Inhibition of proliferation and induction of apoptosis by tetrandrine in HepG2 cells

Journal of Ethnopharmacology

Volumn 81, Issue 2, 2002, Pages 225-229

  Yoo, Su Mi ^a   Oh, Seon Hee ^a   Lee, Sang Jun ^a   Lee, Bang Wool ^a   Ko, Won Gil ^a   Moon, Chang Kiu ^b   Lee, Byung Hoon ^a  

^a Wonkwang University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Apoptosis; Hepatocellular carcinoma; HepG2 cell; Tetrandrine

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TETRANDRINE;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INCUBATION TIME; LIVER CELL CARCINOMA; PROTEIN DEGRADATION;

ALKALOIDS; APOPTOSIS; BENZYLISOQUINOLINES; CELL DIVISION; DRUGS, CHINESE HERBAL; GROWTH INHIBITORS; HUMANS; TUMOR CELLS, CULTURED;

EID: 0036281314     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(02)00082-X     Document Type: Article

References (17)

1. Enhancement of radiosensitivity in human glioblastoma U138MG cells by tetrandrine
2. The bisbenzylisoquinoline alkaloids, tetrandrine and fangchinoline, enhance the cytotoxicity of multidrug resistance-related drugs via modulation of p-glycoprotein
3. The role of hepatitis C virus in hepatocellular carcinoma
4. Antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization
5. A new calcium antagonist of Chinese medicinal origin: Tetrandrine
6. Antitumor effect of bisbenzylisoquinoline alkaloids
7. Induction of apoptosis in human leukemic U937 cells by tetrandrine
8. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c - Mediated activation of caspase-3 protease
9. Dual effects of tetrandrine on cytosolic calcium in human leukaemic HL-60 cells: Intracellular calcium release and calcium entry blockade
10. The therapeutic effect of tetrandrine on silicosis
11. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
12. In vitro immunosuppressive properties of the plant alkaloid tetrandrine
13. Synergistic anticancer effects of tetrandrine combined with doxorubicin or vincristine in vitro
14. Demonstration of the induction of apoptosis (programmed cell death) by tetrandrine, a novel anti-inflammatory agent
15. Intraarterial chemoembolization in patients with hepatocellular carcinoma
16. Bisbenzylisoquinoline alkaloids inhibit tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin