Diazonamide A and a synthetic structural analog: Disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin

Molecular Pharmacology

Volumn 63, Issue 6, 2003, Pages 1273-1280

  Cruz Monserrate, Zobeida ^a   Vervoort, Hélène C ^b   Bai, Ruoli ^a   Newman, David J ^a   Howell, Stephen B ^c   Los, Gerrit ^c   Mullaney, Jeffrey T ^d   Williams, Michael D ^d   Pettit, George R ^d   Fenical, William ^b   Hamel, Ernest ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; DIAZONAMIDE A; DOLASTATIN 10; DOLASTATIN 15; GUANOSINE TRIPHOSPHATE; NITROGEN; OXYGEN; PEPTIDE; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID;

ARTICLE; ASCIDIACEA; BINDING AFFINITY; CYTOTOXICITY; DRUG ACTIVITY; DRUG BINDING; DRUG BINDING SITE; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; INTERPHASE; MICROTUBULE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; STRUCTURE ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DEPSIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; GUANOSINE TRIPHOSPHATE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; HYDROLYSIS; MICROTUBULES; MITOSIS; OLIGOPEPTIDES; OXAZOLES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0038102301     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.6.1273     Document Type: Article

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