Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice

Medical Microbiology and Immunology

Volumn 193, Issue 2-3, 2004, Pages 91-100

  Zell, Roland ^a   Markgraf, René ^a   Schmidtke, Michaela ^a   Görlach, Matthias ^b   Stelzner, Axel ^a   Henke, Andreas ^a   Sigusch, Holger H ^c   Glück, Brigitte ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Enterovirus; Nitric oxide; S nitrosylation; Virus protease

Indexed keywords

4 PHENYL 3 FUROXANCARBONITRILE; GLYCERYL TRINITRATE; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOSORBIDE DINITRATE; LINSIDOMINE; METHYLISOTHIOUREA; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PROTEINASE 2A PROTEIN; PROTEINASE 3C PROTEIN; UNCLASSIFIED DRUG; VASODILATOR AGENT; VIRUS PROTEIN;

ANGINA PECTORIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BACTERIUM; CELL STRAIN; CLINICAL FEATURE; CONTROLLED STUDY; COXSACKIE VIRUS; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; MOUSE; MYOCARDITIS; NONHUMAN; OUTBRED STRAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; VIRUS INFECTION;

ANIMALS; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENTEROVIRUS B, HUMAN; ENTEROVIRUS INFECTIONS; HELA CELLS; HUMANS; ISOSORBIDE DINITRATE; MICE; MYOCARDITIS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITROGLYCERIN; PENICILLAMINE; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 2542547259     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-003-0198-6     Document Type: Article

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