Inhibition of STAT1 accelerates bone fracture healing

Journal of Orthopaedic Research

Volumn 28, Issue 7, 2010, Pages 937-941

  Tajima, Kosuke ^a   Takaishi, Hironari ^a   Takito, Jiro ^a   Tohmonda, Takahide ^a   Yoda, Masaki ^a   Ota, Norikazu ^a   Kosaki, Naoto ^a   Matsumoto, Morio ^a   Ikegami, Hiroyasu ^a   Nakamura, Toshiyasu ^a   Kimura, Tokuhiro ^a   Okada, Yasunori ^a   Horiuchi, Keisuke ^a   Chiba, Kazuhiro ^a   Toyama, Yoshiaki ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Fludarabine; NF B p65; Osterix; Skeletal fracture healing; STAT1

Indexed keywords

FLUDARABINE; STAT1 PROTEIN; TRANSCRIPTION FACTOR OSTERIX;

ANIMAL TISSUE; ARTICLE; BONE REMODELING; BONE TURNOVER; CALLUS; CELL DIFFERENTIATION; FRACTURE HEALING; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL;

ANIMALS; BONY CALLUS; CALCIFICATION, PHYSIOLOGIC; CERCOPITHECUS AETHIOPS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; COS CELLS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FRACTURE HEALING; GENE EXPRESSION; MICE; MICE, MUTANT STRAINS; OSTEOBLASTS; OSTEOGENESIS; STAT1 TRANSCRIPTION FACTOR; TIBIAL FRACTURES; TRANSCRIPTION FACTORS; VIDARABINE;

EID: 77953189042     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21086     Document Type: Article

References (18)

1. Burge R, Dawson-Hughes B, Solomon DH, et al. 2007. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 22: 465-475.
2. Manolagas SC. 2000. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21:115-137.
3. Gerstenfeld LC, Cullinane DM, Barnes GL, et al. 2003. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88:873-884.
4. Meraz MA, White JM, Sheehan KC, et al. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431-442.
5. Takayanagi H, Ogasawara K, Hida S, et al. 2000. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408:600-605.
6. Takayanagi H, Kim S, Matsuo K, et al. 2002. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature 416:744-749.
7. Kim S, Koga T, Isobe M, et al. 2003. Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev 17:1979-1991.
8. Shimoaka T, Kamekura S, Chikuda H, et al. 2004. Impairment of bone healing by insulin receptor substrate-1 deficiency. J Biol Chem 279:15314-15322.
9. Street J, Bao M, deGuzman L, et al. 2002. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99: 9656-9661.
10. Kosaki N, Takaishi H, Kamekura S, et al. 2007. Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun 354:846-851.
11. Matsubara T, Kida K, Yamaguchi A, et al. 2008. BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem 283:29119-29125.
12. Lu X, Gilbert L, He X, et al. 2006. Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways. J Biol Chem 281:6297-6306.
13. Suk K, Kim YH, Chang I, et al. 2001. IFNalpha sensitizes ME- 180 human cervical cancer cells to TNFalpha-induced apoptosis by inhibiting cytoprotective NF-kappaB activation. FEBS Lett 495:66-70.
14. Hayashi T, Ishida Y, Kimura A, et al. 2007. IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation. J Immunol 178:7385-7394. (Pubitemid 46847466)
15. Ganster RW, Guo Z, Shao L, Geller DA. 2005. Differential effects of TNF-alpha and IFN-gamma on gene transcription mediated by NF-kappaB-Stat1 interactions. J. Interferon Cytokine Res 25:707-719.
16. Plosker GL, Figgitt DP. 2003. Oral fludarabine. Drugs 63: 2317-2323.
17. Battle TE, Lynch RA, Frank DA. 2006. Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res 66:3649-3657.
18. Sahni M, Raz R, Coffin JD, et al. 2001. STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128:2119-2129. (Pubitemid 32600472)