Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin

Japanese Journal of Cancer Research

Volumn 91, Issue 7, 2000, Pages 737-747

  Natsume, T ^a   Watanabe, J I ^a   Tamaoki, S ^a   Fujio, N ^a   Miyasaka, K ^a   Kobayashi, M ^a  

^a Grelan Pharmaceutical Co Ltd   (Japan)

Author keywords

Antimicrotubule agent; Dolastatin 10; Microtubule polymerization; Tubulin binding; TZT 1027

Indexed keywords

AURISTATIN PE; DOLASTATIN 10; DOLASTATIN 15; GLUTAMATE SODIUM; GUANOSINE TRIPHOSPHATE; TUBULIN; VINBLASTINE; VINCA ALKALOID; VINCRISTINE; VINDESINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; HYDROLYSIS; IC 50; MICROTUBULE ASSEMBLY; MOLLUSC; NONHUMAN; PRIORITY JOURNAL; SCATCHARD PLOT; SWINE;

EID: 0033853789     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb01007.x     Document Type: Article

References (44)

1. The isolation and structure of a remarkable marine animal antineoplastic constituent: Dolastatin 10
2. Isolation of dolastatin 10-15 from the marine mollusk Dalabella auricularia
3. The absolute configuration and synthesis of natural (-)-dolastatin 10
4. Efficient stereoselective synthesis of dolastatin 10, an antineoplastic peptide from a sea hare
5. Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class
6. Action of Vinca alkaloids vincristine, vinblastine and desacetyl vinblastine amide on microtubules in vitro
7. Photoaffinity labeling of tubulin subunits with a photoactive analogue of vinblastine
8. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal
9. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and Vinca alkaloid sites
10. Interaction of dolastatin 10 with bovine brain tubulin
11. Interaction of marine toxin dolastatin 10 with porcine brain tubulin: Competitive inhibition of rhizoxin and phomopsin A binding
12. Synthesis and antitumor activity of novel dolastatin 10 analogs
13. Antitumor activity of TZT-1027, a novel dolastatin 10 derivative
14. Microtubule-based motor proteins: New targets for enhancing drug delivery
15. Microtubule assembly in the absence of added nucleotides
16. Preparation of tubulin from brain
17. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
18. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
19. Binding of maytansine to rat brain tubulin
20. A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters
21. Glutamate-induced polymerization of tubulin: Characteristics of the reaction and application to the large-scale purification of tubulin
22. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia
23. Rhizoxin binding to tubulin at the maytansine-binding site
24. Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site
25. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
26. Interaction of dolastatin 10 with tubulin: Induction of aggregation and binding and association reactions
27. Maytansine inhibits nucleotide binding at the exchangeable site of tubulin
28. Promotion of microtubule assembly in vitro by taxol
29. Taxol binds to polymerized tubulin in vitro
30. Taxol binds to cellular microtubules
31. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
32. Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity
33. Activities of microtubule-stabilizing agents epothilone A and B with purified tubulin and in cells resistant to paclitaxel (taxol)
34. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
35. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest
36. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resis
37. Vinorelbine tartrate and paclitaxel combinations: Enhanced activity against in vivo P388 murine leukemia cells
38. In vitro synergy of paclitaxel (taxol) and vinorelbine (navelbine) against human melanoma cell lines
39. Pilot study of vinorelbine (navelbine) and paclitaxel (taxol) in patients with refractory breast cancer and lung cancer
40. Taxol and vinorelbine: A new active combination for disseminated malignant melanoma
41. Combined anti-microtubule activity of estramustine and taxol in human prostatic carcinoma cell lines
42. Calcium-sensitivity of the micro-tubule reassembly system. Difference between crude brain extract and purified microtubular proteins
43. LU103793 (NSC D-669356): A synthetic peptide that interacts with microtubules and inhibits mitosis