An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 23771-23779

  Rybchyn, Mark S ^a   Slater, Michael ^a   Conigrave, Arthur D ^b   Mason, Rebecca S ^a  

^a Bosch Institute   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BONE FORMATION; BONE HOMEOSTASIS; CALCIUM-SENSING RECEPTORS; CANONICAL WNT SIGNALING; FRACTURE RISKS; HUMAN OSTEOBLAST; KEY REGULATORS; NEGATIVE REGULATORS; NUCLEAR TRANSLOCATIONS; OSTEOGENESIS; OSTEOGENIC EFFECTS; PRIMARY CULTURE; PROTEIN LEVEL; SCLEROSTIN; SECRETED PROTEIN; SIGNALING CASCADES;

BONE; STRONTIUM;

SIGNALING;

BETA CATENIN; CALCIUM SENSING RECEPTOR; COLLAGEN TYPE 1; G PROTEIN COUPLED RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCLEROSTIN; STRONTIUM RANELATE; THREONINE; WNT PROTEIN;

APOPTOSIS; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL CULTURE; CELL DIVISION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; BETA CATENIN; BONE DENSITY CONSERVATION AGENTS; BONE MORPHOGENETIC PROTEINS; CALCIFICATION, PHYSIOLOGIC; CELL NUCLEUS; CELLS, CULTURED; GENETIC MARKERS; HUMANS; ORGANOMETALLIC COMPOUNDS; OSTEOBLASTS; OSTEOCYTES; OSTEOGENESIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THIOPHENES; WNT PROTEINS;

EID: 79959894497     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.251116     Document Type: Article

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