Inhibition of inducible nitric oxide synthase in respiratory diseases

Biochemical Society Transactions

Volumn 37, Issue 4, 2009, Pages 886-891

  Hesslinger, Christian ^a   Strub, Andreas ^a   Boer, Rainer ^a   Ulrich, Wolf Rüdiger ^a   Lehner, Martin D ^a,b   Braun, Clemens ^a  

^a Nycomed GmbH   (Germany)

^b Almirall Prodesfarma S A   (Spain)

Author keywords

Asthma; Chronic obstructive pulmonary disease (COPD); Inducible nitric oxide synthase inhibitor (iNOS inhibitor); Lung disease; Nitrative stress; Nitric oxide

Indexed keywords

1 (2 MERCAPTOETHYL)GUANIDINE; 7 CHLORO 3 IMINO 5 METHYL 2 AZABICYCLO[4.1.0]HEPTANE; 7 NITROINDAZOLE; AMINOGUANIDINE; ARC 102222; BYK 191023; BYK 402750; GLUCOCORTICOID; INDUCIBLE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; N6 (1 IMINOETHYL)LYSINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGENASE INHIBITOR; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; SULFIDE;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANTIINFLAMMATORY ACTIVITY; ASTHMA; BRONCHODILATING ACTIVITY; BRONCHUS HYPERREACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFICACY; DRUG PROTEIN BINDING; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME REGULATION; FIBROSING ALVEOLITIS; HUMAN; LUNG DISEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SINGLE DRUG DOSE; ANIMAL; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; REVIEW;

ANIMALIA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTHMA; HUMANS; LUNG DISEASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SULFIDES;

EID: 70349308062     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0370886     Document Type: Conference Paper

References (50)

1. Alderton, W.K., Cooper, C.E. and Knowles, R.G. (2001) Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357, 593-615
2. Vo, P.A., Lad, B., Tomlinson, J.A., Francis, S. and Ahluwalia, A. (2005) Autoregulatory role of endothelium-derived nitric oxide (NO) on lipopolysaccharide-induced vascular inducible NO synthase expression and function. J. Biol. Chem. 280, 7236-7243
3. Tinker, A.C. and Wallace, A.V. (2006) Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases? Curr. Top. Med. Chem. 6, 77-92
4. Boer, R., Ulrich, W.R., Klein, T., Mirau, B., Haas, S. and Baur, I. (2000) The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol. Pharmacol. 58, 1026-1034
5. McMillan, K., Adler, M., Auld, D.S., Baldwin, J.J., Blasko, E., Browne, L.J., Chelsky, D., Davey, D., Dolle, R.E., Eagen, K.A. et al. (2000) Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry. Proc. Natl. Acad. Sci. U.S.A. 97, 1506-1511
6. Garvey, E.P., Oplinger, J.A., Furfine, E.S., Kiff, R.J., Laszlo, F., Whittle, B.J. and Knowles, R.G. (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J. Biol. Chem. 272, 4959-4963
7. Young, R.J., Beams, R.M., Carter, K., Clark, H.A., Coe, D.M., Chambers, C.L., Davies, P.I., Dawson, J., Drysdale, M.J., Franzman, K.W. et al. (2000) Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. Bioorg. Med. Chem. Lett. 10, 597-600
8. Beaton, H., Hamley, P., Nicholls, D.J., Tinker, A.C. and Wallace, A.V. (2001) 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency. Bioorg. Med. Chem. Lett. 11, 1023-1026
9. Strub, A., Ulrich, W.R., Hesslinger, C., Eltze, M., Fuchss, T., Strassner, J., Strand, S., Lehner, M.D. and Boer, R. (2006) The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-[i b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol. Pharmacol. 69, 328-337
10. Lehner, M.D., Marx, D., Boer, R., Strub, A., Hesslinger, C., Eltze, M., Ulrich, W.R., Schwoebel, F., Schermuly, R.T. and Barsig, J. (2006) In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5- b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase. J. Pharmacol. Exp. Ther. 313, 181-187
11. Hesslinger, C., Lehner, M.D., Strub, A., Boer, R., Ulrich, W.R., Kuelzer, R., Lauer, G., Lin, D., Spicer, D., Fitzgerald, M. et al. (2008) The highly selective iNOS inhibitor BYK402750 exerts potent anti-inflammatory effects in a mouse model of cigarette smoke-induced inflammation. Nitric Oxide 19, (Suppl. 1), 35
12. Feder, L.S., Stelts, D., Chapman, R.W., Manfra, D., Crawlea, Y., Jones, H., Minnicozzi, M., Fernandez, X., Paster, T., Egan, R.W. et al. (1997) Role of nitric oxide on eosinophilic lung inflammation in allergic mice. Am. J. Respir. Cell Mol. Biol. 17, 436-442
13. Trifilieff, A., Fujitani, Y., Mentz, F., Dugas, B., Fuentes, M. and Bertrand, C. (2000) Inducible nitric oxide synthase inhibitors suppress airway inflammation in mice through down-regulation of chemokine expression. J. Immunol. 165, 1526-1533
14. Eynott, P.R., Groneberg, D.A., Caramori, G., Adcock, I.M., Donnelly, L.E., Kharitonov, S.A., Barnes, P.J. and Chung, K.F. (2002) Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness. Eur. J. Pharmacol. 452, 123-133
15. Eynott, P.R., Paavolainen, N., Groneberg, D.A., Noble, A., Salmon, M., Nath, P., Leung, S.Y. and Chung, K.F. (2003) Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation. J. Pharmacol. Exp. Ther. 304, 22-29
16. De Sanctis, G.T., MacLean, J.A., Hamada, K., Mehta, S., Scott, J.A., Jiao, A., Yandava, C.N., Kobzik, L., Wolyniec, W.W., Fabian, A.J. et al. (1999) Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J. Exp. Med. 189, 1621-1630
17. Landgraf, R.G., Russo, M. and Jancar, S. (2005) Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses. Eur. J. Pharmacol. 518, 212-220
18. Hamid, Q., Springall, D.R., Riveros-Moreno, V., Chanez, P., Howarth, P., Redington, A., Bousquet, J., Godard, P., Holgate, S. and Polak, J.M. (1993) Induction of nitric oxide synthase in asthma. Lancet 342, 1510-1513
19. Lane, C., Knight, D., Burgess, S., Franklin, P., Horak, F., Legg, J., Moeller, A. and Stick, S. (2004) Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath. Thorax 59, 757-760
20. Kharitonov, S.A., Yates, D., Robinson, R.G., Logan-Siclair, R., Shinebourne, E.A. and Barnes, P.J. (1994) Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343, 133-135
21. Smith, A.D., Cowan, J.O., Brasset, K.P., Herbison, G.P. and Taylor, D.R. (2005) Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N. Engl. J. Med. 352, 2163-2173
22. Saleh, D., Ernst, P., Lim, S., Barnes, P.J. and Giaid, A. (1998) Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J. 12, 929-937
23. Ricciardolo, F.L., Caramori, G., Ito, K., Capelli, A., Brun, P., Abatangelo, G., Papi, A., Chung, K.F., Adcock, I.M., Barnes, P.J. et al. (2005) Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 116, 1028-1035
24. Singh, D., Richards, D., Knowles, R.G., Schwartz, S., Woodcock, A., Langley, S. and O'Connor, B.J. (2007) Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. Am. J. Respir. Crit. Care Med. 176, 988-993
25. Anazawa, T., Dimayuga, P., Li, H., Tani, S., Bradfield, J., Chyu, K., Kaul, S., Shah, P. and Cercek, B. (2004) Effect of exposure to cigarette smoke on carotid artery intimal thickening: the role of inducible NO synthase. Arterioscler. Thromb. Vasc. Biol. 24, 1652-1658
26. Ichinose, M., Sugiura, H., Yamagata, S., Koarai, A. and Shirato, K. (2000) Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am. J. Respir. Crit. Care Med. 162, 701-716
27. Agusti, A., Morla, M., Sauleda, J., Saus, C. and Busquets, X. (2004) NF-κB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight. Thorax 59, 483-487
28. Brindicci, C., Ito, K., Resta, O., Pride, N., Barnes, P.J. and Kharitonov, S.A. (2005) Exhaled nitric oxide from lung periphery is increased in COPD. Eur. Respir. J. 26, 52-59
29. Agusti, A., Villaverde, J.M., Togores, B. and Bosch, M. (1999) Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease. Eur. J. Pharmacol. 14, 523-528
30. Maziak, W., Loukides, S., Culpitt, S., Sullivan, P., Kharitonov, S.A. and Barnes, P.J. (1998) Exhaled nitric oxide in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 153, 998-1002
31. Osoata, G.O., Hanazawa, T., Brindicci, C., Ito, M., Barnes, P.J., Kharitonov, S.A. and Ito, K. (2009) Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine. Chest 135, 1513-1520
32. Genovese, T., Cuzzocrea, S., Di Paola, R., Failla, M., Mazzon, E., Sortino, M.A., Frasca, G., Gili, E., Crimi, N., Caputi, A.P. and Vancheri, C. (2005) Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury. Respir. Res. 6, 58-74
33. Jang, A.S., Lee, J.U., Choi, I.S., Park, K.O., Lee, J.H., Park, S.W. and Park, C.S. (2004) Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation. Intensive Care Med. 30, 489-495
34. Saleh, D., Barnes, P.J. and Giaid, A. (1997) Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 155, 1763-1769
35. McCluskie, K., Birrell, M.A., Wong, S. and Belvisi, M.G. (2004) Nitric oxide as a noninvasive biomarker of lipopolysaccharide-induced airway inflammation: possible role in lung neutrophilia. J. Pharmacol. Exp. Ther. 311, 625-633
36. Razavi, H.M., Wang, F., Weicker, S., Rohan, M., McCormack, D.G. and Mehta, S. (2004) Pulmonary neutrophil infiltration in murine sepsis: role of inducible nitric oxide synthase. Am. J. Respir. Crit. Care Med. 170, 227-233
37. Enkhbaatar, P., Murakami, K., Shimoda, K., Mizutani, A., Traber, L., Phillips, G.B., Parkinson, J.F., Cox, R., Hawkins, H., Herndorn, D. and Traber, D. (2003) The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury. Am. J. Respir. Crit. Care Med. 167, 1021-1026
38. Enkhbaatar, P., Murakami, K., Shimoda, K., Mizutani, A., McGuire, R., Schmalstieg, F., Cox, R., Hawkins, H., Jodoin, J., Lee, S. et al. (2003) Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R366-R372
39. Yuba, T., Nagata, K., Yamad, T., Osugi, S., Kuwahara, H., Iwasaki, Y., Hand, O., Naito, Y., Fushiki, S., Yoshikawa, T. and Marunaka, Y. (2007) A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice. Respir. Med. 101, 793-799
40. Atochina-Vasserman, E.N., Beers, M.F., Kadire, H., Tomer, Y., Inch, A., Scott, P., Guo, C.J. and Gow, A.J. (2007) Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice. J. Immunol. 179, 8090-8097
41. Laskin, D.L., Fakhrzadeh, L. and Laskin, J.D. (2001) Nitric oxide and peroxynitrite in ozone-induced lung injury. Adv. Exp. Med. Biol. 500, 183-190
42. Dugo, L., Marzocco, S., Mazzon, E., Di Paola, R., Genovese, T., Caputi, A.P. and Cuzzocrea, S. (2004) Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br. J. Pharmacol. 141, 979-987
43. Ohsugi, S., Iwasaki, Y., Takemura, Y., Nagata, K., Harada, H., Yokomura, I., Hosogi, S., Yuba, T., Niisato, N., Miyazaki, H. et al. (2007) An inhaled inducible nitric oxide synthase inhibitor reduces damage of Candida-induced acute lung injury. Biomed. Res. 28, 91-99
44. Hampl, V., Bbová, J., Banasová, A., Uhlík, J., Miková, D., Hnilickov,́ O., Lachmanová, V. and Herget, J. (2006) Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 290, L11-L20
45. Jiang, B.H., Maruyama, J., Yokochi, A., Mitani, Y. and Maruyama, K. (2007) A novel inhibitor of inducible nitric oxide synthase, ONO-1714, does not ameliorate hypoxia-induced pulmonary hypertension in rats. Lung 185, 303-308
46. Bekes, C.E., Dellinger, R.P., Brooks, D., Edmondson, R., Olivia, C.T. and Parrillo, J.E. (2004) Critical care medicine as a distinct product line with substantial financial profitability: the role of business planning. Crit. Care Med. 32, 1207-1214
47. Taylor, D.A., McGrath, J.L., O'Connor, B.J. and Barnes, P.J. (1998) Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide. Am. J. Respir. Crit. Care Med. 158, 99-106
48. Brindicci, C., Ito, K., Barnes, P.J. and Kharitonov, S.A. (2007) Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity. Chest 131, 1353-1362
49. Hansel, T.T., Kharitonov, S.A., Donnelly, L.E., Erin, E.M., Currie, M.G., Moore, W.M., Manning, P.T., Recker, D.P. and Barnes, P.J. (2003) A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J. 17, 1298-1300
50. Brindicci, C., Ito, K., Torre, O., Barnes, P.J. and Kharitonov, S.A. (2009) Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients. Chest 135, 353-367