Juan, S.-C.12
Sun, Y.13
Tarpley, J.14
Martin, L.15
Christensen, K.16
McCabe, J.17
Kostenuik, P.18
Hsu, H.19
Fletcher, F.20
Dunstan, C.R.21
Lacey, D.L.22
Boyle, W.J.23
more..
-
6
-
-
0031005576
-
Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
-
1:CAS:528:DyaK2sXislCgtLc%3D 10.1016/S0092-8674(00)80209-3 9108485
-
WS Simonet DL Lacey CR Dunstan, et al. 1997 Osteoprotegerin: a novel secreted protein involved in the regulation of bone density Cell 89 309 319 1:CAS:528:DyaK2sXislCgtLc%3D 10.1016/S0092-8674(00)80209-3 9108485
-
(1997)
Cell
, vol.89
, pp. 309-319
-
-
Simonet, W.S.1
Lacey, D.L.2
Dunstan, C.R.3
-
7
-
-
3242781731
-
Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
-
DOI 10.1001/jama.292.4.490
-
LC Hofbauer M Schoppet 2004 Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases JAMA 282 490 495 10.1001/jama.292.4.490 (Pubitemid 38988958)
-
(2004)
Journal of the American Medical Association
, vol.292
, Issue.4
, pp. 490-495
-
-
Hofbauer, L.C.1
Schoppet, M.2
-
8
-
-
34347394402
-
The RANKL inhibitor OPG-Fc increases cortical and trabecular bone mass in young gonad-intact cynomolgus monkeys
-
DOI 10.1007/s00198-007-0363-7
-
MS Ominsky PJ Kostenuik P Cranmer, et al. 2007 The RANKL inhibitor OPG-Fc increases cortical and trabecular bone mass in young gonad-intact cynomolgus monkeys Osteoporos Int 18 1073 1082 1:CAS:528:DC%2BD2sXntVOlsrk%3D 10.1007/s00198-007-0363-7 17384898 (Pubitemid 47020009)
-
(2007)
Osteoporosis International
, vol.18
, Issue.8
, pp. 1073-1082
-
-
Ominsky, M.S.1
Kostenuik, P.J.2
Cranmer, P.3
Smith, S.Y.4
Atkinson, J.E.5
-
9
-
-
3342982829
-
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
-
DOI 10.1359/JBMR.040305
-
PJ Bekker DL Holloway AS Rasmussen, et al. 2004 A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women J Bone Miner Res 19 1059 1066 1:CAS:528: DC%2BD2cXlvFWrtr0%3D 10.1359/JBMR.040305 15176987 (Pubitemid 41110556)
-
(2004)
Journal of Bone and Mineral Research
, vol.19
, Issue.7
, pp. 1059-1066
-
-
Bekker, P.J.1
Holloway, D.L.2
Rasmussen, A.S.3
Murphy, R.4
Martin, S.W.5
Leese, P.T.6
Holmes, G.B.7
Dunstan, C.R.8
DePaoli, A.M.9
-
10
-
-
33344469853
-
Denosumab in postmenopausal women with low bone mineral density
-
DOI 10.1056/NEJMoa044459
-
MR McClung EM Lewiecki SB Cohen, et al. 2006 Denosumab in post menopausal women with low bone mineral density N Engl J Med 354 821 831 1:CAS:528:DC%2BD28Xhsl2gs7o%3D 10.1056/NEJMoa044459 16495394 (Pubitemid 43290920)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.8
, pp. 821-831
-
-
McClung, M.R.1
Michael Lewiecki, E.2
Cohen, S.B.3
Bolognese, M.A.4
Woodson, G.C.5
Moffett, A.H.6
Peacock, M.7
Miller, P.D.8
Lederman, S.N.9
Chesnut, C.H.10
Lain, D.11
Kivitz, A.J.12
Holloway, D.L.13
Zhang, C.14
Peterson, M.C.15
Bekker, P.J.16
-
11
-
-
38749105490
-
Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD
-
DOI 10.1359/jbmr.070809
-
EM Lewiecki PD Miller MR McClung, et al. 2007 Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD J Bone Miner Res 22 1832 1841 1:CAS:528:DC%2BD2sXhsVyjtrjF 10.1359/jbmr.070809 17708711 (Pubitemid 351229299)
-
(2007)
Journal of Bone and Mineral Research
, vol.22
, Issue.12
, pp. 1832-1841
-
-
Lewiecki, E.M.1
Miller, P.D.2
McClung, M.R.3
Cohen, S.B.4
Bolognese, M.A.5
Liu, Y.6
Wang, A.7
Siddhanti, S.8
Fitzpatrick, L.A.9
-
12
-
-
52449112052
-
Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy. A randomized blinded phase 2 clinical trial
-
1:CAS:528:DC%2BD1cXosVOitrk%3D 10.1016/j.bone.2008.04.007 18539106 This discusses the 4-year extension of the phase 2 denosumab clinical trial data showing the rapid offset effects on BMD and BTM on discontinuation of denosumab and maintenance of the response to denosumab upon rechallenge
-
PD Miller MA Bolognese EM Lewiecki, et al. 2008 Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy. A randomized blinded phase 2 clinical trial Bone 43 222 229 1:CAS:528:DC%2BD1cXosVOitrk%3D 10.1016/j.bone.2008.04.007 18539106 This discusses the 4-year extension of the phase 2 denosumab clinical trial data showing the rapid offset effects on BMD and BTM on discontinuation of denosumab and maintenance of the response to denosumab upon rechallenge
-
(2008)
Bone
, vol.43
, pp. 222-229
-
-
Miller, P.D.1
Bolognese, M.A.2
Lewiecki, E.M.3
-
14
-
-
45149124792
-
Effects of denosumab on bone mineral density and bone turnover in postmenopausal women
-
DOI 10.1210/jc.2007-2814
-
HG Bone MA Bolognese CK Yuen, et al. 2008 Effects of denosumab on bone mineral density and bone turnover in postmenopausal women J Clin Endocrinol Metab 93 2149 2157 1:CAS:528:DC%2BD1cXntFamtrg%3D 10.1210/jc.2007-2814 18381571 (Pubitemid 351831529)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, Issue.6
, pp. 2149-2157
-
-
Bone, H.G.1
Bolognese, M.A.2
Yuen, C.K.3
Kendler, D.L.4
Wang, H.5
Liu, Y.6
San Martin, J.7
-
15
-
-
69049083492
-
Denosumab for prevention of fractures in postmenopausal women with osteoporosis
-
1:CAS:528:DC%2BD1MXhtVWls7nF 10.1056/NEJMoa0809493 19671655 This is the pivotal clinical trial showing a significant reduction in vertebral, hip, and nonvertebral fracture risk with denosumab in postmenopausal women with osteoporosis
-
SR Cummings J San Martin MR McClung, et al. 2009 Denosumab for prevention of fractures in postmenopausal women with osteoporosis N Engl J Med 361 756 765 1:CAS:528:DC%2BD1MXhtVWls7nF 10.1056/NEJMoa0809493 19671655 This is the pivotal clinical trial showing a significant reduction in vertebral, hip, and nonvertebral fracture risk with denosumab in postmenopausal women with osteoporosis
-
(2009)
N Engl J Med
, vol.361
, pp. 756-765
-
-
Cummings, S.R.1
San Martin, J.2
McClung, M.R.3
-
16
-
-
58149099647
-
Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, phase 3 trial
-
1:CAS:528:DC%2BD1MXht1yrtbc%3D 10.1359/jbmr.0809010 18767928 This phase 3, multicenter, double-blind study compared the efficacy and safety of denosumab with alendronate in postmenopausal women with low bone mass, showing that denosumab induced significantly larger gains in BMD and greater reduction in BTMs compared with alendronate
-
JP Brown RL Prince C Deal, et al. 2009 Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial J Bone Miner Res 24 153 161 1:CAS:528:DC%2BD1MXht1yrtbc%3D 10.1359/jbmr.0809010 18767928 This phase 3, multicenter, double-blind study compared the efficacy and safety of denosumab with alendronate in postmenopausal women with low bone mass, showing that denosumab induced significantly larger gains in BMD and greater reduction in BTMs compared with alendronate
-
(2009)
J Bone Miner Res
, vol.24
, pp. 153-161
-
-
Brown, J.P.1
Prince, R.L.2
Deal, C.3
-
17
-
-
77953454405
-
Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy
-
1:CAS:528:DC%2BC3cXksl2lu7c%3D 10.1359/jbmr.090716 19594293
-
DL Kendler C Roux CL Benhamou, et al. 2010 Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy J Bone Miner Res 25 72 81 1:CAS:528:DC%2BC3cXksl2lu7c%3D 10.1359/jbmr.090716 19594293
-
(2010)
J Bone Miner Res
, vol.25
, pp. 72-81
-
-
Kendler, D.L.1
Roux, C.2
Benhamou, C.L.3
-
18
-
-
77957666406
-
Effects of denosumab on bone histomorphometry: The freedom and stand studies
-
Jun 8. [Epub ahead of print]. This is the first description of bone histomorphometry with denosumab use confirming that this agent produces a potent and sustained inhibition of bone turnover and maintains normal bone microarchitecture without evidence of adverse effects on mineralization
-
• Reid I, Miller P, Brown J, et al. Effects of denosumab on bone histomorphometry: The freedom and stand studies. J Bone Miner Res 2010 Jun 8. [Epub ahead of print]. This is the first description of bone histomorphometry with denosumab use confirming that this agent produces a potent and sustained inhibition of bone turnover and maintains normal bone microarchitecture without evidence of adverse effects on mineralization.
-
(2010)
J Bone Miner Res
-
-
Reid, I.1
Miller, P.2
Brown, J.3
-
19
-
-
77953715717
-
Microarchitectural deterioration of cortical and trabecular bone: Differing effects of denosumab and alendronate
-
10.1002/jbmr.81 20222106
-
E Seeman PD Delmas DA Hanley, et al. 2010 Microarchitectural deterioration of cortical and trabecular bone: differing effects of denosumab and alendronate J Bone Miner Res 25 1886 1894 10.1002/jbmr.81 20222106
-
(2010)
J Bone Miner Res
, vol.25
, pp. 1886-1894
-
-
Seeman, E.1
Delmas, P.D.2
Hanley, D.A.3
-
20
-
-
79551532158
-
A single dose study of denosumab in patients with various degrees of renal impairment
-
10.1053/j.ajkd.2010.02.064
-
G Block HG Bone L Fang, et al. 2010 A single dose study of denosumab in patients with various degrees of renal impairment Am J Kid Dis 55 A46 10.1053/j.ajkd.2010.02.064
-
(2010)
Am J Kid Dis
, vol.55
, pp. 46
-
-
Block, G.1
Bone, H.G.2
Fang, L.3
-
21
-
-
43949139580
-
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial
-
DOI 10.1002/art.23417
-
SB Cohen RK Dore NE Lane, et al. 2008 Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial Arthritis Rheum 58 1299 1309 1:CAS:528:DC%2BD1cXms1ehu70%3D 10.1002/art.23417 18438830 (Pubitemid 351705919)
-
(2008)
Arthritis and Rheumatism
, vol.58
, Issue.5
, pp. 1299-1309
-
-
Cohen, S.B.1
Dore, R.K.2
Lane, N.E.3
Ory, P.A.4
Peterfy, C.G.5
Sharp, J.T.6
Van Der Heijde, D.7
Zhou, L.8
Tsuji, W.9
Newmark, R.10
-
22
-
-
69049105440
-
Denosumab in men receiving androgen-deprivation therapy for prostate cancer
-
1:CAS:528:DC%2BD1MXhtVWls7rF 10.1056/NEJMoa0809003 19671656
-
MR Smith B Egerdie N Hernández Toriz, et al. 2009 Denosumab in men receiving androgen-deprivation therapy for prostate cancer N Engl J Med 361 745 755 1:CAS:528:DC%2BD1MXhtVWls7rF 10.1056/NEJMoa0809003 19671656
-
(2009)
N Engl J Med
, vol.361
, pp. 745-755
-
-
Smith, M.R.1
Egerdie, B.2
Hernández Toriz, N.3
-
23
-
-
54449084015
-
Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for non-metastatic breast cancer
-
1:CAS:528:DC%2BD1cXhtlGitrzO 10.1200/JCO.2008.16.3832 18725648
-
GK Ellis HG Bone R Chlebowski, et al. 2008 Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for non-metastatic breast cancer J Clin Oncol 26 4875 4882 1:CAS:528:DC%2BD1cXhtlGitrzO 10.1200/JCO.2008.16.3832 18725648
-
(2008)
J Clin Oncol
, vol.26
, pp. 4875-4882
-
-
Ellis, G.K.1
Bone, H.G.2
Chlebowski, R.3
-
24
-
-
78349290889
-
A randomized phase III trial of denosumab versus zolendronic acid in patients with bone metastases from castration-resistant prostate cancer
-
K Fizazi MA Carducci MR Smith, et al. 2010 A randomized phase III trial of denosumab versus zolendronic acid in patients with bone metastases from castration-resistant prostate cancer J Clin Oncol 28 Suppl 18S
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Fizazi, K.1
Carducci, M.A.2
Smith, M.R.3
-
25
-
-
78649760710
-
Denosumab in the treatment of bone metastases from advanced cancer or multiple myeloma (MM): Analysis from a phase III randomized trial
-
S Vadhan-Raj DH Henry R von Moos, et al. 2010 Denosumab in the treatment of bone metastases from advanced cancer or multiple myeloma (MM): analysis from a phase III randomized trial J Clin Oncol 28 Suppl 15S
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Vadhan-Raj, S.1
Henry, D.H.2
Von Moos, R.3
-
26
-
-
72149124320
-
Denosumab versus zolendronic acid for the treatment of breast cancer patients with bone metastases: Results of a randomized phase III study
-
10.1016/S1359-6349(09)72028-2
-
A Stopeck JJ Body Y Fujiwara, et al. 2009 Denosumab versus zolendronic acid for the treatment of breast cancer patients with bone metastases: results of a randomized phase III study Eur J Can Suppl 7 2 10.1016/S1359-6349(09)72028- 2
-
(2009)
Eur J Can Suppl
, vol.7
, pp. 2
-
-
Stopeck, A.1
Body, J.J.2
Fujiwara, Y.3
-
27
-
-
78149409580
-
Increased risk of serious infections in women with osteopenia or osteoporosis treated with denosumab
-
1:STN:280:DC%2BC3cflsVGjtg%3D%3D 10.1007/s00198-009-1145-1
-
A Toulis D Anastasilakis 2010 Increased risk of serious infections in women with osteopenia or osteoporosis treated with denosumab Osteoporosis Int 21 1963 1964 1:STN:280:DC%2BC3cflsVGjtg%3D%3D 10.1007/s00198-009-1145-1
-
(2010)
Osteoporosis Int
, vol.21
, pp. 1963-1964
-
-
Toulis, A.1
Anastasilakis, D.2
|