Cannabioids and the brain: Review of MRI studies;Wirkung von cannabinoiden auf das gehirn: Ein überblick über MRI befunde

Sucht

Volumn 57, Issue 3, 2011, Pages 161-171

  Hermann, Derik ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Cannabis; CBD; MRI; THC

Indexed keywords

CANNABINOID DERIVATIVE; TETRAHYDROCANNABINOL;

AMYGDALOID NUCLEUS; ANTICIPATION; ATTENTION; BASAL GANGLION; BRAIN; BRAIN REGION; BRAIN SIZE; DRUG EFFECT; EMOTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; LEARNING; MOTOR PERFORMANCE; NERVE CELL PLASTICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREFRONTAL CORTEX; REVIEW; REWARD; WHITE MATTER; WORKING MEMORY;

EID: 79959481970     PISSN: 09395911     EISSN: None     Source Type: Journal    
DOI: 10.1024/0939-5911.a000108     Document Type: Review

References (68)

1. Ameri, A. (1999). The effects of cannabinoids on the brain, Progress in Neurobiology, 58, 315-348.
2. Arnone, D., Barrick, T.R., Chengappa, S., Mackay, C.E., Clark, C.A. &Abou-Saleh,M.T. (2008). Corpus callosum damage in heavy marijuana use: preliminary evidence from diffusion tensor tractography and tract-based spatial statistics, Neuro-image, 41, 1067-1074.
3. Ashtari, M., Cervellione, K., Cottone, J., Ardekani, B.A., Sevy, S. & Kumra, S. (2009). Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use. Journal of Psychiatric Research, 43, 189-204.
4. Bava, S., Frank, L.R., McQueeny, T., Schweinsburg, B.C., Schweinsburg, A.D. & Tapert, S.F. (2009). Altered white matter microstructure in adolescent substance users. Psychiatry Research, 173, 228-237.
5. Becker, B.,Wagner,D., Gouzoulis-Mayfrank, E., Spuentrup, E.& Daumann, J. (2010a). The impact of early-onset cannabis use on functional brain correlates of working memory. Progress in Neuropsychopharmacolgy & Biological Psychiatry, 34, 837-845.
6. Becker, B.,Wagner,D., Gouzoulis-Mayfrank, E., Spuentrup, E.& Daumann, J. (2010b). Altered parahippocampal functioning in cannabis users is related to the frequency of use. Psychopharmacology (Berl), 209, 361-374.
7. Berghuis, P., Rajnicek, A.M., Morozov, Y.M., Ross, R.A., Mulder, J., Urbán, G.M. et al. (2007). Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science, 316, 1212-1216. (Pubitemid 46880959)
8. Bhattacharyya, S., Morrison, P.D., Fusar-Poli, P., Martin-Santos, R., Borgwardt, S., Winton-Brown, T. et al. (2010). Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology, 35, 764-774.
9. Bhattacharyya, S., Fusar-Poli, P., Borgwardt, S., Martin-Santos, R., Nosarti, C., O'Carroll, C. et al. (2009). Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis. Archives of General Psychiatry, 66, 442-451.
10. Block, R. I., O'Leary, D.S., Ehrhardt, J.C., Augustinack, J.C., Ghoneim, M.M., Arndt, S. et al. (2000). Effects of frequent marijuana use on brain tissue volume and composition. Neuroreport, 11, 491-496.
11. Borgwardt, S. J., Allen, P., Bhattacharyya, S., Fusar-Poli, P., Crippa, J.A., Seal, M.L. et al. (2008). Neural basis of Delta-9- tetrahydrocannabinol and cannabidiol: effects during response inhibition. Biological Psychiatry, 64 966-973.
12. Boulanger, Y., Labelle, M. & Khiat, A. (2000). Role of phospholipase A(2) on the variations of the choline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases. Brain Research Brain Research Reviews, 33, 380-389.
13. Chan, G.C.K., Hinds, T.R., Impey, S. & Storm, D.R. (1998). Hippocampal neurotoxicity of delta-9-tetrahydrocannabinol. Journal of Neuroscience, 18, 5322-5332.
14. Chang, L., Cloak, C., Yakupov, R. & Ernst, T. (2006a). Combined and independent effects of chronic marijuana use and HIVon brain metabolites. Journal of Neuroimmune Pharmacology, 1, 65-76. (Pubitemid 44257501)
15. Chang, L., Yakupov, R., Cloak, C. & Ernst, T. (2006b). Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain, 129(Pt 5), 1096-1112.
16. Cheung, J.T., Mann, R. E., Ialomiteanu, A., Stoduto,G., Chan,V., Ala-Leppilampi, K. et al. (2010). Anxiety and mood disorders and cannabis use. American Journal of Drug and Alcohol Abuse, 36, 118-122.
17. Crippa, J.A., Zuardi, A.W.,Martín-Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P. et al. (2009). Cannabis and anxiety: a critical review of the evidence. Human Psychopharmacology, 24, 515-523.
18. DeLisi, L. E., Bertisch, H.C., Szulc, K.U., Majcher, M., Brown, K., Bappal, A. et al. (2006). A preliminary DTI study showing no brain structural change associated with adolescent cannabis use. Harm Reduction Journal, 3, 17.
19. Demirakca, T., Sartorius, A., Ende, G., Meyer, N., Welzel H., Skopp, G. et al. (2011). Diminished Gray Matter in the Hippocampus of Cannabis Users: Possible Protective Effects of Cannabidiol. Drug and Alcohol Dependence, 114, 242-245.
20. Everitt, B. J. & Robbins,T.W. (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nature Neuroscience, 8, 1481-1489. (Pubitemid 41573659)
21. Filbey, F.M., Schacht, J.P., Myers, U.S., Chavez, R.S. & Hutchison, K.E. (2010). Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology, 35, 967-75.
22. Filbey, F.M., Schacht, J.P., Myers, U.S., Chavez, R.S. & Hutchison, K.E. (2009). Marijuana craving in the brain. Proceedings of the National Academy of Sciences of the United States of America, 106, 13016-13021.
23. Fusar-Poli, P.,Allen, P., Bhattacharyya, S., Crippa, J.A.,Mechelli, A., Borgwardt, S. et al. (2010). Modulation of effective connectivity during emotional processing by Delta 9-tetrahydro-cannabinol and cannabidiol. International Journal of Neuropsychopharmacology, 13, 421-432.
24. Fusar-Poli, P., Crippa, J.A., Bhattacharyya, S., Borgwardt, S. J., Allen, P., Martin-Santos, R. et al. (2009). Distinct effects of {delta}9- tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Archives of General Psychiatry, 66, 95-105.
25. Gonzalez, R., Carey, C. & Grant, I. (2002). Nonacute (residual) neuropsychological effects of cannabis use: a qualitative analysis and systematic review. Journal of Clinical Pharmacology, 42, 48S-57S.
26. Grant, I., Gonzalez, R., Carey, C.L., Natarajan, L. & Wolfson, T. (2003). Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study. Journal of the International Neuropsychological Society, 9, 679-689. (Pubitemid 36889595)
27. Gruber, S.A. & Yurgelun-Todd, D.A. (2005) Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation. Brain Research Cognitive Brain Research, 23, 107-118. (Pubitemid 40417511)
28. Gruber, S.A., Rogowska, J. & Yurgelun-Todd, D.A. (2009). Altered affective response in marijuana smokers: an FMRI study. Drug and Alcohol Dependence, 105, 139-153.
29. Hall,W.&Solowij, N. (1998). Adverse effects of cannabis. Lancet, 352, 1611-1616.
30. Hampson, A.J., Grimaldi, M., Axelrod, J. & Wink, D. (1998). Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences USA, 95, 8268-8273. (Pubitemid 28326102)
31. Hampson, A.J. & Grimaldi, M. (2001). Cannabinoid receptor activation and elevated cyclic AMP reduce glutamate neurotoxicity. European Journal of Neuroscience, 13, 1529-1536. (Pubitemid 32423339)
32. Hermann, D., Sartorius, A., Welzel, H., Walter, S., Skopp, G., Ende, G. et al. (2007). Dorsolateral prefrontal cortex N-acetylaspartate/ total creatine (NAA/tCr) loss in male recreational cannabis users. Biological Psychiatry, 61, 1281-1289. (Pubitemid 46726261)
33. Hester, R., Nestor, L. & Garavan, H. (2009). Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users. Neuropsychopharmacology, 34, 2450-2458.
34. Jacobus, J., McQueeny, T., Bava, S., Schweinsburg, B.C., Frank, L.R., Yang, T.T. et al. (2009). White matter integrity in adolescents with histories of marijuana use and binge drinking. Neurotoxicology and Teratology, 31, 349-355.
35. Jager, G., Kahn, R.S., Van Den Brink, W., Van Ree, J.M. & Ramsey, N.F. (2006). Long-term effects of frequent cannabis use on working memory and attention: an fMRI study. Psychopharmacology (Berl), 185, 358-368.
36. Jager, G., Van Hell, H.H., De Win, M.M., Kahn, R.S., Van Den Brink, W., Van Ree, J.M. et al. (2007). Effects of frequent cannabis use on hippocampal activity during an associative memory task. European Neuropsychopharmacology, 17, 289-297. (Pubitemid 46156994)
37. Kanayama, G., Rogowska, J., Pope, H.G., Gruber, S.A. & Yurgelun-Todd, D.A. (2004). Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology (Berl), 176, 239-247.
38. Kim, D. & Thayer, S.A., (2001). Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture. The Journal of Neuroscience, 21, RC146.
39. Koethe, D. & Schulz-Lutzer, P. (2005). The endocannabinoid modulator cannabidiol as an antipsychotic. Pharmacopsychiatry, 38, 260.
40. Landfield, P.W., Cadwallader, L.B. & Vinsant, S., (1988). Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems. Brain Research, 443, 47-62. (Pubitemid 18062771)
41. Lastres-Becker, I., Molina-Holgado, F.,Ramos, J.A., Mechoulam, R. & Fernandez-Ruiz, J. (2005). Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease. Neurobiology of Disease, 19, 96-107. (Pubitemid 40544727)
42. Leweke, F.M., Gerth, C.W. & Klosterkötter, J. (2004). Cannabis associated psychosis: current status of research. CNS Drugs, 18, 895-910. (Pubitemid 39612018)
43. Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A. et al. (2003). CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science, 302, 84-88. (Pubitemid 37210691)
44. Mato, S., Chevaleyre, V., Robbe, D., Pazos, A., Castillo, P.E. & Manzoni,O. J. (2004).Asingle in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity. Nature Neuroscience, 7, 585-586. (Pubitemid 38691895)
45. Matochik, J.A., Eldreth, D.A., Cadet, J. L. & Bolla, K. I., (2005). Altered brain tissue composition in heavy marijuana users. Drug and Alcohol Dependence, 77, 23-30. (Pubitemid 39656096)
46. Mishima, K., Hayakawa, K., Abe, K., Ikeda, T., Egashira, N., Iwasaki, K. et al. (2005). Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1 A receptor dependent mechanism. Stroke, 36, 1077-1082.
47. Molina-Holgado, E., Vela, J.M., Arévalo-Martín, A., Almazán, G., Molina-Holgado, F., Borrell, J. et al. (2002). Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. The Journal of Neuroscience, 22, 9742-9753. (Pubitemid 35332857)
48. Movsesyan, V.A., Stoica, B.A., Yakovlev, A.G., Knoblach, S.M., Lea, P.M. 4th, Cernak, I. et al. (2004). Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Cell Death and Differentiation, 11, 1121-1132. (Pubitemid 39341638)
49. Nagayama, T., Sinor, A.D., Simon, R.P., Chen, J., Graham, S.H., Jin, K. et al. (1999). Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. The Journal of Neuroscience, 19, 2987-2995. (Pubitemid 29173995)
50. Nestor, L., Hester, R. & Garavan, H. (2010). Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users. Neuroimage, 49, 1133-1143.
51. Nestor, L., Roberts, G., Garavan, H. & Hester, R. (2008). Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users. Neuroimage, 40, 1328-1339.
52. Padula, C.B., Schweinsburg, A.D. & Tapert, S.F. (2007). Spatial working memory performance and fMRI activation interaction in abstinent adolescent marijuana users. Psychology of Addictive Behaviours, 21, 478-487.
53. Panikashvili, D., Simeonidou, C., Ben-Shabat, S., Hanus, L., Breuer, A., Mechoulam, R. et al. (2001). An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature, 413, 527-531. (Pubitemid 32938751)
54. Phan, K. L., Angstadt, M., Golden, J., Onyewuenyi, I., Popovska, A. & deWit, H. (2008). Cannabinoid modulation of amygdala reactivity to social signals of threat in humans. The Journal of Neuroscience, 28, 2313-2319.
55. Pillay, S.S., Rogowska, J., Kanayama,G.,Gruber, S., Simpson, N., Pope, H.G. et al. (2008). Cannabis and motor function: fMRI changes following 28 days of discontinuation. Experimantal and Clinical Psychopharmacology, 16, 22-32. (Pubitemid 351305492)
56. Potter, D. J., Clark, P. & Brown, M.B. (2008). Potency of delta 9- THC and other cannabinoids in cannabis in England in 2005: implications for psychoactivity and pharmacology. Journal of Forensic Sciences, 53, 90-94. (Pubitemid 351239216)
57. Romero, J., Berrendero, F., Manzanares, J., Pérez, A., Corchero, J., Fuentes, J.A. et al. (1998). Time-course of the cannabinoid receptor down-regulation in the adult rat brain caused by repeated exposure to delta9-tetrahydrocannabinol. Synapse, 30, 298-308. (Pubitemid 28447177)
58. Sartorius, A., Henn, F.A. & Ende, G. (2006). Proton magnetic resonance spectroscopy as a monitoring tool for electroconvulsive therapy effects on the brain. Current Psychiatry Reviews, 2, 39-49. (Pubitemid 44027868)
59. Scallet, A.C., Uemura, E., Andrews, A., Ali, S.F., McMillan, D. E., Paule M.G. et al. (1987). Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC). Brain Research, 436, 193-198
60. Schweinsburg, A.D., Nagel, B. J., Schweinsburg, B.C., Park, A., Theilmann, R.J. & Tapert, S.F. (2008). Abstinent adolescent marijuana users show altered fMRI response during spatial working memory. Psychiatry Research, 163, 40-51.
61. Skopp, G., Strohbeck-Kuehner, P., Mann, K. & Hermann, D. (2007). Deposition of cannabinoids in hair after long-term use of cannabis. Forensic Science International, 170, 46-50. (Pubitemid 46991190)
62. Soares Vde, P., Campos, A.C., Bortoli, V.C., Zangrossi, H. Jr., Guimarães, F.S. & Zuardi, A.W. (2010). Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1 A receptors. Behavioural Brain Research, 213, 225-229.
63. Tapert, S.F., Schweinsburg, A.D., Drummond, S.P., Paulus,M.P., Brown, S.A., Yang, T.T. et al. (2007). Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology (Berl), 194, 173-183. (Pubitemid 47457945)
64. Tzilos, G.K., Cintron, C.B., Wood, J.B., Simpson, N.S., Young, A.D., Pope, H.G. Jr. et al. (2005). Lack of hippocampal volume change in long-term heavy cannabis users. The American Journal on Addictions, 14, 64-72. (Pubitemid 40204735)
65. VanHell, H.H.,Vink, M.,Ossewaarde, L., Jager,G.,Kahn, R.S.& Ramsey, N.F. (2010). Chronic effects of cannabis use on the human reward system: an fMRI study. European Neuropsychopharmacology, 20, 153-163.
66. Wagner, J.A., Járai, Z., Bátkai, S. & Kunos, G. (2001). Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors. European Journal of Pharmacology, 423, 203-210. (Pubitemid 32614159)
67. Yücel, M., Solowij, N., Respondek, C., Whittle, S., Fornito, A., Pantelis, C. et al. (2008). Regional brain abnormalities associated with long-term heavy cannabis use. Archives of General Psychiatry, 65, 694-701. (Pubitemid 351787240)
68. Zanelati, T.V., Biojone, C., Moreira, F.A., Guimarães, F.S. & Joca, S.R. (2010). Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1 A receptors. British Journal of Pharmacology, 159, 122-128.