-
1
-
-
33847638137
-
Estimates of the cancer incidence and mortality in Europe in 2006
-
Ferlay J., Autier P., Boniol M., et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007, 18(3):581-592.
-
(2007)
Ann Oncol
, vol.18
, Issue.3
, pp. 581-592
-
-
Ferlay, J.1
Autier, P.2
Boniol, M.3
-
2
-
-
0035467993
-
Global cancer statistics in the year 2000
-
Parkin D.M. Global cancer statistics in the year 2000. Lancet Oncol 2001, 2(9):533-543.
-
(2001)
Lancet Oncol
, vol.2
, Issue.9
, pp. 533-543
-
-
Parkin, D.M.1
-
3
-
-
63049133092
-
Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
-
Altekruse S.F., McGlynn K.A., Reichman M.E. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009, 27(9):1485-1491.
-
(2009)
J Clin Oncol
, vol.27
, Issue.9
, pp. 1485-1491
-
-
Altekruse, S.F.1
McGlynn, K.A.2
Reichman, M.E.3
-
4
-
-
0025761253
-
The role of chronic viral hepatitis in hepatocellular carcinoma in the United States
-
Di Bisceglie A.M., Order S.E., Klein J.L., et al. The role of chronic viral hepatitis in hepatocellular carcinoma in the United States. Am J Gastroenterol 1991, 86(3):335-338.
-
(1991)
Am J Gastroenterol
, vol.86
, Issue.3
, pp. 335-338
-
-
Di Bisceglie, A.M.1
Order, S.E.2
Klein, J.L.3
-
5
-
-
0036894480
-
NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States
-
Marrero J.A., Fontana R.J., Su G.L., et al. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 2002, 36:1349-1354.
-
(2002)
Hepatology
, vol.36
, pp. 1349-1354
-
-
Marrero, J.A.1
Fontana, R.J.2
Su, G.L.3
-
6
-
-
0037464510
-
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
-
Calle E.E., Rodriguez C., Walker-Thurmond K., et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults. N Engl J Med 2003, 348:1625-1638.
-
(2003)
N Engl J Med
, vol.348
, pp. 1625-1638
-
-
Calle, E.E.1
Rodriguez, C.2
Walker-Thurmond, K.3
-
7
-
-
0028302476
-
Obesity and cancer risk: a Danish record-linkage study
-
Møller H., Mellemgaard A., Lindvig K., et al. Obesity and cancer risk: a Danish record-linkage study. Eur J Cancer 1994, 30(3):344-350.
-
(1994)
Eur J Cancer
, vol.30
, Issue.3
, pp. 344-350
-
-
Møller, H.1
Mellemgaard, A.2
Lindvig, K.3
-
8
-
-
0035146815
-
A prospective study of obesity and cancer risk (Sweden)
-
Wolk A., Gridley G., Svensson M., et al. A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control 2001, 12(1):13-21.
-
(2001)
Cancer Causes Control
, vol.12
, Issue.1
, pp. 13-21
-
-
Wolk, A.1
Gridley, G.2
Svensson, M.3
-
9
-
-
1242352395
-
Obesity and diabetes as a risk factor for hepatocellular carcinoma
-
Regimbeau J.M., Colombat M., Mognol P., et al. Obesity and diabetes as a risk factor for hepatocellular carcinoma. Liver Transpl 2004, 10(2 Suppl 1):S69-S73.
-
(2004)
Liver Transpl
, vol.10
, Issue.2 SUPPL. 1
-
-
Regimbeau, J.M.1
Colombat, M.2
Mognol, P.3
-
10
-
-
34948867745
-
Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
-
Larsson S.C., Wolk A. Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies. Br J Cancer 2007, 97(7):1005-1008.
-
(2007)
Br J Cancer
, vol.97
, Issue.7
, pp. 1005-1008
-
-
Larsson, S.C.1
Wolk, A.2
-
11
-
-
20144369342
-
Sex steroids, carcinogenesis, and cancer progression
-
Castagnetta L., Granata O.M., Cocciadiferro L., et al. Sex steroids, carcinogenesis, and cancer progression. Ann N Y Acad Sci 2004, 1028:233-246.
-
(2004)
Ann N Y Acad Sci
, vol.1028
, pp. 233-246
-
-
Castagnetta, L.1
Granata, O.M.2
Cocciadiferro, L.3
-
12
-
-
0842277242
-
Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. American Heart Association; National Heart, Lung, and Blood Institute
-
Grundy S.M., Brewer H.B., Cleeman J.I., et al. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. American Heart Association; National Heart, Lung, and Blood Institute. Circulation 2004, 109(3):433-438.
-
(2004)
Circulation
, vol.109
, Issue.3
, pp. 433-438
-
-
Grundy, S.M.1
Brewer, H.B.2
Cleeman, J.I.3
-
13
-
-
0042330251
-
Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis
-
Rajala M.W., Scherer P.E. Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003, 144:3765-3773.
-
(2003)
Endocrinology
, vol.144
, pp. 3765-3773
-
-
Rajala, M.W.1
Scherer, P.E.2
-
14
-
-
33644888156
-
Liver disease in patients with diabetes mellitus
-
Harrison S.A. Liver disease in patients with diabetes mellitus. J Clin Gastroenterol 2006, 40:68-76.
-
(2006)
J Clin Gastroenterol
, vol.40
, pp. 68-76
-
-
Harrison, S.A.1
-
15
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
-
16
-
-
0842321807
-
Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
-
El-Serag H.B., Tran T., Everhart J.E. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004, 126(2):460-468.
-
(2004)
Gastroenterology
, vol.126
, Issue.2
, pp. 460-468
-
-
El-Serag, H.B.1
Tran, T.2
Everhart, J.E.3
-
17
-
-
0029821203
-
Excess risk of primary liver cancer in patients with diabetes mellitus
-
Adami H.O., Chow W.H., Nyrén O., et al. Excess risk of primary liver cancer in patients with diabetes mellitus. J Natl Cancer Inst 1996, 88(20):1472-1477.
-
(1996)
J Natl Cancer Inst
, vol.88
, Issue.20
, pp. 1472-1477
-
-
Adami, H.O.1
Chow, W.H.2
Nyrén, O.3
-
18
-
-
0030774675
-
Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark
-
Wideroff L., Gridley G., Mellemkjaer L., et al. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 1997, 89(18):1360-1365.
-
(1997)
J Natl Cancer Inst
, vol.89
, Issue.18
, pp. 1360-1365
-
-
Wideroff, L.1
Gridley, G.2
Mellemkjaer, L.3
-
19
-
-
15544382574
-
Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study
-
Davila J.A., Morgan R.O., Shaib Y., et al. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 2005, 54(4):533-539.
-
(2005)
Gut
, vol.54
, Issue.4
, pp. 533-539
-
-
Davila, J.A.1
Morgan, R.O.2
Shaib, Y.3
-
20
-
-
10644220306
-
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
-
Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
-
(2004)
Hepatology
, vol.40
, pp. 1387-1395
-
-
Browning, J.D.1
Szczepaniak, L.S.2
Dobbins, R.3
-
21
-
-
33746700131
-
Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures
-
Zelber-Sagi S., Nitzan-Kaluski D., Halpern Z., et al. Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures. Liver Int 2006, 26:856-863.
-
(2006)
Liver Int
, vol.26
, pp. 856-863
-
-
Zelber-Sagi, S.1
Nitzan-Kaluski, D.2
Halpern, Z.3
-
22
-
-
0037382786
-
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
-
Marchesini G., Bugianesi E., Forlani G., et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003, 37:917-923.
-
(2003)
Hepatology
, vol.37
, pp. 917-923
-
-
Marchesini, G.1
Bugianesi, E.2
Forlani, G.3
-
23
-
-
18244364864
-
NASH and insulin resistance: Insulin hyper-hypersecretion and specific association with the insulin resistance syndrome
-
Chitturi S., Abeygunasekera S., Farrell G.C., et al. NASH and insulin resistance: Insulin hyper-hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002, 35:373-379.
-
(2002)
Hepatology
, vol.35
, pp. 373-379
-
-
Chitturi, S.1
Abeygunasekera, S.2
Farrell, G.C.3
-
24
-
-
0033038672
-
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity
-
Matteoni C.A., Younossi Z.M., Gramlich T., et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999, 116:1413-1419.
-
(1999)
Gastroenterology
, vol.116
, pp. 1413-1419
-
-
Matteoni, C.A.1
Younossi, Z.M.2
Gramlich, T.3
-
25
-
-
34249668818
-
Epidemiology and natural history of NAFLD and NASH
-
Ong J.P., Younossi Z.M. Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis 2007, 11:1-16.
-
(2007)
Clin Liver Dis
, vol.11
, pp. 1-16
-
-
Ong, J.P.1
Younossi, Z.M.2
-
26
-
-
11144351102
-
The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies
-
Adams L.A., Sanderson S., Lindor K.D., et al. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 2005, 42:132-138.
-
(2005)
J Hepatol
, vol.42
, pp. 132-138
-
-
Adams, L.A.1
Sanderson, S.2
Lindor, K.D.3
-
27
-
-
73149120271
-
Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link
-
Siegel A.B., Zhu A.X. Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer 2009, 115:5651-5661.
-
(2009)
Cancer
, vol.115
, pp. 5651-5661
-
-
Siegel, A.B.1
Zhu, A.X.2
-
28
-
-
77955625142
-
Population-based risk factors and resource utilization for HCC: US perspective
-
Sanyal A., Poklepovic A., Moyneur E., et al. Population-based risk factors and resource utilization for HCC: US perspective. Curr Med Res Opin 2010, 26(9):2183-2191.
-
(2010)
Curr Med Res Opin
, vol.26
, Issue.9
, pp. 2183-2191
-
-
Sanyal, A.1
Poklepovic, A.2
Moyneur, E.3
-
29
-
-
77952730428
-
The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
-
Ascha M.S., Hanouneh I.A., Lopez R., et al. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 2010, 51(6):1972-1978.
-
(2010)
Hepatology
, vol.51
, Issue.6
, pp. 1972-1978
-
-
Ascha, M.S.1
Hanouneh, I.A.2
Lopez, R.3
-
30
-
-
77956927733
-
Prospective study of hepatocellular carcinoma in nonalcoholic steatohepatitis in comparison with hepatocellular carcinoma caused by chronic hepatitis C
-
Tokushige K., Hashimoto E., Yatsuji S., et al. Prospective study of hepatocellular carcinoma in nonalcoholic steatohepatitis in comparison with hepatocellular carcinoma caused by chronic hepatitis C. J Gastroenterol 2010, 45(9):960-967.
-
(2010)
J Gastroenterol
, vol.45
, Issue.9
, pp. 960-967
-
-
Tokushige, K.1
Hashimoto, E.2
Yatsuji, S.3
-
31
-
-
0043268063
-
Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
-
Hui J.M., Kench J.G., Chitturi S., et al. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. Hepatology 2003, 38(2):420-427.
-
(2003)
Hepatology
, vol.38
, Issue.2
, pp. 420-427
-
-
Hui, J.M.1
Kench, J.G.2
Chitturi, S.3
-
32
-
-
56649094325
-
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
-
Malhi H., Gores G.J. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis 2008, 28(4):360-369.
-
(2008)
Semin Liver Dis
, vol.28
, Issue.4
, pp. 360-369
-
-
Malhi, H.1
Gores, G.J.2
-
33
-
-
77649337140
-
Nonalcoholic fatty liver disease: pathology and pathogenesis
-
Tiniakos D.G., Vos M.B., Brunt E.M. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 2010, 5:145-171.
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 145-171
-
-
Tiniakos, D.G.1
Vos, M.B.2
Brunt, E.M.3
-
34
-
-
2942628012
-
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
-
Ueki K., Kondo T., Kahn C.R. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 2004, 24:5434-5446.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5434-5446
-
-
Ueki, K.1
Kondo, T.2
Kahn, C.R.3
-
35
-
-
0030061922
-
IRS-1 mediated kinase activity in TNF-a and obesity induced insulin resistance
-
Hotamisligil G.S., Peraldi A., Budavari A., et al. IRS-1 mediated kinase activity in TNF-a and obesity induced insulin resistance. Science 1996, 272:665-668.
-
(1996)
Science
, vol.272
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, A.2
Budavari, A.3
-
36
-
-
0033869778
-
Pathogenesis of liver fibrosis: the role of oxidative stress
-
Poli G. Pathogenesis of liver fibrosis: the role of oxidative stress. Mol Aspects Med 2000, 21:49-98.
-
(2000)
Mol Aspects Med
, vol.21
, pp. 49-98
-
-
Poli, G.1
-
37
-
-
18844389970
-
NASH: a mitochondrial disease
-
Pessayre D., Fromenty B. NASH: a mitochondrial disease. J Hepatol 2005, 42(6):928-940.
-
(2005)
J Hepatol
, vol.42
, Issue.6
, pp. 928-940
-
-
Pessayre, D.1
Fromenty, B.2
-
38
-
-
1242336980
-
Apoptosis: the nexus of liver injury and fibrosis
-
Canbay A., Friedman S., Gores G.J. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 2004, 39:273-278.
-
(2004)
Hepatology
, vol.39
, pp. 273-278
-
-
Canbay, A.1
Friedman, S.2
Gores, G.J.3
-
39
-
-
0033872030
-
Cytochrome dependent activation of caspase 3 by tumor necrosis factor requires induction of the mitochondrial permeability transition
-
Tafani M., Schneider T.G., Pastorino J.G., et al. Cytochrome dependent activation of caspase 3 by tumor necrosis factor requires induction of the mitochondrial permeability transition. Am J Pathol 2000, 156:2111-2121.
-
(2000)
Am J Pathol
, vol.156
, pp. 2111-2121
-
-
Tafani, M.1
Schneider, T.G.2
Pastorino, J.G.3
-
40
-
-
0036850924
-
The major lipid peroxidation product, trans-4 hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma
-
Hu W., Feng Z., Eveleigh J., et al. The major lipid peroxidation product, trans-4 hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis 2002, 23:1781-1789.
-
(2002)
Carcinogenesis
, vol.23
, pp. 1781-1789
-
-
Hu, W.1
Feng, Z.2
Eveleigh, J.3
-
41
-
-
0035810054
-
Regulation of the G2/M transition by p53
-
Taylor W.R., Stark G.R. Regulation of the G2/M transition by p53. Oncogene 2001, 20(15):1803-1815.
-
(2001)
Oncogene
, vol.20
, Issue.15
, pp. 1803-1815
-
-
Taylor, W.R.1
Stark, G.R.2
-
42
-
-
0030941458
-
P53, the cellular gatekeeper for growth and division
-
Levine A.J. p53, the cellular gatekeeper for growth and division. Cell 1997, 88(3):323-331.
-
(1997)
Cell
, vol.88
, Issue.3
, pp. 323-331
-
-
Levine, A.J.1
-
43
-
-
15244359632
-
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
-
Xu Z., Chen L., Leung L., et al. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A 2005, 102:4120-4125.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 4120-4125
-
-
Xu, Z.1
Chen, L.2
Leung, L.3
-
44
-
-
30944455145
-
Insulin resistance: a metabolic pathway to chronic liver disease
-
Bugianesi E., McCullough A.J., Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005, 42:987-1000.
-
(2005)
Hepatology
, vol.42
, pp. 987-1000
-
-
Bugianesi, E.1
McCullough, A.J.2
Marchesini, G.3
-
45
-
-
0035123520
-
Energy balance and cancer: the role of insulin and insulin-like growth factor-I
-
Kaaks R., Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc 2001, 60(1):91-106.
-
(2001)
Proc Nutr Soc
, vol.60
, Issue.1
, pp. 91-106
-
-
Kaaks, R.1
Lukanova, A.2
-
46
-
-
0032998168
-
Western nutrition and the insulin resistance syndrome: a link to breast cancer
-
Stoll B.A. Western nutrition and the insulin resistance syndrome: a link to breast cancer. Eur J Clin Nutr 1999, 53:83-87.
-
(1999)
Eur J Clin Nutr
, vol.53
, pp. 83-87
-
-
Stoll, B.A.1
-
47
-
-
4143074965
-
An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis
-
Alexia C., Fallot G., Lasfer M., et al. An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol 2004, 68:1003-1015.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1003-1015
-
-
Alexia, C.1
Fallot, G.2
Lasfer, M.3
-
48
-
-
65449165664
-
Impact of insulin resistance on the progression of chronic liver diseases
-
Kaji K., Yoshiji H., Kitade M., et al. Impact of insulin resistance on the progression of chronic liver diseases. Int J Mol Med 2008, 22:801-808.
-
(2008)
Int J Mol Med
, vol.22
, pp. 801-808
-
-
Kaji, K.1
Yoshiji, H.2
Kitade, M.3
-
49
-
-
0032923859
-
Insulin and IGF-I receptors signaling in protection from apoptosis
-
Prisco M., Romano G., Peruzzi F., et al. Insulin and IGF-I receptors signaling in protection from apoptosis. Horm Metab Res 1999, 31(2-3):80-89.
-
(1999)
Horm Metab Res
, vol.31
, Issue.2-3
, pp. 80-89
-
-
Prisco, M.1
Romano, G.2
Peruzzi, F.3
-
50
-
-
0346725866
-
The role of the IGF axis in hepatocarcinogenesis
-
Scharf J.G., Braulke T. The role of the IGF axis in hepatocarcinogenesis. Horm Metab Res 2003, 35:685-693.
-
(2003)
Horm Metab Res
, vol.35
, pp. 685-693
-
-
Scharf, J.G.1
Braulke, T.2
-
51
-
-
0036828754
-
Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma
-
Price J.A., Kovach S.J., Johnson T. Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. Hepatology 2002, 36(5):1089-1097.
-
(2002)
Hepatology
, vol.36
, Issue.5
, pp. 1089-1097
-
-
Price, J.A.1
Kovach, S.J.2
Johnson, T.3
-
52
-
-
0022872017
-
Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes
-
Stumpo D.J., Blackshear P.J. Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes. Proc Natl Acad Sci U S A 1986, 83(24):9453-9457.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, Issue.24
, pp. 9453-9457
-
-
Stumpo, D.J.1
Blackshear, P.J.2
-
53
-
-
24044536590
-
Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma
-
Boissan M., Beurel E., Wendum D., et al. Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma. Am J Pathol 2005, 167:869-877.
-
(2005)
Am J Pathol
, vol.167
, pp. 869-877
-
-
Boissan, M.1
Beurel, E.2
Wendum, D.3
-
54
-
-
67649448956
-
Molecular mechanisms involved in NAFLD progression
-
Malaguarnera M., Di Rosa M., Nicoletti F., et al. Molecular mechanisms involved in NAFLD progression. J Mol Med 2009, 87(7):679-695.
-
(2009)
J Mol Med
, vol.87
, Issue.7
, pp. 679-695
-
-
Malaguarnera, M.1
Di Rosa, M.2
Nicoletti, F.3
-
55
-
-
59149105815
-
Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9
-
Chen J.S., Wang Q., Fu X.H., et al. Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9. Hepatol Res 2009, 39(2):177-186.
-
(2009)
Hepatol Res
, vol.39
, Issue.2
, pp. 177-186
-
-
Chen, J.S.1
Wang, Q.2
Fu, X.H.3
-
57
-
-
43749120732
-
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
-
Carnero A., Blanco-Aparicio C., Renner O., et al. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 2008, 8:187-198.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, pp. 187-198
-
-
Carnero, A.1
Blanco-Aparicio, C.2
Renner, O.3
-
58
-
-
0033604585
-
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
-
Kandel E.S., Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 1999, 253(1):210-229.
-
(1999)
Exp Cell Res
, vol.253
, Issue.1
, pp. 210-229
-
-
Kandel, E.S.1
Hay, N.2
-
59
-
-
0034845958
-
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
-
Lawlor M.A., Alessi D.R. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?. J Cell Sci 2001, 114(Pt 16):2903-2910.
-
(2001)
J Cell Sci
, vol.114
, Issue.PART 16
, pp. 2903-2910
-
-
Lawlor, M.A.1
Alessi, D.R.2
-
60
-
-
11844259994
-
Fasting serum glucose level and cancer risk in Korean men and women
-
Jee S.H., Ohrr H., Sull J.W., et al. Fasting serum glucose level and cancer risk in Korean men and women. JAMA 2005, 293:194-202.
-
(2005)
JAMA
, vol.293
, pp. 194-202
-
-
Jee, S.H.1
Ohrr, H.2
Sull, J.W.3
-
61
-
-
0034927064
-
Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
-
Ikejima K., Honda H., Yoshikawa M., et al. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 2001, 34:288-297.
-
(2001)
Hepatology
, vol.34
, pp. 288-297
-
-
Ikejima, K.1
Honda, H.2
Yoshikawa, M.3
-
62
-
-
7044241291
-
Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin
-
Sahai A., Malladi P., Pan X., et al. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol 2004, 287(5):G1035-G1043.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
, Issue.5
-
-
Sahai, A.1
Malladi, P.2
Pan, X.3
-
63
-
-
33750607736
-
Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats
-
Kitade M., Yoshiji H., Kojima H., et al. Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. Hepatology 2006 Oct, 44(4):983-991.
-
(2006)
Hepatology
, vol.44
, Issue.4
, pp. 983-991
-
-
Kitade, M.1
Yoshiji, H.2
Kojima, H.3
-
64
-
-
43549114292
-
Mechanisms of leptin action and leptin resistance
-
Myers M.G., Cowley M.A., Münzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 2008, 70:537-556.
-
(2008)
Annu Rev Physiol
, vol.70
, pp. 537-556
-
-
Myers, M.G.1
Cowley, M.A.2
Münzberg, H.3
-
65
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal weight and obese humans
-
Considine R.V., Sinha M.K., Heiman M.L., et al. Serum immunoreactive-leptin concentrations in normal weight and obese humans. N Engl J Med 1996, 334:292-295.
-
(1996)
N Engl J Med
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
-
66
-
-
56149125083
-
Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism
-
Vilà L., Roglans N., Alegret M., et al. Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism. Hepatology 2008, 48(5):1506-1516.
-
(2008)
Hepatology
, vol.48
, Issue.5
, pp. 1506-1516
-
-
Vilà, L.1
Roglans, N.2
Alegret, M.3
-
67
-
-
0033023477
-
Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal
-
Henriksen J.H., Holst J.J., Møller S., et al. Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal. Hepatology 1999, 29(6):1818-1824.
-
(1999)
Hepatology
, vol.29
, Issue.6
, pp. 1818-1824
-
-
Henriksen, J.H.1
Holst, J.J.2
Møller, S.3
-
68
-
-
9444223845
-
Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation
-
Saxena N.K., Titus M.A., Ding X., et al. Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB J 2004, 18(13):1612-1614.
-
(2004)
FASEB J
, vol.18
, Issue.13
, pp. 1612-1614
-
-
Saxena, N.K.1
Titus, M.A.2
Ding, X.3
-
69
-
-
0029863684
-
Endotoxin and cytokines induce expression of leptin, the OB gene product, in hamsters. A role for leptin in the anorexia of infection
-
Grunfeld C., Zhao C., Fuller J., et al. Endotoxin and cytokines induce expression of leptin, the OB gene product, in hamsters. A role for leptin in the anorexia of infection. J Clin Invest 1996, 97:2152-2157.
-
(1996)
J Clin Invest
, vol.97
, pp. 2152-2157
-
-
Grunfeld, C.1
Zhao, C.2
Fuller, J.3
-
70
-
-
0029665017
-
Acute and chronic effects of insulin on leptin production in humans in vivo and in vitro
-
Kolacynski J.W., Nyce M.R., Considine R.V., et al. Acute and chronic effects of insulin on leptin production in humans in vivo and in vitro. Diabetes 1996, 45:699-701.
-
(1996)
Diabetes
, vol.45
, pp. 699-701
-
-
Kolacynski, J.W.1
Nyce, M.R.2
Considine, R.V.3
-
71
-
-
0031158923
-
Leptin concentrations, sex hormones, and cortisol in non-diabetic men
-
Hafner S.M., Miettinen H., Karhapaa, et al. Leptin concentrations, sex hormones, and cortisol in non-diabetic men. J Clin Endocrinol Metab 1997, 82:1807-1809.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 1807-1809
-
-
Hafner, S.M.1
Miettinen, H.K.2
-
72
-
-
4444337948
-
Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma
-
Wang X.J., Yuan S.L., Lu Q., et al. Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma. World J Gastroenterol 2004, 10(17):2478-2481.
-
(2004)
World J Gastroenterol
, vol.10
, Issue.17
, pp. 2478-2481
-
-
Wang, X.J.1
Yuan, S.L.2
Lu, Q.3
-
73
-
-
30044434035
-
Intracellular signalling pathways activated by leptin
-
Frühbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006, 393(Pt 1):7-20.
-
(2006)
Biochem J
, vol.393
, Issue.PART 1
, pp. 7-20
-
-
Frühbeck, G.1
-
74
-
-
39549114272
-
Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta
-
Ramani K., Yang H., Xia M., et al. Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta. Hepatology 2008, 47(2):521-531.
-
(2008)
Hepatology
, vol.47
, Issue.2
, pp. 521-531
-
-
Ramani, K.1
Yang, H.2
Xia, M.3
-
75
-
-
0036234147
-
Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
-
Ikejima K., Takei Y., Honda H., et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002, 122(5):1399-1410.
-
(2002)
Gastroenterology
, vol.122
, Issue.5
, pp. 1399-1410
-
-
Ikejima, K.1
Takei, Y.2
Honda, H.3
-
76
-
-
35948964347
-
Hepatic stellate cells and liver fibrosis
-
Moreira R.K. Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 2007, 131(11):1728-1734.
-
(2007)
Arch Pathol Lab Med
, vol.131
, Issue.11
, pp. 1728-1734
-
-
Moreira, R.K.1
-
77
-
-
0034723290
-
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
-
Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000, 275(4):2247-2250.
-
(2000)
J Biol Chem
, vol.275
, Issue.4
, pp. 2247-2250
-
-
Friedman, S.L.1
-
78
-
-
0042887507
-
Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis
-
Yoshiji H., Kuriyama S., Yoshii J., et al. Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis. Gut 2003, 52:1347-1354.
-
(2003)
Gut
, vol.52
, pp. 1347-1354
-
-
Yoshiji, H.1
Kuriyama, S.2
Yoshii, J.3
-
79
-
-
32444433860
-
Suppression of hepatocellular carcinoma growth in mice via leptin, is associated with inhibition of tumor cell growth and natural killer cell activation
-
Elinav E., Abd-Elnabi A., Pappo O., et al. Suppression of hepatocellular carcinoma growth in mice via leptin, is associated with inhibition of tumor cell growth and natural killer cell activation. J Hepatol 2006, 44(3):529-536.
-
(2006)
J Hepatol
, vol.44
, Issue.3
, pp. 529-536
-
-
Elinav, E.1
Abd-Elnabi, A.2
Pappo, O.3
-
80
-
-
17544382289
-
AdipoQ is a novel adipose-specific gene dysregulated in obesity
-
Hu E., Liang P., Spiegelman B.M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996, 271:10697-10703.
-
(1996)
J Biol Chem
, vol.271
, pp. 10697-10703
-
-
Hu, E.1
Liang, P.2
Spiegelman, B.M.3
-
81
-
-
33748992313
-
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
-
Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006, 6(10):772-783.
-
(2006)
Nat Rev Immunol
, vol.6
, Issue.10
, pp. 772-783
-
-
Tilg, H.1
Moschen, A.R.2
-
82
-
-
0036063777
-
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
-
Maeda N., Shimomura I., Kishida K., et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002, 8(7):731-737.
-
(2002)
Nat Med
, vol.8
, Issue.7
, pp. 731-737
-
-
Maeda, N.1
Shimomura, I.2
Kishida, K.3
-
83
-
-
0035039227
-
Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
-
Hotta K., Funahashi T., Bodkin N.L., et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001, 50(5):1126-1133.
-
(2001)
Diabetes
, vol.50
, Issue.5
, pp. 1126-1133
-
-
Hotta, K.1
Funahashi, T.2
Bodkin, N.L.3
-
84
-
-
79953737949
-
Emerging role of adipokines as mediators in atherosclerosis
-
Zhang H., Cui J., Zhang C. Emerging role of adipokines as mediators in atherosclerosis. World J Cardiol 2010, 2(11):370-376.
-
(2010)
World J Cardiol
, vol.2
, Issue.11
, pp. 370-376
-
-
Zhang, H.1
Cui, J.2
Zhang, C.3
-
85
-
-
0036125944
-
Effects of pioglitazone on metabolic parameters, body fat distribution and serum adiponectin levels in Japanese male patients with type 2 diabetes
-
Hirose H., Kawai T., Yamamoto Y., et al. Effects of pioglitazone on metabolic parameters, body fat distribution and serum adiponectin levels in Japanese male patients with type 2 diabetes. Metabolism 2002, 51:314-317.
-
(2002)
Metabolism
, vol.51
, pp. 314-317
-
-
Hirose, H.1
Kawai, T.2
Yamamoto, Y.3
-
86
-
-
0034999667
-
Hypoadiponectimia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
-
Weyer C., Funahashi T., Tanaka S., et al. Hypoadiponectimia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001, 86:1930-1935.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 1930-1935
-
-
Weyer, C.1
Funahashi, T.2
Tanaka, S.3
-
87
-
-
67649220834
-
Adenosine monophosphate-activated protein kinase (AMPK) as a new target for antidiabetic drugs: a review on metabolic, pharmacological and chemical considerations
-
Gruzman A., Babai G., Sasson S. Adenosine monophosphate-activated protein kinase (AMPK) as a new target for antidiabetic drugs: a review on metabolic, pharmacological and chemical considerations. Rev Diabet Stud 2009, 6(1):13-36.
-
(2009)
Rev Diabet Stud
, vol.6
, Issue.1
, pp. 13-36
-
-
Gruzman, A.1
Babai, G.2
Sasson, S.3
-
88
-
-
0037014743
-
Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer
-
Sandhu M.S., Dunger D.B., Giovannucci E.L. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst 2002, 94(13):972-980.
-
(2002)
J Natl Cancer Inst
, vol.94
, Issue.13
, pp. 972-980
-
-
Sandhu, M.S.1
Dunger, D.B.2
Giovannucci, E.L.3
-
89
-
-
3142701401
-
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity
-
Tsuchida A., Yamauchi T., Ito Y., et al. Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 2004, 279:30817-30822.
-
(2004)
J Biol Chem
, vol.279
, pp. 30817-30822
-
-
Tsuchida, A.1
Yamauchi, T.2
Ito, Y.3
-
90
-
-
0036303146
-
Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome
-
Kondo H., Shimomura I., Matsukawa Y., et al. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 2002, 51(7):2325-2328.
-
(2002)
Diabetes
, vol.51
, Issue.7
, pp. 2325-2328
-
-
Kondo, H.1
Shimomura, I.2
Matsukawa, Y.3
-
91
-
-
84655166459
-
Adiponectin and breast cancer
-
[Epub ahead of print]
-
Chen X., Wang Y. Adiponectin and breast cancer. Med Oncol 2010, [Epub ahead of print].
-
(2010)
Med Oncol
-
-
Chen, X.1
Wang, Y.2
-
92
-
-
27944506001
-
Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study
-
Wei E.K., Giovannucci E., Fuchs C.S., et al. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst 2005, 97(22):1688-1694.
-
(2005)
J Natl Cancer Inst
, vol.97
, Issue.22
, pp. 1688-1694
-
-
Wei, E.K.1
Giovannucci, E.2
Fuchs, C.S.3
-
93
-
-
33847703646
-
Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study
-
Michalakis K., Williams C.J., Mitsiades N., et al. Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol Biomarkers Prev 2007, 16(2):308-313.
-
(2007)
Cancer Epidemiol Biomarkers Prev
, vol.16
, Issue.2
, pp. 308-313
-
-
Michalakis, K.1
Williams, C.J.2
Mitsiades, N.3
-
94
-
-
56749116073
-
Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women
-
Rzepka-Górska I., Bedner R., Cymbaluk-Płoska A., et al. Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women. Eur J Gynaecol Oncol 2008, 29(6):594-597.
-
(2008)
Eur J Gynaecol Oncol
, vol.29
, Issue.6
, pp. 594-597
-
-
Rzepka-Górska, I.1
Bedner, R.2
Cymbaluk-Płoska, A.3
-
95
-
-
34548249277
-
Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model
-
Kamada Y., Matsumoto H., Tamura S., et al. Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. J Hepatol 2007, 47(4):556-564.
-
(2007)
J Hepatol
, vol.47
, Issue.4
, pp. 556-564
-
-
Kamada, Y.1
Matsumoto, H.2
Tamura, S.3
-
96
-
-
77958546532
-
Obesity affects the liver-the link between adipocytes and hepatocytes
-
Wree A., Kahraman A., Gerken G., et al. Obesity affects the liver-the link between adipocytes and hepatocytes. Digestion 2011, 83(1-2):124-133.
-
(2011)
Digestion
, vol.83
, Issue.1-2
, pp. 124-133
-
-
Wree, A.1
Kahraman, A.2
Gerken, G.3
-
97
-
-
78049478003
-
Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma
-
1773.e1-5
-
Saxena N.K., Fu P.P., Nagalingam A., et al. Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma. Gastroenterology 2010, 139(5):1762-1773. 1773.e1-5.
-
(2010)
Gastroenterology
, vol.139
, Issue.5
, pp. 1762-1773
-
-
Saxena, N.K.1
Fu, P.P.2
Nagalingam, A.3
-
98
-
-
18844432308
-
Adiponectin and adiponectin receptors
-
Kadowaki T., Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005, 26(3):439-451.
-
(2005)
Endocr Rev
, vol.26
, Issue.3
, pp. 439-451
-
-
Kadowaki, T.1
Yamauchi, T.2
-
99
-
-
33744514139
-
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
-
Cool B., Zinker B., Chiou W., et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metabolism 2006, 3:403-416.
-
(2006)
Cell Metabolism
, vol.3
, pp. 403-416
-
-
Cool, B.1
Zinker, B.2
Chiou, W.3
-
100
-
-
33745213627
-
AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer
-
Motoshima H., Goldstein B.J., Igata M., et al. AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol 2006, 574(Pt 1):63-71.
-
(2006)
J Physiol
, vol.574
, Issue.PART 1
, pp. 63-71
-
-
Motoshima, H.1
Goldstein, B.J.2
Igata, M.3
-
101
-
-
33749431713
-
The mTOR pathway in the control of protein synthesis
-
Wang X., Proud C.G. The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 2006, 21:362-369.
-
(2006)
Physiology (Bethesda)
, vol.21
, pp. 362-369
-
-
Wang, X.1
Proud, C.G.2
-
102
-
-
20444363122
-
The coordinate regulation of the p53 and mTOR pathways in cells
-
Feng Z., Zhang H., Levine A.J., et al. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A 2005, 102(23):8204-8209.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.23
, pp. 8204-8209
-
-
Feng, Z.1
Zhang, H.2
Levine, A.J.3
-
103
-
-
20444472687
-
Adiponectin activates c-Jun NH2 terminal kinase and inhibits signal transducer and activator of transcription 3
-
Miyazaki T., Bub J.D., Uzuki M., et al. Adiponectin activates c-Jun NH2 terminal kinase and inhibits signal transducer and activator of transcription 3. Biochem Biophys Res Commun 2005, 333(1):79-87.
-
(2005)
Biochem Biophys Res Commun
, vol.333
, Issue.1
, pp. 79-87
-
-
Miyazaki, T.1
Bub, J.D.2
Uzuki, M.3
|