The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells

Biochemical and Biophysical Research Communications

Volumn 361, Issue 3, 2007, Pages 745-750

  Xu, Guangwu ^a   Zhang, Yingyu ^a   Zhang, Liying ^a   Ren, Guangwen ^a   Shi, Yufang ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Cytokines; Lymphocytes; Mesenchymal stem cells

Indexed keywords

INTERLEUKIN 6;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DEATH; CELL INTERACTION; CELL PROTECTION; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; INHIBITION KINETICS; LYMPHOCYTE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DNA; INTERLEUKIN-6; LYMPHOCYTES; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL;

EID: 34547791338     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.07.052     Document Type: Article

References (33)

1. Uccelli A., Pistoia V., and Moretta L. Mesenchymal stem cells: a new strategy for immunosuppression?. Trends in Immunology 28 5 (2007) 219-226
2. Bartholomew A., Sturgeon C., Siatskas M., et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Experimental Hematology 30 1 (2002) 42-48
3. Rasmusson I. Immune modulation by mesenchymal stem cells. Experimental Cell Research 312 12 (2006) 2169-2179
4. Le Blanc K., and Ringden O. Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation 11 5 (2005) 321-334
5. Uccelli A., Zappia E., Benvenuto F., Frassoni F., and Mancardi G. Stem cells in inflammatory demyelinating disorders: a dual role for immunosuppression and neuroprotection. Expert Opinion on Biological Therapy 6 1 (2006) 17-22
6. Ringden O., Uzunel M., Rasmusson I., et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 81 10 (2006) 1390-1397
7. Le Blanc K., Rasmusson I., Sundberg B., et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363 9419 (2004) 1439-1441
8. Welch P.A., Burrows P.D., Namen A., Gillis S., and Cooper M.D. Bone marrow stromal cells and interleukin-7 induce coordinate expression of the BP-1/6C3 antigen and pre-B cell growth. International Immunology 2 8 (1990) 697-705
9. Dorshkind K., and Landreth K.S. Regulation of B cell differentiation by bone marrow stromal cells. International Journal of Cell Cloning 10 1 (1992) 12-17
10. Ame-Thomas P., Maby-El Hajjami H., Monvoisin C., et al. Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis. Blood 109 2 (2007) 693-702
11. Ramasamy R., Lam E.W., Soeiro I., et al. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 21 2 (2007) 304-310
12. Zhu W., Xu W., Jiang R., et al. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Experimental and molecular pathology 80 3 (2006) 267-274
13. Siggs O.M., Makaroff L.E., and Liston A. The why and how of thymocyte negative selection. Current Opinion in Immunology 18 2 (2006) 175-183
14. Green D.R., Bissonnette R.P., Glynn J.M., and Shi Y. Activation-induced apoptosis in lymphoid systems. Seminars in Immunology 4 6 (1992) 379-388
15. Williams M.A., and Bevan M.J. Effector and memory CTL differentiation. Annual Review of Immunology 25 (2007) 171-192
16. Badovinac V.P., and Harty J.T. Programming, demarcating, and manipulating CD8+ T-cell memory. Immunological Reviews 211 (2006) 67-80
17. Xu G., Zhang L., Ren G., et al. Immunosuppressive properties of cloned bone marrow mesenchymal stem cells. Cell Research 17 3 (2007) 240-248
18. Wang R., and Shi Y.F. A simplified protocol for apoptosis assay by DNA content analysis. BioTechniques Suppl. (2002) 88-91
19. Zubiaga A.M., Munoz E., and Huber B.T. IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis. Journal of Immunology 149 1 (1992) 107-112
20. Mor F., and Cohen I.R. IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. Correlation with induction of Bcl-2. Journal of Immunology 156 2 (1996) 515-522
21. Pajusto M., Ihalainen N., Pelkonen J., Tarkkanen J., and Mattila P.S. Human in vivo-activated CD45R0(+) CD4(+) T cells are susceptible to spontaneous apoptosis that can be inhibited by the chemokine CXCL12 and IL-2, -6, -7, and -15. European Journal of Immunology 34 10 (2004) 2771-2780
22. Zamorano J., Mora A.L., Boothby M., and Keegan A.D. NF-kappa B activation plays an important role in the IL-4-induced protection from apoptosis. International Immunology 13 12 (2001) 1479-1487
23. Su L., and David M. Inhibition of B cell receptor-mediated apoptosis by IFN. Journal of Immunology 162 11 (1999) 6317-6321
24. Scheel-Toellner D., Pilling D., Akbar A.N., et al. Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta. European Journal of Immunology 29 8 (1999) 2603-2612
25. Pilling D., Akbar A.N., Girdlestone J., et al. Interferon-beta mediates stromal cell rescue of T cells from apoptosis. European Journal of Immunology 29 3 (1999) 1041-1050
26. Chang L., Crowston J.G., Sabin C.A., Khaw P.T., and Akbar A.N. Human tenon's fibroblast-produced ifnbeta and the prevention of t-cell apoptosis. Investigative Ophthalmology & Visual Science 42 7 (2001) 1531-1538
27. Curnow S.J., Scheel-Toellner D., Jenkinson W., et al. Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling. Journal of Immunology 173 8 (2004) 5290-5297
28. Teague T.K., Marrack P., Kappler J.W., and Vella A.T. IL-6 rescues resting mouse T cells from apoptosis. Journal of Immunology 158 12 (1997) 5791-5796
29. Ito H., Hirotani T., Yamamoto M., Ogawa H., and Kishimoto T. Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease. Journal of Gastroenterology 37 Suppl. 14 (2002) 56-61
30. Mudter J., Wirtz S., Galle P.R., and Neurath M.F. A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis. Pathobiology 70 3 (2002) 170-176
31. Kurita-Ochiai T., Ochiai K., Suzuki N., Otsuka K., and Fukushima K. Human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis. Infection and Immunity 70 5 (2002) 2361-2367
32. Atreya R., Mudter J., Finotto S., et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nature Medicine 6 5 (2000) 583-588
33. Benvenuto F., Ferrari S., Gerdoni E., et al. Human mesenchymal stem cells promote survival of T cells in a quiescent state. Stem Cells 25 7 (2007) 1753-1760