Experimental and theoretical study of the effect of active-site constrained substrate motion on the magnitude of the observed intramolecular isotope effect for the P450 101 catalyzed benzylic hydroxylation of isomeric xylenes and 4,4'-dimethylbiphenyl

Journal of the American Chemical Society

Volumn 121, Issue 1, 1999, Pages 41-47

  Audergon, Christian ^a   Iyer, Krishna R ^a   Jones, Jeffrey P ^b   Darbyshire, John F ^a   Trager, William F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIPHENYL DERIVATIVE; CAMPHOR DERIVATIVE; CYTOCHROME P450; XYLENE;

ARTICLE; CATALYSIS; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; GAS CHROMATOGRAPHY; HYDROXYLATION; ISOMERISM; KINETICS; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NONHUMAN; PSEUDOMONAS PUTIDA;

EID: 0033550491     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja983000w     Document Type: Article

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