Mesenchymal stem cells and inflammatory cardiomyopathy: Cardiac homing and beyond

Cardiology Research and Practice

Volumn 1, Issue 1, 2011, Pages

  Tschope C ^a   Van Linthout, S ^a   Stamm, Ch ^a   Schultheiss, H P ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON; GELATINASE A; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; MATRIX METALLOPROTEINASE 14; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; STROMAL CELL DERIVED FACTOR 1ALPHA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ANGIOGENESIS; CARDIOMYOPATHY; CELL ACTIVATION; CELL ADHESION; CELL DIFFERENTIATION; CELL HOMING; CELL MIGRATION; COXSACKIE VIRUS B; CYTOKINE PRODUCTION; EXTRACELLULAR MATRIX; HEART INFARCTION; HEART PROTECTION; HUMAN; IMMUNOMODULATION; INFLAMMATORY CARDIOMYOPATHY; INFLAMMATORY DISEASE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 79959483605     PISSN: None     EISSN: 20900597     Source Type: Journal    
DOI: 10.4061/2011/757154     Document Type: Review

References (71)

1. Aretz H. T., Billingham M. E., Edwards W. D., Factor S. M., Fallon J. T., Fenoglio J. J., Olsen E. G., Schoen F. J., Myocarditis. A histopathologic definition and classification The American Journal of Cardiovascular Pathology 1987 1 1 3 14
2. Frustaci A., Russo M. A., Chimenti C., Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study European Heart Journal 2009 30 16 1995 2002
3. Khl U., Pauschinger M., Schwimmbeck P. L., Seeberg B., Lober C., Noutsias M., Poller W., Schultheiss H. P., Interferon- treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction Circulation 2003 107 22 2793 2798 (Pubitemid 36705988)
4. Staudt A., Herda L. R., Trimpert C., Lubenow L., Landsberger M., Drr M., Hummel A., Eckerle L. G., Beug D., Mller C., Hoffmann W., Weitmann K., Klingel K., Kandolf R., Kroemer H. K., Greinacher A., Felix S. B., Fcgamma-receptor IIa polymorphism and the role of immunoadsorption in cardiac dysfunction in patients with dilated cardiomyopathy Clinical Pharmacology and Therapeutics 2010 87 4 452 458
5. Nagaya N., Kangawa K., Itoh T., Iwase T., Murakami S., Miyahara Y., Fujii T., Uematsu M., Ohgushi H., Yamagishi M., Tokudome T., Mori H., Miyatake K., Kitamura S., Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy Circulation 2005 112 8 1128 1135 (Pubitemid 41216119)
6. Quevedo H. C., Hatzistergos K. E., Oskouei B. N., Feigenbaum G. S., Rodriguez J. E., Valdes D., Pattany P. M., Zambrano J. P., Hu Q., McNiece I., Heldman A. W., Hare J. M., Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity Proceedings of the National Academy of Sciences of the United States of America 2009 106 33 14022 14027
7. Yerebakan C., Kaminski A., Liebold A., Steinhoff G., Safety of intramyocardial stem cell therapy for the ischemic myocardium: results of the Rostock trial after 5-year follow-up Cell Transplantation 2007 16 9 935 940 (Pubitemid 351448611)
8. Hare J. M., Traverse J. H., Henry T. D., Dib N., Strumpf R. K., Schulman S. P., Gerstenblith G., DeMaria A. N., Denktas A. E., Gammon R. S., Hermiller J. B., Reisman M. A., Schaer G. L., Sherman W., A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction Journal of the American College of Cardiology 2009 54 24 2277 2286
9. Van Ramshorst J., Bax J. J., Beeres S. L. M. A., Dibbets-Schneider P., Roes S. D., Stokkel M. P. M., De Roos A., Fibbe W. E., Zwaginga J. J., Boersma E., Schalij M. J., Atsma D. E., Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial Journal of the American Medical Association 2009 301 19 1997 2004
10. Li J. H., Zhang N., Wangi J. A., Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy Journal of Endocrinological Investigation 2008 31 2 103 110 (Pubitemid 351596969)
11. Mias C., Lairez O., Trouche E., Roncalli J., Calise D., Seguelas M. H., Ordener C., Piercecchi-Marti M. D., Auge N., Salvayre A. N., Bourin P., Parini A., Cussac D., Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction Stem Cells 2009 27 11 2734 2743
12. Sorrell J. M., Baber M. A., Caplan A. I., Influence of adult mesenchymal stem cells on in vitro vascular formation Tissue EngineeringPart A 2009 15 7 1751 1761
13. Ren G., Zhang L., Zhao X., Xu G., Zhang Y., Roberts A. I., Zhao R. C., Shi Y., Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide Cell Stem Cell 2008 2 2 141 150 (Pubitemid 351181031)
14. van Linthout S., Savvatis K., Miteva K., Mesenchymal stem cells improve murine acute Coxsackievurs B3-induced myocarditis European Heart Journal 2010
15. Ohnishi S., Yanagawa B., Tanaka K., Miyahara Y., Obata H., Kataoka M., Kodama M., Ishibashi-Ueda H., Kangawa K., Kitamura S., Nagaya N., Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis Journal of Molecular and Cellular Cardiology 2007 42 1 88 97 (Pubitemid 44958630)
16. Prockop D. J., Marrow stromal cells as stem cells for nonhematopoietic tissues Science 1997 276 5309 71 74 (Pubitemid 27161245)
17. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells Science 1999 284 5411 143 147 (Pubitemid 29282067)
18. Haynesworth S. E., Baber M. A., Caplan A. I., Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies Bone 1992 13 1 69 80
19. Ohnishi S., Sumiyoshi H., Kitamura S., Nagaya N., Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions FEBS Letters 2007 581 21 3961 3966 (Pubitemid 47212103)
20. Xu X., Xu Z., Xu Y., Cui G., Selective down-regulation of extracellular matrix gene expression by bone marrow derived stem cell transplantation into infarcted myocardium Circulation Journal 2005 69 10 1275 1283 (Pubitemid 41382953)
21. Li L., Zhang Y., Li Y., Yu BO., Xu Y., Zhao S., Guan Z., Mesenchymal stem cell transplantation attenuates cardiac fibrosis associated with isoproterenol-induced global heart failure Transplant International 2008 21 12 1181 1189
22. Jiang X. X., Zhang YI., Liu B., Zhang S. X., Wu Y., Yu X. D., Mao N., Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells Blood 2005 105 10 4120 4126 (Pubitemid 40656164)
23. Krampera M., Cosmi L., Angeli R., Pasini A., Liotta F., Andreini A., Santarlasci V., Mazzinghi B., Pizzolo G., Vinante F., Romagnani P., Maggi E., Romagnani S., Annunziato F., Role for interferon- in the immunomodulatory activity of human bone marrow mesenchymal stem cells Stem Cells 2006 24 2 386 398 (Pubitemid 44464808)
24. Sotiropoulou P. A., Perez S. A., Gritzapis A. D., Baxevanis C. N., Papamichail M., Interactions between human mesenchymal stem cells and natural killer cells Stem Cells 2006 24 1 74 85
25. Meisel R., Zibert A., Laryea M., Gbel U., Dubener W., Dilloo D., Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation Blood 2004 103 12 4619 4621 (Pubitemid 38745993)
26. Xu G., Zhang Y., Zhang L., Ren G., Shi Y., The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells Biochemical and Biophysical Research Communications 2007 361 3 745 750 (Pubitemid 47238033)
27. Schuleri K. H., Amado L. C., Boyle A. J., Centola M., Saliaris A. P., Gutman M. R., Hatzistergos K. E., Oskouei B. N., Zimmet J. M., Young R. G., Heldman A. W., Lardo A. C., Hare J. M., Early improvement in cardiac tissue perfusion due to mesenchymal stem cells American Journal of Physiology 2008 294 5 H2002 H2011
28. Oswald J., Boxberger S., Jrgensen B., Feldmann S., Ehninger G., Bornhuser M., Werner C., Mesenchymal stem cells can be differentiated into endothelial cells in vitro Stem Cells 2004 22 3 377 384 (Pubitemid 38736621)
29. Hung S. C., Pochampally R. R., Chen S. Y. C., Hsu S. C., Prockop D. J., Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis Stem Cells 2007 25 9 2363 2370 (Pubitemid 47480496)
30. Kinnaird T., Burnett E. S., Shou M., Lee C. W., Barr S., Fuchs S., Epstein S. E., Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms Circulation 2004 109 12 1543 1549 (Pubitemid 38420184)
31. Prather W. R., Toren A., Meiron M., Ofir R., Tschope C., Horwitz E., The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemi Cytotherapy 2009 11 4 427 434
32. Nagaya N., Fujii T., Iwase T., Ohgushi H., Itoh T., Uematsu M., Yamagishi M., Mori H., Kangawa K., Kitamura S., Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis American Journal of Physiology 2004 287 6 H2670 H2676
33. Sheng H., Wang Y., Jin Y., Zhang Q., Zhang Y., Wang LI., Shen B., Yin S., Liu W., Cui L., Li N., A critical role of IFN in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1 Cell Research 2008 18 8 846 857
34. Ren G., Zhao X., Zhang L., Zhang J., L'Huillier A., Ling W., Roberts A. I., Le A. D., Shi S., Shao C., Shi Y., Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression Journal of Immunology 2010 184 5 2321 2328
35. Oh I., Ozaki K., Sato K., Meguro A., Tatara R., Hatanaka K., Nagai T., Muroi K., Ozawa K., Interferon- and NF- B mediate nitric oxide production by mesenchymal stromal cells Biochemical and Biophysical Research Communications 2007 355 4 956 962 (Pubitemid 46366921)
36. Razavi H. M., Hamilton J. A., Feng Q., Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure Pharmacology and Therapeutics 2005 106 2 147 162 (Pubitemid 40613056)
37. Zell R., Markgraf R., Schmidtke M., Grlach M., Stelzner A., Henke A., Sigusch H. H., Glck B., Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice Medical Microbiology and Immunology 2004 193 2-3 91 100 (Pubitemid 38703776)
38. Kemp K., Gray E., Mallam E., Scolding N., Wilkins A., Inflammatory cytokine induced regulation of superoxide dismutase 3 expression by human mesenchymal stem cells Stem Cell Reviews and Reports 2010 6 4 548 559
39. Chamberlain G., Fox J., Ashton B., Middleton J., Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing Stem Cells 2007 25 11 2739 2749 (Pubitemid 350127858)
40. Ponte A. L., Marais E., Gallay N., Langonné A., Delorme B., Hérault O., Charbord P., Domenech J., The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities Stem Cells 2007 25 7 1737 1745 (Pubitemid 47121852)
41. Ringe J., Strassburg S., Neumann K., Endres M., Notter M., Burmester G. R., Kaps C., Sittinger M., Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2 Journal of Cellular Biochemistry 2007 101 1 135 146 (Pubitemid 46652579)
42. Honczarenko M., Le Y. I., Swierkowski M., Ghiran I., Glodek A. M., Silberstein L. E., Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors Stem Cells 2006 24 4 1030 1041 (Pubitemid 44464736)
43. Kucia M., Jankowski K., Reca R., Wysoczynski M., Bandura L., Allendorf D. J., Zhang J., Ratajczak J., Ratajczak M. Z., CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion Journal of Molecular Histology 2004 35 3 233 245 (Pubitemid 40585309)
44. Ceradini D. J., Kulkarni A. R., Callaghan M. J., Tepper O. M., Bastidas N., Kleinman M. E., Capla J. M., Galiano R. D., Levine J. P., Gurtner G. C., Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 Nature Medicine 2004 10 8 858 864 (Pubitemid 39070860)
45. Askari A. T., Unzek S., Popovićc Z. B., Goldman C. K., Forudi F., Kiedrowski M., Rovner A., Ellis S. G., Thomas J. D., DiCorleto P. E., Topol E. J., Penn M. S., Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy The Lancet 2003 362 9385 697 703 (Pubitemid 37101067)
46. Pillarisetti K., Gupta S. K., Cloning and relative expression analysis of rat stromal cell derived factor-1 (SDF-1): SDF-1 mRNA is selectively induced in rat model of myocardial infarction Inflammation 2001 25 5 293 300 (Pubitemid 34093585)
47. Abbott J. D., Huang Y., Liu D., Hickey R., Krause D. S., Giordano F. J., Stromal cell-derived factor-1 plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury Circulation 2004 110 21 3300 3305 (Pubitemid 39557491)
48. Yamani M. H., Ratliff N. B., Cook D. J., Tuzcu E. M., Yu Y., Hobbs R., Rincon G., Bott-Silverman C., Young J. B., Smedira N., Starling R. C., Peritransplant ischemic injury is associated with up-regulation of stromal cell-derived factor-1 Journal of the American College of Cardiology 2005 46 6 1029 1035 (Pubitemid 41316511)
49. Zhang D., Fan G. C., Zhou X., Zhao T., Pasha Z., Xu M., Zhu YI., Ashraf M., Wang Y., Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium Journal of Molecular and Cellular Cardiology 2008 44 2 281 292
50. Schenk S., Mal N., Finan A., Zhang M., Kiedrowski M., Popovićc Z., McCarthy P. M., Penn M. S., Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor Stem Cells 2007 25 1 245 251 (Pubitemid 46052996)
51. Shen Y., Xu W., Chu Y. I. W., Wang Y., Liu Q. S., Xiong S. I. D., Coxsackievirus group B type 3 infection upregulates expression of monocyte chemoattractant protein 1 in cardiac myocytes, which leads to enhanced migration of mononuclear cells in viral myocarditis Journal of Virology 2004 78 22 12548 12556 (Pubitemid 39458773)
52. Belema-Bedada F., Uchida S., Martire A., Kostin S., Braun T., Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2 Cell Stem Cell 2008 2 6 566 575 (Pubitemid 351729213)
53. Wynn R. F., Hart C. A., Corradi-Perini C., O'Neill L., Evans C. A., Wraith J. E., Fairbairn L. J., Bellantuono I., A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow Blood 2004 104 9 2643 2645 (Pubitemid 39434942)
54. Shi M., Li J., Liao L., Chen B., Li B., Chen L., Jia H., Zhao R. C., Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice Haematologica 2007 92 7 897 904 (Pubitemid 350144236)
55. Croitoru-Lamoury J., Lamoury F. M. J., Zaunders J. J., Veas L. A., Brew B. J., Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-, and copaxone Journal of Interferon and Cytokine Research 2007 27 1 53 64 (Pubitemid 46185062)
56. Rster B., Gttig S., Ludwig R. J., Bistrian R., Mller S., Seifried E., Gille J., Henschler R., Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells Blood 2006 108 12 3938 3944 (Pubitemid 44864580)
57. Krampera M., Pizzolo G., Aprili G., Franchini M., Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair Bone 2006 39 4 678 683 (Pubitemid 44311724)
58. Segers V. F. M., Van Riet I., Andries L. J., Lemmens K., Demolder M. J., De Becker A. J. M. L., Kockx M. M., De Keulenaer G. W., Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms American Journal of Physiology 2006 290 4 H1370 H1377
59. Huang J., Zhang Z., Guo J., Ni A., Deb A., Zhang L., Mirotsou M., Pratt R. E., Dzau V. J., Genetic modification of mesenchymal stem cells overexpressing ccr1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium Circulation Research 2010 106 11 1753 1762
60. Song H., Chang W., Lim S., Seo H. S., Chi Y. S., Park S., Yoo K. J., Kim B. S., Min B. H., Lee H., Jang Y., Chung N., Hwang KI. C., Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells Stem Cells 2007 25 6 1431 1438 (Pubitemid 47106010)
61. Song S. W., Chang W., Song B. W., Song H., Lim S., Kim H. J., Cha M. J., Choi E., Im S. H., Chang B. C., Chung N., Jang Y., Hwang KI. C., Integrin-linked kinase is required in hypoxic mesenchymal stem cells for strengthening cell adhesion to ischemic myocardium Stem Cells 2009 27 6 1358 1365
62. Schmidt A., Ladage D., Steingen C., Brixius K., Schinkthe T., Klinz F. J., Schwinger R. H. G., Mehlhorn U., Bloch W., Mesenchymal stem cells transmigrate over the endothelial barrier European Journal of Cell Biology 2006 85 11 1179 1188 (Pubitemid 44524624)
63. Steingen C., Brenig F., Baumgartner L., Schmidt J., Schmidt A., Bloch W., Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells Journal of Molecular and Cellular Cardiology 2008 44 6 1072 1084
64. Ries C., Egea V., Karow M., Kolb H., Jochum M., Neth P., MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines Blood 2007 109 9 4055 4063 (Pubitemid 46641761)
65. Freyman T., Polin G., Osman H., Crary J., Lu M., Cheng L., Palasis M., Wilensky R. L., A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction European Heart Journal 2006 27 9 1114 1122
66. Swirski F. K., Nahrendorf M., Etzrodt M., Wildgruber M., Cortez-Retamozo V., Panizzi P., Figueiredo J. L., Kohler R. H., Chudnovskiy A., Waterman P., Aikawa E., Mempel T. R., Libby P., Weissleder R., Pittet M. J., Identification of splenic reservoir monocytes and their deployment to inflammatory sites Science 2009 325 5940 612 616
67. Frangogiannis N. G., Smith C. W., Entman M. L., The inflammatory response in myocardial infarction Cardiovascular Research 2002 53 1 31 47 (Pubitemid 34020764)
68. Leuschner F., Panizzi P., Chico-Calero I., Lee W. W., Ueno T., Cortez-Retamozo V., Waterman P., Gorbatov R., Marinelli B., Iwamoto Y., Chudnovskiy A., Figueiredo J.-L., Sosnovik D. E., Pittet M. J., Swirski F. K., Weissleder R., Nahrendorf M., Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction Circulation Research 2010 107 11 1364 1373
69. Matteucci D., Toniolo A., Conaldi P. G., Systemic lymphoid atrophy in coxsackievirus B3-infected mice: effects of virus and immunopotentiating agents Journal of Infectious Diseases 1985 151 6 1100 1108 (Pubitemid 15065983)
70. Klingel K., Stephan S., Sauter M., Zell R., McManus B. M., Bltmann B., Kandolf R., Pathogenesis of murine enterovirus myocarditis: virus dissemination and immune cell targets Journal of Virology 1996 70 12 8888 8895 (Pubitemid 26378473)
71. Plumas J., Chaperot L., Richard M. J., Molens J. P., Bensa J. C., Favrot M. C., Mesenchymal stem cells induce apoptosis of activated T cells Leukemia 2005 19 9 1597 1604 (Pubitemid 43090404)