Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays

Analytical Chemistry

Volumn 81, Issue 8, 2009, Pages 3008-3016

  Courtois, Fabienne ^a   Olguin, Luis F ^a   Whyte, Graeme ^a   Theberge, Ashleigh B ^a   Huck, Wilhelm T S ^a   Hollfelder, Florian ^a   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL SCREENINGS; BOVINE-SERUM ALBUMINS; CONCENTRATION OF; DIRECTED EVOLUTIONS; ENZYMATIC ACTIVITIES; ESCHERICHIA COLI CELLS; HIGH THROUGHPUTS; IN CELLS; MICRO-DROPLETS; MINERAL OIL; OIL PHASE; ON CHIPS; POLYMERIC SURFACTANTS; REACTION PRODUCTS; SMALL MOLECULES; TEST SYSTEMS; WATER-IN-OIL;

BODY FLUIDS; DROP FORMATION; EMULSIFICATION; ESCHERICHIA COLI; FLUOROPHORES; HYDROCARBONS; MINERAL OILS; OIL WELL PRODUCTION; SILICONES; SURFACE ACTIVE AGENTS;

LEAKAGE (FLUID);

ALKALINE PHOSPHATASE; BOVINE SERUM ALBUMIN; BUFFER; FLUORESCEIN DERIVATIVE; MINERAL OIL; SILICONE; SURFACTANT;

ARTICLE; CELL ASSAY; CELL COMPARTMENTALIZATION; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; GENOTYPE; MICROEMULSION; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REACTION TIME; TRANSPORT KINETICS;

ANIMALS; CATTLE; EMULSIONS; ESCHERICHIA COLI; FLUORESCEIN; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROSCOPY, FLUORESCENCE; MICROSPHERES; MINERAL OIL; WATER;

EID: 65249121358     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac802658n     Document Type: Article

References (69)

1. Song, H.; Chen, D. L.; Ismagilov, R. F. Angew. Chem., Int. Ed. 2006, 45, 7336-7356.
2. Gunther, A.; Jensen, K. F. Lab Chip 2006, 6, 1487-1503.
3. Kelly, B. T.; Baret, J. C.; Taly, V.; Griffiths, A. D. Chem. Commun. (Cambridge, U.K.) 2007, 1773-1788.
4. Liau, A.; Karnik, R.; Majumdar, A.; Cate, J. H. Anal. Chem. 2005, 77, 7618-7625.
5. Zheng, B.; Ismagilov, R. F. Angew. Chem., Int. Ed. 2005, 44, 2520-2523.
6. Song, H.; Ismagilov, R. F. J. Am. Chem. Soc. 2003, 125, 14613-14619.
7. Ahn, K.; Agresti, J.; Chong, H.; Marquez, M.; Weitz, D. A. Appl. Phys. Lett. 2006, 88, 264105.
8. Song, H.; Li, H. W.; Munson, M. S.; Van Ha, T. G.; Ismagilov, R. F. Anal. Chem. 2006, 78, 4839-4849.
9. Martin, K; Henkel, T.; Baier, V.; Grodrian, A.; Schon, T.; Roth, M.; Michael Kohler, J.; Metze, J. Lab Chip 2003, 3, 202-207.
10. Grodrian, A.; Metze, J.; Henkel, T.; Martin, K.; Roth, M.; Kohler, J. M. Biosens. Bioelectron. 2004, 19, 1421-1428.
11. He, M.; Edgar, J. S.; Jeffries, G. D.; Lorenz, R. M.; Shelby, J. P.; Chiu, D.T. Anal. Chem. 2005, 77, 1539-1544.
12. Luo, C.; Yang, X.; Fu, Q.; Sun, M.; Ouyang, Q.; Chen, Y.; Ji, H. Electrophoresis 2006, 27, 1977-1983.
13. Sgro, A. E.; Allen, P. B.; Chiu, D. T. Anal. Chem. 2007, 79, 4845-4851.
14. Huebner, A.; Olguin, L. F.; Bratton, D.; Whyte, G.; Huck, W. T.; de Mello, A. J.; Edel, J. B.; Abell, C.; Hollfelder, F. Anal. Chem. 2008, 80, 3890-3896.
15. Huebner, A.; Srisa-Art, M.; Holt, D.; Abell, C.; Hollfelder, F.; deMello, A. J.; Edel, J. B. Chem. Commun. (Cambridge, U.K.) 2007, 1218-1220.
16. Clausell-Tormos, J.; Lieber, D.; Baret, J. C.; El-Harrak, A.; Miller, O. J.; Frenz, L.; Blouwolff, J.; Humphry, K. J.; Koster, S.; Duan, H.; Holtze, C.; Weitz, D. A.; Griffiths, A. D.; Merten, C. A. Chem. Biol. 2008, 15, 427-437.
17. Boedicker, J. Q.; Li, L.; Kline, T. R.; Ismagilov, R. F. Lab Chip 2008, 8, 1265-1272.
18. Burns, M. A.; Johnson, B. N.; Brahmasandra, S. N.; Handique, K; Webster, J. R.; Krishnan, M.; Sammarco, T. S.; Man, P. M.; Jones, D.; Heldsinger, D.; Mastrangelo, C. H.; Burke, D. T. Science 1998, 282, 484-487.
19. Srisa-Art, M.; deMello, A. J.; Edel, J. B. Anal. Chem. 2007, 79, 6682-6689.
20. Curcio, M.; Roeraade, J. Anal. Chem. 2003, 75, 1-7.
21. Dorfman, K. D.; Chabert, M.; Codarbox, J. H.; Rousseau, G.; de Cremoux, P.; Viovy, J. L. Anal. Chem. 2005, 77, 3700-3704.
22. Chabert, M.; Dorfman, K. D.; de Cremoux, P.; Roeraade, J.; Viovy, J. L. Anal. Chem. 2006, 78, 7722-7728.
23. Beer, N. R.; Hindson, B. J.; Wheeler, E. K.; Hall, S. B.; Rose, K. A.; Kennedy, I. M.; Colston, B. W. Anal. Chem. 2007, 79, 8471-8475. Beer, N. R.; Wheeler, E. K.; Lee-Houghton, L.; Watkins, N.; Nasarabadi, S.; Hebert, N.; Leung, P.; Arnold, D. W.; Bailey, C. G.; Colston, B. W. Anal. Chem. 2008, 80, 1854-1858.
24. Kiss, M. M.; Ortoleva-Donnelly, L.; Beer, N. R.; Warner, J.; Bailey, C. G.; Colston, B. W.; Rothberg, J. M.; Link, D. R.; Leamon, J. H.; Anal Chem. 2008, 80, (23), 8975-8981.
25. Kumaresan, P.; Yang, C. J.; Cronier, S. A.; Blazej, R. G.; Mathies, R. A Anal. Chem. 2008, 80, 3522-3529.
26. Schaerli, Y.; Wootton, R. C.; Robinson, T.; Stein, V.; Dunsby, C.; Neil, M. A. A.; French, P. M. W.; deMello, A. J.; Abell, C.; Hollfelder, F. Anal. Chem. 2009, 81, 302-306.
27. Dittrich, P. S.; Jahnz, M.; Schwille, P. ChemBioChem 2005, 6, 811-814.
28. Courtois, F.; Olguin, L. F.; Whyte, G.; Bratton, D.; Huck, W. T.; Abell, C.; Hollfelder, F. ChemBioChem 2008, 9, 439-446.
29. Zheng, B.; Roach, L S.; Ismagilov, R. F. J. Am. Chem. Soc. 2003, 125, 11170-11171.
30. Zheng, B.; Tice, J. D.; Ismagilov, R. F. Anal. Chem. 2004, 76, 4977-4982.
31. Yadav, M. K.; Gerdts, C. J.; Sanishvili, R.; Smith, W. W.; Roach, L. S.; Ismagilov, R. F.; Kuhn, P.; Stevens, R. C. J. Appl. Crystallogr. 2005, 38, 900-905.
32. Chen, D. L.; Gerdts, C. J.; Ismagilov, R. F. J. Am. Chem. Soc. 2005, 127, 9672-9673.
33. Chen, D. L.; Li, L.; Reyes, S.; Adamson, D. N.; Ismagilov, R. F. Langmuir 2007, 23, 2255-2260.
34. Shim, J. U.; Cristobal, G.; Link, D. R.; Thorsen, T.; Jia, Y.; Piattelli, K; Fraden, S. J. Am. Chem. Soc. 2007, 129, 8825-8835.
35. Aharoni, A.; Griffiths, A. D.; Tawfik, D. S. Curr. Opin. Chem. Biol. 2005, 9, 210-216.
36. Bernath, K.; Hai, M.; Mastrobattista, E.; Griffiths, A. D.; Magdassi, S.; Tawfik, D. S. Anal. Biochem. 2004, 325, 151-157.
37. Burns, J. R.; Ramshaw, C. Lab Chip 2001, 1, 10-15.
38. Chen, H.; Fang, Q.; Yin, X. F.; Fang, Z. L. Lab Chip 2005, 5, 719-725.
39. Koroleva, M. Y.; Yurtov, E. V. J. Colloid Interface Sci. 2006, 297, 778-784.
40. Kralj, J. G.; Schmidt, M. A.; Jensen, K. F. Lab Chip 2005, 5, 531-535.
41. Kumemura, M.; Korenaga, T. Anal. Chim. Acta 2006, 558, 75-79.
42. Mary, P.; Studer, V.; Tabeling, P. Anal. Chem. 2008, 80, 2680-2687.
43. Önal, Y.; Lucas, M.; Claus, P. Chem. Eng. Technol. 2005, 28, 972-978.
44. Zheng, B.; Tice, J. D.; Roach, L. S.; Ismagilov, R. F. Angew. Chem., Int. Ed. 2004, 43, 2508-2511.
45. Dummann, G.; Quittmann, U.; Groschel, L.; Agar, D. W.; Worz, O.; Morgenschweis, K. Catal. Today 2003, 79-80, 433-439.
46. Cygan, Z. T.; Cabral, J. T.; Beers, K. L.; Amis, E. J. Langmuir 2005, 21, 3629-3634.
47. de Mas, N.; Gunther, A.; Schmidt, M. A.; Jensen, K. F. Ind. Eng. Chem. Res. 2003, 42, 698-710.
48. Günther, P. M.; Möller, F. T.; Henkel, T.; Köhler, J. M.; Gross, G. A. Chem. Eng. Technol. 2005, 28, 520-527.
49. Poe, S. L.; Cummings, M. A.; Haaf, M. P.; McQuade, D. T. Angew. Chem., Int. Ed. 2006, 45, 1544-1548.
50. Scheigetz, J.; Gilbert, M.; Zamboni, R. Org. Pret). Proc. Int. 1997, 29, 561-568.
51. Campbell, R. E.; Tour, O.; Palmer, A. E.; Steinbach, P. A.; Baird, G. S.; Zacharias, D. A.;Tsien, R. Y. Proc. Natl Acad. Sci. U.S.A. 2002, 99, 7877-7882.
52. Koster, S.; Angile, F. E.; Duan, H.; Agresti, J. J.; Wintner, A.; Schmitz, C.; Rowat, A. C.; Merten, C. A.; Pisignano, D.; Griffiths, A. D.; Weitz, D. A. Lab Chip 2008, 8, 1110-1115.
53. Bjerregaard, S.; Pedersen, H.; Vedstesen, H.; Vermehren, C.; Soderberg, I.; Frokjaer, S. Int. J. Pharm. 2001, 215, 13-27.
54. Mehta, S. K.; Kaur, G.; Bhasin, K. K. Colloids Surf., B 2007, 60, 95-104.
55. Garti, N. Colloids Surf., A 1997, 123-124, 233-246.
56. Hai, M.; Magdassi, S. J. Controlled Release 2004, 96, 393-402.
57. Pays, K.; Giermanska-Kahn, J.; Pouligny, B.; Bibette, J.; Leal-Calderon, F. J. Controlled Release 2002, 79, 193-205.
58. Sela, Y.; Magdassi, S.; Garti, N. J. Controlled Release 1995, 33, 1-12.
59. Bibette, J.; Leal Calderon, F.; Poulin, P. Rep. Prog. Phys. 1999, 62, 969-1033.
60. Hai, M.; Bernath, K.; Tawfik, D.; Magdassi, S. Langmuir 2004, 20, 2081-2085.
61. Cheng, J.; Chen, J. F.; Zhao, M.; Luo, Q.; Wen, L. X.; Papadopoulos, K. D. J. Colloid Interface Sci. 2007, 305, 175-182.
62. Wen, L.; Papadopoulos, K. D. Colloids Surf., A 2000, 174, 159-167.
63. Weinstein, J. N.; Yoshikami, S.; Henkart, P.; Blumenthal, R.; Hagins, W. A. Science 1977, 195, 489-492.
64. Ariyaprakai, S.; Dungan, S. R. Langmuir 2008, 24, 3061-3069.
65. Garti, N.; Aserin, A.; Cohen, Y. J. Controlled Release 1994, 29, 41-51.
66. Mastrobattista, E.; Taly, V.; Chanudet, E.; Treacy, P.; Kelly, B. T.; Griffiths, A. D. Chem. Biol. 2005, 12, 1291-1300.
67. Rotman, B. Proc. Natl. Acad. Sci. U.S.A. 1961, 47, 1981-1991.
68. Holtze, C.; Rowat, A. C.; Agresti, J. J.; Hutchison, J. B.; Angile, F. E.; Schmitz, C. H.; Koster, S.; Duan, H.; Humphry, K. J.; Scanga, R. A.; Johnson, J. S.; Pisignano, D.; Weitz, D. A. Lab Chip 2008, 8, 1632-1639.
69. a values for these molecules are unknown.