Akt downregulation by flavin oxidase-induced ROS generation mediates dose-dependent endothelial cell damage elicited by natural antioxidants

Toxicological Sciences

Volumn 114, Issue 1, 2009, Pages 101-112

  Pasciu, Valeria ^a   Posadino, Anna Maria ^a   Cossu, Annalisa ^a   Sanna, Bastiano ^a   Tadolini, Bruna ^a   Gaspa, Leonardo ^a   Marchisio, Andrea ^a   Dessole, Salvatore ^a   Capobianco, Giampiero ^a   Pintus, Gianfranco ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

Akt; Antioxidant and pro oxidant effect; Cell damage; Endothelial cells; Natural antioxidants; ROS

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; COUMARIC ACID; DIPHENYLIODONIUM SALT; FLAVOPROTEIN; INSULIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RESVERATROL;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL FUNCTION; CELL LEVEL; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PROTEIN CARBONYLATION;

EID: 77951592375     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp301     Document Type: Article

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