Conditional deletion of insulin-like growth factor-I in collagen type 1α2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion

Endocrinology

Volumn 148, Issue 12, 2007, Pages 5706-5715

  Govoni, Kristen E ^a   Wergedal, Jon E ^a,b   Florin, Lore ^c   Angel, Peter ^c   Baylink, David J ^b   Mohan, Subburaman ^a,b  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 1ALPHA2; CRE RECOMBINASE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BONE CELL; BONE DENSITY; BONE GROWTH; BONE MINERALIZATION; BONE TISSUE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMUR; GENE DELETION; HOMOZYGOSITY; LETHALITY; LOXP SITE; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PARACRINE SIGNALING; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; COLLAGEN TYPE I; FEMALE; GENE DELETION; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MALE; MICE; MICE, TRANSGENIC; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL ANALYSIS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 36348993763     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0608     Document Type: Article

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