An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway

Biochemical Journal

Volumn 437, Issue 1, 2011, Pages 25-34

  Marín Argany, Marta ^a   Rivera Hernández, Geovanny ^a   Martí, Joaquim ^a   Villegas, Sandra ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Aggregation; Alzheimer's disease; Amyloid (A ) peptide; Immunotherapy; Single chain variable fragment (ScFv); Worm like fibril

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-42]; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SECRETORY PATHWAY; THERMODYNAMICS;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; HUMANS; PROTEIN FOLDING; SINGLE-CHAIN ANTIBODIES; TEMPERATURE;

EID: 79958773791     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101712     Document Type: Article

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