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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4228-4232

Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights

(9) Grädler, Ulrich a Fuchß, Thomas a Ulrich, Wolf Rüdiger a Boer, Rainer a Strub, Andreas a Hesslinger, Christian a Anézo, Céline a Diederichs, Kay b Zaliani, Andrea a

a Nycomed GmbH (Germany)

b UNIVERSITY OF KONSTANZ (Germany)

Author keywords

Crystal structure; Inflammation; Inhibitor; Nitric oxide synthase; Selectivity; Structure based design

Indexed keywords

2 (4 METHOXYPYRIDIN 2 YLMETHYLSULFANYL) 3H IMIDAZO[4,5 B]PYRIDINE; 2 [2 (4 METHOXY PYRIDIN 2 YL) ETHYL] 3H IMIDAZO[4,5 B]PYRIDINE; 3 (4 METHOXYPYRIDIN 2 YL)ACRYLIC ACID METHYL ESTER; 3 (4 METHOXYPYRIDIN 2 YL)PROPIONIC ACID; 4 METHOXY 2 METHYLSULFANYLMETHYL PYRIDINE; 4 METHOXY PYRIDINE 2 CARBALDEHYDE; ANTIINFLAMMATORY AGENT; ARC 102222; ARC 133057XX; BYK 191023; CYTOCHROME P450; IMIDAZO[4,5 B]PYRIDINE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG STRUCTURE; IC 50; NONHUMAN; PROTEIN DOMAIN; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MICE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959898633 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.05.073 Document Type: Article

Times cited : (34)

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