28-Day repeated dose oral toxicity of recombinant human apo-lactoferrin or recombinant human lysozyme in rats

Regulatory Toxicology and Pharmacology

Volumn 51, Issue 2, 2008, Pages 162-167

  Cerven, D ^a   DeGeorge, G ^a   Bethell, D ^b  

^a MB Research Laboratories   (United States)

^b Clinical Development   (United States)

Author keywords

Apo lactoferrin; Lysozyme; Oral toxicity rat; Recombinant human lactoferrin; Recombinant human lysozyme; Short term toxicity

Indexed keywords

RECOMBINANT LACTOFERRIN; RECOMBINANT LYSOZYME; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD ANALYSIS; CLINICAL CHEMISTRY; CONTROLLED STUDY; DEATH; DRUG MEGADOSE; FEMALE; FOOD INTAKE; FOOD SAFETY; HEMATOLOGY; HISTOPATHOLOGY; LOW DRUG DOSE; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; RICE; TOXICOLOGY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; APOPROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EATING; FEMALE; HUMANS; LACTOFERRIN; MALE; MURAMIDASE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORYZA SATIVA; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; TOXICITY TESTS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 44649198352     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.03.007     Document Type: Article

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