Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway

Physiological Genomics

Volumn 43, Issue 12, 2011, Pages 749-757

  Xing, Weirong ^a,b   Pourteymoor, Sheila ^a   Mohan, Subburaman ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Department of Medicine ^*  (United States)

^c LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone formation; Hypoxia inducible factor 1 ; Osteoblast; Runx2; Transcription; Transcriptional repressor

Indexed keywords

ALKALINE PHOSPHATASE; ASCORBIC ACID; BENZOIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN; ETHYL 3, 4 DIHYDROXYBENZOATE; GLYCINE DERIVATIVE; GROWTH FACTOR; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; NOGGIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEASOME; SCLEROPROTEIN; SHORT HAIRPIN RNA; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 4; TRANSCRIPTION FACTOR OSTERIX; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REPRESSION; HYDROXYLATION; LENTIVIRINAE; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; UBIQUITINATION;

ANALYSIS OF VARIANCE; ANIMALS; ASCORBIC ACID; BLOTTING, WESTERN; CELLS, CULTURED; DNA PRIMERS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; MICE; OSTEOBLASTS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEASOME ENDOPEPTIDASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; UBIQUITINATION;

LENTIVIRUS;

EID: 79959824189     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00229.2010     Document Type: Article

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