Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat

Japanese Journal of Cancer Research

Volumn 90, Issue 3, 1999, Pages 262-267

  Ushida, Yoshihiko ^a   Sekine, Kazunori ^a   Kuhara, Tetsuya ^a   Takasuka, Nobuo ^a   Iigo, Masaaki ^a   Maeda, Mitsuaki ^a   Tsuda, Hiroyuki ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Bovine lactoferrin; Chemoprevention; Esophagus; Lung; Rat

Indexed keywords

BIS(2 HYDROXYPROPYL)NITROSAMINE; DIETHYLNITROSAMINE; LACTOFERRIN; N BENZYL N METHYLNITROSAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INCIDENCE; CATTLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ESOPHAGUS CANCER; HISTOPATHOLOGY; LUNG ADENOMA; LUNG CARCINOGENESIS; LUNG CARCINOMA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PAPILLOMA; PRIORITY JOURNAL; RAT; TUMOR VOLUME;

EID: 0032913302     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1999.tb00742.x     Document Type: Article

References (21)

1. Levay, P. F. and Viljoen, M. Lactoferrin: a general review. Haematologica, 80, 252-267 (1995).
2. Lonnerdal, B. and Iyer, S. Lactoferrin: molecular structure and biological function. Annu. Rev. Nutr., 15, 93-110 (1995).
3. Lu, L., Hangoc, G., Oliff, A., Chen, L. T., Shen, R. N. and Broxmeyer, H. E. Protective influence of lactoferrin on mice infected with the polycythemia-inducing strain of Friend virus complex. Cancer Res., 47, 4184-4188 (1987).
4. Ikeda, M., Sugiyama, K., Tanaka, T., Tanaka, K., Sekihara, H., Shimotohno, K. and Kato, N. Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes. Biochem. Biophys. Res. Commun., 245, 549-553 (1998).
5. Nishiya, K. and Horwitz, D. A. Contrasting effects of lactoferrin on human lymphocyte and monocyte natural killer activity and antibody-dependent cell-mediated cytotoxicity. J. Immunol., 129, 2519-2523 (1982).
6. Shau, H., Kim, A. and Golub, S. H. Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin. J. Leukoc. Biol., 51, 343-349 (1992).
7. McCormick, J. A., Markey, G. M. and Morris, T. C. Lactoferrin-inducible monocyte cytotoxicity for K562 cells and decay of natural killer lymphocyte cytotoxicity. Clin. Exp. Immunol., 83, 154-156 (1991).
8. Damiens, E., Mazurier, J., el Yazidi, I., Masson, M., Duthille, I., Spik, G. and Boilly-Marer, Y. Effects of human lactoferrin on NK cell cytotoxicity against haematopoietic and epithelial tumour cells. Biochim, Biophys. Acta, 1402, 277-287 (1998).
9. Sekine, K., Ushida, Y., Kuhara, T., Iigo, M., Baba-Toriyama, H., Moore, M. A., Murakoshi, M., Satomi, Y., Nishino, H., Kakizoe, T. and Tsuda, H. Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane. Cancer Lett., 121, 211-216 (1997).
10. Sekine, K., Watanabe, E., Nakamura, J., Takasuka, N., Kim, D. J., Asamoto, M., Krutovskikh, V., Baba-Toriyama, H., Ota, T., Moore, M. A., Masuda, M., Sugimoto, H., Nishino, H., Kakizoe, T. and Tsuda, H. Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats. Jpn. J. Cancer Res., 88, 523-526 (1997).
11. Bezault, J., Bhimani, R., Wiprovnick, J. and Furmanski, P. Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Cancer Res., 54, 2310-2312 (1994).
12. Sandler, R. S. Aspirin and other nonsteroidal anti-inflammatory agents in the prevention of colorectal cancer. Important Adv. Oncol., 123-137 (1996).
13. Murasaki, G., Zenser, T. V., Davis, B. B. and Cohen, S. M. Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder carcinogenesis and enhancement of forestomach carcinogenesis. Carcinogenesis, 5, 53-55 (1984).
14. Hirose, M., Shirai, T., Takahashi, S., Ogawa, K. and Ito, N. Organ-specific modification of carcinogenesis by antioxidants in rats. Basic Life Sci., 61, 181-188 (1993).
15. Kim, D. J., Takasuka, N., Kim, J. M., Sekine, K., Ota, T., Asamoto, M., Murakoshi, M., Nishino, H., Nir, Z. and Tsuda, H. Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH. Cancer Lett., 120, 15-22 (1997).
16. Kitano, M., Takada, N., Chen, T., Ito, H., Nomura, T., Tsuda, H., Wild, C. P. and Fukushima, S. Carcinogenicity of methylurea or morpholine in combination with sodium nitrite in a rat multi-organ carcinogenesis bioassay. Jpn. J. Cancer Res., 88, 797-806 (1997).
17. Hagiwara, A., Tanaka, H., Imaida, K., Tamano, S., Fukushima, S. and Ito, N. Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats. Jpn. J. Cancer Res., 84, 237-245 (1993).
18. Ito, N., Hasegawa, R., Imaida, K., Hirose, M. and Shirai, T. Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp. Toxicol. Pathol., 48, 113-119 (1996).
19. Law, B. A. and Reiter, B. The isolation and bacteriostatic properties of lactoferrin from bovine milk whey. J. Dairy Res., 44, 595-599 (1977).
20. Min mouse. Cancer Lett., 134, 141-145 (1998).
21. Kelloff, G. J., Johnson, J. R., Crowell, J. A., Boone, C. W., DeGeorge, J. J., Steele, V. E., Mehta, M. U., Temeck, J. W., Schmidt, W. J. and Burke, G. Approaches to the development and marketing approval of drugs that prevent cancer. Cancer Epidemiol. Biomarkers Prev., 4, 1-10 (1995).