Interactions of halichondrin B and eribulin with tubulin

Journal of Chemical Information and Modeling

Volumn 51, Issue 6, 2011, Pages 1393-1404

  Bai, Ruoli ^a   Nguyen, Tam Luong ^b   Burnett, James C ^b   Atasoylu, Onur ^c   Munro, Murray H G ^d   Pettit, George R ^e   Smith, Amos B ^c   Gussio, Rick ^a   Hamel, Ernest ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF CANTERBURY   (New Zealand)

^e ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; COLUMN CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTICANCER DRUG; BINDING INTERACTION; BINDING MODELS; HALICHONDRIN B; MICROTUBULE DYNAMICS; MOLECULAR DYNAMICS SIMULATIONS; NATURAL PRODUCTS; NUCLEOTIDE EXCHANGE;

MOLECULAR DYNAMICS;

2 (3 AMINO 2 HYDROXYPROPYL)HEXACOSAHYDRO 3 METHOXY 26 METHYL 20,27 BIS(METHYLENE)11,15 18,21 24,28 TRIEPOXY 7,9 ETHANO 12,15 METHANO 9H,15H FURO(3,2 I)FURO(2',3' 5,6)PYRANO(4,3 B)(1,4)DIOXACYCLOPENTACOSIN 5 (4H) ONE; 2-(3-AMINO-2-HYDROXYPROPYL)HEXACOSAHYDRO-3-METHOXY-26-METHYL-20,27-BIS(METHYLENE)11,15-18,21-24,28-TRIEPOXY-7,9-ETHANO-12,15-METHANO-9H,15H-FURO(3,2-I)FURO(2',3'-5,6)PYRANO(4,3-B)(1,4)DIOXACYCLOPENTACOSIN-5-(4H)-ONE; ANTIMITOTIC AGENT; ETHER DERIVATIVE; FURAN DERIVATIVE; HALICHONDRIN B; KETONE; TUBULIN;

ANIMAL; ARTICLE; BINDING SITE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SPONGE (PORIFERA);

ANIMALS; ANTIMITOTIC AGENTS; BINDING SITES; CATTLE; ETHERS, CYCLIC; FURANS; KETONES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PORIFERA; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; TUBULIN;

EID: 79959730843     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci200077t     Document Type: Article

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