Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 32557-32567

  Angelucci, Francesco ^a   Dimastrogiovanni, Daniela ^a   Boumis, Giovanna ^a   Brunori, Maurizio ^a   Miele, Adriana E ^a   Saccoccia, Fulvio ^a   Bellelli, Andrea ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CATALYTIC ACTIVITY; CATALYTIC CYCLES; CHIMERIC ENZYMES; COMPUTER MODELING; CONFORMATIONAL CHANGE; CRYSTAL FORMS; CRYSTALLOGRAPHIC ANALYSIS; CRYSTALLOGRAPHIC DATA; DRUG TARGETS; GLUTAREDOXIN DOMAIN; INTERCONVERSIONS; KINETIC METHOD; MECHANISM OF ACTION; OXIDATION STATE; REDOX SITES; SCHISTOSOMA MANSONI; SELENOCYSTEINE; THIOREDOXIN GLUTATHIONE REDUCTASE; THIOREDOXINS;

CATALYST ACTIVITY; RATE CONSTANTS; X RAY CRYSTALLOGRAPHY;

ENZYMES;

GLUTATHIONE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOREDOXIN GLUTATHIONE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME MECHANISM; MUTANT; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ELECTRONS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; NADP; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; SCHISTOSOMA MANSONI;

SCHISTOSOMA MANSONI;

EID: 77957793022     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.141960     Document Type: Article

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