13-Week oral repeated administration toxicity study of bovine lactoferrin in rats

Food and Chemical Toxicology

Volumn 38, Issue 6, 2000, Pages 503-512

  Yamauchi, K ^a   Toida, T ^a   Nishimura, S ^b   Nagano, E ^b   Kusuoka, O ^b   Teraguchi, S ^a   Hayasawa, H ^a   Shimamura, S ^a   Tomita, M ^a  

^a MORINAGA MILK INDUSTRY CO LTD   (Japan)

^b BoZo Research Center Inc   (Japan)

Author keywords

Bovine lactoferrin; Oral administration; Rats; Repeated dose toxicity study

Indexed keywords

LACTOFERRIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FOOD INTAKE; FOOD SAFETY; MALE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFECTIVE AGENTS; BODY WEIGHT; CATTLE; EATING; FEMALE; LACTOFERRIN; MALE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; BOVINAE;

EID: 0034028209     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(00)00036-3     Document Type: Article

References (15)

1. Altman P. L. (1985) Hematopoietic and lymphopoietic systems. In Pathology of Laboratory Mice and Rats, ed. Biology Databook Editorial Board, pp. 264-298. Pergamon Infoline, VA.
2. Bennett R.M., Kokocinski T. Lactoferrin turnover in man. Clinical Science. 57:1979;453-460.
3. 1 hybrids: Carcinogenic effect of total-body x-irradiation. Proceedings of the National Academy of Sciences of the U.S.A. 76:1979;5910-5918.
4. Hutchens T.W., Henry J.F., Yip T.T., Hachey D.L., Schanler R.J., Motil K.J., Garza C. Origin of intact lactoferrin and its DNA-binding fragments found in the urine of human milk-fed preterm infants. Evaluation by stable isotopic enrichment. Pediatric Research. 29:1991;243-250.
5. Iigo M., Kuhara T., Ushida Y., Sekine K., Moore M.A., Tsuda H. Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice. Clinical Experimental Metastasis. 17:1999;35-40.
6. Kakuta I. Reduction of stress response in carp, Cryprinus carpio L, held under deteriorating environmental conditions, by oral administration of bovine lactoferrin. Journal of Fish Diseases. 21:1998;161-167.
7. Kurose I., Yamada T., Wolf R., Granger D.N. P-selectin-dependent leukocyte recruitment and intestinal mucosal injury induced by lactoferrin. Journal of Leukocyte Biology. 55:1994;771-777.
8. Levay P.F., Viljoen M. Lactoferrin: a general review. Haematologica. 80:1995;252-267.
9. Lönnerdal B., Iyer S. Lactoferrin: molecular structure and biological function. Annual Review of Nutrition. 15:1995;93-110.
10. Nagasawa T., Kiyosawa I., Kuwahara K. Amounts of lactoferrin in human colostrum and milk. Journal of Dairy Science. 55:1972;1651-1659.
11. Sato R., Inanami O., Tanaka Y., Takase M., Naito Y. Oral administration of bovine lactoferrin for treatment of intractable stomatitis in feline immunodeficiency virus (FIV)-positive and FIV-negative cats. American Journal of Veterinary Research. 57:1996;1443-1446.
12. Sekine K., Watanabe E., Nakamura J., Takasuka N., Joong D.K., Asamoto M., Krutovskikh V., Baba-Toriyama H., Ota T., Moore M.A., Masuda M., Sugimoto H., Nishino H., Kakizoe T., Tsuda H. Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats. Japan Journal of Cancer Research. 88:1997;523-526.
13. Shimazaki K., Yoshimoto Y. Distribution of bovine lactoferin in curd and whey. Japan Journal of Dairy Food Science. 37:1988;A106-A108. (in Japanese).
14. Suzuki T., Nonaka M., Kiyosawa I., Ogasa K. Lactoferrin contents in bovine colostrum and milk. Eiyou to Syokuryou. 30:1977;317-322. (in Japanese).
15. Tanaka K., Ikeda M., Nozaki A., Kato N., Tsuda H., Saito S., Sekihara H. Lactoferrin inhibits hepatitis C Virus Viremia in patients with chronic hepatitis C: A pilot study. Japan Journal of Cancer Research. 90:1999;367-371.