Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders

European Neuropsychopharmacology

Volumn 21, Issue 7, 2011, Pages 532-544

  Kas, Martien J H ^a   Krishnan, Vaishnav ^b   Gould, Todd D ^c   Collier, David A ^d   Olivier, Berend ^a,e,f   Lesch, Klaus Peter ^g   Domenici, Enrico ^h   Fuchs, Eberhard ⁱ   Gross, Cornelius ^j   Castrén, Eero ^k  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UTRECHT UNIVERSITY   (Netherlands)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Molecular Psychiatry   (Germany)

^h GSK   (Italy)

ⁱ GERMAN PRIMATE CENTER   (Germany)

^j EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

^k UNIVERSITY OF HELSINKI   (Finland)

more..

Author keywords

Ageing; Behavior; Development; Endophenotype; Gene by environment; Mouse; Psychiatry; Sex differences

Indexed keywords

AGE DISTRIBUTION; AGING; ARTICLE; ENDOPHENOTYPE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR DEPRESSION; MENTAL DISEASE; NEUROBIOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA; SEX DIFFERENCE; TRANSLATIONAL RESEARCH;

AGING; ENDOPHENOTYPES; FEMALE; HUMANS; INTERDISCIPLINARY COMMUNICATION; MALE; MENTAL DISORDERS; NEUROBIOLOGY; NEUROPSYCHIATRY; SEX FACTORS; SPECIES SPECIFICITY;

EID: 79959213372     PISSN: 0924977X     EISSN: 0924977X     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2010.12.001     Document Type: Article

References (150)

1. Aloisi A.M., Ceccarelli I., Lupo C. Behavioural and hormonal effects of restraint stress and formalin test in male and female rats. Brain Res. Bull. 1998, 47:57-62.
2. Antoniades A., Kalvari I., Pattichis C., Jones N., Matthews P.M., Domenici E., Muglia P. Discovering genetic polymorphism associated with gene expression levels across the whole genome. Conf Proc IEEE Eng Med Biol Soc 2009, 5466-5469.
3. Avramopoulos D., Willour V.L., Zandi P.P., Huo Y., Mackinnon D.F., Potash J.B., Depaulo J.R., McInnis M.G. Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis. Mol. Psychiatry 2004, 9:191-196.
4. Barr C.S., Newman T.K., Becker M.L., Parker C.C., Champoux M., Lesch K.P., Goldman D., Suomi S.J., Higley J.D. The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav. 2003, 2:336-340.
5. Bartolomucci A., Carola V., Pascucci T., Puglisi-Allegra S., Cabib S., Lesch K.P., Parmigiani S., Palanza P., Gross C. Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice. Dis. Model Mech. 2010, 3:459-470.
6. Becker C., Zeau B., Rivat C., Blugeot A., Hamon M., Benoliel J.J. Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. Mol. Psychiatry 2008, 13:1079-1092.
7. Bengel D., Murphy D.L., Andrews A.M., Wichems C.H., Feltner D., Heils A., Mossner R., Westphal H., Lesch K.P. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol. Pharmacol. 1998, 53:649-655.
8. Bennett A.J., Lesch K.P., Heils A., Long J.C., Lorenz J.G., Shoaf S.E., Champoux M., Suomi S.J., Linnoila M.V., Higley J.D. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol. Psychiatry 2002, 7:118-122.
9. Bilder R.M., Sabb F.W., Cannon T.D., London E.D., Jentsch J.D., Parker D.S., Poldrack R.A., Evans C., Freimer N.B. Phenomics: the systematic study of phenotypes on a genome-wide scale. Neuroscience 2009, 164:30-42.
10. Bilder R.M., Sabb F.W., Parker D.S., Kalar D., Chu W.W., Fox J., Freimer N.B., Poldrack R.A. Cognitive ontologies for neuropsychiatric phenomics research. Cogn. Neuropsychiatry 2009, 14:419-450.
11. Bulik C.M., Sullivan P.F., Wade T.D., Kendler K.S. Twin studies of eating disorders: a review. Int. J. Eat. Disord. 2000, 27:1-20.
12. Cahill L. Why sex matters for neuroscience. Nat. Rev. Neurosci. 2006, 7:477-484.
13. Canli T., Lesch K.P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat. Neurosci. 2007, 10:1103-1109.
14. Cardno A.G., Gottesman I.I. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am. J. Med. Genet. 2000, 97:12-17.
15. Carola V., Frazzetto G., Pascucci T., Audero E., Puglisi-Allegra S., Cabib S., Lesch K.P., Gross C. Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression. Biol. Psychiatry 2008, 63:840-846.
16. Carrasco G.A., Van de Kar L.D. Neuroendocrine pharmacology of stress. Eur. J. Pharmacol. 2003, 463:235-272.
17. Caspi A., Moffitt T.E. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 2006, 7:583-590.
18. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
19. Castren M., Tervonen T., Karkkainen V., Heinonen S., Castren E., Larsson K., Bakker C.E., Oostra B.A., Akerman K. Altered differentiation of neural stem cells in fragile X syndrome. Proc. Natl Acad. Sci. USA 2005, 102:17834-17839.
20. Catania K.C., Remple M.S. Somatosensory cortex dominated by the representation of teeth in the naked mole-rat brain. Proc. Natl Acad. Sci. USA 2002, 99:5692-5697.
21. Chamberlain S.J., Li X.J., Lalande M. Induced pluripotent stem (iPS) cells as in vitro models of human neurogenetic disorders. Neurogenetics 2008, 9:227-235.
22. Champoux M., Bennett A., Shannon C., Higley J.D., Lesch K.P., Suomi S.J. Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Mol. Psychiatry 2002, 7:1058-1063.
23. Couillard-Despres S., Wuertinger C., Kandasamy M., Caioni M., Stadler K., Aigner R., Bogdahn U., Aigner L. Ageing abolishes the effects of fluoxetine on neurogenesis. Mol. Psychiatry 2009, 14:856-864.
24. Dao D.T., Mahon P.B., Cai X., Kovacsics C.E., Blackwell R.A., Arad M., Shi J., Zandi P.P., O'Donnell P., Knowles J.A., Weissman M.M., Coryell W., Scheftner W.A., Lawson W.B., Levinson D.F., Thompson S.M., Potash J.B., Gould T.D. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biol. Psychiatry 2010, 68(9):801-810.
25. de Mooij-van Malsen A.J., Olivier B., Kas M.J. Behavioural genetics in mood and anxiety: a next step in finding novel pharmacological targets. Eur. J. Pharmacol. 2008, 585:436-440.
26. de Mooij-van Malsen A.J., van Lith H.A., Oppelaar H., Hendriks J., de Wit M., Kostrzewa E., Breen G., Collier D.A., Olivier B., Kas M.J. Interspecies trait genetics reveals association of Adcy8 with mouse avoidance behavior and a human mood disorder. Biol. Psychiatry 2009, 66:1123-1130.
27. Dekker J., Koelen J.A., Peen J., Schoevers R.A., Gijsbers-van Wijk C. Gender differences in clinical features of depressed outpatients: preliminary evidence for subtyping of depression?. Women Health 2007, 46:19-38.
28. Dempster E.L., Toulopoulou T., McDonald C., Bramon E., Walshe M., Wickham H., Sham P.C., Murray R.M., Collier D.A. Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene. Am. J. Psychiatry. 2006, 163(10):1832-1834.
29. Einat H., Manji H.K. Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder. Biol. Psychiatry 2006, 59:1160-1171.
30. Eleftherohorinou H., Wright V., Hoggart C., Hartikainen A.L., Jarvelin M.R., Balding D., Coin L., Levin M. Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS ONE 2009, 4:e8068.
31. Emilsson V., et al. Genetics of gene expression and its effect on disease. Nature 2008, 452:423-428.
32. Etherton M.R., Blaiss C.A., Powell C.M., Sudhof T.C. Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc. Natl Acad. Sci. USA 2009, 106:17998-18003.
33. Fan M., Liu B., Jiang T., Jiang X., Zhao H., Zhang J. Meta-analysis of the association between the monoamine oxidase-A gene and mood disorders. Psychiatr. Genet. 2010, 20:1-7.
34. Feder A., Nestler E.J., Charney D.S. Psychobiology and molecular genetics of resilience. Nat. Rev. Neurosci. 2009, 10:446-457.
35. Ferreira M.A., et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat. Genet. 2008, 40:1056-1058.
36. Fonio E., Benjamini Y., Golani I. Freedom of movement and the stability of its unfolding in free exploration of mice. Proc. Natl Acad. Sci. USA 2009, 106:21335-21340.
37. Friedel R.H., Seisenberger C., Kaloff C., Wurst W. EUCOMM - the European conditional mouse mutagenesis program. Brief Funct. Genomic Proteomic 2007, 6:180-185.
38. Frye C.A., Walf A.A. Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites. Physiol. Behav. 2009, 97:266-269.
39. Fuchs E., Flugge G. Social stress in tree shrews: effects on physiology, brain function, and behavior of subordinate individuals. Pharmacol. Biochem. Behav. 2002, 73:247-258.
40. Gage F.H. Mammalian neural stem cells. Science 2000, 287:1433-1438.
41. Gauthier J., et al. De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proc. Natl Acad. Sci. USA 2010, 107:7863-7868.
42. Ge B., et al. Global patterns of cis variation in human cells revealed by high-density allelic expression analysis. Nat. Genet. 2009, 41:1216-1222.
43. Gibson G. Hints of hidden heritability in GWAS. Nat. Genet. 2010, 42:558-560.
44. Gillespie C.F., Phifer J., Bradley B., Ressler K.J. Risk and resilience: genetic and environmental influences on development of the stress response. Depress. Anxiety 2009, 26:984-992.
45. Goring H.H., Curran J.E., Johnson M.P., Dyer T.D., Charlesworth J., Cole S.A., Jowett J.B., Abraham L.J., Rainwater D.L., Comuzzie A.G., Mahaney M.C., Almasy L., MacCluer J.W., Kissebah A.H., Collier G.R., Moses E.K., Blangero J. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat. Genet. 2007, 39:1208-1216.
46. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 2003, 160:636-645.
47. Gottesman I.I., Shields J. Schizophrenia and Genetics: a Twin Study Vantage Point 1972, Academic Press, New York.
48. Gould T.D., Gottesman I.I. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav. 2006, 5:113-119.
49. Gould E., Reeves A.J., Fallah M., Tanapat P., Gross C.G., Fuchs E. Hippocampal neurogenesis in adult Old World primates. Proc. Natl Acad. Sci. USA 1999, 96:5263-5267.
50. Gourley S.L., Kiraly D.D., Howell J.L., Olausson P., Taylor J.R. Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone. Biol. Psychiatry 2008, 64:884-890.
51. Gourley S.L., Kedves A.T., Olausson P., Taylor J.R. A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF. Neuropsychopharmacology 2009, 34:707-716.
52. Halbreich U., Kahn L.S. Atypical depression, somatic depression and anxious depression in women: are they gender-preferred phenotypes?. J. Affect. Disord. 2007, 102:245-258.
53. Haller J., Fuchs E., Halasz J., Makara G.B. Defeat is a major stressor in males while social instability is stressful mainly in females: towards the development of a social stress model in female rats. Brain Res. Bull. 1999, 50:33-39.
54. Hammen C. Stress and depression. Annu. Rev. Clin. Psychol. 2005, 1:293-319.
55. Hawkins E.H. A tale of two systems: co-occurring mental health and substance abuse disorders treatment for adolescents. Annu. Rev. Psychol. 2009, 60:197-227.
56. Heiming R.S., Jansen F., Lewejohann L., Kaiser S., Schmitt A., Lesch K.P., Sachser N. Living in a dangerous world: the shaping of behavioral profile by early environment and 5-HTT genotype. Front. Behav. Neurosci. 2009, 3:26. Epub;%2009 Sep 9.:26.
57. Herzog C.J., Czeh B., Corbach S., Wuttke W., Schulte-Herbruggen O., Hellweg R., Flugge G., Fuchs E. Chronic social instability stress in female rats: a potential animal model for female depression. Neuroscience 2009, 159:982-992.
58. Homberg J.R., Lesch K.P. Looking on the Bright Side of Serotonin Transporter Gene Variation. Biol. Psychiatry 2011, 69:513-519.
59. Insel T.R. From animal models to model animals. Biol. Psychiatry 2007, 62:1337-1339.
60. Jansen F., Heiming R.S., Lewejohann L., Touma C., Palme R., Schmitt A., Lesch K.P., Sachser N. Modulation of behavioural profile and stress response by 5-HTT genotype and social experience in adulthood. Behav. Brain Res. 2010, 207:21-29.
61. Kas M.J., van Ree J.M. Dissecting complex behaviours in the post-genomic era. Trends Neurosci. 2004, 27:366-369.
62. Kas M.J., Fernandes C., Schalkwyk L.C., Collier D.A. Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men. Mol. Psychiatry 2007, 12:324-330.
63. Kas M.J., de Mooij-van Malsen A.J., Olivier B., Spruijt B.M., van Ree J.M. Differential genetic regulation of motor activity and anxiety-related behaviors in mice using an automated home cage task. Behav. Neurosci. 2008, 122:769-776.
64. Kas M.J., Gelegen C., Schalkwyk L.C., Collier D.A. Interspecies comparisons of functional genetic variations and their implications in neuropsychiatry. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009, 150B:309-317.
65. Kessler R.C. The effects of stressful life events on depression. Annu. Rev. Psychol. 1997, 48:191-214.
66. Kessler R.C., McGonagle K.A., Swartz M., Blazer D.G., Nelson C.B. Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence. J. Affect. Disord. 1993, 29:85-96.
67. Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 2005, 62:593-602.
68. Kessler R.C., Chiu W.T., Demler O., Merikangas K.R., Walters E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 2005, 62:617-627.
69. Kim K.S. Induced pluripotent stem (iPS) cells and their future in psychiatry. Neuropsychopharmacology 2010, 35:346-348.
70. Kim S., Webster M.J. Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. Mol. Psychiatry 2011, 16:452-461.
71. Kim H.G., et al. Disruption of neurexin 1 associated with autism spectrum disorder. Am. J. Hum. Genet. 2008, 82:199-207.
72. Knight H.M., Pickard B.S., Maclean A., Malloy M.P., Soares D.C., McRae A.F., Condie A., White A., Hawkins W., McGhee K., Van Beck M., MacIntyre D.J., Starr J.M., Deary I.J., Visscher P.M., Porteous D.J., Cannon R.E., St Clair D., Muir W.J., Blackwood D.H. A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression. Am. J. Hum. Genet. 2009, 85:833-846.
73. Knott, Cheryl Orangutan Behavior and Ecology 1999, 50-57. Mayfield Publishing Co, Mountain View, CA. P. Dolhinow, A. Fuentes (Eds.).
74. Kovacsics C.E., Gottesman I.I., Gould T.D. Lithium's antisuicidal efficacy: elucidation of neurobiological targets using endophenotype strategies. Annu. Rev. Pharmacol. Toxicol. 2009, 49:175-198.
75. Krishnan V., Nestler E.J. The molecular neurobiology of depression. Nature 2008, 455:894-902.
76. Kudielka B.M., Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol. Psychol. 2005, 69:113-132.
77. Kurian S.M., Le Niculescu H., Patel S.D., Bertram D., Davis J., Dike C., Yehyawi N., Lysaker P., Dustin J., Caligiuri M., Lohr J., Lahiri D.K., Nurnberger J.I., Faraone S.V., Geyer M.A., Tsuang M.T., Schork N.J., Salomon D.R., Niculescu A.B. Identification of blood biomarkers for psychosis using convergent functional genomics. Mol. Psychiatry 2011, 16(1):37-58.
78. Lango A.H., et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010, 467:832-838.
79. Le Niculescu H., Balaraman Y., Patel S., Tan J., Sidhu K., Jerome R.E., Edenberg H.J., Kuczenski R., Geyer M.A., Nurnberger J.I., Faraone S.V., Tsuang M.T., Niculescu A.B. Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007, 144B:129-158.
80. Le Niculescu H., Kurian S.M., Yehyawi N., Dike C., Patel S.D., Edenberg H.J., Tsuang M.T., Salomon D.R., Nurnberger J.I., Niculescu A.B. Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol. Psychiatry 2009, 14:156-174.
81. Le Niculescu H., Patel S.D., Bhat M., Kuczenski R., Faraone S.V., Tsuang M.T., McMahon F.J., Schork N.J., Nurnberger J.I., Niculescu A.B. Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009, 150B:155-181.
82. Lein E.S., et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 2007, 445:168-176.
83. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531.
84. Lewejohann L., Kloke V., Heiming R.S., Jansen F., Kaiser S., Schmitt A., Lesch K.P., Sachser N. Social status and day-to-day behaviour of male serotonin transporter knockout mice. Behav. Brain Res. 2010, 211:220-228.
85. Lipa S.M., Kavaliers M. Sex differences in the inhibitory effects of the NMDA antagonist, MK-801, on morphine and stress-induced analgesia. Brain Res. Bull. 1990, 24:627-630.
86. Lopez A.D., Murray C.C. The global burden of disease, 1990-2020. Nat. Med. 1998, 4:1241-1243.
87. Luykx J.J., Boks M.P., Terwindt A.P., Bakker S., Kahn R.S., Ophoff R.A. The involvement of GSK3beta in bipolar disorder: integrating evidence from multiple types of genetic studies. Eur. Neuropsychopharmacol. 2010, 20:357-368.
88. Lyons D.M., Parker K.J., Katz M., Schatzberg A.F. Developmental cascades linking stress noculation, arousal regulation, and resilience. Front. Behav. Neurosci. 2009, 3:32. Epub;%2009 Sep 18.:32.
89. Macri S., Granstrem O., Shumilina M., Gomes Antunes, dos Santos F.J., Berry A., Saso L., Laviola G. Resilience and vulnerability are dose-dependently related to neonatal stressors in mice. Horm. Behav. 2009, 56:391-398.
90. Maher B. Personal genomes: the case of the missing heritability. Nature 2008, 456:18-21.
91. McGuffin P., Rijsdijk F., Andrew M., Sham P., Katz R., Cardno A. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch. Gen. Psychiatry 2003, 60:497-502.
92. McInnis M.G., et al. Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12. Mol. Psychiatry 2003, 8:288-298.
93. Monroe S.M., Slavich G.M., Torres L.D., Gotlib I.H. Severe life events predict specific patterns of change in cognitive biases in major depression. Psychol. Med. 2007, 37:863-871.
94. Montag C., Basten U., Stelzel C., Fiebach C.J., Reuter M. The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans. Psychiatry Res. 2010, 179:86-90.
95. Moore J.H., Williams S.M. Epistasis and its implications for personal genetics. Am. J. Hum. Genet. 2009, 85:309-320.
96. Murgatroyd C., Patchev A.V., Wu Y., Micale V., Bockmuhl Y., Fischer D., Holsboer F., Wotjak C.T., Almeida O.F., Spengler D. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat. Neurosci. 2009, 12:1559-1566.
97. Murphy D.L., Lesch K.P. Targeting the murine serotonin transporter: insights into human neurobiology. Nat. Rev. Neurosci. 2008, 9:85-96.
98. Myers A.J., et al. A survey of genetic human cortical gene expression. Nat. Genet. 2007, 39:1494-1499.
99. Nestler E.J., Gould E., Manji H., Buncan M., Duman R.S., Greshenfeld H.K., Hen R., Koester S., Lederhendler I., Meaney M., Robbins T., Winsky L., Zalcman S. Preclinical models: status of basic research in depression. Biol. Psychiatry 2002, 52:503-528.
100. Ng S.B., Turner E.H., Robertson P.D., Flygare S.D., Bigham A.W., Lee C., Shaffer T., Wong M., Bhattacharjee A., Eichler E.E., Bamshad M., Nickerson D.A., Shendure J. Targeted capture and massively parallel sequencing of 12 human exomes. Nature 2009, 461:272-276.
101. Nica A.C., Montgomery S.B., Dimas A.S., Stranger B.E., Beazley C., Barroso I., Dermitzakis E.T. Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations. PLoS Genet. 2010, 6:e1000895.
102. Nithianantharajah J., Hannan A.J. The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disorders. Prog. Neurobiol. 2009, 89:369-382.
103. Nottebohm F., Liu W.C. The origins of vocal learning: new sounds, new circuits, new cells. Brain Lang. 2010, 115:3-17.
104. Palanza P. Animal models of anxiety and depression: how are females different?. Neurosci. Biobehav. Rev. 2001, 25:219-233.
105. Patchev V.K., Almeida O.F. Gender specificity in the neural regulation of the response to stress: new leads from classical paradigms. Mol. Neurobiol. 1998, 16:63-77.
106. Pawitan Y., Seng K.C., Magnusson P.K. How many genetic variants remain to be discovered?. PLoS ONE 2009, 4:e7969.
107. Peeters F., Nicholson N.A., Berkhof J. Cortisol responses to daily events in major depressive disorder. Psychosom. Med. 2003, 65:836-841.
108. Peri F., Nusslein-Volhard C. Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. Cell 2008, 133:916-927.
109. Perry W., Minassian A., Paulus M.P., Young J.W., Kincaid M.J., Ferguson E.J., Henry B.L., Zhuang X., Masten V.L., Sharp R.F., Geyer M.A. A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. Arch. Gen. Psychiatry 2009, 66:1072-1080.
110. Pooley E.C., Fineberg N., Harrison P.J. The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis. Mol. Psychiatry 2007, 12:556-561.
111. Raj A., Rifkin S.A., Andersen E., van Oudenaarden A. Variability in gene expression underlies incomplete penetrance. Nature 2010, 463:913-918.
112. Risch N., Herrell R., Lehner T., Liang K.Y., Eaves L., Hoh J., Griem A., Kovacs M., Ott J., Merikangas K.R. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 2009, 301:2462-2471.
113. Rosenberg R.E., Law J.K., Yenokyan G., McGready J., Kaufmann W.E., Law P.A. Characteristics and concordance of autism spectrum disorders among 277 twin pairs. Arch. Pediatr. Adolesc. Med. 2009, 163:907-914.
114. Rujescu D., Collier D.A. Dissecting the many genetic faces of schizophrenia. Epidemiol. Psichiatr. Soc. 2009, 18:91-95.
115. Rujescu D., et al. Disruption of the neurexin 1 gene is associated with schizophrenia. Hum. Mol. Genet. 2009, 18:988-996.
116. Rutten B.P., Mill J. Epigenetic mediation of environmental influences in major psychotic disorders. Schizophr. Bull. 2009, 35:1045-1056.
117. Rygula R., Abumaria N., Havemann-Reinecke U., Ruther E., Hiemke C., Zernig G., Fuchs E., Flugge G. Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam. Behav. Pharmacol. 2008, 19:183-196.
118. Schmidt M.V. Molecular mechanisms of early life stress - lessons from mouse models. Neurosci. Biobehav. Rev. 2010, 34:845-852.
119. Simon M., Czeh B., Fuchs E. Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress. Brain Res. 2005, 1049:244-248.
120. Smith D.J., Kyle S., Forty L., Cooper C., Walters J., Russell E., Caesar S., Farmer A., McGuffin P., Jones I., Jones L., Craddock N. Differences in depressive symptom profile between males and females. J. Affect. Disord. 2008, 108:279-284.
121. Spear L.P. The adolescent brain and age-related behavioral manifestations. Neurosci. Biobehav. Rev. 2000, 24:417-463.
122. St Clair D. Copy number variation and schizophrenia. Schizophr. Bull. 2009, 35:9-12.
123. Stefansson H., et al. Large recurrent microdeletions associated with schizophrenia. Nature 2008, 455:232-236.
124. Stefansson H., et al. Common variants conferring risk of schizophrenia. Nature 2009, 460:744-747.
125. Stiedl O., Meyer M. Fractal dynamics in circadian cardiac time series of corticotropin-releasing factor receptor subtype-2 deficient mice. J. Math. Biol. 2003, 47:169-197.
126. Stranger B.E., Forrest M.S., Clark A.G., Minichiello M.J., Deutsch S., Lyle R., Hunt S., Kahl B., Antonarakis S.E., Tavare S., Deloukas P., Dermitzakis E.T. Genome-wide associations of gene expression variation in humans. PLoS Genet. 2005, 1:e78.
127. Stranger B.E., Forrest M.S., Dunning M., Ingle C.E., Beazley C., Thorne N., Redon R., Bird C.P., de Grassi A., Lee C., Tyler-Smith C., Carter N., Scherer S.W., Tavare S., Deloukas P., Hurles M.E., Dermitzakis E.T. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 2007, 315:848-853.
128. Stranger B.E., Nica A.C., Forrest M.S., Dimas A., Bird C.P., Beazley C., Ingle C.E., Dunning M., Flicek P., Koller D., Montgomery S., Tavare S., Deloukas P., Dermitzakis E.T. Population genomics of human gene expression. Nat. Genet. 2007, 39:1217-1224.
129. Stratton M. Genome resequencing and genetic variation. Nat. Biotechnol. 2008, 26:65-66.
130. Troisi A. The concept of alternative strategies and its relevance to psychiatry and clinical psychology. Neurosci. Biobehav. Rev. 2005, 29:159-168.
131. Tsankova N.M., Berton O., Renthal W., Kumar A., Neve R.L., Nestler E.J. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat. Neurosci. 2006, 9:519-525.
132. Tsankova N., Renthal W., Kumar A., Nestler E.J. Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 2007, 8:355-367.
133. Uher R., McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol. Psychiatry 2010, 15:18-22.
134. Ulrich-Lai Y.M., Herman J.P. Neural regulation of endocrine and autonomic stress responses. Nat. Rev. Neurosci. 2009, 10(6):397-409.
135. van Os J., Rutten B.P., Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr. Bull. 2008, 34:1066-1082.
136. Vassos E., Collier D.A., Holden S., Patch C., Rujescu D., St Clair D., Lewis C.M. Penetrance for copy number variants associated with schizophrenia. Hum. Mol. Genet. 2010, 19:3477-3481.
137. Vidal J., Bie J., Granneman R.A., Wallinga A.E., Koolhaas J.M., Buwalda B. Social stress during adolescence in Wistar rats induces social anxiety in adulthood without affecting brain monoaminergic content and activity. Physiol. Behav. 2007, 92:824-830.
138. Vinkers C.H., van Bogaert M.J., Klanker M., Korte S.M., Oosting R., Hanania T., Hopkins S.C., Olivier B., Groenink L. Translational aspects of pharmacological research into anxiety disorders: the stress-induced hyperthermia (SIH) paradigm. Eur. J. Pharmacol. 2008, 585:407-425.
139. A and GABAB receptor functions in anxiety using the stress-induced hyperthermia model: a review. Open Pharmacol. J. 2010, 4:22-35.
140. Vinkers C.H., Olivier B., Bouwknecht J.A., Groenink L., Olivier J.D.A. Stress-induced hyperthermia: the serotonin system and anxiety. Open Pharmacol. J. 2010, 4:1-15.
141. Vinkers C.H., Penning R., Ebbens M.M., Hellhammer J., Verster J.C., Kalkman C.J., Olivier B. Stress-induced hyperthermia in translational stress research. Open Pharmacol. J. 2010, 4:16-21.
142. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., Meaney M.J. Epigenetic programming by maternal behavior. Nat. Neurosci. 2004, 7:847-854.
143. Weissman M.M., Olfson M. Depression in women: implications for health care research. Science 1995, 269:799-801.
144. Wellman C.L., Izquierdo A., Garrett J.E., Martin K.P., Carroll J., Millstein R., Lesch K.P., Murphy D.L., Holmes A. Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J. Neurosci. 2007, 27:684-691.
145. Wilkinson M.B., Xiao G., Kumar A., LaPlant Q., Renthal W., Sikder D., Kodadek T.J., Nestler E.J. Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. J. Neurosci. 2009, 29:7820-7832.
146. Williams H.J., Craddock N., Russo G., Hamshere M.L., Moskvina V., Dwyer S., Smith R.L., Green E., Grozeva D., Holmans P., Owen M.J., O'Donovan M.C. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Hum. Mol. Genet. 2010.
147. Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 2007, 1:39-49.
148. Yang J., Benyamin B., McEvoy B.P., Gordon S., Henders A.K., Nyholt D.R., Madden P.A., Heath A.C., Martin N.G., Montgomery G.W., Goddard M.E., Visscher P.M. Common SNPs explain a large proportion of the heritability for human height. Nat. Genet. 2010, 42:565-569.
149. Zandi P.P., Avramopoulos D., Willour V.L., Huo Y., Miao K., Mackinnon D.F., McInnis M.G., Potash J.B., Depaulo J.R. SNP fine mapping of chromosome 8q24 in bipolar disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007, 144B:625-630.
150. Zucker I., Beery A.K. Males still dominate animal studies. Nature 2010, 465:690.