메뉴 건너뛰기




Volumn 37, Issue 4, 2009, Pages 886-891

Inhibition of inducible nitric oxide synthase in respiratory diseases

Author keywords

Asthma; Chronic obstructive pulmonary disease (COPD); Inducible nitric oxide synthase inhibitor (iNOS inhibitor); Lung disease; Nitrative stress; Nitric oxide

Indexed keywords

1 (2 MERCAPTOETHYL)GUANIDINE; 7 CHLORO 3 IMINO 5 METHYL 2 AZABICYCLO[4.1.0]HEPTANE; 7 NITROINDAZOLE; AMINOGUANIDINE; ARC 102222; BYK 191023; BYK 402750; GLUCOCORTICOID; INDUCIBLE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; N6 (1 IMINOETHYL)LYSINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGENASE INHIBITOR; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; SULFIDE;

EID: 70349308062     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0370886     Document Type: Conference Paper
Times cited : (92)

References (50)
  • 1
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • Alderton, W.K., Cooper, C.E. and Knowles, R.G. (2001) Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357, 593-615
    • (2001) Biochem. J , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 2
    • 14844286922 scopus 로고    scopus 로고
    • Autoregulatory role of endothelium-derived nitric oxide (NO) on lipopolysaccharide-induced vascular inducible NO synthase expression and function
    • Vo, P.A., Lad, B., Tomlinson, J.A., Francis, S. and Ahluwalia, A. (2005) Autoregulatory role of endothelium-derived nitric oxide (NO) on lipopolysaccharide-induced vascular inducible NO synthase expression and function. J. Biol. Chem. 280, 7236-7243
    • (2005) J. Biol. Chem , vol.280 , pp. 7236-7243
    • Vo, P.A.1    Lad, B.2    Tomlinson, J.A.3    Francis, S.4    Ahluwalia, A.5
  • 3
    • 33646169337 scopus 로고    scopus 로고
    • Selective inhibitors of inducible nitric oxide synthase: Potential agents for the treatment of inflammatory diseases?
    • Tinker, A.C. and Wallace, A.V. (2006) Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases? Curr. Top. Med. Chem. 6, 77-92
    • (2006) Curr. Top. Med. Chem , vol.6 , pp. 77-92
    • Tinker, A.C.1    Wallace, A.V.2
  • 4
    • 0033789703 scopus 로고    scopus 로고
    • The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes
    • Boer, R., Ulrich, W.R., Klein, T., Mirau, B., Haas, S. and Baur, I. (2000) The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol. Pharmacol. 58, 1026-1034
    • (2000) Mol. Pharmacol , vol.58 , pp. 1026-1034
    • Boer, R.1    Ulrich, W.R.2    Klein, T.3    Mirau, B.4    Haas, S.5    Baur, I.6
  • 6
    • 0031040613 scopus 로고    scopus 로고
    • 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
    • Garvey, E.P., Oplinger, J.A., Furfine, E.S., Kiff, R.J., Laszlo, F., Whittle, B.J. and Knowles, R.G. (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J. Biol. Chem. 272, 4959-4963
    • (1997) J. Biol. Chem , vol.272 , pp. 4959-4963
    • Garvey, E.P.1    Oplinger, J.A.2    Furfine, E.S.3    Kiff, R.J.4    Laszlo, F.5    Whittle, B.J.6    Knowles, R.G.7
  • 8
    • 0035938426 scopus 로고    scopus 로고
    • 3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency
    • Beaton, H., Hamley, P., Nicholls, D.J., Tinker, A.C. and Wallace, A.V. (2001) 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency. Bioorg. Med. Chem. Lett. 11, 1023-1026
    • (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 1023-1026
    • Beaton, H.1    Hamley, P.2    Nicholls, D.J.3    Tinker, A.C.4    Wallace, A.V.5
  • 9
    • 30044444530 scopus 로고    scopus 로고
    • The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-[i b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase
    • Strub, A., Ulrich, W.R., Hesslinger, C., Eltze, M., Fuchss, T., Strassner, J., Strand, S., Lehner, M.D. and Boer, R. (2006) The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-[i b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol. Pharmacol. 69, 328-337
    • (2006) Mol. Pharmacol , vol.69 , pp. 328-337
    • Strub, A.1    Ulrich, W.R.2    Hesslinger, C.3    Eltze, M.4    Fuchss, T.5    Strassner, J.6    Strand, S.7    Lehner, M.D.8    Boer, R.9
  • 10
    • 33645114356 scopus 로고    scopus 로고
    • In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5- b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase
    • Lehner, M.D., Marx, D., Boer, R., Strub, A., Hesslinger, C., Eltze, M., Ulrich, W.R., Schwoebel, F., Schermuly, R.T. and Barsig, J. (2006) In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5- b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase. J. Pharmacol. Exp. Ther. 313, 181-187
    • (2006) J. Pharmacol. Exp. Ther , vol.313 , pp. 181-187
    • Lehner, M.D.1    Marx, D.2    Boer, R.3    Strub, A.4    Hesslinger, C.5    Eltze, M.6    Ulrich, W.R.7    Schwoebel, F.8    Schermuly, R.T.9    Barsig, J.10
  • 11
    • 70349395592 scopus 로고    scopus 로고
    • The highly selective iNOS inhibitor BYK402750 exerts potent anti-inflammatory effects in a mouse model of cigarette smoke-induced inflammation
    • Hesslinger, C., Lehner, M.D., Strub, A., Boer, R., Ulrich, W.R., Kuelzer, R., Lauer, G., Lin, D., Spicer, D., Fitzgerald, M. et al. (2008) The highly selective iNOS inhibitor BYK402750 exerts potent anti-inflammatory effects in a mouse model of cigarette smoke-induced inflammation. Nitric Oxide 19, (Suppl. 1), 35
    • (2008) Nitric Oxide , vol.19 , Issue.SUPPL. 1 , pp. 35
    • Hesslinger, C.1    Lehner, M.D.2    Strub, A.3    Boer, R.4    Ulrich, W.R.5    Kuelzer, R.6    Lauer, G.7    Lin, D.8    Spicer, D.9    Fitzgerald, M.10
  • 13
    • 0034254471 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase inhibitors suppress airway inflammation in mice through down-regulation of chemokine expression
    • Trifilieff, A., Fujitani, Y., Mentz, F., Dugas, B., Fuentes, M. and Bertrand, C. (2000) Inducible nitric oxide synthase inhibitors suppress airway inflammation in mice through down-regulation of chemokine expression. J. Immunol. 165, 1526-1533
    • (2000) J. Immunol , vol.165 , pp. 1526-1533
    • Trifilieff, A.1    Fujitani, Y.2    Mentz, F.3    Dugas, B.4    Fuentes, M.5    Bertrand, C.6
  • 17
    • 23644445216 scopus 로고    scopus 로고
    • Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses
    • Landgraf, R.G., Russo, M. and Jancar, S. (2005) Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses. Eur. J. Pharmacol. 518, 212-220
    • (2005) Eur. J. Pharmacol , vol.518 , pp. 212-220
    • Landgraf, R.G.1    Russo, M.2    Jancar, S.3
  • 19
    • 4544317836 scopus 로고    scopus 로고
    • Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath
    • Lane, C., Knight, D., Burgess, S., Franklin, P., Horak, F., Legg, J., Moeller, A. and Stick, S. (2004) Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath. Thorax 59, 757-760
    • (2004) Thorax , vol.59 , pp. 757-760
    • Lane, C.1    Knight, D.2    Burgess, S.3    Franklin, P.4    Horak, F.5    Legg, J.6    Moeller, A.7    Stick, S.8
  • 21
    • 19444385389 scopus 로고    scopus 로고
    • Use of exhaled nitric oxide measurements to guide treatment in chronic asthma
    • Smith, A.D., Cowan, J.O., Brasset, K.P., Herbison, G.P. and Taylor, D.R. (2005) Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N. Engl. J. Med. 352, 2163-2173
    • (2005) N. Engl. J. Med , vol.352 , pp. 2163-2173
    • Smith, A.D.1    Cowan, J.O.2    Brasset, K.P.3    Herbison, G.P.4    Taylor, D.R.5
  • 22
    • 0031857283 scopus 로고    scopus 로고
    • Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: Effect of inhaled glucocorticoid
    • Saleh, D., Ernst, P., Lim, S., Barnes, P.J. and Giaid, A. (1998) Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J. 12, 929-937
    • (1998) FASEB J , vol.12 , pp. 929-937
    • Saleh, D.1    Ernst, P.2    Lim, S.3    Barnes, P.J.4    Giaid, A.5
  • 26
    • 0033841255 scopus 로고    scopus 로고
    • Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways
    • Ichinose, M., Sugiura, H., Yamagata, S., Koarai, A. and Shirato, K. (2000) Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am. J. Respir. Crit. Care Med. 162, 701-716
    • (2000) Am. J. Respir. Crit. Care Med , vol.162 , pp. 701-716
    • Ichinose, M.1    Sugiura, H.2    Yamagata, S.3    Koarai, A.4    Shirato, K.5
  • 27
    • 2942662046 scopus 로고    scopus 로고
    • NF-κB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight
    • Agusti, A., Morla, M., Sauleda, J., Saus, C. and Busquets, X. (2004) NF-κB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight. Thorax 59, 483-487
    • (2004) Thorax , vol.59 , pp. 483-487
    • Agusti, A.1    Morla, M.2    Sauleda, J.3    Saus, C.4    Busquets, X.5
  • 29
    • 0032884546 scopus 로고    scopus 로고
    • Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease
    • Agusti, A., Villaverde, J.M., Togores, B. and Bosch, M. (1999) Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease. Eur. J. Pharmacol. 14, 523-528
    • (1999) Eur. J. Pharmacol , vol.14 , pp. 523-528
    • Agusti, A.1    Villaverde, J.M.2    Togores, B.3    Bosch, M.4
  • 31
    • 66649127216 scopus 로고    scopus 로고
    • Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine
    • Osoata, G.O., Hanazawa, T., Brindicci, C., Ito, M., Barnes, P.J., Kharitonov, S.A. and Ito, K. (2009) Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine. Chest 135, 1513-1520
    • (2009) Chest , vol.135 , pp. 1513-1520
    • Osoata, G.O.1    Hanazawa, T.2    Brindicci, C.3    Ito, M.4    Barnes, P.J.5    Kharitonov, S.A.6    Ito, K.7
  • 33
    • 1642291707 scopus 로고    scopus 로고
    • Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation
    • Jang, A.S., Lee, J.U., Choi, I.S., Park, K.O., Lee, J.H., Park, S.W. and Park, C.S. (2004) Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation. Intensive Care Med. 30, 489-495
    • (2004) Intensive Care Med , vol.30 , pp. 489-495
    • Jang, A.S.1    Lee, J.U.2    Choi, I.S.3    Park, K.O.4    Lee, J.H.5    Park, S.W.6    Park, C.S.7
  • 34
    • 0030915094 scopus 로고    scopus 로고
    • Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis
    • Saleh, D., Barnes, P.J. and Giaid, A. (1997) Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 155, 1763-1769
    • (1997) Am. J. Respir. Crit. Care Med , vol.155 , pp. 1763-1769
    • Saleh, D.1    Barnes, P.J.2    Giaid, A.3
  • 35
    • 6344258223 scopus 로고    scopus 로고
    • Nitric oxide as a noninvasive biomarker of lipopolysaccharide-induced airway inflammation: Possible role in lung neutrophilia
    • McCluskie, K., Birrell, M.A., Wong, S. and Belvisi, M.G. (2004) Nitric oxide as a noninvasive biomarker of lipopolysaccharide-induced airway inflammation: possible role in lung neutrophilia. J. Pharmacol. Exp. Ther. 311, 625-633
    • (2004) J. Pharmacol. Exp. Ther , vol.311 , pp. 625-633
    • McCluskie, K.1    Birrell, M.A.2    Wong, S.3    Belvisi, M.G.4
  • 40
    • 40049099026 scopus 로고    scopus 로고
    • Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice
    • Atochina-Vasserman, E.N., Beers, M.F., Kadire, H., Tomer, Y., Inch, A., Scott, P., Guo, C.J. and Gow, A.J. (2007) Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice. J. Immunol. 179, 8090-8097
    • (2007) J. Immunol , vol.179 , pp. 8090-8097
    • Atochina-Vasserman, E.N.1    Beers, M.F.2    Kadire, H.3    Tomer, Y.4    Inch, A.5    Scott, P.6    Guo, C.J.7    Gow, A.J.8
  • 41
    • 0035699905 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in ozone-induced lung injury
    • Laskin, D.L., Fakhrzadeh, L. and Laskin, J.D. (2001) Nitric oxide and peroxynitrite in ozone-induced lung injury. Adv. Exp. Med. Biol. 500, 183-190
    • (2001) Adv. Exp. Med. Biol , vol.500 , pp. 183-190
    • Laskin, D.L.1    Fakhrzadeh, L.2    Laskin, J.D.3
  • 42
  • 45
    • 34548555767 scopus 로고    scopus 로고
    • A novel inhibitor of inducible nitric oxide synthase, ONO-1714, does not ameliorate hypoxia-induced pulmonary hypertension in rats
    • Jiang, B.H., Maruyama, J., Yokochi, A., Mitani, Y. and Maruyama, K. (2007) A novel inhibitor of inducible nitric oxide synthase, ONO-1714, does not ameliorate hypoxia-induced pulmonary hypertension in rats. Lung 185, 303-308
    • (2007) Lung , vol.185 , pp. 303-308
    • Jiang, B.H.1    Maruyama, J.2    Yokochi, A.3    Mitani, Y.4    Maruyama, K.5
  • 46
    • 2442452661 scopus 로고    scopus 로고
    • Critical care medicine as a distinct product line with substantial financial profitability: The role of business planning
    • Bekes, C.E., Dellinger, R.P., Brooks, D., Edmondson, R., Olivia, C.T. and Parrillo, J.E. (2004) Critical care medicine as a distinct product line with substantial financial profitability: the role of business planning. Crit. Care Med. 32, 1207-1214
    • (2004) Crit. Care Med , vol.32 , pp. 1207-1214
    • Bekes, C.E.1    Dellinger, R.P.2    Brooks, D.3    Edmondson, R.4    Olivia, C.T.5    Parrillo, J.E.6
  • 47
    • 0031815595 scopus 로고    scopus 로고
    • Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide
    • Taylor, D.A., McGrath, J.L., O'Connor, B.J. and Barnes, P.J. (1998) Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide. Am. J. Respir. Crit. Care Med. 158, 99-106
    • (1998) Am. J. Respir. Crit. Care Med , vol.158 , pp. 99-106
    • Taylor, D.A.1    McGrath, J.L.2    O'Connor, B.J.3    Barnes, P.J.4
  • 48
    • 34248577155 scopus 로고    scopus 로고
    • Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity
    • Brindicci, C., Ito, K., Barnes, P.J. and Kharitonov, S.A. (2007) Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity. Chest 131, 1353-1362
    • (2007) Chest , vol.131 , pp. 1353-1362
    • Brindicci, C.1    Ito, K.2    Barnes, P.J.3    Kharitonov, S.A.4
  • 49
    • 0038604348 scopus 로고    scopus 로고
    • A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics
    • Hansel, T.T., Kharitonov, S.A., Donnelly, L.E., Erin, E.M., Currie, M.G., Moore, W.M., Manning, P.T., Recker, D.P. and Barnes, P.J. (2003) A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J. 17, 1298-1300
    • (2003) FASEB J , vol.17 , pp. 1298-1300
    • Hansel, T.T.1    Kharitonov, S.A.2    Donnelly, L.E.3    Erin, E.M.4    Currie, M.G.5    Moore, W.M.6    Manning, P.T.7    Recker, D.P.8    Barnes, P.J.9
  • 50
    • 60249100136 scopus 로고    scopus 로고
    • Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients
    • Brindicci, C., Ito, K., Torre, O., Barnes, P.J. and Kharitonov, S.A. (2009) Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients. Chest 135, 353-367
    • (2009) Chest , vol.135 , pp. 353-367
    • Brindicci, C.1    Ito, K.2    Torre, O.3    Barnes, P.J.4    Kharitonov, S.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.