Lactoferrin for human health

Dairy-Derived Ingredients: Food and Nutraceutical Uses

Volumn , Issue , 2009, Pages 290-307

  Marnila, P ^a   Korhonen, H J ^a  

^a FINNISH FOREST RESEARCH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79958715631     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1533/9781845697198.2.290     Document Type: Chapter

References (84)

1. Andrews S.C., Robinson A.K., Rodríguez-Quiñones F. Bacterial iron homeostasis. FEMS Microbiol Rev 2003, 27(2-3):215-237. DOI: 10.1016/S0168-6445(03)00055-X.
2. Appel M.J., Van Veen H.A., Vietsch H., Salaheddine M., Nuijens J.H., Ziere B., De Loos F. Sub-chronic (13-week) oral toxicity study in rats with recombinant human lactoferrin produced in the milk of transgenic cows. Food Chem Toxicol 2006, 44(7):964-973. DOI: 10.1016/j.fct.2005.11.012.
3. Braun V., Killmann H. Bacterial solutions to the iron-supply problem. Trends Biochem Sci 1999, 24(3):104-109. DOI: 10.1016/S0968-0004(99)01359-6.
4. Brown C.A., Wang B., Oh J.H. Antimicrobial activity of lactoferrin against foodborne pathogenic bacteria incorporated into edible chitosan film. J Food Prot 2008, 71(2):319-324.
5. Byrd T.F., Horwitz M.A. Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila. J Clin Invest 1991, 88(4):1103-1112. DOI: 10.1172/JCI115409.
6. Cerven D., Degeorge G., Bethell D. 28-Day repeated dose oral toxicity of recombinant human apo-lactoferrin or recombinant human lysozyme in rats. Regul Toxicol Pharmacol 2008, 51(2):162-167. DOI: 10.1016/j.yrtph.2008.03.007.
7. Cerven D., Degeorge G., Bethell D. 28-Day repeated dose oral toxicity of recombinant human holo-lactoferrin in rats. Regul Toxicol Pharmacol 2008, [Epub ahead of print] DOI: 10.1016/j.yrtph.2008.07.003.
8. Chiu C.K., Etzel M.R. Fractionation of lactoperoxidase and lactoferrin from bovine whey using a cation exchange membrane. J Food Sci 1997, 62:996-1000.
9. Conesa C., Sánchez L., Rota C., Pérez M.-D., Calvo M., Farnaud S., Evans R.W. Isolation of lactoferrin from milk of different species: Calorimetric and antimicrobial studies. Comp. Biochem Physiol. B 2008, 150:131-139. DOI: 10.1016/j.cbpb.2008.02.005.
10. Cornish J. Lactoferrin promotes bone growth. Biometals 2004, 17(3):331-335. DOI: 10.1023/B:BIOM.0000027713.18694.91.
11. Cornish J., Palmano K., Callon K.E., Watson M., Lin J.M., Valenti P., Naot D., Grey A.B., Reid I.R. Lactoferrin and bone: Structure-activity relationships. Biochem Cell Biol 2006, 84(3):297-302. DOI: 10.1139/O06-057.
12. Constantino D., Guaraldi C. Preliminary evaluation of a vaginal cream containing lactoferrin in the treatment of vulvovaginal candidosis. Minerva Ginecol 2008, 60(2):121-125.
13. Damiens E., El Yazidi I., Mazurier J., Duthille I., Spik G., Boilly-Marer Y. Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells. J Cell Biochem 1999, 74(3):486-498.
14. Diarra M.S., Petitclerc D., Lacasse P. Effect of lactoferrin in combination with penicillin on the morphology and the physiology of Staphylococcus aureus isolated from bovine mastitis. J Dairy Sci 2002, 85(5):1141-1149.
15. Eliassen L.T., Berge G., Sveinbjørnsson B., Svendsen J.S., Vorland L.H., Rekdal Ø Evidence for a direct antitumor mechanism of action of bovine lactoferricin. Anticancer Res 2002, 22(5):2703-2710.
16. Ellison R.T., Giehl T.J. Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest 1991, 88(4):1080-1091. DOI: 10.1172/JCI115407.
17. Engelmayer J., Blezinger P., Varadhachary A. Talactoferrin stimulates wound healing with modulation of inflammation. J Surg Res 2008, 149(2):278-286. DOI: 10.1016/j.jss.2007.12.754.
18. Fujihara T., Nagano T., Endo K., Nakamura M., Nakata K. Lactoferrin protects against UV-B irradiation-induced corneal epithelial damage in rats. Cornea 2000, 19(2):207-211.
19. Gomez H.F., Ochoa T.J., Carlin L.G., Cleary T.G. Human lactoferrin impairs virulence of Shigella flexneri. J Infect Dis 2003, 187(1):87-95. DOI: 10.1086/345875.
20. Groves M.L. The isolation of a red protein from milk. J Am Chem Soc 1960, 82:3345-3350.
21. Hayes T.G., Falchook G.F., Varadhachary G.R., Smith D.P., Davis L.D., Dhingra H.M., Hayes B.P., Varadhachary A. Phase I trial of oral talactoferrin alfa in refractory solid tumors. Invest New Drugs 2006, 24(3):233-240. DOI: 10.1007/s10637-005-3690-6.
22. Hirotani Y., Ikeda K., Kato R., Myotoku M., Umeda T., Ijiri Y., Tanaka K. Protective effects of lactoferrin against intestinal mucosal damage induced by lipopolysaccharide in human intestinal Caco-2 cells. Yakugaku Zasshi 2008, 128(9):1363-1368. DOI: 10.1248/yakushi.128.1363.
23. Koikawa N., Nagaoka I., Yamaguchi M., Hamano H., Yamauchi K., Sawaki K. Preventive effect of lactoferrin intake on anemia in female long distance runners. Biosci Biotechnol Biochem 2008, 72(4):931-935. DOI: 10.1271/bbb.70383.
24. Komine Y., Kuroishi T., Kobayashi J., Aso H., Obara Y., Kumagai K., Sugawara S., Komine K. Inflammatory effect of cleaved bovine lactoferrin by elastase on staphylococcal mastitis. J Vet Med Sci 2006, 68(7):715-723. DOI:10.1292/jvms.68.715.
25. Kruzel M.L., Harari Y., Mailman D., Actor J.K., Zimecki M. Differential effects of prophylactic, concurrent and therapeutic lactoferrin treatment on LPS-induced inflammatory responses in mice. Clin Exp Immunol 2002, 130(1):25-31. DOI: 10.1046/j.1365-2249.2002.01956.x.
26. Kruzel M.L., Actor J.K., Boldogh I., Zimecki M. Lactoferrin in health and disease. Postepy Hig Med Dosw 2007, 61:261-267.
27. Kuhara T., Iigo M., Itoh T., Ushida Y., Sekine K., Terada N., Okamura H., Tsuda H. Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr Cancer 2000, 38(2):192-199.
28. Kuwata H., Yamauchi K., Teraguchi S., Ushida Y., Shimokawa Y., Toida T., Hayasawa H. Functional fragments of ingested lactoferrin are resistant to proteolytic degradation in the gastrointestinal tract of adult rats. J Nutr 2001, 131(8):2121-2127.
29. Lacasse P., Lauzon K., Diarra M.S., Petitclerc D. Utilization of lactoferrin to fight antibiotic-resistant mammary gland pathogens. J Anim Sci 2008, 86(13):66-71. DOI:10.2527/jas.2007-0216.
30. Law B., Reiter B. The isolation and bacteriostatic properties oflactoferrin from bovine milk whey. J Dairy Res 1977, 44:561-595.
31. Leitch E.C., Willcox M.D. Synergic antistaphylococcal properties of lactoferrin and lysozyme. J Med Microbiol 1998, 47(9):837-842.
32. Longhi C., Conte M.P., Ranaldi S., Penta M., Valenti P., Tinari A., Superti F., Seganti L. Apoptotic death of Listeria monocytogenes-infected human macrophages induced by lactoferricin B, a bovine lactoferrin-derived peptide. Int J Immunopathol Pharmacol 2005, 18(2):317-325.
33. Lönnerdal B., Iyer S. Lactoferrin: A general review. Haematologica 1995, 80:252-267.
34. Lönnerdal B., Bryant A. Absorption of iron from recombinant human lactoferrin in young US women. Am J Clin Nutr 2006, 83(2):305-309.
35. Lyons T.E., Miller M.S., Serena T., Sheehan P., Lavery L., Kirsner R.S., Armstrong D.G., Reese A., Yankee E.W., Veves A. Talactoferrin alfa, a recombinant human lactoferrin promotes healing of diabetic neuropathic ulcers: A phase 1/2 clinical study. Am J Surg 2007, 193(1):49-54. DOI:10.1016/j.amjsurg.2006.07.010.
36. Mader J.S., Salsman J., Conrad D.M., Hoskin D.W. Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines. Mol Cancer Ther 2005, 4(4):612-624.
37. Makino Y., Nishimura S. High-performance liquid chromatographic separation of human apolactoferrin and monoferric and diferric lactoferrins. J Chromatogr 1992, 579(2):346-349.
38. Masci J.R. Complete response of severe, refractory oral candidiasis to mouthwash containing lactoferrin and lysozyme. AIDS 2000, 14(15):2403-2404. DOI: 00000478-199706000-00008.
39. Mohan K.V., Letchoumy P.V., Hara Y., Nagini S. Combination chemoprevention of hamster buccal pouch carcinogenesis by bovine milk lactoferrin and black tea polyphenols. Cancer Invest 2008, 26(2):193-201. DOI: 10.1080/07357900701511961.
40. Mulvihill D.M., Ennis M.P., Fox P.F., Mcsweeney P.L.H. Adv Dairy Chem Proteins. Functional milk proteins: Production and utilization 2003, Kluwer Academic/Plenum Publishers, New York, 1175-228.
41. Norrby K., Mattsby-Baltzer I., Innocenti M., Tuneberg S. Orally administered bovine lactoferrin systemically inhibits VEGF(165)-mediated angiogenesis in the rat. Int J Cancer 2001, 91(2):236-240. DOI: 10.1002/1097-0215(200002)9999:9999 ,::AID-IJC1024. 3.0.CO;2-T.
42. Ochoa T.J., Noguera-Obenza M., Ebel F., Guzman C.A., Gomez H.F., Cleary T.G. Lactoferrin impairs Type III secretory system function in enteropathogenic Escherichia coli. Infect Immun 2003, 71(9):5149-5155. DOI: 10.1128/IAI.71.9.5149-5155.2003.
43. Ochoa T.J., Clearly T.G. Lactoferrin disruption of bacterial Type III secretion systems. Biometals 2004, 17(3):257-260. DOI: 10.1023/B:BIOM.0000027701.12965.d4.
44. Ochoa T.J., Chea-Woo E., Campos M., Pecho I., Prada A., Mcmahon R.J., Cleary T.G. Impact of lactoferrin supplementation on growth and prevalence of Giardia colonization in children. Clin Infect Dis 2008, 46(12):1881-1883. DOI: 10.1086/588476.
45. Paesano R., Torcia F., Berlutti F., Pacifici E., Ebano V., Moscarini M., Valenti P. Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women. Biochem Cell Biol 2006, 84(3):377-380. DOI: 10.1139/O06-040.
46. Pan Y., Lee A., Wan J., Coventry M.J., Michalski W.P., Shiell B., Roginski H. Antiviral properties of milk proteins and peptides. Int Dairy J 2006, 16(11):1252-1261.
47. Petitclerc D., Lauzon K., Cochu A., Ster C., Diarra M.S., Lacasse P. Efficacy of a lactoferrin-penicillin combination to treat {beta}-lactam-resistant Staphylococcus aureus mastitis. J Dairy Sci 2007, 90(6):2778-2787. DOI:10.3168/jds.2006-598.
48. Plaut A.G., Qiu J., St Geme J.W. Human lactoferrin proteolytic activity: Analysis of the cleaved region in the IgA protease of Haemophilus influenzae. Vaccine 2000, 19(1):S148-S152. DOI:10.1016/S0264-410X(00)00296-6.
49. Roberts A.K., Chierici R., Sawatzki G., Hill M.J., Volpato S., Vigi V. Supplementation of an adapted formula with bovine lactoferrin: 1. Effect on the infant faecal flora. Acta Paediatr 1992, 81(2):119-124.
50. Samuelsen Ø, Haukland H.H., Ulvatne H., Vorland L.H. Anti-complement effects of lactoferrin-derived peptides. FEMS Immunol Med Microbiol 2004, 41(2):141-148. DOI: 10.1016/j.femsim.2004.02.006.
51. Samuelsen Ø, Haukland H.H., Jenssen H., Krämer M., Sandvik K., Ulvatne H., Vorland L.H. Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus. FEBS Lett 2005, 579(16):3421-3426. DOI: 10.1016/j.febslet.2005.05.017.
52. Shimamura M., Yamamoto Y., Ashino H., Oikawa T., Hazato T., Tsuda H., Iigo M. Bovine lactoferrin inhibits tumor-induced angiogenesis. Int J Cancer 2004, 111(1):111-116. DOI: 10.1002/ijc.20187.
53. Shin K., Wakabayashi H., Yamauchi K., Teraguchi S., Tamura Y., Kurokawa M., Shiraki K. Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice. J Med Microbiol 2005, 54(8):717-723. DOI: 10.1099/jmm.0.46018-0.
54. Singh P.K., Parsek M.R., Greenberg E.P., Welsh M.J. A component of innate immunity prevents bacterial biofilm development. Nature 2002, 417(6888):552-555.
55. Spadaro M., Caorsi C., Ceruti P., Varadhachary A., Forni G., Pericle F., Giovarelli M. Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells. FASEB J 2008, 22(8):2747-2757.
56. Suzuki Y.A., Lopez V., Lönnerdal B. Mammalian lactoferrin receptors: Structure and function. Cell Mol Life Sci 2005, 62(22):2560-2575. DOI: 10.1007/s00018-005-5371-1.
57. Tamano S., Sekine K., Takase M., Yamauchi K., Iigo M., Tsuda H. Lack of Chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats. Asian Pac J Cancer Prev 2008, 9(2):313-316.
58. Tamura Y. Production and application of bovine lactoferrin. IDF Bulletin 2004, 389:64-68.
59. Taylor S., Brock J., Kruger C., Berner T., Murphy M. Safety determination for the use of bovine milk-derived lactoferrin as a component of an antimicrobial beef carcass spray. Regul Toxicol Pharmacol 2004, 39(1):12-24. DOI: 10.1016/j.yrtph.2003.10.001.
60. Teng C.T. Lactoferrin gene expression and regulation: An overview. Biochem Cell Biol 2002, 80(1):7-16.
61. Tomita M., Wakabayashi H., Yamauchi K., Teraguchi S., Hayasawa H. Bovine lactoferrin and lactoferricin derived from milk: Production and applications. Biochem Cell Biol 2002, 80(1):109-112.
62. Tomita M., Wakabayashi H., Shin K., Yamauchi K., Yaeshima T., Iwatsuki K. Twenty-five years of research on bovine lactoferrin appications. Biochimie 2008, Epub ahead. DOI: 10.1016/j.biochi.2008.05.021.
63. Tsuji S., Hirata Y., Matsuoka K. Two apparent molecular forms of bovine lactoferrin. J Dairy Sci 1989, 72(5):1130-1136.
64. Uchida T., Sato K., Kawasaki Y., Dosako S. Separation of lactoperoxidase, secretory component and lactoferrin from milk or whey with a cation exchange resin 1996, US Patent No 5,516,675.
65. Ueta E., Tanida T., Osaki T. A novel bovine lactoferrin peptide, FKCRRWQWRM, suppresses Candida cell growth and activates neutrophils. J Pept Res 2001, 57(3):240-249. DOI: 10.1111/j.1399-3011.2001.00821.
66. Ulvatne H., Haukland H.H., Olsvik O., Vorland L.H. Lactoferricin B causes depolarization of the cytoplasmic membrane of Escherichia coli ATCC 25922 and fusion of negatively charged liposomes. FEBS Lett 2001, 492(1-2):62-65. DOI: 10.1016/S0014-5793(01)02233-5.
67. Ulvatne H., Haukland H.H., Samuelsen Ø, Krämer M., Vorland L.H. Proteases in Escherichia coli and Staphylococcus aureus confer reduced susceptibility to lactoferricin B. J Antimicrob Chemother 2002, 50(4):461-467.
68. Ulvatne H., Samuelsen Ø, Haukland H.H., Krämer M., Vorland L.H. Lactoferricin B inhibits bacterial macromolecular synthesis in Escherichia coli and Bacillus subtilis. FEMS Microbiol Lett 2004, 237(2):377-384. DOI: 10.1016/j.femsle.2004.07.001.
69. Ushida Y., Sekine K., Kuhara T., Takasuka N., Iigo M., Maeda M., Tsuda H. Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat. Jpn J Cancer Res 1999, 90(3):262-267.
70. Valenti P., Greco R., Pitari G., Rossi P., Ajello M., Melino G., Antonini G. Apoptosis of Caco-2 intestinal cells invaded by Listeria monocytogenes: Protective effect of lactoferrin. Exp Cell Res 1999, 250(1):197-202. DOI: 10.1006/excr.1999.4500.
71. Valenti P., Antonini G. Lactoferrin: An important host defence against microbial and viral attack. Cell Mol Life Sci 2005, 62(22):2576-2587. DOI: 10.1007/s00018-005-5372-0.
72. Venkatesh M.P., Rong L. Human recombinant lactoferrin acts synergistically with antimicrobials commonly used in neonatal practice against coagulase-negative staphylococci and Candida albicans causing neonatal sepsis. J Med Microbiol 2008, 57(Pt 9):1113-1121.
73. Viejo-Díaz M., Andrés M.T., Fierro J.F. Modulation of in vitro fungicidal activity of human lactoferrin against Candida albicans by extracellular cation concentration and target cell metabolic activity. Antimicrob Agents Chemother 2004, 48(4):1242-1248. DOI: 10.1128/AAC.48.4.1242-1248.2004.
74. Wakabayashi H., Takase M., Tomita M. Lactoferricin derived from milk protein lactoferrin. Curr Pharm Des 2003, 9(16):1277-1287.
75. Wakabayashi H., Kuwata H., Yamauchi K., Teraguchi S., Tamura Y. No detectable transfer of dietary lactoferrin or its functional fragments to portal blood in healthy adult rats. Biosci Biotechnol Biochem 2004, 68(4):853-860. DOI:10.1271/bbb.68.853.
76. Wakabayashi H., Yamauchi K., Takase M. Lactoferrin research, technology and applications. Int Dairy J 2006, 16:1241-1251.
77. Weinberg E.D. The therapeutic potential of lactoferrin. Expert Opin Investig Drugs 2003, 12(5):841-851. DOI: 10.1517/13543784.12.5.841.
78. Weinberg E.D. Antibiotic properties and applications of lactoferrin. Curr Pharm Des 2007, 13(8):801-811.
79. Yamauchi K., Hiruma M., Yamazaki N., Wakabayashi H., Kuwata H., Teraguchi S., Hayasawa H., Suegara N., Yamaguchi H. Oral administration of bovine lactoferrin for treatment of tinea pedis. A placebo-controlled, double-blind study. Mycoses 2000, 43(5):197-202. DOI: 10.1046/j.1439-0507.2000.00571.x.
80. Yamauchi K., Toida T., Nishimura S., Nagano E., Kusuoka O., Teraguchi S., Hayasawa H., Shimamura S., Tomita M. 13-Week oral repeated administration toxicity study of bovine lactoferrin in rats. Food Chem Toxicol 2000, 38(6):503-512. DOI: 10.1016/S0278-6915(00)00036-3.
81. Yoo Y.C., Watanabe R., Koike Y., Mitobe M., Shimazaki K., Watanabe S., Azuma I. Apoptosis in human leukemic cells induced by lactoferricin, a bovine milk protein-derived peptide: Involvement of reactive oxygen species. Biochem Biophys Res Commun 1997, 237(3):624-628. DOI:10.1006/bbrc.1997.7199.
82. Zhang N.T., Nakano T., Ozimek L. Isolation of lactoferrin from bovine colostrum by SP-Sepharose cation-exchange chromatography. Milchwissenschaft 2002, 57:614-617.
83. Zimecki M., Spiegel K., Właszczyk A., Kübler A., Kruzel M.L. Lactoferrin increases the output of neutrophil precursors and attenuates the spontaneous production of TNF-alpha and IL-6 by peripheral blood cells. Arch Immunol Ther Exp (Warsz) 1999, 47(2):113-118.
84. Zimecki M., Kruzel M.L. Milk-derived proteins and peptides of potential therapeutic and nutritive value. J Exp Ther Oncol 2007, 6(2):89-106.