Tetrandrine-induced apoptosis in rat primary hepatocytes is initiated from mitochondria: Caspases and Endonuclease G (Endo G) pathway

Toxicology

Volumn 218, Issue 1, 2006, Pages 1-12

  Yan, Cai ^a,b   Xin Ming, Qi ^a,b   Li Kun, Gong ^a,b   Lin Lin, Liu ^a,b   Fang Ping, Chen ^a,b   Ying, Xiao ^a,b   Xiong Fei, Wu ^a,b   Xiang Hong, Li ^a   Jin, Ren ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Caspase 3; Endo G; Mitochondria; Rat primary hepatocytes; Tetrandrine

Indexed keywords

CASPASE 3; COUMARIN DERIVATIVE; CYCLOSPORIN A; CYTOCHROME C; DEOXYRIBONUCLEASE; DNA FRAGMENT; ENDONUCLEASE; ENDONUCLEASE G; GLUTATHIONE; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; TETRANDRINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME ACTIVITY; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE;

ALKALOIDS; ANIMALS; APOPTOSIS; BCL-X PROTEIN; BENZYLISOQUINOLINES; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL SURVIVAL; CYTOCHROMES C; DRUGS, CHINESE HERBAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDODEOXYRIBONUCLEASES; ENZYME INHIBITORS; HEPATOCYTES; IN SITU NICK-END LABELING; INTRACELLULAR MEMBRANES; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 28844463729     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.08.024     Document Type: Article

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