메뉴 건너뛰기




Volumn 3, Issue 2, 2011, Pages 1975-1995

Essential gene pathways for glioblastoma stem cells: Clinical implications for prevention of tumor recurrence

Author keywords

Cancer stem cells; Glioblastoma; Neural crest cells; Neural stem cells; Radial glial cells; Radio chemoresistance

Indexed keywords

ALPHA6 INTEGRIN; BMI1 PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN BINDING PROTEIN 2; STAT3 PROTEIN; TEMOZOLOMIDE; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA;

EID: 79959745426     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3021975     Document Type: Review
Times cited : (12)

References (97)
  • 6
    • 65349115320 scopus 로고    scopus 로고
    • SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma
    • Son, M.J.; Woolard, K.; Nam, D.H.; Lee, J.; Fine, H.A. SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell 2009, 4, 440-452.
    • (2009) Cell Stem Cell , vol.4 , pp. 440-452
    • Son, M.J.1    Woolard, K.2    Nam, D.H.3    Lee, J.4    Fine, H.A.5
  • 11
    • 60149107175 scopus 로고    scopus 로고
    • Nestin and CD133: Valuable stem cell-specific markers for determining clinical outcome of glioma patients
    • Zhang, M.; Song, T.; Yang, L.; Chen, R.; Wu, L.; Yang, Z.; Fang, J. Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients. J. Exp. Clin. Cancer Res. 2008, 27, 85.
    • (2008) J. Exp. Clin. Cancer Res , vol.27 , pp. 85
    • Zhang, M.1    Song, T.2    Yang, L.3    Chen, R.4    Wu, L.5    Yang, Z.6    Fang, J.7
  • 15
    • 50149117285 scopus 로고    scopus 로고
    • Control of the reversibility of cellular quiescence by the transcriptional repressor HES1
    • Sang, L.; Coller, H.A.; Roberts, J.M. Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science 2008, 321, 1095-1100.
    • (2008) Science , vol.321 , pp. 1095-1100
    • Sang, L.1    Coller, H.A.2    Roberts, J.M.3
  • 17
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray, S.J. Notch signalling: A simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 2006, 7, 678-689.
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 18
    • 34548825987 scopus 로고    scopus 로고
    • Differential Notch signalling distinguishes neural stem cells from intermediate progenitors
    • Mizutani, K.; Yoon, K.; Dang, L.; Tokunaga, A.; Gaiano, N. Differential Notch signalling distinguishes neural stem cells from intermediate progenitors. Nature 2007, 449, 351-355.
    • (2007) Nature , vol.449 , pp. 351-355
    • Mizutani, K.1    Yoon, K.2    Dang, L.3    Tokunaga, A.4    Gaiano, N.5
  • 19
    • 42049103185 scopus 로고    scopus 로고
    • Notch signaling in leukemias and lymphomas
    • Jundt, F.; Schwarzer, R.; Dorken, B. Notch signaling in leukemias and lymphomas. Curr. Mol. Med. 2008, 8, 51-59.
    • (2008) Curr. Mol. Med , vol.8 , pp. 51-59
    • Jundt, F.1    Schwarzer, R.2    Dorken, B.3
  • 21
    • 0242582168 scopus 로고    scopus 로고
    • The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain
    • Sakamoto, M.; Hirata, H.; Ohtsuka, T.; Bessho, Y.; Kageyama, R. The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J. Biol. Chem. 2003, 278, 44808-44815.
    • (2003) J. Biol. Chem , vol.278 , pp. 44808-44815
    • Sakamoto, M.1    Hirata, H.2    Ohtsuka, T.3    Bessho, Y.4    Kageyama, R.5
  • 22
    • 23944479758 scopus 로고    scopus 로고
    • Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas
    • Liang, Y.; Bollen, A.W.; Nicholas, M.K.; Gupta, N. Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. BMC Clin. Pathol. 2005, 5, 6.
    • (2005) BMC Clin. Pathol , vol.5 , pp. 6
    • Liang, Y.1    Bollen, A.W.2    Nicholas, M.K.3    Gupta, N.4
  • 23
    • 18244386723 scopus 로고    scopus 로고
    • Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
    • Anthony, T.E.; Mason, H.A.; Gridley, T.; Fishell, G.; Heintz, N. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev. 2005, 19, 1028-1033.
    • (2005) Genes Dev , vol.19 , pp. 1028-1033
    • Anthony, T.E.1    Mason, H.A.2    Gridley, T.3    Fishell, G.4    Heintz, N.5
  • 24
    • 34948908683 scopus 로고    scopus 로고
    • B-FABP-expressing radial glial cells: The malignant glioma cell of origin?
    • Mita, R.; Coles, J.E.; Glubrecht, D.D.; Sung, R.; Sun, X.; Godbout, R. B-FABP-expressing radial glial cells: The malignant glioma cell of origin? Neoplasia 2007, 9, 734-744.
    • (2007) Neoplasia , vol.9 , pp. 734-744
    • Mita, R.1    Coles, J.E.2    Glubrecht, D.D.3    Sung, R.4    Sun, X.5    Godbout, R.6
  • 27
    • 33845461219 scopus 로고    scopus 로고
    • The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord
    • Deneen, B.; Ho, R.; Lukaszewicz, A.; Hochstim, C.J.; Gronostajski, R.M.; Anderson, D.J. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron 2006, 52, 953-968.
    • (2006) Neuron , vol.52 , pp. 953-968
    • Deneen, B.1    Ho, R.2    Lukaszewicz, A.3    Hochstim, C.J.4    Gronostajski, R.M.5    Anderson, D.J.6
  • 30
    • 77956503727 scopus 로고    scopus 로고
    • Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres
    • Bar, E.E.; Lin, A.; Mahairaki, V.; Matsui, W.; Eberhart, C.G. Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am. J. Pathol. 2010, 177, 1491-1502.
    • (2010) Am. J. Pathol , vol.177 , pp. 1491-1502
    • Bar, E.E.1    Lin, A.2    Mahairaki, V.3    Matsui, W.4    Eberhart, C.G.5
  • 34
    • 70350225829 scopus 로고    scopus 로고
    • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    • Heddleston, J.M.; Li, Z.; McLendon, R.E.; Hjelmeland, A.B.; Rich, J.N. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 2009, 8, 3274-3284.
    • (2009) Cell Cycle , vol.8 , pp. 3274-3284
    • Heddleston, J.M.1    Li, Z.2    McLendon, R.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 35
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • Clement, V.; Sanchez, P.; de Tribolet, N.; Radovanovic, I.; Ruizi Altaba, A. HEDGEHOG-GLI1signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 2007, 17, 165-172.
    • (2007) Curr. Biol , vol.17 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    de Tribolet, N.3    Radovanovic, I.4    Ruizi Altaba, A.5
  • 36
    • 77955428416 scopus 로고    scopus 로고
    • NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1and p53
    • Zbinden, M.; Duquet, A.; Lorente-Trigos, A.; Ngwabyt, S.N.; Borges, I.; Ruizi Altaba, A. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1and p53. EMBO J. 2010, 29, 2659-2674.
    • (2010) EMBO J , vol.29 , pp. 2659-2674
    • Zbinden, M.1    Duquet, A.2    Lorente-Trigos, A.3    Ngwabyt, S.N.4    Borges, I.5    Ruizi Altaba, A.6
  • 38
    • 62649094925 scopus 로고    scopus 로고
    • A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
    • Stecca, B.; Ruizi Altaba, A. A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J. 2009, 28, 663-676.
    • (2009) EMBO J , vol.28 , pp. 663-676
    • Stecca, B.1    Ruizi Altaba, A.2
  • 39
    • 37249048319 scopus 로고    scopus 로고
    • TGF-beta in neural stem cells and in tumors of the central nervous system
    • Aigner, L.; Bogdahn, U. TGF-beta in neural stem cells and in tumors of the central nervous system. Cell Tissue Res. 2008, 331, 225-241.
    • (2008) Cell Tissue Res , vol.331 , pp. 225-241
    • Aigner, L.1    Bogdahn, U.2
  • 40
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas, A.; Heldin, C.H. Non-Smad TGF-beta signals. J. Cell Sci. 2005, 118, 3573-3584.
    • (2005) J. Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 41
    • 49249095430 scopus 로고    scopus 로고
    • Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells
    • Zhao, S.; Venkatasubbarao, K.; Lazor, J.W.; Sperry, J.; Jin, C.; Cao, L.; Freeman, J.W. Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. Cancer Res. 2008, 68, 4221-4228.
    • (2008) Cancer Res , vol.68 , pp. 4221-4228
    • Zhao, S.1    Venkatasubbarao, K.2    Lazor, J.W.3    Sperry, J.4    Jin, C.5    Cao, L.6    Freeman, J.W.7
  • 42
    • 24644439547 scopus 로고    scopus 로고
    • TGF-beta, neuronal stem cells and glioblastoma
    • Golestaneh, N.; Mishra, B. TGF-beta, neuronal stem cells and glioblastoma. Oncogene 2005, 24, 5722-5730.
    • (2005) Oncogene , vol.24 , pp. 5722-5730
    • Golestaneh, N.1    Mishra, B.2
  • 44
    • 70350212976 scopus 로고    scopus 로고
    • STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
    • Sherry, M.M.; Reeves, A.; Wu, J.K.; Cochran, B.H. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 2009, 27, 2383-2392.
    • (2009) Stem Cells , vol.27 , pp. 2383-2392
    • Sherry, M.M.1    Reeves, A.2    Wu, J.K.3    Cochran, B.H.4
  • 45
    • 77953207270 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells
    • Li, G.H.; Wei, H.; Lv, S.Q.; Ji, H.; Wang, D.L. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. Int. J. Oncol. 2010, 37, 103-110.
    • (2010) Int. J. Oncol , vol.37 , pp. 103-110
    • Li, G.H.1    Wei, H.2    Lv, S.Q.3    Ji, H.4    Wang, D.L.5
  • 47
    • 70350497349 scopus 로고    scopus 로고
    • Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors
    • Ikushima, H.; Todo, T.; Ino, Y.; Takahashi, M.; Miyazawa, K.; Miyazono, K. Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell 2009, 5, 504-514.
    • (2009) Cell Stem Cell , vol.5 , pp. 504-514
    • Ikushima, H.1    Todo, T.2    Ino, Y.3    Takahashi, M.4    Miyazawa, K.5    Miyazono, K.6
  • 51
    • 77957351780 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis
    • Mazzoleni, S.; Politi, L.S.; Pala, M.; Cominelli, M.; Franzin, A.; Sergi Sergi, L.; Falini, A.; De Palma, M.; Bulfone, A.; Poliani, P.L.; Galli, R. Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis. Cancer Res. 2010, 70, 7500-7513.
    • (2010) Cancer Res , vol.70 , pp. 7500-7513
    • Mazzoleni, S.1    Politi, L.S.2    Pala, M.3    Cominelli, M.4    Franzin, A.5    Sergi Sergi, L.6    Falini, A.7    de Palma, M.8    Bulfone, A.9    Poliani, P.L.10    Galli, R.11
  • 55
    • 78649831949 scopus 로고    scopus 로고
    • Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells
    • Sunayama, J.; Matsuda, K.; Sato, A.; Tachibana, K.; Suzuki, K.; Narita, Y.; Shibui, S.; Sakurada, K.; Kayama, T.; Tomiyama, A.; Kitanaka, C. Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells 2010, 28, 1930-1939.
    • (2010) Stem Cells , vol.28 , pp. 1930-1939
    • Sunayama, J.1    Matsuda, K.2    Sato, A.3    Tachibana, K.4    Suzuki, K.5    Narita, Y.6    Shibui, S.7    Sakurada, K.8    Kayama, T.9    Tomiyama, A.10    Kitanaka, C.11
  • 56
    • 0037630079 scopus 로고    scopus 로고
    • Reconstructing MYC
    • Levens, D.L. Reconstructing MYC. Genes Dev. 2003, 17, 1071-1077.
    • (2003) Genes Dev , vol.17 , pp. 1071-1077
    • Levens, D.L.1
  • 57
    • 33644871338 scopus 로고    scopus 로고
    • Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a)
    • Guney, I.; Wu, S.; Sedivy, J.M. Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc. Natl. Acad. Sci. USA 2006, 103, 3645-3650.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 3645-3650
    • Guney, I.1    Wu, S.2    Sedivy, J.M.3
  • 61
    • 77954586994 scopus 로고    scopus 로고
    • L1CAM malfunction in the nervous system and human carcinomas
    • Schafer, M.K.; Altevogt, P. L1CAM malfunction in the nervous system and human carcinomas. Cell Mol. Life Sci. 2010, 67, 2425-2437.
    • (2010) Cell Mol. Life Sci , vol.67 , pp. 2425-2437
    • Schafer, M.K.1    Altevogt, P.2
  • 72
    • 25144506210 scopus 로고    scopus 로고
    • Model of quiescent tumour microregions for evaluating multicellular resistance to chemotherapeutic drugs
    • Mellor, H.R.; Ferguson, D.J.; Callaghan, R. A model of quiescent tumour microregions for evaluating multicellular resistance to chemotherapeutic drugs. Br. J. Cancer 2005, 93, 302-309.
    • (2005) Br. J. Cancer , vol.93 , pp. 302-309
    • Mellor, H.R.1    Ferguson, D.J.2    Callaghan, R.A.3
  • 73
    • 55349141070 scopus 로고    scopus 로고
    • Imatinib mesylate induces quiescence in gastrointestinal stromal tumor cells through the CDH1-SKP2-p27Kip1 signaling axis
    • Liu, Y.; Perdreau, S.A.; Chatterjee, P.; Wang, L.; Kuan, S.F.; Duensing, A. Imatinib mesylate induces quiescence in gastrointestinal stromal tumor cells through the CDH1-SKP2-p27Kip1 signaling axis. Cancer Res. 2008, 68, 9015-9023.
    • (2008) Cancer Res , vol.68 , pp. 9015-9023
    • Liu, Y.1    Perdreau, S.A.2    Chatterjee, P.3    Wang, L.4    Kuan, S.F.5    Duensing, A.6
  • 74
    • 0032863842 scopus 로고    scopus 로고
    • Potentially lethal damage repair by total and quiescent tumor cells following various DNA-damaging treatments
    • Masunaga, S.; Ono, K.; Hori, H.; Suzuki, M.; Kinashi, Y.; Takagaki, M.; Kasai, S.; Nagasawa, H.; Uto, Y. Potentially lethal damage repair by total and quiescent tumor cells following various DNA-damaging treatments. Radiat. Med. 1999, 17, 259-264.
    • (1999) Radiat. Med , vol.17 , pp. 259-264
    • Masunaga, S.1    Ono, K.2    Hori, H.3    Suzuki, M.4    Kinashi, Y.5    Takagaki, M.6    Kasai, S.7    Nagasawa, H.8    Uto, Y.9
  • 80
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau, A.M.; Hambardzumyan, D.; Ozawa, T.; Fomchenko, E.I.; Huse, J.T.; Brennan, C.W.; Holland, E.C. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 2009, 4, 226-235.
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3    Fomchenko, E.I.4    Huse, J.T.5    Brennan, C.W.6    Holland, E.C.7
  • 82
    • 70350150304 scopus 로고    scopus 로고
    • Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma
    • Nakai, E.; Park, K.; Yawata, T.; Chihara, T.; Kumazawa, A.; Nakabayashi, H.; Shimizu, K. Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma. Cancer Invest. 2009, 27, 901-908.
    • (2009) Cancer Invest , vol.27 , pp. 901-908
    • Nakai, E.1    Park, K.2    Yawata, T.3    Chihara, T.4    Kumazawa, A.5    Nakabayashi, H.6    Shimizu, K.7
  • 83
    • 79251492356 scopus 로고    scopus 로고
    • Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells
    • Hsieh, A.; Ellsworth, R.; Hsieh, D. Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells. J. Cell Physiol. 2011, 226, 1118-1127.
    • (2011) J. Cell Physiol , vol.226 , pp. 1118-1127
    • Hsieh, A.1    Ellsworth, R.2    Hsieh, D.3
  • 85
    • 77956294442 scopus 로고    scopus 로고
    • Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence
    • Gilbert, C.A.; Daou, M.C.; Moser, R.P.; Ross, A.H. Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Cancer Res. 2010, 70, 6870-6879.
    • (2010) Cancer Res , vol.70 , pp. 6870-6879
    • Gilbert, C.A.1    Daou, M.C.2    Moser, R.P.3    Ross, A.H.4
  • 86
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of polycomb gene silencing: Knowns and unknowns
    • Simon, J.A.; Kingston, R.E. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat. Rev. Mol. Cell Biol. 2009, 10, 697-708.
    • (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 87
    • 29144487990 scopus 로고    scopus 로고
    • Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing
    • Cao, R.; Tsukada, Y.; Zhang, Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 2005, 20, 845-854.
    • (2005) Mol Cell , vol.20 , pp. 845-854
    • Cao, R.1    Tsukada, Y.2    Zhang, Y.3
  • 88
    • 77955381770 scopus 로고    scopus 로고
    • BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery
    • Facchino, S.; Abdouh, M.; Chatoo, W.; Bernier, G. BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. J. Neurosci. 2010, 30, 10096-10111.
    • (2010) J. Neurosci , vol.30 , pp. 10096-10111
    • Facchino, S.1    Abdouh, M.2    Chatoo, W.3    Bernier, G.4
  • 89
    • 69349095324 scopus 로고    scopus 로고
    • CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines
    • McCord, A.M.; Jamal, M.; Williams, E.S.; Camphausen, K.; Tofilon, P.J. CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines. Clin. Cancer Res. 2009, 15, 5145-5153.
    • (2009) Clin. Cancer Res , vol.15 , pp. 5145-5153
    • McCord, A.M.1    Jamal, M.2    Williams, E.S.3    Camphausen, K.4    Tofilon, P.J.5
  • 92
    • 70349628642 scopus 로고    scopus 로고
    • Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas
    • Lin, Y.; Jiang, T.; Zhou, K.; Xu, L.; Chen, B.; Li, G.; Qiu, X.; Zhang, W.; Song, S.W. Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas. Neuro. Oncol. 2009, 11, 468-476.
    • (2009) Neuro. Oncol , vol.11 , pp. 468-476
    • Lin, Y.1    Jiang, T.2    Zhou, K.3    Xu, L.4    Chen, B.5    Li, G.6    Qiu, X.7    Zhang, W.8    Song, S.W.9
  • 93
    • 0043092322 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes
    • Wang, H.; Shen, W.; Huang, H.; Hu, L.; Ramdas, L.; Zhou, Y.H.; Liao, W.S.; Fuller, G.N.; Zhang, W. Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes. Cancer Res. 2003, 63, 4315-4321.
    • (2003) Cancer Res , vol.63 , pp. 4315-4321
    • Wang, H.1    Shen, W.2    Huang, H.3    Hu, L.4    Ramdas, L.5    Zhou, Y.H.6    Liao, W.S.7    Fuller, G.N.8    Zhang, W.9
  • 94
    • 34547138438 scopus 로고    scopus 로고
    • Silencing of insulin-like growth factor-binding protein-2 in human glioblastoma cells reduces both invasiveness and expression of progression-associated gene CD24
    • Fukushima, T.; Tezuka, T.; Shimomura, T.; Nakano, S.; Kataoka, H. Silencing of insulin-like growth factor-binding protein-2 in human glioblastoma cells reduces both invasiveness and expression of progression-associated gene CD24. J. Biol. Chem. 2007, 282, 18634-18644.
    • (2007) J. Biol. Chem , vol.282 , pp. 18634-18644
    • Fukushima, T.1    Tezuka, T.2    Shimomura, T.3    Nakano, S.4    Kataoka, H.5
  • 96
    • 77954667472 scopus 로고    scopus 로고
    • Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma
    • Evers, P.; Lee, P.P.; DeMarco, J.; Agazaryan, N.; Sayre, J.W.; Selch, M.; Pajonk, F. Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma. BMC Cancer 2010, 10, 384.
    • (2010) BMC Cancer , vol.10 , pp. 384
    • Evers, P.1    Lee, P.P.2    Demarco, J.3    Agazaryan, N.4    Sayre, J.W.5    Selch, M.6    Pajonk, F.7
  • 97
    • 36749090553 scopus 로고    scopus 로고
    • Location, location, location: The cancer stem cell niche
    • Sneddon, J.B.; Werb, Z. Location, location, location: The cancer stem cell niche. Cell Stem Cell 2007, 1, 607-611.
    • (2007) Cell Stem Cell , vol.1 , pp. 607-611
    • Sneddon, J.B.1    Werb, Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.