IgE and FcεRI regulation

Annals of the New York Academy of Sciences

Volumn 1050, Issue , 2005, Pages 73-88

  MacGlashan Jr , Donald ^a  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Antibody; Fc RI; FC RI subunit; Function; Ige; Receptor; Regulation; Role; Variant

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; RECEPTOR SUBUNIT; IMMUNOGLOBULIN E RECEPTOR;

ALLERGIC REACTION; ALTERNATIVE RNA SPLICING; ATOPY; BASOPHIL; CAPPING PHENOMENON; CELL FUNCTION; CELL TYPE; CONFERENCE PAPER; GENE EXPRESSION; GENE FUNCTION; GENETIC POLYMORPHISM; HUMAN; MAST CELL; NONHUMAN; ANIMAL; ATOPIC DERMATITIS; BIOLOGICAL MODEL; BLOOD; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; REVIEW;

ALTERNATIVE SPLICING; ANIMALS; BASOPHILS; DERMATITIS, ATOPIC; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN E; MODELS, IMMUNOLOGICAL; POLYMORPHISM, GENETIC; RECEPTORS, IGE;

EID: 23744445247     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1313.009     Document Type: Conference Paper

References (96)

1. WANG, B., A. RIEGER, O. KILGUS, et al. 1992. Epidermal Langerhans cells from normal human skin bind monomeric IgE via FcεRI. J. Exp. Med. 175: 1353-1365.
2. MAURER, D., E. FIEBIGER, B. REININGER, et al. 1994. Expression of functional high affinity immunoglobulin E receptors (FcεRI) on monocytes of atopic individuals. J. Exp. Med. 179: 745-750.
3. MAURER, D., S. FIEBIGER, C. EBNER, et al. 1996. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J. Immunol. 157:607-616.
4. KITA, H., M. KANEKO, K.R. BARTEMES, et al. 1999. Does IgE bind to and activate eosinophils from patients with allergy? J. Immunol. 162: 6901-6911.
5. GOUNNI, A.S., B. LAMKHIOUED, K. OCHIAI, et al. 1994. High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature 367: 183-186.
6. SEMINARIO, M.C., S.S. SAINI, D.W. MACGLASHAN, JR. & B.S. BOCHNER. 1999. Intracellular expression and release of FcεRIα by human eosinophils. J. Immunol. 162: 6893-6900.
7. GOUNNI, A.S., B. LAMKHIOUED, L. KOUSSIH, et al. 2001. Human neutrophils express the high-affinity receptor for immunoglobulin E (FcεRI): role in asthma. FASEB J. 15: 940-949.
8. JOSEPH, M., A.S. GOUNNI, J.P. KUSNIERZ, et al. 1997. Expression and functions of the high-affinity IgE receptor on human platelets and megakaryocyte precursors. Eur. J. Immunol. 27: 2212-2218.
9. BJERKE, T., H.J. HOFFMANN, E.I. CHRISTENSEN, et al. 1999. Regulation of FcεARI synthesis in human eosinophils. Int. Arch. Allergy Immunol. 118: 440-442.
10. TERADA, N., A. KONNO, Y. TERADA, et al. 1995. IL-4 upregulates FcεRIα-chain messenger RNA in eosinophils. J. Allergy Clin. Immunol. 96: 1161-1169.
11. MALVEAUX, F.J., M.C. CONROY, N.F.J. ADKINSON & L.M. LICHTENSTEIN. 1978. IgE receptors on human basophils: relationship to serum IgE concentration. J. Clin. Invest. 62: 176-181.
12. SAINI, S.S., A.D. KLION, S.M. HOLLAND, et al. 2000. The relationship between serum IgE and surface levels of FcεR on human leukocytes in various diseases: correlation of expression with FcεRI on basophils but not on monocytes or eosinophils. J. Allergy Clin. Immunol. 106: 514-520.
13. FURUICHI, K., J. RIVERA & C. ISERSKY. 1985. The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression. Proc. Natl. Acad. Sci. USA 82: 1522-1525.
14. HSU, C. & D. MACGLASHAN, JR. 1996. IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells. Immunol. Lett. 52: 129-134.
15. TORU, H., C. RA, S. NONOYAMA, et al. 1997. Induction of high affinity IgE receptor on human mast cells by IL-4. J. Allergy Clin. Immunol. 99: S103.
16. LANTZ, C.S., M. YAMAGUCHI, H.C. OETTGEN, et al. 1997. IgE regulates mouse basophil Fc epsilon RI expression in vivo. J. Immunol. 158: 2517-2521.
17. YAMAGUCHI, M., K. SAYAMA, K. YANO, et al. 1999. IgE enhances Fcεreceptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fcε receptor I expression and mediator release. J. Immunol. 162: 5455-5465.
18. GARMAN, S.C., B.A. WURZBURG, S.S. TARCHEVSKAYA, et al. 2000. Structure of the Fc fragment of human IgE bound to its high-affinity receptor FcεRIα. Nature 406: 259-266.
19. HENRY, A.J., J.P. COOK, J.M. MCDONNELL, et al. 1997. Participation of the N-terminal region of Cε3 in the binding of human IgE to its high-affinity receptor FcεRI. Biochemistry 36: 15568-15578.
20. GARMAN, S.C., S. SECHI, J.P. KINET & T.S. JARDETZKY. 2001. The analysis of the human high affinity IgE receptor FcεRIα from multiple crystal forms. J. Mol. Biol. 311: 1049-1062.
21. WURZBURG, B.A., S.C. GARMAN & T.S. JARDETZKY. 2000. Structure of the human IgE-Fc C epsilon 3-C epsilon 4 reveals conformational flexibility in the antibody effector domains. Immunity 13: 375-385.
22. MILLER, L., U. BLANK, H. METZGER & J.P. KINET. 1989. Expression of high-affinity binding of human immunoglobulin E by transfected cells. Science 244: 334-337.
23. HIRAOKA, S., Y. FURUMOTO, H. KOSEKI, et al. 1999. Fc receptor β subunit is required for full activation of mast cells through Fc receptor engagement. Int. Immunol. 11: 199-207.
24. FUNG-LEUNG, W.P., J. DE SOUSA-HITZLER, A. ISHAQUE, et al. 1996. Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor α chain respond to human IgE in mast cell degranulation and in allergic reactions. J. Exp. Med. 183: 49-56.
25. REISCHL, I.G., G.R. DUBOIS, S. PEIRITSCH, et al. 2000. Regulation of FcεRI expression on human monocytic cells by ligand and IL-4. Clin. Exp. Allergy 30: 1033-1040.
26. DUBOIS, G.R., I.G. REISCHL, S. PEIRITSCH, et al. 1999. Regulation of FcARI expression on monocytic cell lines. Int. Arch. Allergy Immunol. 118: 294-295.
27. SIHRA, B.S., O.M. KON, J.A. GRANT & A.B. KAY. 1997. Expression of high-affinity IgE receptors (Fc epsilon RI) on peripheral blood basophils, monocytes, and eosinophils in atopic and nonatopic subjects: relationship to total serum IgE concentrations. J. Allergy Clin. Immunol. 99: 699-706.
28. FOSTER, B., D.D. METCALFE & C. PRUSSIN. 2003. Human dendritic cell 1 and dendritic cell 2 subsets express FcεRI: correlation with serum IgE and allergic asthma. J. Allergy Clin. Immunol. 112: 1132-1138.
29. DONNADIEU, E., M.H. JOUVIN & J.P. KINET. 2000. A second amplifier function for the allergy-associated Fc(epsilon)RI-beta subunit. Immunity 12: 515-523.
30. LIN, S., C. CICAIA, A.M. SCHARENBERG & J.P. KINET. 1996. The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma- mediated cell activation signals. Cell 85: 985-995.
31. TORU, H., C. RA, S. NONOYAMA, et al. 1996. Induction of the high-affinity IgE receptor (Fc epsilon RI) on human mast cells by IL-4. Int. Immunol. 8: 1367-1373.
32. XIA, H.Z., Z. DU, S. CRAIG, et al. 1997. Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells. J. Immunol. 159: 2911-2921.
33. THOMPSON, H.L., D.D. METCALFE & J.P. KINET. 1990. Early expression of high-affinity receptor for immunoglobulin E (Fc epsilon RI) during differentiation of mouse mast cells and human basophils. J. Clin. Invest. 85: 1227-1233.
34. ZON, L.L, M.F. GURISH, R.L. STEVENS, et al. 1991. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J. Biol. Chem. 266: 22948-22953.
35. NISHIYAMA, C., T. YOKOTA, K. OKUMURA & C. RA. 1999. The transcription factors Elf-1 and GATA-1 bind to cell-specific enhancer elements of human high-affinity IgE receptor α-chain gene. J. Immunol. 163: 623-630.
36. COOKSON, W.O., P.A. SHARP, J.A. FAUX & J.M. HOPKIN. 1989. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1(8650): 1292-1295.
37. SHIRAKAWA, T., A. LI, M. DUBOWITZ, et al. 1994. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat. Genet. 7: 125-129.
38. SANDFORD, A.J., T. SHIRAKAWA, M.F. MOFFATT, et al. 1993. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet 341: 332-334.
39. PALMER, L.J., P.D. PARE, J.A. FAUX, et al. 1997. Fc epsilon R1-beta polymorphism and total serum IgE levels in endemically parasitized Australian aborigines. Am. J. Hum. Genet. 61: 182-188.
40. SHIRAKAWA, T., X.Q. MAO, S. SASAKI, et al. 1996. Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. Hum. Mol. Genet. 5: 2068.
41. LAPRISE, C., L.P. BOULET, J. MORISSETTE, et al. 2000. Evidence for association and linkage between atopy, airway hyper-responsiveness, and the β subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian population. Immunogenetics 51: 695-702.
42. NAGATA, H., H. MUTOH, K. KUMAHARA, et al. 2001. Association between nasal allergy and a coding variant of the FcεRIβ gene Glu237Gly in a Japanese population. Hum. Genet. 109: 262-266.
43. COX, H.E., M.F. MOFFATT, J.A. FAUX, et al. 1998. Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor. Br. J. Dermatol. 138: 182-187.
44. DONNADIEU, E., W.O. COOKSON, M.H. JOUVIN & J.P. KINET. 2000. Allergy-associated polymorphisms of the FcεRIβ subunit do not impact its two amplification functions. J. Immunol. 165: 3917-3922.
45. TRAHERNE, J.A., M.R. HILL, P. HYSI, et al. 2003. LD mapping of maternally and non-maternally derived alleles and atopy in FcεRI-β. Hum. Mol. Genet. 12: 2577-2585.
46. NISHIYAMA, C., Y. AKIZAWA, M. NISHIYAMA, et al. 2004. Polymorphisms in the FcεRIβ promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between FcεRIβ and atopy. J. Immunol. 173: 6458-6464.
47. DONNADIEU, E., M.H. JOUVIN, S. RANA, et al. 2003. Competing functions encoded in the allergy-associated F(c)εRIβ gene. Immunity 18: 665-674.
48. SAINI, S., J.J. RICHARDSON, C. WOFSY, et al. 2001. Expression and modulation of FcεRIα and FcεRIβ in human blood basophils. J. Allergy Clin. Immunol. 107: 832-841.
49. MAEDA, K., C. NISHIYAMA, T. TOKURA, et al. 2003. Regulation of cell type-specific mouse FcεRI β-chain gene expression by GATA-1 via four GATA motifs in the promoter. J. Immunol. 170: 334-340.
50. AKIZAWA, Y., C. NISHIYAMA, M. HASEGAWA, et al. 2003. Regulation of human FcεRIβ chain gene expression by Oct-1. Int. Immunol. 15: 549-556.
51. SHIKANAI, T, E.S. SILVERMAN, B.W. MORSe, et al. 2002. Sequence variants in the FcεRI alpha chain gene. J. Appl. Physiol. 93: 37-41.
52. HASEGAWA, M., C. NISHIYAMA, M. NISHIYAMA, et al. 2003. A novel -66T/C polymorphism in FcεRI α-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J. Immunol. 171: 1927-1933.
53. DOMBROWICZ, D., V. FLAMAND, I. MIYAJIMA, et al. 1997. Absence of FcεRI αchain results in upregulation of FcγRIII-dependent mast cell degranulation and anaphylaxis: evidence of competition between FcεRI and FcγRIII for limiting amounts of FcR β and γ chains. J. Clin. Invest. 99: 915-925.
54. WU, J., J.C. EDBERG, A.W. GIBSON & R.P. KIMBERLY. 2002. Conservation of FcεRI gamma chain coding region in normals and in SLE patients. Lupus 11: 42-45.
55. SHIUE, L., J. GREEN, O.M. GREEN, et al. 1995. Interaction of p72syk with the γ and βsubunits of the high-affinity receptor for immunoglobulin E, FcεRI. Mol. Cell. Biol. 15:272-281.
56. WILSON, B.S., N. KAPP, R.J. LEE, et al. 1995. Distinct functions of the FcεR1 γ and β subunits in the control of FcεR1-mediated tyrosine kinase activation and signaling responses in RBL-2H3 mast cells. J. Biol. Chem. 270: 4013-4022.
57. MACGLASHAN, D.W., JR., L.M. LICHTENSTEIN, J. MCKENZIE-WHITE, et al. 1999. Upregulation of FcεRI on human basophils by IgE antibody is mediated by interaction of IgE with FcεRI. J. Allergy Clin. Immunol. 104: 492-498.
58. MACGLASHAN, D.W., JR., J. MCKENZIE-WHITE, K. CHICHESTER, et al. 1998. In vitro regulation of FcεRIα expression on human basophils by IgE antibody. Blood 91: 1633-1643.
59. MACGLASHAN, D.W., JR., H.Z. XIA, L.B. SCHWARTZ & J.P. GONG. 2001. IgE-regulated loss, not IgE-regulated synthesis, controls expression of FcεRI in human basophils. J. Leukoc. Biol. 70: 207-218.
60. BORKOWSKI, T.A., M.H. JOUVIN, S.Y. LIN & J.P. KINET. 2001. Minimal requirements for IgE-mediated regulation of surface FcεRI. J. Immunol. 167: 1290-1296.
61. DAERON, M. & K. ISHIZAKA. 1986. Induction of Fc epsilon receptors on mouse macrophages and lymphocytes by homologous IgE. J. Immunol. 136: 1612-1619.
62. LEE, W.T. & D.H. CONRAD. 1986. Murine B cell hybridomas bearing ligand-inducible Fc receptors for IgE. J. Immunol. 136: 4573-45780.
63. LEE, W.T., M. RAO & D.H. CONRAD. 1987. The murine lymphocyte receptor for IgE. IV. The mechanism of ligand-specific receptor upregulation on B cells. J. Immunol. 139: 1191-1198.
64. KALESNIKOFF, J., M. HUBER, V. LAM, et al. 2001. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 14:801-811.
65. KITAURA, J., J. SONG, M. TSAI, et al. 2003. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI. Proc. Natl. Acad. Sci. USA 100: 12911-12916.
66. JAMES, L.C., P. ROVERSI & D.S. TAWFIK. 2003. Antibody multispecificity mediated by conformational diversity. Science 299: 1362-1367.
67. DAERON, M. & G.A. VOISIN. 1979. Mast cell membrane antigens and Fc receptors in anaphylaxis. I. Products of the major histocompatibility complex involved in alloantibody-induced mast cell activation. Immunology 38: 447-458.
68. WEIS, R.M., K. BALAKRISHNAN, B. SMITH & H.M. MCCONNELL. 1982. Stimulation of fluorescence in a small contact region between rat basophil leukemia cells and planar lipid membrane targets by coherent evanescent radiation. J. Biol. Chem. 257: 6440-6445.
69. COOPER, A.D., K. BALAKRISHNAN & H.M. MCCONNELL. 1981. Mobile haptens in liposomes stimulate serotonin release by rat basophil leukemia cells in the presence of specific immunoglobulin E. J. Biol. Chem. 256: 9379-9381.
70. BALAKRISHNAN, K., F.J. Hsu, A.D. COOPER & H.M. MCCONNELL. 1982. Lipid hapten containing membrane targets can trigger specific immunoglobulin E-dependent degranulation of rat basophil leukemia cells. J. Biol. Chem. 257: 6427-6433.
71. LIU, Z.J., H. HALEEM-SMITH, H. CHEN & H. METZGER. 2001. Unexpected signals in a system subject to kinetic proofreading. Proc. Natl. Acad. Sci. USA 98: 7289-7294.
72. ASAI, K., J. KITAURA, Y. KAWAKAMI, et al. 2001. Regulation of mast cell survival by IgE. Immunity 14: 791-800.
73. KITAURA, J., W. XIAO, M. MAEDA-YAMAMOTO, et al. 2004. Early divergence of Fcε receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J. Immunol. 173: 4317-4323.
74. MACGLASHAN, JR., D.W., B.S. BOCHNER, D.C. ADELMAN, et al. 1997. Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J. Immunol. 158: 1438-1445.
75. BECK, L.A., G.V. MARCOTTE, D. MACGLASHAN, et al. 2004. Omalizumab-induced reductions in mast cell FcεRI expression and function. J. Allergy Clin. Immunol. 114: 527-530.
76. MACGLASHAN, D. 2004. Loss of receptors and IgE in vivo during treatment with anti-IgE antibody. J. Allergy Clin. Immunol. 114: 1472-1474.
77. MACGLASHAN, D.W., JR. 1993. Releasability of human basophils: cellular sensitivity and maximal histamine release are independent variables. J. Allergy Clin. Immunol. 91: 605-615.
78. MACGLASHAN, D.W., JR. & L.M. LICHTENSTEIN. 1987. Basic characteristics of human lung mast cell desensitization. J. Immunol. 139: 501-505.
79. MACGLASHAN, D.W., JR., S.P. PETERS, J. WARNER & L.M. LICHTENSTEIN. 1986. Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links. J. Immunol. 136: 2231-2239.
80. SAINI, S.S., D.W. MACGLASHAN, JR., S.A. STERBINSKY, et al. 1999. Down-regulation of human basophil IgE and FCεRIα surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo. J. Immunol. 162: 5624-5630.
81. MACGLASHAN, D.W., JR. & J.T. SCHROEDER. 2000. Functional consequences of FcεRIα up-regulation by IgE in human basophils. J. Leukoc. Biol. 68: 479-486.
82. YAMAGUCHI, M., C.S. LANTZ, H.C. OETTGEN, et al. 1997. IgE enhances mouse mast cell FcεRI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J. Exp. Med. 185: 663-672.
83. DEVOUASSOUX, G., G. FOSTER, L.M. SCOTT, et al. 1999. Frequency and characterization of antigen-specific IL-4- and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects. J. Allergy Clin. Immunol. 104: 811-819.
84. SCHROEDER, J., L. LICHTENSTEIN, E. ROCHE, et al. 2001. IL-4 production by human basophils found in the lung following segmental allergen challenge. J. Allergy Clin. Immunol. 107: 265-271.
85. KASAIAN, M.T., M.J. CLAY, M.P. HAPP, et al. 1996. IL-4 production by allergen-stimulated primary cultures: identification of basophils as the major IL-4-producing cell type. Int. Immunol. 8: 1287-1297.
86. MITRE, E., R.T. TAYLOR, J. KUBOFCIK & T.B. NUTMAN. 2004. Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections. J. Immunol. 172: 2439-2445.
87. LUCCIOLI, S., D.T. BRODY, S. HASAN, et al. 2002. IgE(+), Kit(-), I-A/I-E(-) myeloid cells are the initial source of 11-4 after antigen challenge in a mouse model of allergic pulmonary inflammation. J. Allergy Clin. Immunol. 110: 117-124.
88. KHODOUN, M.V., T. OREKHOVA, C. POTTER, et al. 2004. Basophils initiate IL-4 production during a memory T-dependent response. J. Exp. Med. 200: 857-870.
89. MIN, B., M. PROUT, J. HU-LI, et al. 2004. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med. 200: 507-517.
90. VOEHRINGER, D., K. SHINKAI & R.M. LOCKSLEY. 2004. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 20: 267-277.
91. DURHAM, S.R., L. SMURTHWAITE & H.J. GOULD. 2000. Local IgE production. Am. J. Rhinol. 14: 305-307.
92. SMURTHWAITE, L., S.N. WALKER, D.R. WILSON, et al. 2001. Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur. J. Immunol. 31: 3422-3431.
93. WILSON, D.R., T.G. MERRETT, E.M. VARGA, et al. 2002. Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics. Am. J. Respir. Crit. Care Med. 165: 22-26.
94. GAUCHAT, J.F., S. HENCHOZ, G. MAZZEI, et al. 1993. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365: 340-343.
95. LAMERS, M.C. & P. YU. 1995. Regulation of IgE synthesis. Lessons from the study of IgE transgenic and CD23-deficient mice. Immunol. Rev. 148: 71-95.
96. PAYET, M. & D.H. CONRAD. 1999. IgE regulation in CD23 knockout and transgenic mice. Allergy 54: 1 125-1129.