Effects of peripherally administered neuromedin U on energy and glucose homeostasis

Endocrinology

Volumn 152, Issue 7, 2011, Pages 2644-2654

  Peier, Andrea M ^a   Desai, Kunal ^a   Hubert, James ^a   Du, Xiaobing ^a   Yang, Liming ^a   Qian, Ying ^a   Kosinski, Jennifer R ^a   Metzger, Joseph M ^a   Pocai, Alessandro ^a   Nawrocki, Andrea R ^a   Langdon, Ronald B ^a   Marsh, Donald J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; NEUROMEDIN U; NEUROMEDIN U RECEPTOR 1; UNCLASSIFIED DRUG;

ARTICLE; BODY TEMPERATURE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; GLUCOSE HOMEOSTASIS; METABOLIC RATE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

ANIMALS; APPETITE REGULATION; BASAL METABOLISM; BODY TEMPERATURE REGULATION; DIABETES MELLITUS; ENERGY METABOLISM; FOOD PREFERENCES; GLUCOSE INTOLERANCE; ISOENZYMES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MOLECULAR TARGETED THERAPY; NEUROPEPTIDES; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROTRANSMITTER; WEIGHT LOSS;

EID: 79959396179     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1463     Document Type: Article

References (59)

1. Field BC, Chaudhri OB, Bloom SR 2009 Obesity treatment: novel peripheral targets. Br J Clin Pharmacol 68:830-843
2. Moran TH, Dailey MJ 2009 Minireview: gut peptides: targets for antiobesity drug development? Endocrinology 150:2526-2530
3. Delzenne N, Blundell J, Brouns F, Cunningham K, De Graaf K, Erkner A, Lluch A, Mars M, Peters HP, Westerterp-Plantenga M 2010 Gastrointestinal targets of appetite regulation in humans. Obes Rev 11:234-250
4. Field BC, Chaudhri OB, Bloom SR 2010 Bowels control brain: gut hormones and obesity. Nat Rev Endocrinol 6:444-453
5. Karra E, Batterham RL 2010 The role of gut hormones in the regulation of body weight and energy homeostasis. Mol Cell Endocrinol 316:120-128
6. Wolnerhanssen B, Beglinger C 2010 Therapeutic potential of gut peptides. Forum Nutr 63:54-63
7. Brighton PJ, Szekeres PG, Willars GB 2004 Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 56:231-248 (Pubitemid 38720830)
8. Mitchell JD, Maguire JJ, Davenport AP 2009 Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. Br J Pharmacol 158:87-103
9. Ballesta J, Carlei F, Bishop AE, Steel JH, Gibson SJ, Fahey M, Hennessey R, Domin J, Bloom SR, Polak JM 1988 Occurrence and developmental pattern of neuromedin U-immunoreactive nerves in the gastrointestinal tract and brain of the rat. Neuroscience 25:797-816
10. Nakashima Y, Ida T, Sato T, Nakamura Y, Takahashi T, Mori K, Miyazato M, Kangawa K, Kusukawa J, Kojima M 2010 Neuromedin U is necessary for normal gastrointestinal motility and is regulated by serotonin. Ann NY Acad Sci 1200:104-111
11. Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Habata Y, Hinuma S, Onda H, Nishimura O, Fujino M 2000 Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. J Biol Chem 275:21068-21074 (Pubitemid 30481797)
12. Hedrick JA, Morse K, Shan L, Qiao X, Pang L, Wang S, Laz T, Gustafson EL, Bayne M, Monsma Jr FJ 2000 Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol Pharmacol 58:870-875
13. Hosoya M, Moriya T, Kawamata Y, Ohkubo S, Fujii R, Matsui H, Shintani Y, Fukusumi S, Habata Y, Hinuma S, Onda H, Nishimura O, Fujino M 2000 Identification and functional characterization of a novel subtype of neuromedin U receptor. J Biol Chem 275:29528-29532 (Pubitemid 32043829)
14. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams Jr DL, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q 2000 Identification of receptors for neuromedin U and its role in feeding. Nature 406:70-74 (Pubitemid 30460212)
15. Raddatz R, Wilson AE, Artymyshyn R, Bonini JA, Borowsky B, Boteju LW, Zhou S, Kouranova EV, Nagorny R, Guevarra MS, Dai M, Lerman GS, Vaysse PJ, Branchek TA, Gerald C, Forray C, Adham N 2000 Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J Biol Chem 275:32452-32459
16. Szekeres PG, Muir AI, Spinage LD, Miller JE, Butler SI, Smith A, Rennie GI, Murdock PR, Fitzgerald LR, Wu H, McMillan LJ, Guerrera S, Vawter L, Elshourbagy NA, Mooney JL, Bergsma DJ, Wilson S, Chambers JK 2000 Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J Biol Chem 275:20247-20250 (Pubitemid 30457595)
17. Nakazato M, Hanada R, Murakami N, Date Y, Mondal MS, Kojima M, Yoshimatsu H, Kangawa K, Matsukura S 2000 Central effects of neuromedin U in the regulation of energy homeostasis. Biochem Biophys Res Commun 277:191-194
18. Zeng H, Gragerov A, Hohmann JG, Pavlova MN, Schimpf BA, Xu H, Wu LJ, Toyoda H, Zhao MG, Rohde AD, Gragerova G, Onrust R, Bergmann JE, Zhuo M, Gaitanaris GA 2006 Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Mol Cell Biol 26:9352-9363 (Pubitemid 44904429)
19. Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ 2009 The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2). Endocrinology 150:3101-3109
20. Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M 2004 Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 10:1067-1073 (Pubitemid 39424867)
21. Kowalski TJ, Spar BD, Markowitz L, Maguire M, Golovko A, Yang S, Farley C, Cook JA, Tetzloff G, Hoos L, Del Vecchio RA, Kazdoba TM, McCool MF, Hwa JJ, Hyde LA, Davis H, Vassileva G, Hedrick JA, Gustafson EL 2005 Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice. J Endocrinol 185:151-164 (Pubitemid 40585076)
22. Hainerová I, Torekov SS, Ek J, Finková M, Borch-Johnsen K, Jørgensen T, Madsen OD, Lebl J, Hansen T, Pedersen O 2006 Association between neuromedin U gene variants and overweight and obesity. J Clin Endocrinol Metab 91:5057-5063 (Pubitemid 44917350)
23. Metzger JM, Gagen K, Raustad KA, Yang L, White A, Wang SP, Craw S, Liu P, Lanza T, Lin LS, Nargund RP, Guan XM, Strack AM, Reitman ML 2010 Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 (BRS-3) agonists and other potential obesity treatments. Am J Physiol Endocrinol Metab 299: E816-E824
24. van der Kleij H, O'Mahony C, Shanahan F, O'Mahony L, Bienenstock J 2008 Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve. Am J Physiol Regul Integr Comp Physiol 295:R1131-R1137
25. Moran TH, Baldessarini AR, Salorio CF, Lowery T, Schwartz GJ 1997 Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin. Am J Physiol 272:R1245-R1251
26. Roth KA, Kim S, Gordon JI 1992 Immunocytochemical studies suggest two pathways for enteroendocrine cell differentiation in the colon. Am J Physiol 263:G174-G180
27. Dietrich MO, Horvath TL 2009 Feeding signals and brain circuitry. Eur J Neurosci 30:1688-1696
28. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR 2002 Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:650-654
29. Challis BG, Pinnock SB, Coll AP, Carter RN, Dickson SL, O'Rahilly S 2003 Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem Biophys Res Commun 311:915-919 (Pubitemid 37393405)
30. Fan W, Ellacott KL, Halatchev IG, Takahashi K, Yu P, Cone RD 2004 Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Nat Neurosci 7:335-336 (Pubitemid 38429170)
31. Crawley JN, Kiss JZ, Mezey E 1984 Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats. Brain Res 322:316-321 (Pubitemid 15209389)
32. Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JR, Ghatei MA, Bloom SR 2005 The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 1044:127-131 (Pubitemid 40616060)
33. Koda S, Date Y, Murakami N, Shimbara T, Hanada T, Toshinai K, Niijima A, Furuya M, Inomata N, Osuye K, Nakazato M 2005 The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 146:2369-2375 (Pubitemid 40577525)
34. Roberge JN, Gronau KA, Brubaker PL 1996 Gastrin-releasing peptide is a novel mediator of proximal nutrient-induced proglucagon-derived peptide secretion from the distal gut. Endocrinology 137:2383-2388
35. Hansen L, Hartmann B, Bisgaard T, Mineo H, Jørgensen PN, Holst JJ 2000 Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum. Am J Physiol Endocrinol Metab 278:E1010-E1018 (Pubitemid 30439137)
36. Plaisancie P, Bernard C, Chayvialle JA, Cuber JC 1994 Regulation of glucagon-like peptide-1-(7-36) amide secretion by intestinal neurotransmitters and hormones in the isolated vascularly perfused rat colon. Endocrinology 135:2398-2403 (Pubitemid 24377394)
37. Herrmann-Rinke C, McGregor GP, Göke B 2000 Calcitonin gene-related peptide potently stimulates glucagon-like peptide-1 release in the isolated perfused rat ileum. Peptides 21:431-437 (Pubitemid 30227685)
38. Neary NM, Small CJ, Druce MR, Park AJ, Ellis SM, Semjonous NM, Dakin CL, Filipsson K, Wang F, Kent AS, Frost GS, Ghatei MA, Bloom SR 2005 Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively. Endocrinology 146:5120-5127 (Pubitemid 41653025)
39. Kotz CM, Teske JA, Billington CJ 2008 Neuroregulation of nonexercise activity thermogenesis and obesity resistance. Am J Physiol Regul Integr Comp Physiol 294:R699-R710 (Pubitemid 351346945)
40. Hanada R, Nakazato M, Murakami N, Sakihara S, Yoshimatsu H, Toshinai K, Hanada T, Suda T, Kangawa K, Matsukura S, Sakata T2001Arole for neuromedin U in stress response. Biochem Biophys Res Commun 289:225-228
41. Crawley JN, Beinfeld MC 1983 Rapid development of tolerance to the behavioural actions of cholecystokinin. Nature 302:703-706 (Pubitemid 13120271)
42. Olsson M, Herrington MK, Reidelberger RD, Permert J, Arnelo U 2007 Comparison of the effects of chronic central administration and chronic peripheral administration of islet amyloid polypeptide on food intake and meal pattern in the rat. Peptides 28:1416-1423 (Pubitemid 47096750)
43. Hanada T, Date Y, Shimbara T, Sakihara S, Murakami N, Hayashi Y, Kanai Y, Suda T, Kangawa K, Nakazato M 2003 Central actions of neuromedin U via corticotropin-releasing hormone. Biochem Biophys Res Commun 311:954-958 (Pubitemid 37393411)
44. Wren AM, Small CJ, Abbott CR, Jethwa PH, Kennedy AR, Murphy KG, Stanley SA, Zollner AN, Ghatei MA, Bloom SR 2002 Hypothalamic actions of neuromedin U. Endocrinology 143:4227-4234 (Pubitemid 35239552)
45. Jethwa PH, Smith KL, Small CJ, Abbott CR, Darch SJ, Murphy KG, Seth A, Semjonous NM, Patel SR, Todd JF, Ghatei MA, Bloom SR 2006 Neuromedin U partially mediates leptin-induced hypothalamo- pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat. Endocrinology 147:2886-2892 (Pubitemid 43764623)
46. Domínguez-Gerpe L, Rey-Méndez M 1997 Time-course of the murine lymphoid tissue involution during and following stressor exposure. Life Sci 61:1019-1027 (Pubitemid 27348670)
47. Ulrich-Lai YM, Figueiredo HF, Ostrander MM, Choi DC, Engeland WC, Herman JP 2006 Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner. Am J Physiol Endocrinol Metab 291:E965-E973
48. Deutsch JA, Hardy WT 1977 Cholecystokinin produces bait shyness in rats. Nature 266:196
49. Halatchev IG, Cone RD 2005 Peripheral administration of PYY(3- 36) produces conditioned taste aversion in mice. Cell Metab 1:159-168 (Pubitemid 43960603)
50. Mansouri A, Aja S, Moran TH, Ronnett G, Kuhajda FP, Arnold M, Geary N, Langhans W, Leonhardt M 2008 Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats. Am J Physiol Regul Integr Comp Physiol 295:R799-R805
51. Gantz I, Erondu N, Mallick M, Musser B, Krishna R, Tanaka WK, Snyder K, Stevens C, Stroh MA, Zhu H, Wagner JA, Macneil DJ, Heymsfield SB, Amatruda JM 2007 Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults. J Clin Endocrinol Metab 92:1754-1757 (Pubitemid 46997183)
52. Chavez M, Seeley RJ, Woods SC 1995 A comparison between effects of intraventricular insulin and intraperitoneal lithium chloride on three measures sensitive to emetic agents. Behav Neurosci 109:547-550
53. Makimura H, MizunoTM, Yang XJ, Silverstein J, Beasley J, Mobbs CV 2001 Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting. Diabetes 50:733-739 (Pubitemid 32242628)
54. Baggio LL, Drucker DJ 2007 Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2157 (Pubitemid 46711096)
55. Kaczmarek P, Malendowicz LK, Pruszynska-Oszmalek E, Wojciechowicz T, Szczepankiewicz D, Szkudelski T, Nowak KW 2006 Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets. Int J Mol Med 18:951-955
56. Kaczmarek P, Malendowicz LK, Fabis M, Ziolkowska A, Pruszynska- Oszmalek E, Sassek M, Wojciechowicz T, Szczepankiewicz D, Andralojc K, Szkudelski T, Strowski MZ, Nowak KW 2009 Does somatostatin confer insulinostatic effects of neuromedin U in the rat pancreas? Pancreas 38:208-212
57. Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, Guan XM, Jiang MM, Feng Y, Camacho RE, Shen Z, Frazier EG, Yu H, Metzger JM, Kuca SJ, Shearman LP, Gopal- Truter S, MacNeil DJ, Strack AM, MacIntyre DE, Vander Ploeg LH, Qian S 2002 Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci USA 99:3240-3245 (Pubitemid 34240616)
58. Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T 2006 A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice. Proc Natl Acad Sci USA 103:7154-7158
59. Inui A 2000 Transgenic study of energy homeostasis equation: implications and confounding influences. FASEB J 14:2158-2170