Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10

Biochemical Pharmacology

Volumn 63, Issue 4, 2002, Pages 707-715

  Edler, Michael C ^a   Fernandez, Annette M ^a   Lassota, Peter ^b   Ireland, Chris M ^a   Barrows, Louis R ^a  

^a UNIVERSITY OF UTAH   (United States)

^b PFIZER INC   (United States)

Author keywords

Antitumor agent; Cytoskeletal poison; Marine natural product; Tubulin inhibitor; Vitilevuamide

Indexed keywords

ANTINEOPLASTIC AGENT; COLCHICINE; DOLASTATIN 10; GUANOSINE TRIPHOSPHATE; PROTEIN SYNTHESIS INHIBITOR; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID; VITILEVUAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G2 PHASE; CHO CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG PURIFICATION; GLIOMA CELL; IC 50; LIFESPAN; LYMPHATIC LEUKEMIA; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL DIVISION; CHO CELLS; COLCHICINE; CRICETINAE; DISEASE MODELS, ANIMAL; GLIOMA; HUMANS; LEUKEMIA P388; LEUKEMIA, LYMPHOCYTIC; MICE; NEOPLASM TRANSPLANTATION; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, TERTIARY; TUBULIN; TUMOR CELLS, CULTURED; VINCA ALKALOIDS;

EID: 0037085026     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00898-X     Document Type: Article

References (35)

1. Interactions of tubulin with small ligands
2. Structure elucidation of phomopsin A, a novel cyclic hexapeptide mycotoxin produced by Phomopsis leptostromiformis
3. Ustiloxins, antimitotic cyclic peptides from false smut balls on rice panicles caused by Ustilaginoidea virens
4. Studies on macrocyclic lactone antibiotics. VII. Structure of a phytotoxin "rhizoxin" produced by Rhinzopus chinensis
5. Ansamitocin, a group of novel maytansinoid antibiotics with antitumor properties from Nocardia
6. Halichondrins: Antitumor polyether macrolides from a marine sponge
7. Isolation and structure of the cell growth inhibitory constituents from the Western Pacific marine sponge Axinella sp
8. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin: Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
9. Isolation and structure of halistatin 1 from the Eastern Indian Ocean marine sponge Phakellia carteri
10. Antineoplastic agents. CLII. Isolation and structure of halistatin 2 from the Comoros marine sponge Axinella carteri
11. Isolation and structure of spongistatin 1
12. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and binding of vinblastine to tubulin
13. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain
14. Absolute configuration of curacin A, a novel antimitotic agent from the tropical marine cyanobacterium Lyngbya majuscula
15. The isolation and structure of a remarkable marine animal antineoplastic constituent: Dolastatin 10
16. Isolation and structure of the cytostatic linear depsipeptide dolastatin 15
17. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain
18. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia: Interactions with tubulin and effects on cellular microtubules
19. Cell-based screen for identification of inhibitors of tubulin polymerization
20. Structural studies of marine peptides
21. A pH- and temperature-dependent cycling method that doubles the yield of microtubule protein
22. A brain microtubule protein preparation depleted of mitochondrial and synaptosomal components
23. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
24. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity
25. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
26. Dimethyl sulfoxide-induced self-assembly of tubulin lacking associated proteins
27. Turbidemetric studies of the in vitro assembly and disassembly of porcine neurotubules
28. Interaction of dolastatin 10 with tubulin: Induction of aggregation and binding and dissociation reactions
29. Guanosine 5′-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly
30. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites
31. The interaction of phomopsin A with bovine brain tubulin
32. Antimitotic natural products and their interactions with tubulin
33. Characterization of the interaction of cryptophycin 1 with tubulin: Binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction
34. Mechanism of action of cryptophycin