Thermodynamic compensation upon binding to exosite 1 and the active site of thrombin

Biochemistry

Volumn 50, Issue 21, 2011, Pages 4590-4596

  Treuheit, Nicholas A ^a   Beach, Muneera A ^a   Komives, Elizabeth A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; APTAMERS; AS-LIGANDS; BACKBONE DYNAMICS; BINDING SIGNATURES; BINDING THERMODYNAMICS; CHLOROMETHYL; CONFORMATIONAL CHANGE; ENTHALPY-ENTROPY COMPENSATION; ENTROPY COST; EXPERIMENTAL EVIDENCE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; LIGAND COMPLEXES; NONCOVALENT BINDING; PREPARATION METHOD; REDUCED DYNAMICS; REGULATORY PROTEIN; THERMODYNAMIC COUPLING; THROMBOMODULIN;

AMIDES; AMINO ACIDS; BINDING ENERGY; COMPLEXATION; ENTHALPY; ENTROPY; GLYCOPROTEINS; KETONES; THERMODYNAMICS;

LIGANDS;

AMIDE; DANSYL L ARGININE(3 METHYL 1,5 PANTANEDIYL)AMIDE; PEPTIDE APTAMER; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; ENTHALPY; ENTROPY; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; THERMODYNAMICS;

ANIMALS; APTAMERS, NUCLEOTIDE; CALCIUM; CALORIMETRY, DIFFERENTIAL SCANNING; CATALYTIC DOMAIN; CATTLE; MODELS, MOLECULAR; PROTEIN BINDING; THERMODYNAMICS; THROMBIN;

EID: 79958131993     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2004069     Document Type: Article

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