메뉴 건너뛰기




Volumn 4, Issue , 2011, Pages 59-81

Microfluidics using spatially defined arrays of droplets in one, two, and three dimensions

Author keywords

high throughput screening; immiscible carrier fluid; index; microwell arrays; plugs; two phase

Indexed keywords

CARRIER FLUIDS; HIGH-THROUGHPUT SCREENING; INDEX; MICRO WELLS; PLUGS; TWO-PHASE;

EID: 79959511522     PISSN: 19361327     EISSN: 19361335     Source Type: Book Series    
DOI: 10.1146/annurev.anchem.012809.102303     Document Type: Review
Times cited : (133)

References (151)
  • 3
    • 77952985309 scopus 로고    scopus 로고
    • Analytical chemistry on the femtoliter scale
    • Gorris HH, Walt DR. 2010. Analytical chemistry on the femtoliter scale. Angew. Chem. Int. Ed. 49:3880- 95
    • (2010) Angew. Chem. Int. Ed. , vol.49 , pp. 3880-3895
    • Gorris, H.H.1    Walt, D.R.2
  • 4
    • 67649976792 scopus 로고    scopus 로고
    • Droplets for ultrasmall-volume analysis
    • Chiu DT, Lorenz RM, Jeffries GDM. 2009. Droplets for ultrasmall-volume analysis. Anal. Chem. 81:5111-18
    • (2009) Anal. Chem. , vol.81 , pp. 5111-18
    • Chiu, D.T.1    Lorenz, R.M.2    Gdm, J.3
  • 5
    • 73349141683 scopus 로고    scopus 로고
    • Microdroplet generation in gaseous and liquid environments
    • Ben-Tzvi P, Rone W. 2010. Microdroplet generation in gaseous and liquid environments. Microsyst. Technol. 16:333-56
    • (2010) Microsyst. Technol. , vol.16 , pp. 333-56
    • Ben-Tzvi, P.1    Rone, W.2
  • 7
    • 33747130345 scopus 로고    scopus 로고
    • Miniaturising the laboratory in emulsion droplets
    • DOI 10.1071/MF05190, PII S0167779906001582
    • Griffiths AD, Tawfik DS. 2006. Miniaturising the laboratory in emulsion droplets. Trends Biotechnol. 24:395-402 (Pubitemid 44223819)
    • (2006) Trends in Biotechnology , vol.24 , Issue.9 , pp. 395-402
    • Griffiths, A.D.1    Tawfik, D.S.2
  • 9
    • 77952922120 scopus 로고    scopus 로고
    • Protein crystallization using microfluidic technologies based on valves, droplets and SlipChip
    • Li L, Ismagilov RF. 2010. Protein crystallization using microfluidic technologies based on valves, droplets and SlipChip. Annu. Rev. Biophys. 39:139-58
    • (2010) Annu. Rev. Biophys. , vol.39 , pp. 139-58
    • Li, L.1    Ismagilov, R.F.2
  • 10
    • 33746224336 scopus 로고    scopus 로고
    • On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system
    • DOI 10.1021/ac0601718
    • Song H, Li HW, Munson MS, Van Ha TG, Ismagilov RF. 2006. On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system. Anal. Chem. 78:4839-49 (Pubitemid 44100616)
    • (2006) Analytical Chemistry , vol.78 , Issue.14 , pp. 4839-4849
    • Song, H.1    Li, H.-W.2    Munson, M.S.3    Ha, T.G.V.4    Ismagilov, R.F.5
  • 11
    • 50049100723 scopus 로고    scopus 로고
    • ABO, D blood typing and subtyping using plug-based microfluidics
    • Kline TR, Runyon MK, Pothiawala M, Ismagilov RF. 2008. ABO, D blood typing and subtyping using plug-based microfluidics. Anal. Chem. 80:6190-97
    • (2008) Anal. Chem. , vol.80 , pp. 6190-97
    • Kline, T.R.1    Runyon, M.K.2    Pothiawala, M.3    Ismagilov, R.F.4
  • 13
    • 60149086478 scopus 로고    scopus 로고
    • Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides
    • Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF. 2009. Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides. Angew. Chem. Int. Ed. 48:1487-89
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 1487-89
    • Meier, M.1    Kennedy-Darling, J.2    Choi, S.H.3    Norstrom, E.M.4    Sisodia, S.S.5    Ismagilov, R.F.6
  • 14
    • 47949106623 scopus 로고    scopus 로고
    • Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics
    • Boedicker JQ, Li L, Kline TR, Ismagilov RF. 2008. Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab Chip 8:1265-72
    • (2008) Lab Chip , vol.8 , pp. 1265-72
    • Boedicker, J.Q.1    Li, L.2    Kline, T.R.3    Ismagilov, R.F.4
  • 15
    • 77952496731 scopus 로고    scopus 로고
    • Microfluidic stochastic confinement enhances analysis of rare cells by isolating cells and creating high density environments for control of diffusible signals
    • Vincent ME, Liu W, Haney EB, Ismagilov RF. 2010. Microfluidic stochastic confinement enhances analysis of rare cells by isolating cells and creating high density environments for control of diffusible signals. Chem. Soc. Rev. 39:974-84
    • (2010) Chem. Soc. Rev. , vol.39 , pp. 974-84
    • Vincent, M.E.1    Liu, W.2    Haney, E.B.3    Ismagilov, R.F.4
  • 16
    • 77949894336 scopus 로고    scopus 로고
    • Fibre optic microarrays
    • Walt DR. 2010. Fibre optic microarrays. Chem. Soc. Rev. 39:38-50
    • (2010) Chem. Soc. Rev. , vol.39 , pp. 38-50
    • Walt, D.R.1
  • 17
    • 0032978516 scopus 로고    scopus 로고
    • Evaluation of commonly used electrophoretic methods for the analysis of proteins and peptides and their application to biotechnology
    • Chiou SH, Wu SH. 1999. Evaluation of commonly used electrophoretic methods for the analysis of proteins and peptides and their application to biotechnology. Anal. Chim. Acta 383:47-60
    • (1999) Anal. Chim. Acta , vol.383 , pp. 47-60
    • Chiou, S.H.1    Wu, S.H.2
  • 18
    • 77649087368 scopus 로고    scopus 로고
    • Electrophoresis today and tomorrow: Helping biologists' dreams come true
    • Kleparnik K, Bocek P. 2010. Electrophoresis today and tomorrow: helping biologists' dreams come true. Bio Essays 32:218-26
    • (2010) Bio Essays , vol.32 , pp. 218-26
    • Kleparnik, K.1    Bocek, P.2
  • 19
    • 4344564661 scopus 로고    scopus 로고
    • Capillary electrophoresis of biological particles: Viruses, bacteria, and eukaryotic cells
    • DOI 10.1002/elps.200305868
    • Kremser L, Blaas D, Kenndler E. 2004. Capillary electrophoresis of biological particles: viruses, bacteria, and eukaryotic cells. Electrophoresis 25:2282-91 (Pubitemid 39136348)
    • (2004) Electrophoresis , vol.25 , Issue.14 , pp. 2282-2291
    • Kremser, L.1    Blaas, D.2    Kenndler, E.3
  • 20
    • 66049113715 scopus 로고    scopus 로고
    • Bioanalytical separations using electric field gradient techniques
    • Meighan MM, Staton SJR, Hayes MA. 2009. Bioanalytical separations using electric field gradient techniques. Electrophoresis 30:852-65
    • (2009) Electrophoresis , vol.30 , pp. 852-65
    • Meighan, M.M.1    Sjr, S.2    Hayes, M.A.3
  • 21
    • 34347256054 scopus 로고    scopus 로고
    • Microfluidic large-scale integration: The evolution of design rules for biological automation
    • DOI 10.1146/annurev.biophys.36.040306.132646
    • Melin J, Quake SR. 2007. Microfluidic large-scale integration: the evolution of design rules for biological automation. Annu. Rev. Biophys. Biomol. Struct. 36:213-31 (Pubitemid 46998117)
    • (2007) Annual Review of Biophysics and Biomolecular Structure , vol.36 , pp. 213-231
    • Melin, J.1    Quake, S.R.2
  • 22
    • 77954970051 scopus 로고    scopus 로고
    • Dynamics of microfluidic droplets
    • Baroud CN, Gallaire F, Dangla R. 2010. Dynamics of microfluidic droplets. Lab Chip 10:2032-45
    • (2010) Lab Chip , vol.10 , pp. 2032-45
    • Baroud, C.N.1    Gallaire, F.2    Dangla, R.3
  • 23
    • 1242351493 scopus 로고    scopus 로고
    • Effects of viscosity on droplet formation and mixing in microfluidic channels
    • DOI 10.1016/j.aca.2003.11.024
    • Tice JD, Lyon AD, Ismagilov RF. 2004. Effects of viscosity on droplet formation and mixing in microfluidic channels. Anal. Chim. Acta 507:73-77 (Pubitemid 38224091)
    • (2004) Analytica Chimica Acta , vol.507 , Issue.1 , pp. 73-77
    • Tice, J.D.1    Lyon, A.D.2    Ismagilov, R.F.3
  • 24
    • 45749102897 scopus 로고    scopus 로고
    • Interfacial instabilities in a microfluidic Hele-Shaw cell
    • DOI 10.1039/b715867j
    • Hashimoto M, Garstecki P, Stone HA, Whitesides GM. 2008. Interfacial instabilities in a microfluidic Hele-Shaw cell. Soft Matter 4:1403-13 (Pubitemid 351875595)
    • (2008) Soft Matter , vol.4 , Issue.7 , pp. 1403-1413
    • Hashimoto, M.1    Garstecki, P.2    Stone, H.A.3    Whitesides, G.M.4
  • 25
    • 0037450165 scopus 로고    scopus 로고
    • A microfluidic system for controlling reaction networks in time
    • DOI 10.1002/anie.200390203
    • Song H, Tice JD, Ismagilov RF. 2003. A microfluidic system for controlling reaction networks in time. Angew. Chem. Int. Ed. 42:768-72 (Pubitemid 36288221)
    • (2003) Angewandte Chemie - International Edition , vol.42 , Issue.7 , pp. 768-772
    • Song, H.1    Tice, J.D.2    Ismagilov, R.F.3
  • 26
    • 66749124156 scopus 로고    scopus 로고
    • Kinetic aspects of emulsion stabilization by surfactants: A microfluidic analysis
    • Baret JC, Kleinschmidt F, El Harrak A, Griffiths AD. 2009. Kinetic aspects of emulsion stabilization by surfactants: a microfluidic analysis. Langmuir 25:6088-93
    • (2009) Langmuir , vol.25 , pp. 6088-93
    • Baret, J.C.1    Kleinschmidt, F.2    El Harrak, A.3    Griffiths, A.D.4
  • 27
    • 65249121358 scopus 로고    scopus 로고
    • Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays
    • Courtois F, Olguin LF, Whyte G, Theberge AB, Huck WTS, et al. 2009. Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays. Anal. Chem. 81:3008-16
    • (2009) Anal. Chem. , vol.81 , pp. 3008-16
    • Courtois, F.1    Olguin, L.F.2    Whyte, G.3    Theberge, A.B.4    Wts, H.5
  • 28
    • 72049114735 scopus 로고    scopus 로고
    • Mass transfer and interfacial properties in two-phase microchannel flows
    • Martin JD, Hudson SD. 2009. Mass transfer and interfacial properties in two-phase microchannel flows. New J. Phys. 11:115005
    • (2009) New J. Phys. , vol.11 , pp. 115005
    • Martin, J.D.1    Hudson, S.D.2
  • 29
    • 77954560039 scopus 로고    scopus 로고
    • Enzyme catalysis in an aqueous/organic segment flow microreactor: Ways to stabilize enzyme activity
    • Karande R, Schmid A, Buehler K. 2010. Enzyme catalysis in an aqueous/organic segment flow microreactor: ways to stabilize enzyme activity. Langmuir 26:9152-59
    • (2010) Langmuir , vol.26 , pp. 9152-59
    • Karande, R.1    Schmid, A.2    Buehler, K.3
  • 30
    • 69949160752 scopus 로고    scopus 로고
    • Laterally mobile, functionalized selfassembled monolayers at the fluorous-aqueous interface in a plug-based microfluidic system: Characterization and testing with membrane protein crystallization
    • Kreutz JE, Li L, Roach LS, Hatakeyama T, Ismagilov RF. 2009. Laterally mobile, functionalized selfassembled monolayers at the fluorous-aqueous interface in a plug-based microfluidic system: characterization and testing with membrane protein crystallization. J. Am. Chem. Soc. 131:6042-43
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 6042-43
    • Kreutz, J.E.1    Li, L.2    Roach, L.S.3    Hatakeyama, T.4    Ismagilov, R.F.5
  • 31
    • 13244289982 scopus 로고    scopus 로고
    • Controlling nonspecific protein adsorption in a plug-based microfluidic system by controlling interfacial chemistry using fluorous-phase surfactants
    • DOI 10.1021/ac049061w
    • Roach LS, Song H, Ismagilov RF. 2005. Controlling nonspecific protein adsorption in a plug-based microfluidic system by controlling interfacial chemistry using fluorous-phase surfactants. Anal. Chem. 77:785-96 (Pubitemid 40194142)
    • (2005) Analytical Chemistry , vol.77 , Issue.3 , pp. 785-796
    • Roach, L.S.1    Song, H.2    Ismagilov, R.F.3
  • 33
    • 77949373772 scopus 로고    scopus 로고
    • Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen
    • Kreutz JE, Shukhaev A, Du W, Druskin S, Daugulis O, Ismagilov RF. 2010. Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen. J. Am. Chem. Soc. 132:3128-32
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 3128-32
    • Kreutz, J.E.1    Shukhaev, A.2    Du, W.3    Druskin, S.4    Daugulis, O.5    Ismagilov, R.F.6
  • 34
    • 25844517613 scopus 로고    scopus 로고
    • Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization
    • DOI 10.1016/j.sbi.2005.08.009, PII S0959440X05001570, Carbohydrates and Glycoconjugates/Biophysical Methods
    • Zheng B, Gerdts CJ, Ismagilov RF. 2005. Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization. Curr. Opin. Struct. Biol. 15:548-55 (Pubitemid 41393486)
    • (2005) Current Opinion in Structural Biology , vol.15 , Issue.5 , pp. 548-555
    • Zheng, B.1    Gerdts, C.J.2    Ismagilov, R.F.3
  • 35
    • 4544241033 scopus 로고    scopus 로고
    • Formation of arrayed droplets of soft lithography and two-phase fluid flow, and application in protein crystallization
    • Zheng B, Tice JD, Ismagilov RF. 2004. Formation of arrayed droplets of soft lithography and two-phase fluid flow, and application in protein crystallization. Adv. Mater. 16:1365-68
    • (2004) Adv. Mater. , vol.16 , pp. 1365-68
    • Zheng, B.1    Tice, J.D.2    Ismagilov, R.F.3
  • 36
    • 3342898592 scopus 로고    scopus 로고
    • A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip X-ray diffraction
    • DOI 10.1002/anie.200453974
    • Zheng B, Tice JD, Roach LS, Ismagilov RF. 2004. A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip X-ray diffraction. Angew. Chem. Int. Ed. 43:2508-11 (Pubitemid 39257710)
    • (2004) Angewandte Chemie - International Edition , vol.43 , Issue.19 , pp. 2508-2511
    • Zheng, B.1    Tice, J.D.2    Roach, L.S.3    Ismagilov, R.F.4
  • 38
    • 1442324455 scopus 로고    scopus 로고
    • Concentrating Solutes and Nanoparticles within Individual Aqueous Microdroplets
    • DOI 10.1021/ac035196a
    • He MY, Sun CH, Chiu DT. 2004. Concentrating solutes and nanoparticles within individual aqueous microdroplets. Anal. Chem. 76:1222-27 (Pubitemid 38280468)
    • (2004) Analytical Chemistry , vol.76 , Issue.5 , pp. 1222-1227
    • He, M.1    Sun, C.2    Chiu, D.T.3
  • 40
    • 33947135419 scopus 로고    scopus 로고
    • Using three-phase flow of immiscible liquids to prevent coalescence of droplets in microfluidic channels: Criteria to identify the third liquid and validation with protein crystallization
    • DOI 10.1021/la062152z
    • Chen DLL, Li L, Reyes S, Adamson DN, Ismagilov RF. 2007. Using three-phase flow of immiscible liquids to prevent coalescence of droplets in microfluidic channels: criteria to identify the third liquid and validation with protein crystallization. Langmuir 23:2255-60 (Pubitemid 46406190)
    • (2007) Langmuir , vol.23 , Issue.4 , pp. 2255-2260
    • Chen, D.L.1    Li, L.2    Reyes, S.3    Adamson, D.N.4    Ismagilov, R.F.5
  • 43
    • 72949103270 scopus 로고    scopus 로고
    • The potential of microfluidic water-in-oil droplets in experimental biology
    • Schaerli Y, Hollfelder F. 2009. The potential of microfluidic water-in-oil droplets in experimental biology. Mol. Biosyst. 5:1392-404
    • (2009) Mol. Biosyst. , vol.5 , pp. 1392-404
    • Schaerli, Y.1    Hollfelder, F.2
  • 44
    • 0037413687 scopus 로고    scopus 로고
    • Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization
    • DOI 10.1093/emboj/cdg014
    • Griffiths AD, Tawfik DS. 2003. Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization. EMBO J. 22:24-35 (Pubitemid 36091266)
    • (2003) EMBO Journal , vol.22 , Issue.1 , pp. 24-35
    • Griffiths, A.D.1    Tawfik, D.S.2
  • 46
    • 67649973848 scopus 로고    scopus 로고
    • Fluorescence-activated droplet sorting (FADS): Efficient microfluidic cell sorting based on enzymatic activity
    • Baret JC, Miller OJ, Taly V, Ryckelynck M, El-Harrak A, et al. 2009. Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity. Lab Chip 9:1850-58
    • (2009) Lab Chip , vol.9 , pp. 1850-58
    • Baret, J.C.1    Miller, O.J.2    Taly, V.3    Ryckelynck, M.4    El-Harrak, A.5
  • 47
    • 77955671185 scopus 로고    scopus 로고
    • Single-molecule DNA amplification and analysis using microfluidics
    • Zhang C, Da X. 2010. Single-molecule DNA amplification and analysis using microfluidics. Chem. Rev. 110:4910-47
    • (2010) Chem. Rev. , vol.110 , pp. 4910-47
    • Zhang, C.1    Da, X.2
  • 48
    • 62649132171 scopus 로고    scopus 로고
    • Microfluidic DNA amplification̈a review
    • Zhang YH, Ozdemir P. 2009. Microfluidic DNA amplification̈a review. Anal. Chim. Acta 638:115-25
    • (2009) Anal. Chim. Acta , vol.638 , pp. 115-25
    • Zhang, Y.H.1    Ozdemir, P.2
  • 49
    • 33646029128 scopus 로고    scopus 로고
    • Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling
    • Krutzik PO, Nolan GP. 2006. Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nat. Methods 3:361-68
    • (2006) Nat. Methods , vol.3 , pp. 361-68
    • Krutzik, P.O.1    Nolan, G.P.2
  • 52
    • 70349782198 scopus 로고    scopus 로고
    • Detection and analysis of lowabundance cell-surface biomarkers using enzymatic amplification in microfluidic droplets
    • Joensson H, Samuels M, Brouzes E, Medkova M, Uhlen M, et al. 2009. Detection and analysis of lowabundance cell-surface biomarkers using enzymatic amplification in microfluidic droplets. Angew. Chem. Int. Ed. 48:2518-21
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 2518-21
    • Joensson, H.1    Samuels, M.2    Brouzes, E.3    Medkova, M.4    Uhlen, M.5
  • 53
    • 4544366400 scopus 로고    scopus 로고
    • Dynamic pattern formation in a vesicle-generating microfluidic device
    • DOI 10.1103/PhysRevLett.86.4163
    • Thorsen T, Roberts RW, Arnold FH, Quake SR. 2001. Dynamic pattern formation in a vesiclegenerating microfluidic device. Phys. Rev. Lett. 86:4163-66 (Pubitemid 32443957)
    • (2001) Physical Review Letters , vol.86 , Issue.18 , pp. 4163-4166
    • Thorsen, T.1    Roberts, R.W.2    Arnold, F.H.3    Quake, S.R.4
  • 54
    • 0037455351 scopus 로고    scopus 로고
    • Formation of dispersions using "flow focusing" in microchannels
    • Anna SL, Bontoux N, Stone HA. 2003. Formation of dispersions using "flow focusing" in microchannels. Appl. Phys. Lett. 82:364-66
    • (2003) Appl. Phys. Lett. , vol.82 , pp. 364-66
    • Anna, S.L.1    Bontoux, N.2    Stone, H.A.3
  • 55
    • 33749499530 scopus 로고    scopus 로고
    • Droplet formation in microchannels under static conditions
    • Wu L, Li GP, Xu W, Bachman M. 2006. Droplet formation in microchannels under static conditions. Appl. Phys. Lett. 89:144106
    • (2006) Appl. Phys. Lett. , vol.89 , pp. 144106
    • Wu, L.1    Li, G.P.2    Xu, W.3    Bachman, M.4
  • 56
    • 70450085160 scopus 로고    scopus 로고
    • Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction
    • Zhang QQ, Zeng SJ, Qin JH, Lin BC. 2009. Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction. Electrophoresis 30:3181-88
    • (2009) Electrophoresis , vol.30 , pp. 3181-88
    • Zhang, Q.Q.1    Zeng, S.J.2    Qin, J.H.3    Lin, B.C.4
  • 58
    • 0043194348 scopus 로고    scopus 로고
    • Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets
    • DOI 10.1021/ja037166v
    • Zheng B, Roach LS, Ismagilov RF. 2003. Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets. J. Am. Chem. Soc. 125:11170-71 (Pubitemid 37108033)
    • (2003) Journal of the American Chemical Society , vol.125 , Issue.37 , pp. 11170-11171
    • Zheng, B.1    Roach, L.S.2    Ismagilov, R.F.3
  • 59
    • 4444257582 scopus 로고    scopus 로고
    • Formation of droplets of in microfluidic channels alternating composition and applications to indexing of concentrations in droplet-based assays
    • Zheng B, Tice JD, Ismagilov RF. 2004. Formation of droplets of in microfluidic channels alternating composition and applications to indexing of concentrations in droplet-based assays. Anal. Chem. 76:4977- 82
    • (2004) Anal. Chem. , vol.76 , pp. 4977-4982
    • Zheng, B.1    Tice, J.D.2    Ismagilov, R.F.3
  • 61
    • 65649133038 scopus 로고    scopus 로고
    • Microvalve-actuated precise control of individual droplets in microfluidic devices
    • Zeng SJ, Li BW, Su XO, Qin JH, Lin BC. 2009. Microvalve-actuated precise control of individual droplets in microfluidic devices. Lab Chip 9:1340-43
    • (2009) Lab Chip , vol.9 , pp. 1340-43
    • Zeng, S.J.1    Li, B.W.2    Su, X.O.3    Qin, J.H.4    Lin, B.C.5
  • 62
    • 11844250557 scopus 로고    scopus 로고
    • Reagent-loaded cartridges for valveless and automated fluid delivery in microfluidic devices
    • DOI 10.1021/ac049071x
    • Linder V, Sia SK, Whitesides GM. 2005. Reagent-loaded cartridges for valveless and automated fluid delivery in microfluidic devices. Anal. Chem. 77:64-71 (Pubitemid 40096669)
    • (2005) Analytical Chemistry , vol.77 , Issue.1 , pp. 64-71
    • Linder, V.1    Sia, S.K.2    Whitesides, G.M.3
  • 63
    • 78649696097 scopus 로고    scopus 로고
    • Automated microfluidic screening assay platform based on Drop Lab
    • Du WB, Sun M, Gu SQ, Fang Q. 2010. Automated microfluidic screening assay platform based on Drop Lab. Anal. Chem. 9941-47
    • (2010) Anal. Chem. , pp. 9941-9947
    • Du, W.B.1    Sun, M.2    Gu, S.Q.3    Fang, Q.4
  • 64
    • 33744537288 scopus 로고    scopus 로고
    • Microfluidic cartridges preloaded with nanoliter plugs of reagents: An alternative to 96-well plates for screening
    • DOI 10.1016/j.cbpa.2006.04.004, PII S136759310600055X
    • Chen DLL, Ismagilov RF. 2006. Microfluidic cartridges preloaded with nanoliter plugs of reagents: an alternative to 96-well plates for screening. Curr. Opin. Chem. Biol. 10:226-31 (Pubitemid 43815780)
    • (2006) Current Opinion in Chemical Biology , vol.10 , Issue.3 , pp. 226-231
    • Chen, D.L.1    Ismagilov, R.F.2
  • 65
    • 33644654279 scopus 로고    scopus 로고
    • Microgram-scale testing of reaction conditions in solution using nanoliter plugs in microfluidics with detection by MALDI-MS
    • DOI 10.1021/ja057720w
    • Hatakeyama T, Chen DLL, Ismagilov RF. 2006. Microgram-scale testing of reaction conditions in solution using nanoliter plugs in microfluidics with detection by MALDI-MS. J. Am. Chem. Soc. 128:2518-19 (Pubitemid 43327912)
    • (2006) Journal of the American Chemical Society , vol.128 , Issue.8 , pp. 2518-2519
    • Hatakeyama, T.1    Chen, D.L.2    Ismagilov, R.F.3
  • 66
    • 20444390163 scopus 로고    scopus 로고
    • Contamination-free continuous flow microfluidic polymerase chain reaction for quantitative and clinical applications
    • DOI 10.1021/ac050031i
    • Dorfman KD, Chabert M, Codarbox JH, Rousseau G, deCremoux P, Viovy JL. 2005. Contamination free continuous flow microfluidic polymerase chain reaction for quantitative and clinical applications. Anal. Chem. 77:3700-4 (Pubitemid 40799864)
    • (2005) Analytical Chemistry , vol.77 , Issue.11 , pp. 3700-3704
    • Dorfman, K.D.1    Chabert, M.2    Codarbox, J.-H.3    Rousseau, G.4    De Cremoux, P.5    Viovy, J.-L.6
  • 67
    • 33751212797 scopus 로고    scopus 로고
    • Automated microdroplet platform for sample manipulation and polymerase chain reaction
    • DOI 10.1021/ac061205e
    • Chabert M, Dorfman KD, deCremoux P, Roeraade J, Viovy JL. 2006. Automatedmicrodroplet platform for sample manipulation and polymerase chain reaction. Anal. Chem. 78:7722-28 (Pubitemid 44788715)
    • (2006) Analytical Chemistry , vol.78 , Issue.22 , pp. 7722-7728
    • Chabert, M.1    Dorfman, K.D.2    De Cremoux, P.3    Roeraade, J.4    Viovy, J.-L.5
  • 68
    • 33846984899 scopus 로고    scopus 로고
    • Coding/decoding and reversibility of droplet trains in microfluidic networks
    • Fuerstman MJ, Garstecki P, Whitesides GM. 2007. Coding/decoding and reversibility of droplet trains in microfluidic networks. Science 315:828-32
    • (2007) Science , vol.315 , pp. 828-32
    • Fuerstman, M.J.1    Garstecki, P.2    Whitesides, G.M.3
  • 69
    • 78049281448 scopus 로고    scopus 로고
    • A microdroplet-based shift register
    • Zagnoni M, Cooper JM. 2010. A microdroplet-based shift register. Lab Chip 10:3069-73
    • (2010) Lab Chip , vol.10 , pp. 3069-73
    • Zagnoni, M.1    Cooper, J.M.2
  • 70
    • 0344875161 scopus 로고    scopus 로고
    • Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
    • DOI 10.1021/ja0354566
    • Song H, Ismagilov RF. 2003. Millisecond kinetics on a microfluidic chip using nanoliters of reagents. J. Am. Chem. Soc. 125:14613-19 (Pubitemid 37452397)
    • (2003) Journal of the American Chemical Society , vol.125 , Issue.47 , pp. 14613-14619
    • Song, H.1    Ismagilov, R.F.2
  • 71
    • 67650762821 scopus 로고    scopus 로고
    • Measuring rapid enzymatic kinetics by electrochemical method in droplet-based microfluidic devices with pneumatic valves
    • Han ZY, Li WT, Huang YY, Zheng B. 2009. Measuring rapid enzymatic kinetics by electrochemical method in droplet-based microfluidic devices with pneumatic valves. Anal. Chem. 81:5840-45
    • (2009) Anal. Chem. , vol.81 , pp. 5840-45
    • Han, Z.Y.1    Li, W.T.2    Huang, Y.Y.3    Zheng, B.4
  • 72
    • 51049122628 scopus 로고    scopus 로고
    • Rate of mixing controls rate and outcome of autocatalytic processes: Theory and microfluidic experiments with chemical reactions and blood coagulation
    • Pompano RR, Li HW, Ismagilov RF. 2008. Rate of mixing controls rate and outcome of autocatalytic processes: theory and microfluidic experiments with chemical reactions and blood coagulation. Biophys. J. 95:1531-43
    • (2008) Biophys. J. , vol.95 , pp. 1531-43
    • Pompano, R.R.1    Li, H.W.2    Ismagilov, R.F.3
  • 73
    • 2442650208 scopus 로고    scopus 로고
    • A synthetic reaction network: Chemical amplification using nonequilibrium autocatalytic reactions coupled in time
    • DOI 10.1021/ja031689l
    • Gerdts CJ, Sharoyan DE, Ismagilov RF. 2004. A synthetic reaction network: chemical amplification using nonequilibrium autocatalytic reactions coupled in time. J. Am. Chem. Soc. 126:6327-31 (Pubitemid 38657060)
    • (2004) Journal of the American Chemical Society , vol.126 , Issue.20 , pp. 6327-6331
    • Gerdts, C.J.1    Sharoyan, D.E.2    Ismagilov, R.F.3
  • 75
    • 51949096580 scopus 로고    scopus 로고
    • Monitoring of real-time streptavidin-biotin binding kinetics using droplet microfluidics
    • Srisa-Art M, Dyson EC, deMello AJ, Edel JB. 2008. Monitoring of real-time streptavidin-biotin binding kinetics using droplet microfluidics. Anal. Chem. 80:7063-67
    • (2008) Anal. Chem. , vol.80 , pp. 7063-67
    • Srisa-Art, M.1    Dyson, E.C.2    Demello, A.J.3    Edel, J.B.4
  • 76
    • 62649153787 scopus 로고    scopus 로고
    • Rapid label-free DNA analysis in picoliter microfluidic droplets using FRET probes
    • Hsieh ATH, Pan PJH, Lee AP. 2009. Rapid label-free DNA analysis in picoliter microfluidic droplets using FRET probes. Microfluid. Nanofluid. 6:391-401
    • (2009) Microfluid. Nanofluid. , vol.6 , pp. 391-401
    • Ath, H.1    Pjh, P.2    Lee, A.P.3
  • 77
    • 77951855890 scopus 로고    scopus 로고
    • Mapping of fluidic mixing in microdroplets with 1 μs time resolution using fluorescence lifetime imaging
    • Solvas XCI, Srisa-Art M, deMello AJ, Edel JB. 2010. Mapping of fluidic mixing in microdroplets with 1 μs time resolution using fluorescence lifetime imaging. Anal. Chem. 82:3950-56
    • (2010) Anal. Chem. , vol.82 , pp. 3950-56
    • Xci, S.1    Srisa-Art, M.2    Demello, A.J.3    Edel, J.B.4
  • 78
    • 55949131242 scopus 로고    scopus 로고
    • The chemistrode: A droplet-based microfluidic device for stimulation and recordingwith high temporal, spatial, and chemical resolution
    • Chen D, Du WB, Liu Y, Liu WS, Kuznetsov A, et al. 2008. The chemistrode: a droplet-based microfluidic device for stimulation and recordingwith high temporal, spatial, and chemical resolution. Proc. Natl. Acad. Sci. USA 105:16843-48
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16843-48
    • Chen, D.1    Du, W.B.2    Liu, Y.3    Liu, W.S.4    Kuznetsov, A.5
  • 79
    • 65249187168 scopus 로고    scopus 로고
    • Dynamics of coalescence of plugs with a hydrophilic wetting layer induced by flow in a microfluidic chemistrode
    • Liu Y, Ismagilov RF. 2009. Dynamics of coalescence of plugs with a hydrophilic wetting layer induced by flow in a microfluidic chemistrode. Langmuir 25:2854-59
    • (2009) Langmuir , vol.25 , pp. 2854-59
    • Liu, Y.1    Ismagilov, R.F.2
  • 80
    • 68949159927 scopus 로고    scopus 로고
    • Using TIRF microscopy to quantify and confirm efficient mass transfer at the substrate surface of the chemistrode
    • Chen DL, Du W, Ismagilov RF. 2009. Using TIRF microscopy to quantify and confirm efficient mass transfer at the substrate surface of the chemistrode. New J. Phys. 11:075017
    • (2009) New J. Phys. , vol.11 , pp. 075017
    • Chen, D.L.1    Du, W.2    Ismagilov, R.F.3
  • 81
    • 69549121922 scopus 로고    scopus 로고
    • Isolation, incubation, and parallel functional testing and identification by FISH of rare microbial single-copy cells from multi-species mixtures using the combination of chemistrode and stochastic confinement
    • Liu W, Kim HJ, Lucchetta E, Du W, Ismagilov RF. 2009. Isolation, incubation, and parallel functional testing and identification by FISH of rare microbial single-copy cells from multi-species mixtures using the combination of chemistrode and stochastic confinement. Lab Chip 9:2153-62
    • (2009) Lab Chip , vol.9 , pp. 2153-62
    • Liu, W.1    Kim, H.J.2    Lucchetta, E.3    Du, W.4    Ismagilov, R.F.5
  • 83
    • 49049095113 scopus 로고    scopus 로고
    • Improved temporal resolution for in vivo microdialysis by using segmented flow
    • Wang M, Roman GT, Schultz K, Jennings C, Kennedy RT. 2008. Improved temporal resolution for in vivo microdialysis by using segmented flow. Anal. Chem. 80:5607-15
    • (2008) Anal. Chem. , vol.80 , pp. 5607-15
    • Wang, M.1    Roman, G.T.2    Schultz, K.3    Jennings, C.4    Kennedy, R.T.5
  • 84
    • 55549090701 scopus 로고    scopus 로고
    • Sampling and electrophoretic analysis of segmented flow streams using virtual walls in a microfluidic device
    • Roman GT, Wang M, Shultz KN, Jennings C, Kennedy RT. 2008. Sampling and electrophoretic analysis of segmented flow streams using virtual walls in a microfluidic device. Anal. Chem. 80:8231-38
    • (2008) Anal. Chem. , vol.80 , pp. 8231-38
    • Roman, G.T.1    Wang, M.2    Shultz, K.N.3    Jennings, C.4    Kennedy, R.T.5
  • 85
    • 70350648689 scopus 로고    scopus 로고
    • Microfluidic chip for high efficiency electrophoretic analysis of segmented flow from a microdialysis probe and in vivo chemical monitoring
    • Wang M, Roman GT, Perry ML, Kennedy RT. 2009. Microfluidic chip for high efficiency electrophoretic analysis of segmented flow from a microdialysis probe and in vivo chemical monitoring. Anal. Chem. 81:9072-78
    • (2009) Anal. Chem. , vol.81 , pp. 9072-78
    • Wang, M.1    Roman, G.T.2    Perry, M.L.3    Kennedy, R.T.4
  • 86
    • 77953728878 scopus 로고    scopus 로고
    • Collection of nanoliter microdialysate fractions in plugs for off-line in vivo chemical monitoring with up to 2 s temporal resolution
    • Wang M, Slaney T, Mabrouk O, Kennedy RT. 2010. Collection of nanoliter microdialysate fractions in plugs for off-line in vivo chemical monitoring with up to 2 s temporal resolution. J. Neurosci. Methods 190:39-48
    • (2010) J. Neurosci. Methods , vol.190 , pp. 39-48
    • Wang, M.1    Slaney, T.2    Mabrouk, O.3    Kennedy, R.T.4
  • 88
    • 77951899852 scopus 로고    scopus 로고
    • An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries
    • Clausell-Tormos J, Griffiths AD, Merten CA. 2010. An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries. Lab Chip 10:1302-7
    • (2010) Lab Chip , vol.10 , pp. 1302-7
    • Clausell-Tormos, J.1    Griffiths, A.D.2    Merten, C.A.3
  • 90
    • 60649106614 scopus 로고    scopus 로고
    • Static microdroplet arrays: A microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays
    • Huebner A, Bratton D, Whyte G, Yang M, deMello AJ, et al. 2009. Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. Lab Chip 9:692-98
    • (2009) Lab Chip , vol.9 , pp. 692-98
    • Huebner, A.1    Bratton, D.2    Whyte, G.3    Yang, M.4    Demello, A.J.5
  • 91
    • 77951913728 scopus 로고    scopus 로고
    • A double droplet trap system for studying mass transport across a droplet-droplet interface
    • Bai YP, He XM, Liu DS, Patil SN, Bratton D, et al. 2010. A double droplet trap system for studying mass transport across a droplet-droplet interface. Lab Chip 10:1281-85
    • (2010) Lab Chip , vol.10 , pp. 1281-85
    • Bai, Y.P.1    He, X.M.2    Liu, D.S.3    Patil, S.N.4    Bratton, D.5
  • 93
    • 52649089822 scopus 로고    scopus 로고
    • Droplet-based microfluidic system for individual Caenorhabditis elegans assay
    • Shi WW, Qin JH, Ye NN, Lin BC. 2008. Droplet-based microfluidic system for individual Caenorhabditis elegans assay. Lab Chip 8:1432-35
    • (2008) Lab Chip , vol.8 , pp. 1432-35
    • Shi, W.W.1    Qin, J.H.2    Ye, N.N.3    Lin, B.C.4
  • 94
  • 96
    • 74849126836 scopus 로고    scopus 로고
    • User-loaded SlipChip for equipment-free multiplexed nanoliter-scale experiments
    • Li L, Du WB, Ismagilov R. 2010. User-loaded SlipChip for equipment-free multiplexed nanoliter-scale experiments. J. Am. Chem. Soc. 132:106-11
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 106-11
    • Li, L.1    Du, W.B.2    Ismagilov, R.3
  • 97
    • 74849112398 scopus 로고    scopus 로고
    • Multiparameter screening on SlipChip used for nanoliter protein crystallization combining free interface diffusion and microbatchmethods
    • Li L, Du WB, Ismagilov RF. 2010. Multiparameter screening on SlipChip used for nanoliter protein crystallization combining free interface diffusion and microbatchmethods. J. Am. Chem. Soc. 132:112-19
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 112-19
    • Li, L.1    Du, W.B.2    Ismagilov, R.F.3
  • 101
    • 77956696047 scopus 로고    scopus 로고
    • Dead-end filling of SlipChip evaluated theoretically and experimentally as a function of the surface chemistry and the gap size between the plates for lubricated and dry SlipChips
    • Li L, Karymov MA, Nichols KP, Ismagilov RF. 2010. Dead-end filling of SlipChip evaluated theoretically and experimentally as a function of the surface chemistry and the gap size between the plates for lubricated and dry SlipChips. Langmuir 26:12465-71
    • (2010) Langmuir , vol.26 , pp. 12465-71
    • Li, L.1    Karymov, M.A.2    Nichols, K.P.3    Ismagilov, R.F.4
  • 102
    • 0000242759 scopus 로고    scopus 로고
    • Fabricating large arrays of microwells with arbitrary dimensions and filling them using discontinuous dewetting
    • Jackman RJ, Duffy DC, Ostuni E, Willmore ND, Whitesides GM. 1998. Fabricating large arrays of microwells with arbitrary dimensions and filling them using discontinuous dewetting. Anal. Chem. 70:2280- 87
    • (1998) Anal. Chem. , vol.70 , pp. 2280-2287
    • Jackman, R.J.1    Duffy, D.C.2    Ostuni, E.3    Willmore, N.D.4    Whitesides, G.M.5
  • 103
    • 70349769737 scopus 로고    scopus 로고
    • Microfluidic confinement of single cells of bacteria in small volumes initiates high density behavior of quorum sensing and growth and reveals its variability
    • Boedicker JQ, Vincent ME, Ismagilov RF. 2009. Microfluidic confinement of single cells of bacteria in small volumes initiates high density behavior of quorum sensing and growth and reveals its variability. Angew. Chem. Int. Ed. 48:5908-11
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 5908-11
    • Boedicker, J.Q.1    Vincent, M.E.2    Ismagilov, R.F.3
  • 105
    • 70350331103 scopus 로고    scopus 로고
    • Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments
    • Shim JU, Olguin LF, Whyte G, Scott D, Babtie A, et al. 2009. Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments. J. Am. Chem. Soc. 131:15251-56
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 15251-56
    • Shim, J.U.1    Olguin, L.F.2    Whyte, G.3    Scott, D.4    Babtie, A.5
  • 106
    • 57449107381 scopus 로고    scopus 로고
    • Dropspots: A picoliter array in a microfluidic device
    • Schmitz CHJ, Rowat AC, Koster S, Weitz DA. 2009. Dropspots: a picoliter array in a microfluidic device. Lab Chip 9:44-49
    • (2009) Lab Chip , vol.9 , pp. 44-49
    • Chj, S.1    Rowat, A.C.2    Koster, S.3    Weitz, D.A.4
  • 107
    • 67649973850 scopus 로고    scopus 로고
    • Nucleation and solidification in static arrays of monodisperse drops
    • Edd JF, Humphry KJ, Irimia D, Weitz DA, Toner M. 2009. Nucleation and solidification in static arrays of monodisperse drops. Lab Chip 9:1859-65
    • (2009) Lab Chip , vol.9 , pp. 1859-65
    • Edd, J.F.1    Humphry, K.J.2    Irimia, D.3    Weitz, D.A.4    Toner, M.5
  • 110
    • 65349104793 scopus 로고    scopus 로고
    • Petri dish PCR: Laser-heated reactions in nanoliter droplet arrays
    • Kim H, Vishniakou S, Faris GW. 2009. Petri dish PCR: laser-heated reactions in nanoliter droplet arrays. Lab Chip 9:1230-35
    • (2009) Lab Chip , vol.9 , pp. 1230-35
    • Kim, H.1    Vishniakou, S.2    Faris, G.W.3
  • 111
    • 77249087864 scopus 로고    scopus 로고
    • Amicrofluidic approach for high-throughput droplet interface bilayer (DIB) formation
    • Stanley CE, Elvira KS, Niu XZ, Gee AD, Ces O, et al. 2010. Amicrofluidic approach for high-throughput droplet interface bilayer (DIB) formation. Chem. Commun. 46:1620-22
    • (2010) Chem. Commun. , vol.46 , pp. 1620-22
    • Stanley, C.E.1    Elvira, K.S.2    Niu, X.Z.3    Gee, A.D.4    Ces, O.5
  • 112
    • 0000933795 scopus 로고    scopus 로고
    • Optical tweezer arrays and optical substrates created with diffractive optics
    • Dufresne ER, Grier DG. 1998. Optical tweezer arrays and optical substrates created with diffractive optics. Rev. Sci. Instrum. 69:1974-77 (Pubitemid 128581732)
    • (1998) Review of Scientific Instruments , vol.69 , Issue.5 , pp. 1974-1977
    • Dufresne, E.R.1    Grier, D.G.2
  • 114
    • 33748767181 scopus 로고    scopus 로고
    • Microfluidic and optical systems for the on-demand generation and manipulation of single femtoliter-volume aqueous droplets
    • DOI 10.1021/ac060748l
    • Lorenz RM, Edgar JS, Jeffries GDM, Chiu DT. 2006. Microfluidic and optical systems for the on-demand generation and manipulation of single femtoliter-volume aqueous droplets. Anal. Chem. 78:6433-39 (Pubitemid 44413594)
    • (2006) Analytical Chemistry , vol.78 , Issue.18 , pp. 6433-6439
    • Lorenz, R.M.1    Edgar, J.S.2    Jeffries, G.D.M.3    Chiu, D.T.4
  • 115
    • 61849161597 scopus 로고    scopus 로고
    • Holographic optical trapping of aerosol droplets
    • Burnham DR, McGloin D. 2006. Holographic optical trapping of aerosol droplets. Opt. Express 14:4175- 81
    • (2006) Opt. Express , vol.14 , pp. 4175-4181
    • Burnham, D.R.1    McGloin, D.2
  • 116
    • 59649124105 scopus 로고    scopus 로고
    • Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets
    • Butler JR, Wills JB, Mitchem L, Burnham DR, McGloin D, Reid JP. 2009. Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets. Lab Chip 9:521-28
    • (2009) Lab Chip , vol.9 , pp. 521-28
    • Butler, J.R.1    Wills, J.B.2    Mitchem, L.3    Burnham, D.R.4    McGloin, D.5    Reid, J.P.6
  • 117
    • 67651151109 scopus 로고    scopus 로고
    • Liquid crystallography: 3D microdroplet arrangements using microfluidics
    • Shui LL, Kooij ES, Wijnperle D, Van Den Berg A, Eijkel JCT. 2009. Liquid crystallography: 3D microdroplet arrangements using microfluidics. Soft Matter 5:2708-12
    • (2009) Soft Matter , vol.5 , pp. 2708-12
    • Shui, L.L.1    Kooij, E.S.2    Wijnperle, D.3    Van Den Berg, A.4    Jct, E.5
  • 120
    • 34447299956 scopus 로고    scopus 로고
    • Nanoliter dispensing method by degassed poly(dimethylsiloxane) microchannels and its application in protein crystallization
    • Zhou X, Lau L, Lam WWL, Au SWN, Zheng B. 2007. Nanoliter dispensing method by degassed poly(dimethylsiloxane) microchannels and its application in protein crystallization. Anal. Chem. 79:4924- 30
    • (2007) Anal. Chem. , vol.79 , pp. 4924-4930
    • Zhou, X.1    Lau, L.2    Wwl, L.3    Swn, A.4    Zheng, B.5
  • 122
    • 33847358132 scopus 로고    scopus 로고
    • 3D droplet displacement in microfluidic systems by electrostatic actuation
    • DOI 10.1016/j.sna.2006.05.012, PII S0924424706003517
    • Roux JM, Fouillet Y, Achard JL. 2007. 3D droplet displacement in microfluidic systems by electrostatic actuation. Sens. Actuators A 134:486-93 (Pubitemid 46349545)
    • (2007) Sensors and Actuators, A: Physical , vol.134 , Issue.2 , pp. 486-493
    • Roux, J.-M.1    Fouillet, Y.2    Achard, J.-L.3
  • 123
    • 74049083827 scopus 로고    scopus 로고
    • Droplet-based gene expression analysis using a device with magnetic force-based droplet-handling system
    • Okochi M, Tsuchiya H, Kumazawa F, Shikida M, Honda H. 2010. Droplet-based gene expression analysis using a device with magnetic force-based droplet-handling system. J. Biosci. Bioeng. 109:193-97
    • (2010) J. Biosci. Bioeng. , vol.109 , pp. 193-97
    • Okochi, M.1    Tsuchiya, H.2    Kumazawa, F.3    Shikida, M.4    Honda, H.5
  • 125
    • 0032304485 scopus 로고    scopus 로고
    • Containerless protein crystal growth in rotating levitated drops
    • PII S0022024898005429
    • Chung SK, Trinh EH. 1998. Containerless protein crystal growth in rotating levitated drops. J. Cryst. Growth 194:384-97 (Pubitemid 128425761)
    • (1998) Journal of Crystal Growth , vol.194 , Issue.3-4 , pp. 384-397
    • Chung, S.K.1    Trinh, E.H.2
  • 126
    • 77949890340 scopus 로고    scopus 로고
    • A microfluidic platform for manipulation and separation of oil-inwater emulsion droplets using optically induced dielectrophoresis
    • Hung SH, Lin YH, Lee GB. 2010. A microfluidic platform for manipulation and separation of oil-inwater emulsion droplets using optically induced dielectrophoresis. J. Micromech. Microeng. 20:045026
    • (2010) J. Micromech. Microeng. , vol.20 , pp. 045026
    • Hung, S.H.1    Lin, Y.H.2    Lee, G.B.3
  • 127
    • 3242683662 scopus 로고    scopus 로고
    • Single cell profiling of potentiated phospho-protein networks in cancer cells
    • DOI 10.1016/j.cell.2004.06.028, PII S0092867404006282
    • Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud O, et al. 2004. Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell 118:217-28 (Pubitemid 38962577)
    • (2004) Cell , vol.118 , Issue.2 , pp. 217-228
    • Irish, J.M.1    Hovland, R.2    Krutzik, P.O.3    Perez, O.D.4    Bruserud, O.5    Gjertsen, B.T.6    Nolan, G.P.7
  • 129
    • 50649101988 scopus 로고    scopus 로고
    • From the determination of complex reaction mechanisms to systems biology
    • Ross J. 2008. From the determination of complex reaction mechanisms to systems biology. Annu. Rev. Biochem. 77:479-94
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 479-94
    • Ross, J.1
  • 130
    • 0036320522 scopus 로고    scopus 로고
    • Cancer biomarkers: Easier said than done
    • Pritzker KPH. 2002. Cancer biomarkers: easier said than done. Clin. Chem. 48:1147-50
    • (2002) Clin. Chem. , vol.48 , pp. 1147-50
    • Kph, P.1
  • 131
    • 0037380673 scopus 로고    scopus 로고
    • Biomarkers in drug discovery and development: From target identification through drug marketing
    • DOI 10.1177/0091270003252480
    • Colburn WA. 2003. Biomarkers in drug discovery and development: from target identification through drug marketing. J. Clin. Pharmacol. 43:329-41 (Pubitemid 36368776)
    • (2003) Journal of Clinical Pharmacology , vol.43 , Issue.4 , pp. 329-341
    • Colburn, W.A.1    Keefe, D.L.2
  • 133
    • 69549097381 scopus 로고    scopus 로고
    • A fast and efficient microfluidic system for highly selective one-to-one droplet fusion
    • Mazutis L, Baret JC, Griffiths AD. 2009. A fast and efficient microfluidic system for highly selective one-to-one droplet fusion. Lab Chip 9:2665-72
    • (2009) Lab Chip , vol.9 , pp. 2665-72
    • Mazutis, L.1    Baret, J.C.2    Griffiths, A.D.3
  • 136
    • 42949133329 scopus 로고    scopus 로고
    • Sizing subcellular organelles and nanoparticles confined within aqueous droplets
    • DOI 10.1021/ac8000385
    • Gadd JC, Kuyper CL, Fujimoto BS, Allen RW, Chiu DT. 2008. Sizing subcellular organelles and nanoparticles confined within aqueous droplets. Anal. Chem. 80:3450-57 (Pubitemid 351620734)
    • (2008) Analytical Chemistry , vol.80 , Issue.9 , pp. 3450-3457
    • Gadd, J.C.1    Kuyper, C.L.2    Fujimoto, B.S.3    Allen, R.W.4    Chiu, D.T.5
  • 137
    • 34548550464 scopus 로고    scopus 로고
    • High-throughput DNA droplet assays using picoliter reactor volumes
    • DOI 10.1021/ac070987o
    • Srisa-Art M, deMello AJ, Edel JB. 2007. High-throughput DNA droplet assays using picoliter reactor volumes. Anal. Chem. 79:6682-89 (Pubitemid 47395055)
    • (2007) Analytical Chemistry , vol.79 , Issue.17 , pp. 6682-6689
    • Srisa-Art, M.1    DeMello, A.J.2    Edel, J.B.3
  • 139
    • 68349114950 scopus 로고    scopus 로고
    • Surface-enhanced Raman scattering in nanoliter droplets: Towards high-sensitivity detection of mercury (II) ions
    • Wang G, Lim C, Chen L, Chon H, Choo J, et al. 2009. Surface-enhanced Raman scattering in nanoliter droplets: towards high-sensitivity detection of mercury (II) ions. Anal. Bioanal. Chem. 394:1827-32
    • (2009) Anal. Bioanal. Chem. , vol.394 , pp. 1827-32
    • Wang, G.1    Lim, C.2    Chen, L.3    Chon, H.4    Choo, J.5
  • 141
    • 77953611858 scopus 로고    scopus 로고
    • A plug-based microfluidic system for dispensing lipidic cubic phase (LCP) material validated by crystallizing membrane proteins in lipidic mesophases
    • Li L, Fu Q, Kors C, Stewart L, Nollert P, et al. 2010. A plug-based microfluidic system for dispensing lipidic cubic phase (LCP) material validated by crystallizing membrane proteins in lipidic mesophases. Microfluid. Nanofluid. 8:789-98
    • (2010) Microfluid. Nanofluid. , vol.8 , pp. 789-98
    • Li, L.1    Fu, Q.2    Kors, C.3    Stewart, L.4    Nollert, P.5
  • 143
    • 33845305524 scopus 로고    scopus 로고
    • Electrohydrodynamic generation and delivery of monodisperse picoliter droplets using a poly(dimethylsiloxane) microchip
    • DOI 10.1021/ac061127v
    • Kim SJ, Song Y-A, Skipper PL, Han J. 2006. Electrohydrodynamic generation and delivery of monodisperse picoliter droplets using a poly(dimethylsiloxane) microchip. Anal. Chem. 78:8011-19 (Pubitemid 44871766)
    • (2006) Analytical Chemistry , vol.78 , Issue.23 , pp. 8011-8019
    • Sung, J.K.1    Song, Y.-A.2    Skipper, P.L.3    Han, J.4
  • 144
    • 33749494483 scopus 로고    scopus 로고
    • Capillary electrophoresis separation in the presence of an immiscible boundary for droplet analysis
    • DOI 10.1021/ac0613131
    • Edgar JS, Pabbati CP, Lorenz RM, He MY, Fiorini GS, Chiu DT. 2006. Capillary electrophoresis separation in the presence of an immiscible boundary for droplet analysis. Anal. Chem. 78:6948-54 (Pubitemid 44522548)
    • (2006) Analytical Chemistry , vol.78 , Issue.19 , pp. 6948-6954
    • Edgar, J.S.1    Pabbati, C.P.2    Lorenz, R.M.3    He, M.4    Fiorini, G.S.5    Chiu, D.T.6
  • 145
    • 54349128901 scopus 로고    scopus 로고
    • The electrochemical detection of droplets in microfluidic devices
    • Liu SJ, Gu YF, Le Roux RB, Matthews SM, Bratton D, et al. 2008. The electrochemical detection of droplets in microfluidic devices. Lab Chip 8:1937-42
    • (2008) Lab Chip , vol.8 , pp. 1937-42
    • Liu, S.J.1    Gu, Y.F.2    Le Roux, R.B.3    Matthews, S.M.4    Bratton, D.5
  • 146
    • 33751014520 scopus 로고    scopus 로고
    • A microfluidic chip based sequential injection system with trapped droplet liquid-liquid extraction and chemiluminescence detection
    • DOI 10.1039/b605332g
    • Shen H, Fang Q, Fang ZL. 2006. A microfluidic chip based sequential injection system with trapped droplet liquid-liquid extraction and chemiluminescence detection. Lab Chip 6:1387-89 (Pubitemid 44744307)
    • (2006) Lab on a Chip - Miniaturisation for Chemistry and Biology , vol.6 , Issue.10 , pp. 1387-1389
    • Shen, H.1    Fang, Q.2    Fang, Z.-L.3
  • 147
    • 43949138608 scopus 로고    scopus 로고
    • Simple telemedicine for developing regions: Camera phones and paper-based microfluidic devices for real-time, off-site diagnosis
    • DOI 10.1021/ac800112r
    • Martinez AW, Phillips ST, Carrilho E, Thomas SW, Sindi H, Whitesides GM. 2008. Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis. Anal. Chem. 80:3699-707 (Pubitemid 351705870)
    • (2008) Analytical Chemistry , vol.80 , Issue.10 , pp. 3699-3707
    • Martinez, A.W.1    Phillips, S.T.2    Carrilho, E.3    Thomas III, S.W.4    Sindi, H.5    Whitesides, G.M.6
  • 148
    • 77957904332 scopus 로고    scopus 로고
    • High-throughput sample introduction for droplet-based screening with an onchip integrated sampling probe and slotted-vial array
    • Sun M, Fang Q. 2010. High-throughput sample introduction for droplet-based screening with an onchip integrated sampling probe and slotted-vial array. Lab Chip 10:2864-68
    • (2010) Lab Chip , vol.10 , pp. 2864-68
    • Sun, M.1    Fang, Q.2
  • 149
    • 70450285337 scopus 로고    scopus 로고
    • Preparation of monodisperse emulsions by hydrodynamic size fractionation
    • Mazutis L, Griffiths AD. 2009. Preparation of monodisperse emulsions by hydrodynamic size fractionation. App. Phys. Lett. 95:204103
    • (2009) App. Phys. Lett. , vol.95 , pp. 204103
    • Mazutis, L.1    Griffiths, A.D.2
  • 150
    • 39649099355 scopus 로고    scopus 로고
    • Microfluidic sorting of droplets by size
    • DOI 10.1007/s10404-007-0184-1
    • Tan YC, Ho YL, Lee AP. 2008. Microfluidic sorting of droplets by size. Microfluid. Nanofluid. 4:343-48 (Pubitemid 351285090)
    • (2008) Microfluidics and Nanofluidics , vol.4 , Issue.4 , pp. 343-348
    • Tan, Y.-C.1    Ho, Y.L.2    Lee, A.P.3
  • 151
    • 77952972579 scopus 로고    scopus 로고
    • Microfluidic sorting with high-speed single-layer membrane valves
    • Abate AR, Agresti JJ, Weitz DA. 2010. Microfluidic sorting with high-speed single-layer membrane valves. Appl. Phys. Lett. 96:203509
    • (2010) Appl. Phys. Lett. , vol.96 , pp. 203509
    • Abate, A.R.1    Agresti, J.J.2    Weitz, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.