Amide H/2H exchange reveals a mechanism of thrombin activation

Biochemistry

Volumn 45, Issue 25, 2006, Pages 7724-7732

  Koeppe, Julia R ^a   Komives, Elizabeth A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTAL STRUCTURE; SODIUM; SUBSTRATES;

ACTIVE SITE CONFORMATIONS; BLOOD CLOTTING CASCADE; PROTHROMBIN; THROMBIN ACTIVATION;

ENZYMES;

AMINO ACID; ARGININE; ENZYME PRECURSOR; ISOLEUCINE; MEIZOTHROMBIN; PRETHROMBIN 2; PROTHROMBIN; SODIUM; THROMBIN; UNCLASSIFIED DRUG; AMIDE; PHOSPHINE DERIVATIVE; TRIS(2 CARBOXYETHYL)PHOSPHINE; TRIS(2-CARBOXYETHYL)PHOSPHINE;

ARTICLE; BLOOD CLOTTING; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CATTLE; CHEMISTRY; DEUTERIUM HYDROGEN EXCHANGE; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT;

AMIDES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATTLE; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHINES; PROTEIN CONFORMATION; PROTHROMBIN; SEQUENCE ALIGNMENT; THROMBIN;

EID: 33746921279     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060405h     Document Type: Article

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